lamotrigine liquid oral suspension / OWP Pharma 
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  • ||||||||||  Review, Journal:  Cognitive and behavioral impact of antiseizure medications, neuromodulation, ketogenic diet, and surgery in lennox-gastaut syndrome: A comprehensive review. (Pubmed Central) -  Mar 2, 2025   
    Behavioral outcomes also vary: stability is observed with valproate, lamotrigine, rufinamide, cannabidiol, and fenfluramine, whereas medications like levetiracetam, perampanel, brivaracetam, clobazam, and zonisamide can increase aggression or irritability...Consideration of minimizing ASM polytherapy, careful evaluation of drug-drug interactions, pharmacogenomic implications, and the need for therapeutic drug monitoring in cases of cognitive adverse effects is essential. Future research should focus on developing assessment tools tailored to the unique needs of individuals with LGS, utilizing connectivity measures to assess intervention impacts, and advancing precision therapeutics to improve cognitive and behavioral outcomes.
  • ||||||||||  Review, Journal:  Management of brain tumour related epilepsy (BTRE): a narrative review and therapy recommendations. (Pubmed Central) -  Jan 27, 2025   
    Vagus Nerve Stimulation has been used with partial success. The review highlights the relative dearth of high-quality evidence for the management of BTRE and provides a framework for further studies aiming to improve seizure control, quality of life, and indications for ASMs.KEY POINTSOffer levetiracetam or lamotrigine to all patients with primary or metastatic brain tumours who have seizure(s), irrespective of whether these are partial or generalised.ASM withdrawal for patients in remission is not recommended due to high rates of seizure recurrence.ASM prophylaxis is not generally recommended in the management of seizure-na
  • ||||||||||  Journal:  Promising therapeutic strategies for lennox-gastaut syndrome: what's new? (Pubmed Central) -  Jan 3, 2025   
    Although no major breakthroughs have been reported, several established and novel ASMs, some surgical strategies and other treatment approaches are of benefit or are showing promise. Progress remains incremental but any improvements in the management of this resistant epilepsy syndrome are worthwhile.
  • ||||||||||  lamotrigine liquid oral suspension / OWP Pharma, Fintepla (low-dose fenfluramine) / UCB
    Journal:  Refining management strategies for Lennox-Gastaut syndrome: Updated algorithms and practical approaches. (Pubmed Central) -  Dec 19, 2024   
    If seizure control remains suboptimal, subsequent adjunctive ASM treatment options include (alphabetically) cannabidiol, clobazam, felbamate, fenfluramine, and topiramate, although evidence for these is more limited...Most people with LGS have learning difficulties and need a lot of support, often in residential care. The authors are experts in treating people with LGS and this article provides up-to-date guidance and advice on how best to care for those with the condition.
  • ||||||||||  Fycompa (perampanel) / Eisai, Catalyst Pharma, lamotrigine liquid oral suspension / OWP Pharma
    The Use of Ketogenic Diet During Pregnancy to Treat NORSE (South Hall H - Level 1 - LACC) -  Nov 26, 2024 - Abstract #AES2024AES_2532;    
    KD therapy is one of a paucity of potentially effective treatments for NORSE, but in the setting of pregnancy therapeutic ketosis may not be achievable due to minimum protein requirements. Because other NORSE treatments also have teratogenic potential, a multidisciplinary discussion of the risks and benefits of all treatments, including possible short term protein restriction to maximize KD therapy, should be initiated early with family.
  • ||||||||||  lamotrigine liquid oral suspension / OWP Pharma
    The Epilepsy Spectrum (South Hall H - Level 1 - LACC) -  Nov 26, 2024 - Abstract #AES2024AES_2511;    
    According to earlier ICHD-II criteria for migralepsy, a seizure occurring within 1 hour of a migraine aura applies to PJ's case (1, 2). PJ also experiences a visual aura, a trait seen in migralepsy cases (3).
  • ||||||||||  spironolactone / Generic mfg.
    Seizures Sparked by Spironolactone: A Case Report (South Hall H - Level 1 - LACC) -  Nov 26, 2024 - Abstract #AES2024AES_2440;    
    The effect to which antiandrogen treatments may affect seizure control is not well understood. This case report emphasizes that caution should be exerted when adding oral spironolactone in women with epilepsy as spironolactone holds the potential of negatively affecting seizure control.
  • ||||||||||  lamotrigine liquid oral suspension / OWP Pharma
    Differential Cerebral Cortical Thickness in Juvenile Myoclonic Epilepsy and Epilepsy with Generalized Tonic (South Hall H - Level 1 - LACC) -  Nov 26, 2024 - Abstract #AES2024AES_2098;    
    The thickness variation of the neocortex could be a potential radiologic biomarker for distinguishing JME and GTCA and could provide an explanation of the clinical differences. Limitations are small patient size, not considering left-right dominance, and subcortical and cerebellar structures.
