- |||||||||| levocetirizine / Generic mfg.
Journal: Development of a sensitive LC-MS/MS method for determination of N-nitrosopiperazine in levocetirizine. (Pubmed Central) - Sep 6, 2024
The effectiveness of the method was shown by utilizing it to analyze the NPZ impurity in both levocetirizine API and various drug products, including tablets, capsules, chewables, and syrups. The proposed method and the resulting data would be valuable for determining potentially present impurities in drug substances or products for quality assessment.
- |||||||||| Review, Journal: Advances in the potential of nebulized inhalation for the treatment of pulmonary arterial hypertension. (Pubmed Central) - Jul 27, 2024
Within the past decade or so, nebulized inhalation therapy is considered to have advantages in the treatment of pulmonary hypertension as a safe, limited, and rapid therapy, for example, inhaled vasodilators (prostate analogs, nitroglycerin, carbon monoxide analogs sildenafil, and nitroprusside), inhaled anti-inflammatory and antiproliferative agents (simvastatin, and selatinib), and inhaled peroxides (levocetirizine) have been recognized as emerging therapeutic approaches in the treatment of pulmonary hypertension as emerging therapeutic approaches. Therefore, this article provides a brief review of recent advances in the potential of nebulized inhaled vasodilators, anti-inflammatory and antiproliferative agents, and anti-peroxides for the treatment of pulmonary hypertension, with the aim of providing different therapeutic options for the treatment of pulmonary hypertension, enhancing the quality of survival, alleviating symptoms, and improving the prognosis of patients with this condition.
- |||||||||| levocetirizine / Generic mfg.
Retrospective data, Journal: Clinico-Epidemiologic Profile and Response to Levocetirizine in Chronic Spontaneous Urticaria: A Retrospective Cohort Study from a Tertiary Care Center in North India. (Pubmed Central) - Jul 26, 2024
Patients with higher levels of serum IgE and D-dimer (P < 0.05) were found to require frequent updosing of levocetirizine, while age, sex, duration of illness, presence of angioedema, co-morbidities, identifiable precipitating factors, presence of diurnal variation, family history, and vitamin D deficiency were found to not have an effect on levocetirizine dosing. Ours is a large single-center study exemplifying the biomarkers including baseline serum IgE and D-dimer levels, which could identify a CSU patient who could warrant a higher dose of antihistamine/antihistamine refractory urticaria.
- |||||||||| Preclinical, Journal: Results from a Joined Prospective Study to Evaluate the Sensitivity of the In Vivo Dog QT Assay in Line with the ICH E14/S7B Q&A Best Practices. (Pubmed Central) - Jun 16, 2024
By-timepoint analysis showed QTc prolongation induced by moxifloxacin, dofetilide, dolasetron, ondansetron, and quinine within human relevant plasma exposures ranges...As expected, levocetirizine showed no statistically significant effect on QTc across a range of exposure, well exceeding the therapeutic Cmax...Finally, concentration-QTc modeling enabled to predict the minimal plasma concentration needed to detect a 10?milliseconds QTc prolongation, including for quinine. The comparison with clinical available data supported the relevance of dogs under these experimental conditions as a robust translational predictor of drug-induced QTc prolongation in humans as a key pillar of the integrated risk assessment.
- |||||||||| Alesion (epinastine) / Boehringer Ingelheim
Preclinical, Journal: Anti-edematous effects of epinastine, cetirizine and its enantiomers in ?-carrageenan-induced edema in rat hind paw. (Pubmed Central) - Jun 15, 2024
In summary, second-generation histamine H1 -receptor blockers, at least those examined in this study, may be able to reduce the clinical symptoms of urticaria associated with edema. Levocetirizine hydrochloride is also anticipated to have stronger anti-edematous effects than cetirizine hydrochloride because levocetirizine is responsible for cetirizine's anti-edematous activity.
- |||||||||| levocetirizine / Generic mfg.
Journal: Clinical case of anaphylaxis due to eye drops (Pubmed Central) - Apr 29, 2024
It is essential to give diagnoses, recommendations with treatments and avoidance of the probable triggering agent of the reaction. The administration of immediate medication when the allergic episode begins in these patients can be vital, even more so when they live far from a health center, as was the case in this patient.
- |||||||||| chlorpheniramine / Generic mfg., hydroxyzine hydrochloride / Generic mfg., levocetirizine / Generic mfg.
A case of cetirizine allergy: diagnostic considerations (Poster Zone) - Apr 21, 2024 - Abstract #EAACI2024EAACI_2470;
She was informed to avoid cetirizine and other closely structurally related antihistamines (levocetirizine & hydroxyzine)...In conclusion, although rare, cetirizine allergy can be considered a possible cause of immediate hypersensitivity drug reactions. The value of skin testing is unknown and thus the diagnosis can only be confirmed through cautious drug provocation tests.
