- |||||||||| LAG-3 targeted IL15/IL15Rα-Fc therapeutic / Xencor
LAG3-targeted IL15/IL15Rα-Fc (LAG3 x IL15) fusion proteins for preferential TIL expansion via cis delivery of IL15 to LAG3+ cells (Hall C) - Oct 6, 2022 - Abstract #SITC2022SITC_1387;
In NHP, LAG3 x IL15 has superior PK compared to native IL15-Fc and showed selective targeting of LAG3+ peripheral T cells. Conclusions LAG3 x IL15 shows a promising profile of selective delivery to LAG3+ cells with minimal peripheral activity and may help to preferentially expand LAG3+ TIL in patients with cancer, while potentially avoiding systemic toxicity due to off-target activation and expansion of peripheral lymphocytes.
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