- |||||||||| Alfenta (alfentanil) / Abbott, Sufenta (sufentanil) / Akorn
Enrollment open, Phase classification, Trial primary completion date: Standardised Drug Provocation Testing in Perioperative Hypersensitivity (clinicaltrials.gov) - May 15, 2024 P=N/A, N=50, Recruiting, A loading dose of 0.300 Not yet recruiting --> Recruiting | Phase classification: P4 --> PN/A | Trial primary completion date: Oct 2024 --> Oct 2025
- |||||||||| Alfenta (alfentanil) / Abbott, ByFavo (remimazolam) / PAION, Cosmo Pharma, Mundipharma, Pharmascience, Eagle Pharma
Journal: Effectiveness and safety of remimazolam combined with alfentanil in hysteroscopic examination: A prospective, randomized, single-blind trial. (Pubmed Central) - Apr 16, 2024 In hysteroscopy, the sedative effect of remimazolam is like that of propofol, with 0.25?mg/kg remimazolam showing better safety and efficacy, and less impact on the respiratory and circulatory systems. Additionally, under the influence of alfentanil, the ED50 of remimazolam in hysteroscopy is 0.244?mg/kg, with no severe adverse reactions observed.
- |||||||||| ByFavo (remimazolam) / PAION, Cosmo Pharma, Mundipharma, Pharmascience, Eagle Pharma
Clinical, Journal: Bolus administration of remimazolam was superior to midazolam for deep sedation in elderly patients undergoing diagnostic bronchoscopy: A randomized, double-blind, controlled trial. (Pubmed Central) - Mar 26, 2024 Additionally, under the influence of alfentanil, the ED50 of remimazolam in hysteroscopy is 0.244?mg/kg, with no severe adverse reactions observed. Bolus administration of remimazolam offers advantages over midazolam for deep sedation in elderly patients undergoing DFB, in terms of a higher success rate of sedation and a lower incidence of extra sleep within 6 hours after procedure, though the safety profiles of both groups were favorable.
- |||||||||| Alfenta (alfentanil) / Abbott
Premedication for Neonatal Rapid Sequence Intubation: A Network Meta-analysis (Convention Center Exhibit Hall) - Mar 16, 2024 - Abstract #PAS2024PAS_4512; Twenty-three RCTs enrolled 931 neonates (Figure 1). Pooled analysis identified that premedication with SAO+SH probably results in improved intubation success (network RR 2.54 [vs. placebo], 95% CI 1.02, 6.29; median rank 1, 95% CI 1-3; very low-certainty; Figure 2).
- |||||||||| ByFavo (remimazolam) / PAION, Cosmo Pharma, Mundipharma, Pharmascience, Eagle Pharma
Clinical, Surgery: Clinical Study of Flumazenil Antagonizing Remimazolam on Nausea and Vomiting After Gynecologic Day Surgery. (Pubmed Central) - Mar 15, 2024 Dexamethasone 5 mg, flurbiprofen axetil 50 mg, and droperidol 1 mg were given intravenously before induction of anesthesia in both groups...After the patient fell asleep, mivacurium chloride 0.2mg / kg was injected for 30 seconds and alfentanil 20ug / kg was injected for 30 seconds...The incidence of PONV in the PACU was 5.6% in group F and 8.6% in group C. The difference was not statistically significant (p > 0.05). Flumazenil antagonism of remimazolam increases the incidence of PONV within 24 hours in gynecologic day surgery patients and has no significant effect on the incidence of PONV in the PACU.
- |||||||||| ByFavo (remimazolam) / PAION, Cosmo Pharma, Mundipharma, Pharmascience, Eagle Pharma
Journal, Adverse events: Remimazolam Pilot for Office-Based Dental Sedation: Adverse Events, Awareness and Outcomes. (Pubmed Central) - Dec 9, 2023 These findings suggest that in a limited cohort, the remimazolam-alfentanil regimen appears to be well tolerated and effective for office-based dental procedures in adult patients, with a low risk of adverse events, acceptable hemodynamic effects, rapid onset and recovery and minimal intraoperative awareness. This study provides valuable insights into the potential use of the remimazolam-alfentanil combination in dental sedation practice.
- |||||||||| ByFavo (remimazolam) / PAION, Cosmo Pharma, Mundipharma, Pharmascience, Eagle Pharma
Clinical, Journal: Comparative analysis of the effect of electromyogram to bispectral index and 95% spectral edge frequency under remimazolam and propofol anesthesia: a prospective, randomized, controlled clinical trial. (Pubmed Central) - Aug 23, 2023 However, EMG can hardly affect the accuracy of BIS under propofol anesthesia due to low EMG intensity and a weak negative correlation between EMG and BIS. Moreover, SEF95 may have a great application prospect in predicting the sedation condition of remimazolam.
- |||||||||| Alfenta (alfentanil) / Abbott
Journal: Patient-Controlled Sedation in Port Implantation (PACSPI 1) - A feasibility trial. (Pubmed Central) - Aug 17, 2023 P=N/A Ultimately the efficacy of patient-controlled sedation with propofol and alfentanil needs to be evaluated in an RCT to provide clinicians with evidence-based guidance for choosing the optimal perioperative strategy for subcutaneous venous port implantation. NCT04631393.
- |||||||||| Alfenta (alfentanil) / Abbott, ByFavo (remimazolam) / PAION, Cosmo Pharma, Mundipharma, Pharmascience, Eagle Pharma
Clinical, Journal: Effectiveness of remimazolam besylate combined with alfentanil for fiberoptic bronchoscopy with preserved spontaneous breathing: a prospective, randomized, controlled clinical trial. (Pubmed Central) - Jul 21, 2023 Due to the limited quality and quantity of the included studies, more high-quality studies are needed to validate these above conclusions. Remimazolam besylate combined with alfentanil for painless fiberoptic bronchoscopy can better preserve the patient's spontaneous breathing and reduce the incidence of respiratory depression during the inspection than propofol.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Fentanyl and other New Psychoactive Synthetic Opioids. Challenges to Prevention and Treatment. (Pubmed Central) - Jul 17, 2023 Most NPOs have effects similar to morphine, including euphoria and analgesia, and can produce fatal respiratory depression...We first review the fentanyl group of NPOs, including the four compounds of clinical use (fentanyl, alfentanil, sufentanil, and remifentanil) and the veterinary drug carfentanil...This paper also summarizes the scarce literature on the use of NPOs in Mexico. It concludes with a brief review of the challenges to prevention and treatment posed by NPOs and some recommendations to face them.
- |||||||||| ByFavo (remimazolam) / PAION, Cosmo Pharma, Mundipharma, Pharmascience, Acacia Pharma
Clinical, Adverse events: Cardiopulmonary Adverse Events of Remimazolam versus Propofol During Cervical Conization: A Randomized Controlled Trial. (Pubmed Central) - May 5, 2023 No significant differences were observed in the overall alfentanil dosages administered, bradycardia, bodily movement, or time to losing consciousness between the two groups. In patients who underwent cold knife cervical conization, remimazolam-alfentanil anesthesia was associated with a reduced incidence of intraoperative cardiopulmonary adverse events compared with propofol-alfentanil anesthesia.
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