- |||||||||| prednisone / Generic mfg., levocetirizine / Generic mfg.
Significant worsening of pollen food allergy syndrome after gastric bypass surgery (Poster Zone) - Apr 21, 2024 - Abstract #EAACI2024EAACI_2422;
Conclusion There was a clear worsening of this patient's PFAS after the RYGB, presumably due to decreased denaturation of PR-10 proteins in the stomach. The patient's threshold for tolerance of fruits of the Rosacea family decreased dramatically, to the point that even small quantities now trigger symptoms.
- |||||||||| levocetirizine / Generic mfg.
Chronic spontaneous urticaria in children: Series of 10 cases (E-TPS Display Only Digital section) - Apr 21, 2024 - Abstract #EAACI2024EAACI_1218;
Treatment primarily consisted of second-generation anti-H1 antihistamines, particularly levocetirizine, with good outcomes observed in most cases...Most of patients responded well to monotherapy with 2nd generation antihistamine drugs. A few patients were given leukotriene receptor antagonists and short-term corticosteroids.
- |||||||||| mometasone furoate / Generic mfg., levocetirizine / Generic mfg.
Review, Journal: Follicular Psoriasis: A Case Report and Review of Literature. (Pubmed Central) - Apr 4, 2024
Dermoscopy can help distinguish it by revealing typical features including perifollicular white scales and vascular structures. Further epidemiological studies and long-term follow-up are needed for a comprehensive understanding of FP.
- |||||||||| bilastine / Generic mfg., levocetirizine / Generic mfg.
Clinical, P3 data, Journal, Head-to-Head: Efficacy and safety of bilastine vs. levocetirizine for the treatment of chronic idiopathic urticaria: A multicenter, double-blind, double-dummy, phase III, non-inferiority, randomized clinical trial. (Pubmed Central) - Apr 1, 2024
Further epidemiological studies and long-term follow-up are needed for a comprehensive understanding of FP. No abstract available
- |||||||||| Review, Journal: Treatment of acute urticaria: A systematic review. (Pubmed Central) - Feb 29, 2024
The combination of diphenhydramine (50?mg, IV) and ranitidine (50?mg, IV) or cimetidine (300?mg, IV) was most efficient for relief of urticaria in two out of five studies...The addition of corticosteroids to an antihistamine as treatment for AU needs to be further investigated. Well-designed, high-quality interventional trials are needed to establish evidence-based treatment guidelines for AU.
- |||||||||| levocetirizine / Generic mfg.
Journal: Is Gender an Important Factor in the Precision Medicine Approach to Levocetirizine? (Pubmed Central) - Jan 26, 2024
Regarding the pharmacokinetics and pharmacodynamics of levocetirizine, the gender effect may not be significant when applying the usual dosage (5 mg/day). This study will be useful for bridging the knowledge gap in scientific precision medicine by introducing previously unconfirmed information regarding gender differences in levocetirizine pharmacometrics.
- |||||||||| levocetirizine / Generic mfg.
Trial completion date, Trial primary completion date: COURAGE: COrticosteroids in acUte uRticAria in emerGency dEpartment (clinicaltrials.gov) - Dec 15, 2023
P3, N=240, Recruiting,
Our findings demonstrate that the transfer of cetirizine and levocetirizine into breast milk is low and compatible with breastfeeding. Trial completion date: Sep 2023 --> Sep 2025 | Trial primary completion date: Mar 2022 --> Mar 2025
- |||||||||| levocetirizine / Generic mfg.
Preclinical, Journal: Efficacy of levocetirizine in isolated rat tracheal smooth muscle. (Pubmed Central) - Nov 10, 2023
According to this study, levocetirizine might potentially impede the parasympathetic function of the trachea. If levocetirizine was used prior to menthol addition, it also reduced the function of cold receptors.
- |||||||||| levocetirizine / Generic mfg., fenofibrate / Generic mfg.
Journal: Drug repurposing by in silico prediction of cyclizine derivatives as antihyperlipemic agents. (Pubmed Central) - Oct 30, 2023
The repurposing was done based on the similarity of the selected cyclizine derivatives with the already established antihyperlipidemic drug, fenofibrate...The ADME properties of these compounds were performed and from that etodroxizine and levocetirizine were found to have better properties...MMGBSA was performed on the "prime MMGBSA" segment. Using the "Qikprop" setting in the maestro panel, a number of ADMET properties were predicted, and the program was run in default mode using vsgb as the solvation model.
- |||||||||| prednisone / Generic mfg., fluticasone / Generic mfg., levocetirizine / Generic mfg.
When A Polyp Is Not A Polyp: Unilateral Nasal Masses And Masqueraders Of Nasal Polyps (Monitor 09) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_691;
She was using Fluticasone 2 sprays/nostril daily and Levocetirizine 5 mg daily...Patient was changed to Fluticasone exhalation therapy and treated with Prednisone for 5 days...Warning signs/red flags for tumors include rapid growth, change in symptom pattern, no response to nasal/systemic steroids or biologics, and crusting/bleeding lesions. A high degree of suspicion, sinus imaging and Otolaryngology referral for biopsy are paramount in these scenarios for accurate diagnosis and treatment.