  • ||||||||||  lamotrigine liquid oral suspension / OWP Pharma
    Decoding the Relationship Between Anti-seizure Medication Levels and Neural Excitability (South Hall H - Level 1 - LACC) -  Nov 26, 2024 - Abstract #AES2024AES_2082;    
    The consistent importance of aperiodic features supports the hypothesis that ASMs modulate the E/I balance and EEG background activity. We will expand our dataset to include patients with epilepsy to determine whether these findings generalize across both non-epileptic and epileptic populations to assess how these E/I changes relate to seizure suppression.
  • ||||||||||  Epidiolex (cannabidiol) / Jazz
    Tuberous Sclerosis Complex (TSC) (South Hall H - Level 1 - LACC) -  Nov 26, 2024 - Abstract #AES2024AES_1986;    
    P4
    We will expand our dataset to include patients with epilepsy to determine whether these findings generalize across both non-epileptic and epileptic populations to assess how these E/I changes relate to seizure suppression. A plant-derived, highly purified pharmaceutical formulation of CBD (Epidiolex
  • ||||||||||  Xcopri (cenobamate) / SK Bio
    Is It Forced Normalization or Toxicity Caused by Cenobamate? (South Hall H - Level 1 - LACC) -  Nov 26, 2024 - Abstract #AES2024AES_1758;    
    To our knowledge, this is the first case reported of such a condition with this ASM. However, we cannot totally exclude the possibility that the psychiatric phenomena were the expression of iatrogenic psychiatric symptoms caused by this ASM.
  • ||||||||||  lamotrigine liquid oral suspension / OWP Pharma
    Characterizing the SLC6A1 Phenotypic Spectrum Using a Digital Natural History Database (South Hall H - Level 1 - LACC) -  Nov 26, 2024 - Abstract #AES2024AES_1021;    
    The phenotypic spectrum consisted of generalized epilepsy, autism, developmental delay, intellectual disability and developmental regression, in concordance with previously described clinical features of this disorder. Our findings support the use of de-identified digital data registries for delineating phenotypic spectrum of rare diseases.
  • ||||||||||  carbamazepine / Generic mfg.
    Review, Journal:  Carbamazepine-induced Stevens-Johnson Syndrome: A Case Report with Review of the Literature. (Pubmed Central) -  Nov 7, 2024   
    This report adds to the scientific literature by highlighting the potential dangers associated with anticonvulsant therapies and the necessity for personalized medicine approaches in preventing life-threatening conditions. The main takeaway is the pivotal role of genetic screening and vigilant monitoring in the management of patients requiring anticonvulsant medications to prevent serious adverse reactions.
  • ||||||||||  lamotrigine liquid oral suspension / OWP Pharma
    Journal:  Trigeminal neuralgia and its comorbidities: a nationwide disease trajectory study. (Pubmed Central) -  Oct 4, 2024   
    In the Danish population, a trigeminal neuralgia diagnosis is temporally associated with 27 diseases revealed in systematic disease trajectories. Trigeminal neuralgia itself and its first-line treatment, but not a stroke polygenic risk score, was associated with an increased risk of ischemic stroke indicating that vascular risk factors should be routinely assessed in individuals with trigeminal neuralgia.
  • ||||||||||  lamotrigine liquid oral suspension / OWP Pharma, Belsomra (suvorexant) / Merck (MSD)
    Journal:  Bipolar Disorder in a female with CDKL5 Deficiency Disorder: A Case Report. (Pubmed Central) -  Sep 24, 2024   
    Conclusions : While sleep and behavioral disorders fall within the expected phenotype for CDD, this is the first report of bipolar disorder. Careful attention to patterns of sleep and behavior that may indicate mood cycling in this population is required, particularly in the setting of limited communication and functional abilities.
  • ||||||||||  lamotrigine liquid oral suspension / OWP Pharma
    Planarian model for experimental seizures (MCP Hall A) -  Aug 22, 2024 - Abstract #Neuroscience2024Neuroscience_525;    
    Thereafter, planarians were exposed to pilocarpine and increasing concentrations of lamotrigine to investigate the effects of the anti-seizure medication...Future research would involve conducting histological studies, specifically synaptic analysis, and possibly genetic studies to further assess planarians as a model in experimental epilepsy. This is especially relevant for screening a potential ASM.
  • ||||||||||  lamotrigine liquid oral suspension / OWP Pharma
    Journal:  Overview of acute seizure management in US nursing homes. (Pubmed Central) -  Aug 21, 2024   
    Rescue medications are given regardless of seizure history and often older ASMs are used for long-term management. Our study highlights areas of knowledge deficits and treatment areas for improvement, identifying the need and potential for ASAPs in NHs.
  • ||||||||||  lamotrigine liquid oral suspension / OWP Pharma
    Tacrolimus- a wonder drug in non responsive cases of toxic epidermal necrolysis (Poster Area) -  Aug 5, 2024 - Abstract #EADV2024EADV_2007;    
    There are minimal side effects with the medication and hence it can be considered as a preferred drug in the treatment of TEN. However more studies with increased sample size is needed to further validate the study