fluocinolone acetonide / Generic mfg. 
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 15 Diseases   9 Trials   9 Trials   230 News 


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  • ||||||||||  Desonate (desonide gel) / LEO Pharma, Dupixent (dupilumab) / Sanofi, Regeneron
    ALLERGIC CONTACT DERMATITIS TO TOPICAL CORTICOSTEROIDS: WHAT IS THE NEXT STEP IN MANAGEMENT? (Monitor 15; