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- | Alupent (metaproterenol) / Endo
Journal: Erythrocytes membrane fluidity changes induced by adenylyl cyclase cascade activation: study using fluorescence recovery after photobleaching. (Pubmed Central) - Apr 16, 2024
The effect of the stimulation of protein kinase A with membrane-permeable analog of cAMP followed the same trend but was less significant. The observed effects are assumed to be driven by increased mobility of phospholipids resulting from the weakened interaction between the intermembrane proteins and RBC cytoskeleton due to activation of adenylyl cyclase signaling cascade.
- | Alupent (metaproterenol) / Endo
Preclinical, Journal: The role of alcohol extract of cranberry in improving serum indices of experimental metaproterenol-induced heart damage in rats. (Pubmed Central) - Oct 12, 2023
The utilized extract also exhibited efficacy, albeit with variable effects. Therefore, it is recommended to use cranberry extract synergistically with other chemical and herbal medications to achieve more sustained effects.
- | Alupent (metaproterenol) / Endo
Preclinical, Journal: Involvement of ?- and ?-Adrenergic Receptors in Skeletal Muscle Blood Flow Changes During Hyper-/Hypocapnia in Anesthetized Rabbits. (Pubmed Central) - Jul 2, 2023
Atropine showed no effects on MBF and QBF. These results suggest the skeletal muscle blood flow changes observed during hypercapnia and hypocapnia may mainly involve ?1-adrenergic but not ?2-adrenergic receptor activity.
- | Alupent (metaproterenol) / Endo
Journal: Perioperative escape from dormancy of spontaneous micro-metastases: A role for malignant secretion of IL-6, IL-8, and VEGF, through adrenergic and prostaglandin signaling. (Pubmed Central) - Mar 15, 2023
These results suggest the skeletal muscle blood flow changes observed during hypercapnia and hypocapnia may mainly involve ?1-adrenergic but not ?2-adrenergic receptor activity. In-vitro, ?-adrenergic agonists (epinephrine or metaproterenol) and prostaglandin-E2 markedly increased MDA-MB-231 secretion of the pro-metastatic factors IL-6, IL-8, and VEGF, whereas cortisol reduced their secretion, effects that were maintained even 12
- || Alupent (metaproterenol) / Endo
Clinical, Journal: Why the lower reported prevalence of asthma in patients diagnosed with COVID-19 validates repurposing EDTA solutions to prevent and manage treat COVID-19 disease. (Pubmed Central) - Jan 6, 2021
Finally, the natural history of Coronavirus diseases and further analysis of the fusion loop homologies between the Betacorona SARS-CoV-2 virus and the less pathogenic Alphacorona HC0V-229E virus suggest how to engineer a hybrid virus suitable for an attenuated alpha-beta SARS-CoV-2/COVID-19 vaccine. Thus, replacing SARS-CoV-2 fusion loops (amino acids 816-855) with the less pathogenic HCoV-229E fusion loop (amino acids 923-982) may provide antigenicity of COVID-19, but limit the pathogenicity to the level of HCoV-229E.
- | Alupent (metaproterenol) / Endo
Journal: The Effects of Different Signaling Pathways in Adenylyl Cyclase Stimulation on Red Blood Cells Deformability. (Pubmed Central) - Sep 3, 2019
...We studied (1) the direct stimulation of adenylyl cyclase with forskolin; (2) non-selective adrenoreceptor stimulation with epinephrine; (3) β2-adrenoreceptor agonist metaproterenol; (4) membrane-permeable analog of cAMP (dibutyryl-cAMP)...The results can serve as an evidence of adenylyl cyclase signaling cascade involvement in the regulation of RBC micromechanical properties presenting a complex molecular pathway for fast increase of microcirculation efficiency in case of corresponding physiologic metabolic demands of the organism, e.g., during stress or physical activity. Further studies of this molecular system will reveal new knowledge which may improve the quality of medical treatment of hemorheological disorders.