lamotrigine liquid oral suspension / OWP Pharma 
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  • ||||||||||  levetiracetam / Generic mfg., lamotrigine liquid oral suspension / OWP Pharma
    Retrospective data, Journal:  A 10-year review of periconceptual folic acid supplementation in women with epilepsy taking antiseizure medications. (Pubmed Central) -  Jul 1, 2025   
    These findings need to be communicated to women with epilepsy in their reproductive years and their doctors. Of 75,869 women delivered over 10 years, 250 (0.33%) were on medications for epilepsy at presentation34.4% of women taking medications did not start high dose folic acid before conception23.6% of women did not start folic acid until after conceptionCompliance with recommendations was lowest in women prescribed valproate or polytherapyNo maternal characteristics were identified which were associated with suboptimal compliance.
  • ||||||||||  lamotrigine liquid oral suspension / OWP Pharma
    Journal:  Clinical signatures of SYNGAP1-related disorders through data integration. (Pubmed Central) -  Jun 24, 2025   
    Of 75,869 women delivered over 10 years, 250 (0.33%) were on medications for epilepsy at presentation34.4% of women taking medications did not start high dose folic acid before conception23.6% of women did not start folic acid until after conceptionCompliance with recommendations was lowest in women prescribed valproate or polytherapyNo maternal characteristics were identified which were associated with suboptimal compliance. We delineated the seizure, developmental, and behavioral trajectories in SYNGAP1-related disorders, to improve diagnosis, prognosis, and clinical care, and facilitating clinical trial readiness.
  • ||||||||||  lamotrigine liquid oral suspension / OWP Pharma
    PK/PD data, Journal:  Pharmacodynamic interactions between seletracetam and antiseizure comedications in the human photosensitivity model. (Pubmed Central) -  Jun 16, 2025   
    Patients comedicated with LEV?+?lamotrigine or LEV?+?valproate exhibited significantly lower AUEC (0-8)s than patients without comedication, whereas no significant effects of lamotrigine or valproate alone were found. Despite the significant reduction of AUEC (0-8) in patients on comedication with LEV, SEL still reduced or abolished PPR in the majority (7/9) of exposures.
  • ||||||||||  lamotrigine liquid oral suspension / OWP Pharma
    Journal:  Varying Lamotrigine Concentrations in Patients Following One Anastomosis Gastric Bypass Surgery: A Case Series. (Pubmed Central) -  May 26, 2025   
    This case series shows the complexity of drug treatment after bariatric surgery. The potentially large variability among patients in the effect of the surgery on the bioavailability of lamotrigine, a highly prescribed, life-saving medication, highlights the special care that must be taken with post-bariatric pharmacotherapy in general, and epilepsy treatment in particular.
  • ||||||||||  lamotrigine liquid oral suspension / OWP Pharma
    Journal:  The clinical features and 18F-FDG-PET analysis of absence status epilepsy. (Pubmed Central) -  May 19, 2025   
    Seventeen cases (17/20) became seizure-free after treatment with valproate (VPA) and lamotrigine (LTG)...Interictal brain PET imaging may reveal relative hypometabolism in posterior regions, along with decreased thalamic area and metabolic activity, potentially indicating the key role of posterior regions in sustaining wakefulness. Most patients responded well to VPA and LTG.
  • ||||||||||  lamotrigine liquid oral suspension / OWP Pharma
    Review, Journal:  Brain dysfunction underlying visual snow syndrome: Insights into therapeutic implications. (Pubmed Central) -  May 18, 2025   
    There has been only sporadic therapeutic success with lamotrigine and cognitive behavioral therapy. Given the complexity of its disease state, multidisciplinary therapeutic approaches appear to be required for more effective symptom management.
  • ||||||||||  lamotrigine liquid oral suspension / OWP Pharma
    Journal:  Autoimmune Encephalitis and Musicogenic Epilepsy: A Case of GAD65 Antibody-Associated Seizure. (Pubmed Central) -  Apr 28, 2025   
    This case contributes to the growing evidence supporting an association between ME and autoimmune mechanisms, particularly GAD65 antibody-mediated autoimmunity. It highlights the importance of screening autoimmune factors in ME patients and highlights the need for further research into targeted treatment strategies.
