tobramycin/dexamethasone / Generic mfg. 
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 30 Diseases   7 Trials   7 Trials   149 News 


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  • ||||||||||  tobramycin/dexamethasone / Generic mfg., valacyclovir / Generic mfg.
    Journal:  Conjunctival Phlyctenule and Nodular Scleritis in a Patient with Previous Herpes Simplex Virus-2 Exposure: Causative Agent or Innocent Bystander? (Pubmed Central) -  Nov 17, 2024   
    Initial treatment for epidemic keratoconjunctivitis with tobramycin-dexamethasone improved her symptoms...The patient failed topical corticosteroid monotherapy; however, she responded to oral valacyclovir...Thorough infectious workups and alternative treatment approaches are crucial in managing unconventional cases. Experimental treatments based on laboratory findings can be valuable for patients preferring conservative management, emphasizing the need for close follow-up and personalized care in ocular inflammatory diseases.
  • ||||||||||  tobramycin/dexamethasone / Generic mfg.
    Journal, Surgery:  Topical insulin to treat a conjunctival defect after glaucoma surgery: A case report. (Pubmed Central) -  Aug 19, 2024   
    This regimen also helps restore intraocular pressure and visual acuity of the patients, with relatively low adverse reactions, indicating an ideal clinical outcome. In the left eye, he was on latanoprost/timolol once daily, prednisolone 1
  • ||||||||||  Maxidex (dexamethasone eye drops, suspension) / Novartis
    Journal:  Oculomotor nerve palsy caused by imidacloprid at initial diagnosis: A case report. (Pubmed Central) -  Aug 2, 2024   
    Following therapeutic intervention, the patient showed marked improvement and was discharged from the hospital, providing a point of reference for the treatment of analogous cases in future clinical practice. It also serves as a reminder for the public to take appropriate precautions when using imidacloprid.
  • ||||||||||  tobramycin/dexamethasone / Generic mfg.
    Journal:  Tear film proteome changes following Tobradex therapy in anterior blepharitis. (Pubmed Central) -  Apr 26, 2024   
    Tobradex treatment reversed the expression of plakin proteins in anterior blepharitis. Topical solutions which inhibit the expression of plakin proteins may have the potential to restore the ocular surface integrity in anterior blepharitis and should be explored further.
  • ||||||||||  NN1213 / Novo Nordisk
    Trial completion, Enrollment change:  VisuMax Femtosecond Laser Small Incision Lenticule Extraction for the Correction of High Myopia (clinicaltrials.gov) -  Apr 23, 2024   
    P=N/A,  N=114, Completed, 
    Topical solutions which inhibit the expression of plakin proteins may have the potential to restore the ocular surface integrity in anterior blepharitis and should be explored further. Unknown status --> Completed | N=187 --> 114
  • ||||||||||  tobramycin/dexamethasone / Generic mfg., triamcinolone acetonide topical / Generic mfg.
    Journal:  The treatment of refractory periorbital dermatitis. (Pubmed Central) -  Oct 7, 2023   
    Most patients were refractory during initial use or the first recurrence of periorbital dermatitis flare. By better characterizing the diverse treatment regimens in a unique subset of refractory patients, we hope to better inform potential courses of medical management for periorbital dermatitis.
  • ||||||||||  Maxidex (dexamethasone eye drops, suspension) / Novartis
    A case of secondary syphilis with panuveitis as a manifestation of ocular syphilis in an HIV-positive patient () -  Jul 3, 2023 - Abstract #WCD2023WCD_7055;    
    He also started to receive once a day antiretroviral (ARV) that consists of efavirenz 600 mg, lamivudine 300 mg, and tenofovir 300 mg...KEY MESSAGE: In HIV positive patients without antiretroviral therapy, Treponema pallidum is more common and has manifestations such as skin rash and ocular syphilis. Treatment using penicillin, ARV and steroid therapy will improve the patient symptoms
  • ||||||||||  Gatiflox (gatifloxacin) / Orient Europharma
    Journal:  Corticosteroid-Antibiotic Interactions in Bacteria that Cause Corneal Infection. (Pubmed Central) -  May 19, 2023   
    The drug combinations that showed the most stable effects against Pseudomonas aeruginosa was levofloxacin-prednisolone...The cellular concentrations were changed for the gatifloxacin-fluorometholone, moxifloxacin-fluorometholone, tobramycin-dexamethasone, and tobramycin-prednisolone combinations...Prior knowledge of specific antibiotic/corticosteroid interactions provides valuable information to clinical practitioners by combining data on the antibacterial and intracellular uptake effects of their co-administration. When using antibiotics and corticosteroids, drug combinations can be selected by referring to the results of this study.