- |||||||||| Xolair (omalizumab) / Roche, Novartis
Not All That Meets the Hive: The Initial Presentation of Pediatric Chronic Spontaneous Urticaria (Monitor 04) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_604;
She received >10 doses of intramuscular epinephrine in 2 months...She started Levocetirizine 10 mg twice daily, Famotidine 20 mg daily, Montelukast 5 mg daily, Cromolyn 100 mg four times daily, and Omalizumab 225 mg every 28 days...Discussion Because CSU has similar presenting features to anaphylaxis, it is significant to inform our colleagues regarding pediatric CSU symptoms and management. This patient has not attended school due to her symptoms underscoring the consequences that uncontrolled CSU may have on the development and quality of life of children.
- |||||||||| desloratadine / Generic mfg.
Desloratadine induced fixed drug eruption: An exceedingly rare presentation. (e-Poster Hall) - Aug 30, 2023 - Abstract #EADV2023EADV_2300;
They are rarely incriminated in the development of adverse cutaneous drug eruptions and have an excellent safety profile. There is paucity of reports of FDE caused by second generation H1-antihistamines like cetirizine, levocetirizine, loratadine and desloratadine.
- |||||||||| neramexane (KRP-209) / AbbVie
Journal: Literature-Based Discovery Predicts Antihistamines Are a Promising Repurposed Adjuvant Therapy for Parkinson's Disease. (Pubmed Central) - Aug 16, 2023
The relationship patterns among the identified adjuvant candidates suggest that the likely therapeutic mechanism(s) of action of antihistamines for combatting the multi-factorial PD pathology include counteracting oxidative stress, amending the balance of neurotransmitters, and decreasing the proliferation of inflammatory mediators. Finally, cross-domain text mining interestingly predicted a strong relationship between PD and liver disease.
- |||||||||| Review, Journal: Pollen respiratory allergy: Is it really seasonal? (Pubmed Central) - Jul 31, 2023
The efficacy and safety of fexofenadine for the treatment of seasonal allergic rhinitis (SAR) symptoms have been demonstrated by numerous clinical studies, irrespective of the season and underlying allergen. In this review, we discuss the allergic rhinitis classification, the role of climate change, air pollution, and factors contributing to year-round symptoms in patients with AR and the need for continuous pharmacological treatment for management.
- |||||||||| levocetirizine / Generic mfg.
Treatment of xanthelasma palpebrarum, with liquified nitrogen oxide(cryo-pen): a study of 12cases () - Jul 3, 2023 - Abstract #WCD2023WCD_4842;
In this review, we discuss the allergic rhinitis classification, the role of climate change, air pollution, and factors contributing to year-round symptoms in patients with AR and the need for continuous pharmacological treatment for management. Cryo-pen is an effective modality for treatment of xanthelsma palpebrum , with no side effect to underlying soft tissue or eyes .it is easier to use and cheaper than laser and surgical modality, should be considered in patients with multiple lesion
- |||||||||| nimesulide / Generic mfg.
Psoriasiform Fixed-Drug Eruption due to nimesulide : Deviant presentation of a regular CADR () - Jul 3, 2023 - Abstract #WCD2023WCD_3930;
The most common drug causing FDE is co-trimoxazole...The patient was treated with a topical corticosteroid (mometasone furoate 0.1% cream) and emollient (white soft paraffin 13.2% w/w + light liquid paraffin 10.2 % w/w) with oral antihistamine (levocetirizine 5mg tablet) along with discontinuation of the offending drug...Rare forms of CADR are now becoming common. Hence it
- |||||||||| levocetirizine / Generic mfg.
IL-4 and IL-6 impact on acute urticaria () - Apr 30, 2023 - Abstract #EAACI2023EAACI_1801;
The use of levocetirizine 10 mg daily for a period of 4 weeks improved the clinical signs of skin lesions in all 68 patients over the next 3 months...IL-4 liberated by mast cells, can induce an influx of leukocytes in the dermis, therefore participating in the development of acute urticarial inflammation. Antihistamines with anti-inflammatory features might be particularly effective in this disease
- |||||||||| Xolair (omalizumab) / Roche, Novartis
Paradoxical worsening of Chronic Spontaneous Urticaria following Omalizumab- the missing link (Poster Zone C) - Apr 30, 2023 - Abstract #EAACI2023EAACI_1756;
Anti-IgE Omalizumab may interfere with anti-parasitic immunity (mediated by IgE) and thus favor infestation. Therefore, it is suggested to appropriately screen for occult parasitic infestations before starting Omalizumab in CSU patients living and/or working in endemic settings.
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