  • ||||||||||  lamotrigine liquid oral suspension / OWP Pharma
    Review, Journal:  Diagnostic and Management Strategies of Visual Snow Syndrome: Current Perspectives. (Pubmed Central) -  Mar 25, 2025   
    Based on this review of 27 publications, benzodiazepines and lamotrigine had the best effect (71.4% and 61.5% of patients had an improvement of VS symptoms on each medication, respectively)...FL-41 tinted lenses consistently provide symptom relief, with cognitive behavioral therapy showing promise as an emerging intervention. Due to the small sample size, further research is recommended to enhance the applicability of findings.
  • ||||||||||  lamotrigine liquid oral suspension / OWP Pharma
    Journal:  Trigeminal neuralgia and its comorbidities: a nationwide disease trajectory study. (Pubmed Central) -  Mar 18, 2025   
    In the Danish population, a trigeminal neuralgia diagnosis is temporally associated with 27 diseases revealed in systematic disease trajectories. Trigeminal neuralgia itself and its first-line treatment, but not a stroke polygenic risk score, was associated with an increased risk of ischemic stroke indicating that vascular risk factors should be routinely assessed in individuals with trigeminal neuralgia.
  • ||||||||||  Review, Journal:  Cognitive and behavioral impact of antiseizure medications, neuromodulation, ketogenic diet, and surgery in lennox-gastaut syndrome: A comprehensive review. (Pubmed Central) -  Mar 2, 2025   
    Behavioral outcomes also vary: stability is observed with valproate, lamotrigine, rufinamide, cannabidiol, and fenfluramine, whereas medications like levetiracetam, perampanel, brivaracetam, clobazam, and zonisamide can increase aggression or irritability...Consideration of minimizing ASM polytherapy, careful evaluation of drug-drug interactions, pharmacogenomic implications, and the need for therapeutic drug monitoring in cases of cognitive adverse effects is essential. Future research should focus on developing assessment tools tailored to the unique needs of individuals with LGS, utilizing connectivity measures to assess intervention impacts, and advancing precision therapeutics to improve cognitive and behavioral outcomes.
  • ||||||||||  Fycompa (perampanel) / Eisai, Catalyst Pharma, lamotrigine liquid oral suspension / OWP Pharma
    Status Epilepticus in Melas; Will There Ever Be a Solution? (Area J, Hall F (North Building, Exhibition Level), Moscone Center; Poster Board # P1195) -  Feb 24, 2025 - Abstract #ATS2025ATS_4733;    
    Unfortunately, attempts to wean midazolam infusion failed as seizure activity recurred despite the addition of perampanel to her antiepileptic regimen...It is worth wondering whether status epilepticus could have been avoided if her VNS had been active. Unfortunately, given the complexity, mortality remains high with reported mean survival only into the third decade of life.
  • ||||||||||  Review, Journal:  Management of brain tumour related epilepsy (BTRE): a narrative review and therapy recommendations. (Pubmed Central) -  Jan 27, 2025   
    Vagus Nerve Stimulation has been used with partial success. The review highlights the relative dearth of high-quality evidence for the management of BTRE and provides a framework for further studies aiming to improve seizure control, quality of life, and indications for ASMs.KEY POINTSOffer levetiracetam or lamotrigine to all patients with primary or metastatic brain tumours who have seizure(s), irrespective of whether these are partial or generalised.ASM withdrawal for patients in remission is not recommended due to high rates of seizure recurrence.ASM prophylaxis is not generally recommended in the management of seizure-na
  • ||||||||||  Journal:  Promising therapeutic strategies for lennox-gastaut syndrome: what's new? (Pubmed Central) -  Jan 3, 2025   
    Although no major breakthroughs have been reported, several established and novel ASMs, some surgical strategies and other treatment approaches are of benefit or are showing promise. Progress remains incremental but any improvements in the management of this resistant epilepsy syndrome are worthwhile.
  • ||||||||||  lamotrigine liquid oral suspension / OWP Pharma, Fintepla (low-dose fenfluramine) / UCB
    Journal:  Refining management strategies for Lennox-Gastaut syndrome: Updated algorithms and practical approaches. (Pubmed Central) -  Dec 19, 2024   
    If seizure control remains suboptimal, subsequent adjunctive ASM treatment options include (alphabetically) cannabidiol, clobazam, felbamate, fenfluramine, and topiramate, although evidence for these is more limited...Most people with LGS have learning difficulties and need a lot of support, often in residential care. The authors are experts in treating people with LGS and this article provides up-to-date guidance and advice on how best to care for those with the condition.