  • ||||||||||  Nocardia abscessus (A / 07) -  Feb 4, 2023 - Abstract #ECCMID2023ECCMID_5093;    
  • ||||||||||  tobramycin/dexamethasone / Generic mfg.
    Journal:  Lens subluxation after use of a percussion massage gun: A case report. (Pubmed Central) -  Jan 11, 2023   
    Caregivers, sports professionals and the general public should be aware of the dangers of PMGs and the need to use them appropriately and safely, for example during self-massage and rehabilitation therapy. In particular, we recommend not using PMGs above the neck, which should be clearly indicated in instruction manuals.
  • ||||||||||  tobramycin/dexamethasone / Generic mfg.
    Journal:  High-frequency deep sclerotomy as adjunctive therapy in open angle glaucoma patients. (Pubmed Central) -  Nov 19, 2022   
    This study presents the data on our first surgical experience with high-frequency deep sclerotomy that was conducted on 23 patients who had medically-uncontrolled, primary, open-angle glaucoma. The results indicate that HFDS is safe and efficient in reducing IOP.
  • ||||||||||  tobramycin/dexamethasone / Generic mfg., ofloxacin ophthalmic / Generic mfg.
    Journal:  Unilateral vortex keratopathy of unknown etiology. (Pubmed Central) -  Oct 7, 2022   
    What would be the most appropriate surgical and/or medical interventions? What would you counsel in prognosis for this patient?
  • ||||||||||  Maxidex (dexamethasone eye drops, suspension) / Novartis
    PK/PD data, Preclinical, Journal:  Topical Pharmacokinetics of Dexamethasone Suspensions in the Rabbit Eye: Bioavailability Comparison. (Pubmed Central) -  Feb 16, 2022   
    This study provides for the first-time comprehensive and quantitative ocular pharmacokinetic parameters (including absolute bioavailability) for topically instilled dexamethasone suspensions. Furthermore, the new intracameral pharmacokinetic parameters allow rational and quantitative basis for the design of improved ocular dexamethasone delivery systems.
  • ||||||||||  tobramycin/dexamethasone / Generic mfg.
    COMBINED CONJUNCTIVAL AUTOGRAPH TRANSPLANTATION AND AMNIOTIC MEMBRANE OVERLAY IN PTERYGIUM SURGERY () -  Feb 8, 2022 - Abstract #ESCRSWM2022ESCRS_WM_651;    
    Combined conjunctival autograft transplantation and amniotic membrane overlay technique in pterygium surgery can be effective in the immediate post-operative period by reducing pain as well as in the long term outcomes by reducing the rates of pterygium recurrence. Further randomized controlled trials are needed to prove the benefits of this technique over CAT alone.
  • ||||||||||  Vekacia (ciclosporin ophthalmic) / Santen
    USAGE OF CICLOSPORIN EYE DROPS IN PEDIATRIC AGE: CASE REPORTS (Track 1) -  Feb 8, 2022 - Abstract #ESCRSWM2022ESCRS_WM_331;    
    The usage of immunomodulatory agents such as topical ciclosporin is effective in the long- term treatment, since it is corticosteroid sparing in steroid-dependent patients when other treatments have failed.(3) In Portugal, the commercialized ciclosporin (Ikervis®) is only approved for administration in adults.(4) However, its off-label usage in the pediatric population has shown great benefits...She was treated with tobramycin + dexamethasone and ketotifen with significant improvement...They were both forwarded to a pediatrician specialized in allergies to study them systemically. Conclusion / Take home message: In pediatric patients presenting with corticosteroid dependent VKC the ciclosporin can be a helpful ally in the disease control, avoiding chronic usage of corticosteroids and providing a significant improvement of the clinical status and quality of life of these patients.(3)
  • ||||||||||  tobramycin/dexamethasone / Generic mfg.
    Clinical, Journal:  Effectiveness of oral probiotics supplementation in the treatment of adult small chalazion. (Pubmed Central) -  Jan 21, 2022   
    Conclusion / Take home message: In pediatric patients presenting with corticosteroid dependent VKC the ciclosporin can be a helpful ally in the disease control, avoiding chronic usage of corticosteroids and providing a significant improvement of the clinical status and quality of life of these patients.(3) The considerable difference in time taken for complete resolution of small chalazia between the two groups in favor of the experimental one confirms the presence of a gut-eye axis.
  • ||||||||||  Maxidex (dexamethasone eye drops, suspension) / Novartis
    Clinical, Review, Journal:  A One-Week Course of Levofloxacin/Dexamethasone Eye Drops: A Review on a New Approach in Managing Patients After Cataract Surgery. (Pubmed Central) -  Dec 24, 2021   
    In addition, this study underlines that a follow-up visit after 1 week allows for a decision about whether to stop or continue a treatment in patients still experiencing symptoms or inflammation. In conclusion, this new dose combination could represent a turning point in managing patients after cataract surgery, while mostly avoiding antibiotic resistance and improving treatment adherence.
