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Sinoatrial Node Dysfunction in Lithium Toxicity: A Rare Complication () - Mar 13, 2025 - Abstract #NKFSCM2025NKF_SCM_687;
For hemodialysis in lithium toxicity resulting in SND, physicians should consider the severity of symptoms, lithium's narrow therapeutic range, and variation in "toxic dose" due to varying factors such as renal function, volume status, concomitant drug abuse, and chronic lithium usage. Although HD may have been useful, the ultimate decision to transcutaneously pace then transfer the patient for permanent pacemaker placement is consistent with treatment recommendations for heart block and symptomatic SND.
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Novel ALG9 Mutation Unmasked in Cystic Kidney Disease with Lithium Usage History () - Mar 13, 2025 - Abstract #NKFSCM2025NKF_SCM_679;
While it is possible this patient's novel mutation may have resulted in more severe disease, we posit that lithium, which is also associated with damage to the ER, may have been the "second hit" leading to decline in renal function and larger and more numerous cysts. Overall, this case provides further support for the use of genetic testing in atypical presentations of cystic kidney disease.
- |||||||||| Journal: Glycogen synthase kinase-3 (Pubmed Central) - Mar 9, 2025
Possible protection against PC from olanzapine or famotidine is not supported by a period, dose, or duration response and this effect could be due to chance and/or residual confounding. Valproate was possibly associated with a lower risk of PC in epilepsy patients, but a larger analysis would be needed to confirm that this association was not due to chance given the uncertainty in the period, dose, and duration analyses.
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Journal: Ten Years of Bipolar Telehealth: Program Evaluation of a Team-Based Telemental Health Clinic. (Pubmed Central) - Mar 7, 2025
These analyses provide further support for the general effectiveness and safety of telemental health via videoconferencing. Future research should examine the generalizability of these findings across various subgroups (e.g., minority patients, patients in rural areas), populations, and health care systems.
- |||||||||| lithium carbonate ER / Generic mfg., olanzapine / Generic mfg.
Journal: Treatment Patterns for Incident Bipolar Disorder Among Nonrefugee Immigrants, Refugees, Second-Generation Immigrants, and Host Population in Sweden. (Pubmed Central) - Mar 7, 2025
Immigrants, especially refugees, are at risk of not receiving adequate treatment following BD diagnosis, putatively owing to a lack of transcultural competence in healthcare, economic restraints, and community factors. Antidepressant monotherapy should be reduced, while recommended options such as mood stabilizers and specifically lithium should be considered more often.
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Journal: Molecular Insights into Anion-Specific Freezing Point Depression in Lithium Salt Solutions. (Pubmed Central) - Feb 27, 2025
Our results further indicate that rather than the intrinsic structure?disrupting ability of Hofmeister anions, the mobility of water molecules within the ions' hydration shells is a primary determinant of freezing behavior, challenging the conventional view and revealing the critical influence of local water dynamics on solid/liquid transitions. These findings provide molecular-level insights into the ion-specific effects governing freezing point depression in electrolyte solutions, with implications for lithium-ion battery electrolytes and other concentrated ionic systems.
- |||||||||| lithium carbonate ER / Generic mfg., aripiprazole / Generic mfg.
Journal, Adverse events: Early Detection of Adverse Drug Events via 24-h Telephone Services in a Community Pharmacy: A Case Report. (Pubmed Central) - Feb 26, 2025
A 57-year-old woman with bipolar disorder (BD) was started on combination therapy with aripiprazole and lithium...Ultimately, valproic acid was prescribed instead of lithium, resulting in a dramatic improvement in speech difficulties. These results indicate that community pharmacist-administered follow-up and intervention, especially through 24-h telephone services, is crucial for drug safety management, such as early detection of adverse events caused by combination therapy in patients with BD.
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Journal: The Potential of Using Screening Tools for Bipolar Disorder to Predict Lithium Response. (Pubmed Central) - Feb 26, 2025
Linear regression analysis revealed that HCL-32 scores were a significant predictor of Alda Scale scores, with no associations found for age, gender, or MDQ scores. Our study underscores the importance of considering hypomanic symptoms when estimating lithium response in BD, particularly by utilizing the HCL-32 during screening.
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Review, Journal: History of Suicide Prevention with Lithium Treatment. (Pubmed Central) - Feb 26, 2025
However, it is believed that lithium may produce anti-aggressive/anti-impulsive effects that directly contribute to anti-suicidal outcomes and mood-stabilizing effects that indirectly lead to the same results. Anti-aggressive/anti-impulsive effects may be obtained at the very low levels of lithium present in drinking water, whereas recurrence prevention may be attained at therapeutic levels.
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Journal: Rapid Fluorescent Probe Detection of Magnesium Impurities in High-Purity Lithium Carbonate Brine Systems. (Pubmed Central) - Feb 26, 2025
Meanwhile, the Mg2+ impeded the phototropic electron transfer effect process, resulting in enhanced fluorescence and completing this process within 3 to 10 s, with a detection limit of 6.06 ?mol/L. This method can promote the real-time and rapid quality control of Mg2+ impurities in the refining and purification of lithium carbonate, as well as effectively reduce production costs.
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Biomarker, Review, Journal: Pharmacogenomics and response to lithium in bipolar disorder. (Pubmed Central) - Feb 25, 2025
Pharmacogenomics may support further discoveries in precision medicine further enlarging our understanding of the underlying mechanisms of lithium for its efficacy. However, clinical applications currently appear out of reach in the near future.
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Journal: Kidney function decline improves after lithium discontinuation. (Pubmed Central) - Feb 22, 2025
This effect was more pronounced in participants with lower eGFR at the time of lithium discontinuation. In participants who restarted lithium, the annual decline of eGFR reverted to pre-lithium discontinuation levels.
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Journal: Cancer Risk and Estimated Lithium Exposure in Drinking Groundwater in the US. (Pubmed Central) - Feb 20, 2025
In this cohort study of 252?178 participants, estimated lithium exposure in drinking groundwater was associated with reduced cancer risk. Given the sparse evidence and unknown mechanisms of this association, follow-up investigation is warranted.
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Journal: Immediate-release vs. prolonged-release lithium formulations in bipolar disorder: a 2-year comparative study. (Pubmed Central) - Feb 18, 2025
Despite its limitations, including the observational design, potential confounders such as concomitant medications, and a high dropout rate, these findings suggest that PR lithium formulations provide similar clinical efficacy to IR formulations but offer superior tolerability. Therefore, PR lithium represents a favorable option for improving adherence, particularly in patients at risk of treatment discontinuation.
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Journal: Antidepressants in the Treatment of Bipolar Depression: Commentary. (Pubmed Central) - Feb 18, 2025
Optimal treatment of depression requires further investigation, particularly for long-term maintenance. Nevertheless, treatment for acute depressive episodes can usefully and safely include some antidepressants in moderate doses for limited duration, best combined with lithium, some anticonvulsants or certain atypical antipsychotics, and more safely with BD-2 than BD-1 with close clinical supervision.
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Journal: Lithium compromises the bioenergetic reserve of cardiomyoblasts mitochondria. (Pubmed Central) - Feb 15, 2025
In addition, lithium treatment altered the composition of cellular membranes, including mitochondrial cardiolipin, a lipid essential for mitochondrial function. These findings suggest that impaired complex I activity, oxidative stress, and cardiolipin depletion collectively impair the ability of cells to meet high energy demands.
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Journal: Synaptic protein expression in bipolar disorder patient-derived neurons implicates PSD-95 as a marker of lithium response. (Pubmed Central) - Feb 15, 2025
However, lithium only increased PSD-95 expression selectively in neurons from lithium-responders and not in neurons from lithium non-responders, leading to group differences in the colocalization of SYN1 and PSD-95. In conclusion, this preliminary work indicates synaptic protein markers are associated with BD pathology and correction of post-synaptic protein expression may be an important mechanism underlying lithium response.
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Journal: Nose-to-brain delivery of lithium via a sprayable in situ-forming hydrogel composed of chelating starch nanoparticles. (Pubmed Central) - Feb 15, 2025
Effective IN delivery of lithium to the brain is demonstrated for the first time, with both solution-based and hydrogel-loaded lithium showing in vivo efficacy in an amphetamine-induced pre-clinical rat bipolar manic phase model; specifically, IN-delivered NNHs can maintain successful attenuation of locomotor activity for up to 6?h while all other tested treatments (drug-only IN or conventional intraperitoneal delivery) failed to retain attenuation for more than two hours at the same lithium dose. As such, in situ-gelling and ion-chelating NNHs represent a new material that can effectively enable metal ion management in biomedical applications.
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Journal: Pediatric Bipolar Disorder: Challenges in Diagnosis and Treatment. (Pubmed Central) - Feb 15, 2025
Converging evidence from disparate sites describe a developmentally distinct presentation of bipolar disorder in youth that is highly morbid, persistent and responds to treatment with the mood stabilizer medications used in the treatment of adult bipolar disorder, such as divalproex sodium and carbamazepine. Some are additionally approved for use in pediatric populations including, for manic or mixed states, risperidone, aripiprazole, and asenapine for those aged 10-17
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Journal: Pharmacotherapy in Comorbid Bipolar Disorder and Post-Traumatic Stress Disorder From the STEP-BD Cohort. (Pubmed Central) - Feb 15, 2025
Clinical trial participants with BD and PTSD reported worse symptoms and outcomes across 24?months of the STEP-BD study compared to those without comorbid PTSD, regardless of baseline medication use. These results highlight the importance of considering comorbidity in the treatment of mental health conditions, specifically BD, and the need for further exploration of effective treatment options.
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Review, Journal: How pharmacology can aid in the diagnosis of mental disorders. (Pubmed Central) - Feb 13, 2025
In several fields of medicine, drugs are already used as molecular diagnostic tools. Thus, there is already precedence for the concept proposed here for mental disorders.
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Retrospective data, Journal: Lithium for Bipolar Disorder and Risk of Thyroid Dysfunction and Chronic Kidney Disease. (Pubmed Central) - Feb 11, 2025
Valproate, olanzapine, quetiapine, and risperidone generally exhibited reduced likelihood of thyroid dysfunction and CKD3+ compared with lithium, without any difference in advanced CKD...In this cohort study of patients with incident BD, lithium was associated with a mildly increased risk of thyroid dysfunction and CKD in a predominantly Chinese population. The identified lithium level thresholds associated with risks of physical complications may facilitate the development of evidence-based guidelines recommending lithium treatment, particularly in Asian populations, and the promotion of personalized care and risk-benefit balancing in the treatment for BD.
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Journal: Lithium for depression-related hospitalisation in bipolar disorder. (Pubmed Central) - Feb 9, 2025
The identified lithium level thresholds associated with risks of physical complications may facilitate the development of evidence-based guidelines recommending lithium treatment, particularly in Asian populations, and the promotion of personalized care and risk-benefit balancing in the treatment for BD. No abstract available
- |||||||||| lithium carbonate ER / Generic mfg., quetiapine / Generic mfg.
Journal: Paraphilia and Hypersexuality in Bipolar I Disorder and Histrionic Personality Disorder: A Case Report. (Pubmed Central) - Feb 7, 2025
This case also underscores gaps in specific guidelines for managing paraphilic behaviors in psychiatric populations, particularly in contemporary sociocultural contexts with evolving sexual dynamics. Future studies are warranted to develop structured, evidence-based approaches to address this complex interplay of psychiatric comorbidities and paraphilias.
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Preclinical, Journal: A dual-phase biologic augmentation of rotator cuff healing in a preclinical rat model using interleukin-17F and low-dose lithium. (Pubmed Central) - Feb 3, 2025
This study examines the outcome of peritendinous interleukin-17F (IL-17F) administration and oral low-dose lithium carbonate (Li) on rotator cuff healing following acute surgical repair in a rat model...These findings are consistent with an increase in biomechanical stiffness. We demonstrated that the combined treatment of IL-17F and oral low-dose lithium improved rotator cuff tendon healing quality following acute surgical repair in a rat model.
- |||||||||| lithium carbonate ER / Generic mfg., oxcarbazepine / Generic mfg.
Journal: Endoxifen in Bipolar Disorder With Hyperammonemia and Renal Impairment: A Case Report. (Pubmed Central) - Feb 3, 2025
Endoxifen, a protein kinase C inhibitor and selective estrogen receptor modulator, originally used in breast cancer treatment, has recently emerged as a potential therapeutic option for managing manic episodes in bipolar disorder. This case report highlights the use of endoxifen in the management of severe manic symptoms of bipolar disorder in a 65-year-old male patient with medical comorbidities arising from traditional mood stabilizer drugs and its potential as an alternative treatment
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Journal: Lithium restores nuclear REST and Mitigates oxidative stress in down syndrome iPSC-Derived neurons. (Pubmed Central) - Feb 2, 2025
This case report highlights the use of endoxifen in the management of severe manic symptoms of bipolar disorder in a 65-year-old male patient with medical comorbidities arising from traditional mood stabilizer drugs and its potential as an alternative treatment Results showed the significantly lower nuclear REST expression in DS neurons was restored after 24
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Journal: Bipolar disorder in people with HIV: A nationwide, population-based matched case-control and matched cohort study. (Pubmed Central) - Jan 29, 2025
Our findings suggest that BD may be associated with mitochondrial dysfunctions, and that exposure to lithium but not to other mood stabilizers may restore these abnormalities, though this does not appear correlated with the clinical efficacy of lithium. Bipolar disorders are associated with the risk of HIV infection, and PWH have increased risk of bipolar disorder and receipt of lithium beyond what familial factors could explain.
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Journal: Rapid Detection of Aluminium and Iron Impurities in Lithium Carbonate Using Water-Soluble Fluorescent Probes. (Pubmed Central) - Jan 12, 2025
Probe A and Probe B exhibited good stability in the pH range of 4-9 in aqueous solutions, high sensitivity, as well as high selectivity for Al3+ and Fe3+; the detection limits for Al3+ and Fe3+ were 1.180 and 1.683 ?mol/L, whereas the response times for Al3+ and Fe3+ were as low as 10 and 30 s, respectively. Electrostatic potential (ESP) analysis and density functional theory calculations identified the binding sites and fluorescence recognition mechanism; theoretical calculations showed that the enhanced fluorescence emission of Probe A when detecting Al3+ was due to the excited intramolecular proton transfer (ESIPT) effect, whereas the fluorescence quenching of Probe B when detecting Fe3+ was due to the electrons turning off fluorescence when binding through the photoelectron transfer (PET) mechanism.
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