- |||||||||| lidocaine topical / Generic mfg., epinephrine / Generic mfg.
Journal: Injection of Lidocaine With Epinephrine for Bee Sting Large Local Reactions. (Pubmed Central) - Feb 27, 2025
The lidocaine rapidly reversed the symptoms of pain and pressure, and the low dose of epinephrine, within 2 hours, significantly reversed the allergic periorbital and eyelid edema. No further symptoms evolved, suggesting that the epinephrine terminated the allergic cascade.
- |||||||||| Embolia Cutis Medicamentosa: An Underrecognized Diagnosis Associated with Injectable Medication Use (Orange County Convention Center (West Building, Exhibit Hall B4, Poster Center 1)) - Feb 26, 2025 - Abstract #AAD2025AAD_3431;
A 42-year-old female with a history of multiple sclerosis on glatiramer acetate injections presented to dermatology clinic with a two-week history of painful skin changes on left hip that started one day after her last glatiramer acetate injection...The patient was diagnosed with embolia cutis medicamentosa and started on triamcinolone 0.1% ointment daily for two weeks, vaseline, and warm compress...Other injectables linked to Nicolau syndrome include NSAIDs (especially diclofenac), IM benzathine penicillin, local anesthetics such as lidocaine, and, less commonly, injectable vitamins including Vitamin K and cyanocobalamin...Early pharmacological interventions, such as vasodilators (nitroglycerin or nifedipine) to enhance blood flow, and anticoagulants to prevent vascular occlusion, may also be considered. In severe cases, surgical debridement may be required for extensive necrosis.
- |||||||||| lidocaine topical / Generic mfg., cefuroxime / Generic mfg.
Journal, Surgery: Changes in rates of endophthalmitis after cataract surgery over the last 23years. (Pubmed Central) - Feb 23, 2025
The incidence of endophthalmitis after cataract surgery has significantly decreased over the past twenty-three years in our tertiary care center. The use of PVI before surgery along with systematic intracameral cefuroxime has allowed us to achieve very low rates of endophthalmitis.
- |||||||||| Journal: Lasting Effects of Surgically Used Topical Vasodilators on DIEP Artery Vascular Function. (Pubmed Central) - Feb 13, 2025
?Surgically used doses of papaverine and verapamil, but not lidocaine, have lasting negative effects on arterial vasodilatory function despite the acute effects of the drugs having worn off. These findings, in conjunction with the spasmolytic properties of each drug, may help guide the selection of an optimal topical vasodilator for use during microvascular surgeries.
- |||||||||| lidocaine topical / Generic mfg.
Enrollment closed, Trial completion date, Trial primary completion date: Sphenopalatine Ganglion Block and Cold Induced Headaches (clinicaltrials.gov) - Jan 31, 2025
P1, N=30, Active, not recruiting,
Future studies should evaluate drugs that can reach and act on the posterior segment of the eye. Not yet recruiting --> Active, not recruiting | Trial completion date: Dec 2024 --> Jul 2025 | Trial primary completion date: Nov 2024 --> May 2025
- |||||||||| ByFavo (remimazolam) / PAION, Cosmo Pharma, Mundipharma, Pharmascience, Eagle Pharma
Journal, Intubation: Remimazolam for Sedation and Trachospray for Topicalization During Flexible Nasal Intubation in a Spontaneously Breathing Patient. (Pubmed Central) - Jan 16, 2025
In addition, topical anesthesia of the upper airway was performed using a specifically designed device called the Trachospray, which nebulizes lidocaine into a fine mist that precipitates in the upper airway of the patient upon inhalation...This combination led to adequate anxiolysis and sedation, preservation of spontaneous breathing throughout the procedure, good conditions for successful intubation, and amnesia for the endoscopy and intubation. Further research is needed to establish the superiority of any of these techniques in comparison to other accepted methods.
- |||||||||| lidocaine topical / Generic mfg., gabapentin / Generic mfg.
Review, Journal: Vulvodynia - A contemporary understanding and practical approach in primary care settings. (Pubmed Central) - Jan 12, 2025
Referral to a multidisciplinary team may be required in a proportion of patients who do not respond to conventional treatment. This concise review highlights the contemporary understanding of vulvodynia and proposes a practical approach within primary care settings.