  • ||||||||||  Zylet (loteprednol etabonate/tobramycin ophthalmic suspension) / Bausch Health
    Review, Journal:  Review of Loteprednol Etabonate 0.5%/Tobramycin 0.3% in the Treatment of Blepharokeratoconjunctivitis. (Pubmed Central) -  Oct 30, 2021   
    Results of published studies indicate that LE/T is effective in the treatment of blepharokeratoconjunctivitis in adults, with similar efficacy as dexamethasone 0.1%/tobramycin 0.3%, but is associated with a lower risk of clinically significant increases in intraocular pressure as demonstrated in both efficacy and safety studies and studies with healthy volunteers...Separately, tobramycin demonstrated potent in vitro activity against most bacterial species associated with blepharitis. In conclusion, published data demonstrate the utility of LE/T for the treatment of the various clinical manifestations of blepharokeratoconjunctivitis in adults.
  • ||||||||||  Maxidex (dexamethasone eye drops, suspension) / Novartis
    Clinical, Journal:  Thelazia callipaeda infection during phacoemulsification cataract surgery: a case report. (Pubmed Central) -  Oct 27, 2021   
    In conclusion, published data demonstrate the utility of LE/T for the treatment of the various clinical manifestations of blepharokeratoconjunctivitis in adults. This report highlights the physician should ask the patient's history carefully before operation and it is necessary to strengthen health publicity and education, maintaining clean environment and keeping personal eye hygiene.
  • ||||||||||  Maxidex (dexamethasone eye drops, suspension) / Novartis
    [VIRTUAL] RARE EXPRESSION OF SYSTEMIC SARCOIDOSIS AFTER A NOVEL RNA VACCINE () -  Oct 13, 2021 - Abstract #CHEST2021CHEST_1604;    
    Before these symptoms, the patient experienced multiple desquamating tattoos and bilateral eye redness after the first dose of the vaccine, which presumed that resolved with tobramycin and dexamethasone eye drops...Treatment consisted of prednisone and azathioprine resulting in an improvement of symptoms the following days. More studies and data are required on side effects to assess other possible complications, response to the vaccine, and which patients are at risk of developing autoimmune or serious health conditions.
  • ||||||||||  tobramycin/dexamethasone / Generic mfg.
    Preclinical, Journal:  In vitro validation of the amoebicidal activity of commercial eye drops as second activity. (Pubmed Central) -  Oct 13, 2021   
    A treatment of 24 h with 5% of TobraDex or Cusimolol was able to show DNA condensation, collapse in the mitochondrial membrane potential and reduction of the ATP level production in Acanthamoeba. We could assume that the present eye drops could induce programed cell death like process in Acanthamoeba via mitochondrial pathway.
  • ||||||||||  Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J
    [VIRTUAL] Orbital Pseudotumor After Kawasaki Disease: A Case Report () -  Sep 25, 2021 - Abstract #AAPNCE2021AAP_NCE_1696;    
    Though this is rare in children, it may occur in relation to Kawasaki disease or other autoimmune processes. CT or MRI with contrast-enhanced sequences allow for diagnosis to facilitate treatment with systemic corticosteroids, which is essential for management.
  • ||||||||||  Netildex (netilmicin/dexamethasone) / Knight Therap, SIFI
    Journal:  Comparison of the Anti-Inflammatory and Cytotoxic Potential of Different Corticosteroid Eye Drop Preparations. (Pubmed Central) -  Jul 11, 2021   
    We also found that the eye drops preparations reduced proliferation of HCE cells, with D+T showing the higher anti-proliferative potency and B+C showing the lower cytotoxic potential. Our study points out that it may be erroneous to consider routinely-used anti-inflammatory eye drops preparations with analogous formulations as readily interchangeable and of similar potency and tolerability.
  • ||||||||||  tobramycin/dexamethasone / Generic mfg.
    Clinical, Journal:  Intestinal microbiome: a new target for chalaziosis treatment in children? (Pubmed Central) -  Jun 24, 2021   
    P=N/A
    The first group received medical treatment (lid hygiene, warm compression and dexamethasone/tobramycin ointment for at least 20 days), and the second group received medical treatment plus a daily supplementation of oral probiotics (≥ 1 × 10^9 live cells of Streptococcus thermophilus ST10 (DSM 25246), ≥ 1 × 10^9 live cells of Lactococcus lactis LCC02 (DSM 29536) and ≥ 1 × 10^9 live cells of Lactobacillus delbrueckii subsp...What is New: • In children probiotic supplementation is safe and effective. • Probiotic supplementation reduced the time required for complete resolution of the chalazion.