Alfenta (alfentanil) / Abbott 
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  • ||||||||||  Alfenta (alfentanil) / Abbott, Sufenta (sufentanil) / Akorn
    Enrollment open, Phase classification, Trial primary completion date:  Standardised Drug Provocation Testing in Perioperative Hypersensitivity (clinicaltrials.gov) -  May 15, 2024   
    P=N/A,  N=50, Recruiting, 
    A loading dose of 0.300 Not yet recruiting --> Recruiting | Phase classification: P4 --> PN/A | Trial primary completion date: Oct 2024 --> Oct 2025
  • ||||||||||  Alfenta (alfentanil) / Abbott
    Enrollment open:  REHAB: Is the Rate of Early Mobilisation in Hip Fracture Patients Using Alfentanil Better Than Standard Opioid Analgesia? (clinicaltrials.gov) -  Mar 21, 2024   
    P=N/A,  N=64, Recruiting, 
    Bolus administration of remimazolam offers advantages over midazolam for deep sedation in elderly patients undergoing DFB, in terms of a higher success rate of sedation and a lower incidence of extra sleep within 6 hours after procedure, though the safety profiles of both groups were favorable. Not yet recruiting --> Recruiting
  • ||||||||||  Alfenta (alfentanil) / Abbott
    Premedication for Neonatal Rapid Sequence Intubation: A Network Meta-analysis (Convention Center Exhibit Hall) -  Mar 16, 2024 - Abstract #PAS2024PAS_4512;    
    Twenty-three RCTs enrolled 931 neonates (Figure 1). Pooled analysis identified that premedication with SAO+SH probably results in improved intubation success (network RR 2.54 [vs. placebo], 95% CI 1.02, 6.29; median rank 1, 95% CI 1-3; very low-certainty; Figure 2).
  • ||||||||||  ByFavo (remimazolam) / PAION, Cosmo Pharma, Mundipharma, Pharmascience, Eagle Pharma
    Clinical, Surgery:  Clinical Study of Flumazenil Antagonizing Remimazolam on Nausea and Vomiting After Gynecologic Day Surgery. (Pubmed Central) -  Mar 15, 2024   
    Dexamethasone 5 mg, flurbiprofen axetil 50 mg, and droperidol 1 mg were given intravenously before induction of anesthesia in both groups...After the patient fell asleep, mivacurium chloride 0.2mg / kg was injected for 30 seconds and alfentanil 20ug / kg was injected for 30 seconds...The incidence of PONV in the PACU was 5.6% in group F and 8.6% in group C. The difference was not statistically significant (p > 0.05). Flumazenil antagonism of remimazolam increases the incidence of PONV within 24 hours in gynecologic day surgery patients and has no significant effect on the incidence of PONV in the PACU.
  • ||||||||||  ByFavo (remimazolam) / PAION, Cosmo Pharma, Mundipharma, Pharmascience, Eagle Pharma
    Journal, Adverse events:  Remimazolam Pilot for Office-Based Dental Sedation: Adverse Events, Awareness and Outcomes. (Pubmed Central) -  Dec 9, 2023   
    These findings suggest that in a limited cohort, the remimazolam-alfentanil regimen appears to be well tolerated and effective for office-based dental procedures in adult patients, with a low risk of adverse events, acceptable hemodynamic effects, rapid onset and recovery and minimal intraoperative awareness. This study provides valuable insights into the potential use of the remimazolam-alfentanil combination in dental sedation practice.
  • ||||||||||  Alfenta (alfentanil) / Abbott
    Enrollment change, Trial withdrawal:  Pain Evaluation During Follicle Aspiration: Comparison of Two Sedation Protocols (clinicaltrials.gov) -  Nov 14, 2023   
    P4,  N=0, Withdrawn, 
    This study provides valuable insights into the potential use of the remimazolam-alfentanil combination in dental sedation practice. N=300 --> 0 | Unknown status --> Withdrawn
  • ||||||||||  Alfenta (alfentanil) / Abbott
    Journal:  Patient-Controlled Sedation in Port Implantation (PACSPI 1) - A feasibility trial. (Pubmed Central) -  Aug 17, 2023   
    P=N/A
    Ultimately the efficacy of patient-controlled sedation with propofol and alfentanil needs to be evaluated in an RCT to provide clinicians with evidence-based guidance for choosing the optimal perioperative strategy for subcutaneous venous port implantation. NCT04631393.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Fentanyl and other New Psychoactive Synthetic Opioids. Challenges to Prevention and Treatment. (Pubmed Central) -  Jul 17, 2023   
    Most NPOs have effects similar to morphine, including euphoria and analgesia, and can produce fatal respiratory depression...We first review the fentanyl group of NPOs, including the four compounds of clinical use (fentanyl, alfentanil, sufentanil, and remifentanil) and the veterinary drug carfentanil...This paper also summarizes the scarce literature on the use of NPOs in Mexico. It concludes with a brief review of the challenges to prevention and treatment posed by NPOs and some recommendations to face them.
  • ||||||||||  ByFavo (remimazolam) / PAION, Cosmo Pharma, Mundipharma, Pharmascience, Acacia Pharma
    Clinical, Adverse events:  Cardiopulmonary Adverse Events of Remimazolam versus Propofol During Cervical Conization: A Randomized Controlled Trial. (Pubmed Central) -  May 5, 2023   
    No significant differences were observed in the overall alfentanil dosages administered, bradycardia, bodily movement, or time to losing consciousness between the two groups. In patients who underwent cold knife cervical conization, remimazolam-alfentanil anesthesia was associated with a reduced incidence of intraoperative cardiopulmonary adverse events compared with propofol-alfentanil anesthesia.