- |||||||||| lidocaine topical / Generic mfg.
Journal, Intubation: Successful awake intubation using Airtraq (Pubmed Central) - Jan 12, 2025
This concise review highlights the contemporary understanding of vulvodynia and proposes a practical approach within primary care settings. This case emphasizes that safe awake intubation with an Airtraq
- |||||||||| lidocaine topical / Generic mfg.
Retrospective data, Journal: Efficacy and safety of topical antibiotic therapy in patients with acute external bacterial otitis: results of a retrospective study (Pubmed Central) - Dec 27, 2024
Out of 2545 patients included in the analysis 92.1% received a combination drug containing polymyxin B sulfate, neomycin sulfate and lidocaine hydrochloride (Anauran) as monotherapy, whereas 7.9% received it in combination with other antimicrobials...Eradication of pathogens was observed in 95.1% of cases. In total 99.6% of patients reported completely no side effects during the treatment course suggesting high level of effectiveness and safety of the drug.
- |||||||||| lidocaine topical / Generic mfg.
Clinical, Journal, Head-to-Head: Cold and vibration for children undergoing needle-related procedures: A non-inferiority randomized clinical trial. (Pubmed Central) - Dec 16, 2024
Participants were randomly assigned to either the cold vibrating device or topical anesthetic (4% liposomal lidocaine; standard of care)...The cold vibrating device was not considered non-inferior to the topical anesthetic cream for pain management in children during a needle-related procedure in the ED. As topical anesthetic creams require an application time of 30?min, cost approximately CAD $40.00 per tube, are underused in the ED setting, the cold vibrating device remains a promising alternative as it is a rapid, easy-to-use, and reusable device.
- |||||||||| morphine sulphate / Generic mfg., methotrexate / Generic mfg.
Journal: Effective Treatment of Methotrexate Induced Oral Mucositis With a Morphine Mouthwash Solution: A Case Report. (Pubmed Central) - Dec 12, 2024
It is a safer alternative to systemic opioids and topical opioids may influence cell proliferation and migration, which can positively impact healing of oral lesions. A morphine mouthwash solution can provide effective pain management for oral mucositis lesions in patients who do not respond adequately to magic mouthwash.
- |||||||||| remifentanil / Generic mfg., lidocaine topical / Generic mfg., epinephrine / Generic mfg.
Journal, Surgery: Anesthetic recovery outcomes after 2 methods of nasal mucosal preparation for endoscopic sinus surgery. (Pubmed Central) - Dec 11, 2024
Patients who received preparation of the nasal mucosa with TCLE, compared with TE, were less likely to report severe pain or receive an opioid analgesic in the postanesthesia recovery room and had faster anesthetic recovery. This observation from our large clinical practice indicates that use topical and local anesthetic during endoscopic sinus surgery may have benefit for ambulatory ESS patients.
- |||||||||| Review, Journal: Pharmacological Pain Treatment in Older Persons. (Pubmed Central) - Dec 11, 2024
The choice of analgesic(s) and the route of administration should be guided by the pain characteristics, as well as by the patient's comorbidities, organ function and medications. Several directions have been highlighted to optimise pharmacological pain management in older individuals: (1) before starting pain treatment adequately detect and assess pain and always perform a full geriatric assessment, (2) consider kidney function systematically to adjust the doses of analgesics and avoid the risks of overdose, (3) start with the lowest dose of an analgesic and increase it gradually under the control of the effect, (4) involve the older persons and family in their treatment, (5) reevaluate pain regularly during treatment and (6) combine pharmacological treatment with non-pharmacological approaches.
- |||||||||| remifentanil / Generic mfg., sevoflurane / Generic mfg., lidocaine topical / Generic mfg.
Journal: Anesthetic Management of a Pediatric Patient With Pfeiffer Syndrome. (Pubmed Central) - Nov 6, 2024
Anesthesia was maintained using desflurane and remifentanil, and no postoperative complications were observed. General anesthesia for patients with PS requires careful planning, which should include preoperative assessment of the airway to determine the feasibility of nasotracheal intubation and identify airway irregularities.
