- |||||||||| Journal: Molecular detection of virulence genes and antimicrobial resistance in Salmonella isolates from avian and human sources in northeastern Algeria. (Pubmed Central) - Jul 9, 2025
Low resistance levels were detected for tetracycline, ciprofloxacin, and amikacin, at 26%, 20%, and 6.6%, respectively.These findings along with the widespread presence of virulence genes (spvA, spiC, spvC, and pefA) in both human and poultry isolates, underscore the potential for cross-species transmission and the urgent need for enhanced surveillance. The regional findings from Annaba and Constantine emphasize the importance of stricter antibiotic use policies in poultry farming.
- |||||||||| ciprofloxacin oral / Generic mfg., nalidixic acid / Generic mfg.
Journal: Nalidixic acid-a good marker of fluoroquinolone resistance mechanisms in Escherichia coli. (Pubmed Central) - May 22, 2025 When plasmid-mediated quinolone-resistance determinants are present, they are a potential risk for treatment failures due to accumulation of resistance mechanisms during the antimicrobial treatment. Therefore, when it is clinically relevant, fluoroquinolone resistance mechanisms in E. coli should be monitored more closely, and we also recommend testing nalidixic acid susceptibility.
- |||||||||| Journal: Prevalence of Vibrio cholerae in an Acute Watery Diarrhea Outbreak in Sulaymaniyah City, Iraq. (Pubmed Central) - May 14, 2025
Molecular techniques provided crucial insights into outbreak tracking and genetic relatedness, while AST profiling highlighted the urgent need for revised treatment guidelines. Strengthening water sanitation, continuous antimicrobial resistance monitoring, and targeted public health interventions are essential for preventing future outbreaks.
- |||||||||| Retrospective data, Review, Journal: Antimicrobial resistance in community-acquired enteric pathogens among children aged???10-years in low-and middle-income countries: a systematic review and meta-analysis. (Pubmed Central) - May 13, 2025
The pooled estimates of E. coli AMR for clinically important antibiotics were as follows: sulfamethoxazole/trimethoprim (SXT) 71% [95%CI: 57-82%]; ampicillin (AMP) 56% [95%CI: 44-67%]; ciprofloxacin (CIP) 10% [95%CI: 5-20%]; and ceftriaxone (CRO) 8% [95%CI: 2-31%]...were AMP 76% [95%CI: 60-87%]; nalidixic acid (NA) 9% [95%CI: 2-31%]; CIP 3% [95%CI: 0-15%]; and CRO 2% [95%CI: 0-19%]...AMR were erythromycin (ERY) 33% [95%CI: 12-64%] and CIP 27% [95%CI: 8-61%]...The limitations of our findings include high regional variability, significant interstudy heterogeneity, and underrepresentation of certain LMICs. https://inplasy.com/inplasy-2024-2-0051/, registration number: INPLASY202420051.
- |||||||||| nalidixic acid / Generic mfg., cloxacillin / Generic mfg.
Journal: Membrane-Active Peptides Derived from Natural Transmembrane Domains Function as Antibiotic Potentiators. (Pubmed Central) - May 12, 2025 The molecular basis for peptide-based permeabilization of the bacterial outer and inner membranes that contributes to the observed antibiotic potentiation was studied through several in vitro liposome-based assays and in vivo fluorescence-based assays. The overall results suggest that membrane proteins harbor a wealth of peptide sequences that may function as effective membrane-active peptides for the targeting of difficult-to-treat Gram-negative bacterial infections, and as such, provide valuable guidelines for the design of membrane-active peptides with synergistic antibacterial and antibiotic potentiation activity.
- |||||||||| nalidixic acid / Generic mfg.
Journal: An MDR Salmonella Enteritidis sublineage associated with gastroenteritis outbreaks and invasive disease in China. (Pubmed Central) - Mar 6, 2025 These clades have induced extensive outbreaks of gastroenteritis and serious cases of iNTS in China, underscoring the pressing nature and severity of this public health crisis. Implementing the One-Health strategy, longstanding routine surveillance and further genomic epidemiological studies are urgently required to capture epidemics, monitor changes in bacterial populations and determine the consequent risk to global public health.
- |||||||||| nalidixic acid / Generic mfg., tetracycline / Generic mfg.
Retrospective data, Review, Journal: Pooled prevalence of Escherichia coli phenotypic and genotypic antimicrobial resistance profiles in poultry: systematic review and meta-analysis. (Pubmed Central) - Mar 6, 2025 Tetracycline resistance genes had the highest prevalence, with 29.78% of isolates (498/1076) positive for at least one of the three genes (tetA, tetB and/or tetC). The levels of phenotypic and genotypic prevalence of E. coli in poultry can provide a scientific basis for the control of antibiotic-resistant strains and contribute to the competent authorities to guide the management interventions that best suit the different geographical regions.
- |||||||||| Journal: Drug resistance and genotyping studies of Salmonella Enteritidis isolated from broiler chickens in Iran. (Pubmed Central) - Mar 5, 2025
However, all isolates were sensitive to meropenem, ceftazidime and aztreonam...These data highlight the great potential risks of the presence and transmission of highly pathogenic MDR Salmonella to humans from chicken meat sources, as well as the need for more effective surveillance for antimicrobial use in the poultry industry. Reducing/optimizing the use of antimicrobials, improving poultry management procedures, using probiotics and biosecurity or vaccines are essential to deal with this issue.
- |||||||||| ampicillin / Generic mfg., nalidixic acid / Generic mfg., tetracycline / Generic mfg.
Journal: Recent Occurrence and Rapid Spread of Multidrug-Resistant Salmonella Infantis in Broiler Flocks in Korea. (Pubmed Central) - Feb 27, 2025 To mitigate the risks associated with the rapid spread of MDR Salmonella Infantis in poultry production and its potential impact on human health, this study provides valuable insights into implementing effective control measures to reduce Salmonella in broiler production in Korea. Further highlighting the critical importance of enhanced biosecurity and continuous surveillance.
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