  • ||||||||||  Fycompa (perampanel) / Eisai, Catalyst Pharma, lamotrigine liquid oral suspension / OWP Pharma
    The Use of Ketogenic Diet During Pregnancy to Treat NORSE (South Hall H - Level 1 - LACC) -  Nov 26, 2024 - Abstract #AES2024AES_2532;    
    KD therapy is one of a paucity of potentially effective treatments for NORSE, but in the setting of pregnancy therapeutic ketosis may not be achievable due to minimum protein requirements. Because other NORSE treatments also have teratogenic potential, a multidisciplinary discussion of the risks and benefits of all treatments, including possible short term protein restriction to maximize KD therapy, should be initiated early with family.
  • ||||||||||  lamotrigine liquid oral suspension / OWP Pharma
    The Epilepsy Spectrum (South Hall H - Level 1 - LACC) -  Nov 26, 2024 - Abstract #AES2024AES_2511;    
    According to earlier ICHD-II criteria for migralepsy, a seizure occurring within 1 hour of a migraine aura applies to PJ's case (1, 2). PJ also experiences a visual aura, a trait seen in migralepsy cases (3).
  • ||||||||||  spironolactone / Generic mfg.
    Seizures Sparked by Spironolactone: A Case Report (South Hall H - Level 1 - LACC) -  Nov 26, 2024 - Abstract #AES2024AES_2440;    
    The effect to which antiandrogen treatments may affect seizure control is not well understood. This case report emphasizes that caution should be exerted when adding oral spironolactone in women with epilepsy as spironolactone holds the potential of negatively affecting seizure control.
  • ||||||||||  lamotrigine liquid oral suspension / OWP Pharma
    Differential Cerebral Cortical Thickness in Juvenile Myoclonic Epilepsy and Epilepsy with Generalized Tonic (South Hall H - Level 1 - LACC) -  Nov 26, 2024 - Abstract #AES2024AES_2098;    
    The thickness variation of the neocortex could be a potential radiologic biomarker for distinguishing JME and GTCA and could provide an explanation of the clinical differences. Limitations are small patient size, not considering left-right dominance, and subcortical and cerebellar structures.
  • ||||||||||  lamotrigine liquid oral suspension / OWP Pharma
    Decoding the Relationship Between Anti-seizure Medication Levels and Neural Excitability (South Hall H - Level 1 - LACC) -  Nov 26, 2024 - Abstract #AES2024AES_2082;    
    The consistent importance of aperiodic features supports the hypothesis that ASMs modulate the E/I balance and EEG background activity. We will expand our dataset to include patients with epilepsy to determine whether these findings generalize across both non-epileptic and epileptic populations to assess how these E/I changes relate to seizure suppression.
  • ||||||||||  Epidiolex (cannabidiol) / Jazz
    Tuberous Sclerosis Complex (TSC) (South Hall H - Level 1 - LACC) -  Nov 26, 2024 - Abstract #AES2024AES_1986;    
    P4
    We will expand our dataset to include patients with epilepsy to determine whether these findings generalize across both non-epileptic and epileptic populations to assess how these E/I changes relate to seizure suppression. A plant-derived, highly purified pharmaceutical formulation of CBD (Epidiolex
  • ||||||||||  Xcopri (cenobamate) / SK Bio
    Is It Forced Normalization or Toxicity Caused by Cenobamate? (South Hall H - Level 1 - LACC) -  Nov 26, 2024 - Abstract #AES2024AES_1758;    
    To our knowledge, this is the first case reported of such a condition with this ASM. However, we cannot totally exclude the possibility that the psychiatric phenomena were the expression of iatrogenic psychiatric symptoms caused by this ASM.
  • ||||||||||  lamotrigine liquid oral suspension / OWP Pharma
    Characterizing the SLC6A1 Phenotypic Spectrum Using a Digital Natural History Database (South Hall H - Level 1 - LACC) -  Nov 26, 2024 - Abstract #AES2024AES_1021;    
    The phenotypic spectrum consisted of generalized epilepsy, autism, developmental delay, intellectual disability and developmental regression, in concordance with previously described clinical features of this disorder. Our findings support the use of de-identified digital data registries for delineating phenotypic spectrum of rare diseases.
  • ||||||||||  carbamazepine / Generic mfg.
    Review, Journal:  Carbamazepine-induced Stevens-Johnson Syndrome: A Case Report with Review of the Literature. (Pubmed Central) -  Nov 7, 2024   
    This report adds to the scientific literature by highlighting the potential dangers associated with anticonvulsant therapies and the necessity for personalized medicine approaches in preventing life-threatening conditions. The main takeaway is the pivotal role of genetic screening and vigilant monitoring in the management of patients requiring anticonvulsant medications to prevent serious adverse reactions.