- |||||||||| ketorolac / Generic mfg., lidocaine topical / Generic mfg.
Review, Journal: Pain Management Strategies before Pan-Retinal Photocoagulation for Diabetic Retinopathy: A Systematic Review. (Pubmed Central) - Nov 6, 2024
This review synthesizes findings from multiple studies reporting pain as an adverse outcome of PRP in patients with advanced DR. Based on the evidence from reviewed clinical trials, the administration of lidocaine 2% via transconjunctival, retrobulbar, or peribulbar block along with specific NSAIDs, such as topical ketorolac administrated 24?hours before treatment or oral diclofenac potassium (50?mg) prior to PRP, demonstrated beneficial effects among patients with DR.
- |||||||||| lidocaine topical / Generic mfg.
Enrollment open: Comparison of Compounded Topical Anesthetics (clinicaltrials.gov) - Nov 4, 2024
P4, N=60, Recruiting,
Double-blind trial with larger thoracic procedures is recommended for wider application. Not yet recruiting --> Recruiting
- |||||||||| lidocaine topical / Generic mfg.
Review, Journal: Anesthesia Usage and Pain Management in Colposcopy: A Scoping Review of Efficacy and Approaches. (Pubmed Central) - Oct 29, 2024
The search strategy aimed to identify studies involving the utilization of anesthesia or analgesics for pain management or prevention during colposcopy, with a focus on randomized controlled trials. This systematic review aims to review the existing literature on the use of anesthetics in colposcopy and its effect on patient outcomes, investigating the current strategies of anesthesia use in the setting of a colposcopy, as well as their efficacy in improving pain.
- |||||||||| lidocaine topical / Generic mfg.
Review, Journal, Surgery: Topical anesthesia strabismus surgery. (Pubmed Central) - Oct 16, 2024
The results with regards to the successful completion of the procedure and its benefits and limitations support the use of topical anesthesia in strabismus surgery in a select few. This review concludes that topical anesthesia strabismus surgery can be the procedure of choice in select surgical situations in the management of adult strabismus.
- |||||||||| Penthrox (methoxyflurane) / Medical Developments International
Review, Journal: Inhaled Analgesia in Dermatologic Settings: A Comprehensive Overview of Methoxyflurane. (Pubmed Central) - Oct 3, 2024
The limited side effect profile, ease of patient self-administration, rapid onset and quick resolution of central nervous system effects following cessation makes methoxyflurane an ideal choice for analgesia during outpatient dermatologic procedures. This review provides an overview of the supporting evidence for methoxyflurane inhalers and clinical commentary on potential indications for methoxyflurane use in dermatology.
- |||||||||| Review, Journal, Metastases: Navigating the 'Pits and Perils' of Analgesic Therapy in Advanced Liver Disease and Cirrhosis. (Pubmed Central) - Sep 30, 2024
Topical analgesics, including NSAIDs, lidocaine, and rubefacients, are deemed safe for use in cirrhosis, offering localized relief with minimal systemic effects...This review provides healthcare professionals with valuable insights into the complex landscape of analgesic therapy in cirrhosis. Meticulous consideration of drug metabolism, hepatic safety, and individual patient factors is paramount in optimizing pain management strategies for this challenging patient population.
- |||||||||| lidocaine topical / Generic mfg.
ALLERGIC CONTACT DERMATITIS FROM LIDOCAINE IN PAIN RELIEF CREAM: A CASE REPORT (Monitor 3; Hall A) - Sep 29, 2024 - Abstract #ACAAI2024ACAAI_769;
Cross-reactivity between these two groups is rare, therefore it is recommended that patients with ACD to one group should use anesthetics from the other group. Management of ACD involves avoidance of the offending allergens and symptomatic treatment with topical steroids.
- |||||||||| lidocaine topical / Generic mfg.
Trial completion, Enrollment change: Does Topical Lidocaine Decrease Sweat During Exercise in the Heat? (clinicaltrials.gov) - Aug 29, 2024
P=N/A, N=10, Completed,
This trial was prospectively registered with irct.behdasht.gov.ir (registration number: IRCT20210118050067N2) on Aug 19, 2022. Not yet recruiting --> Completed | N=22 --> 10
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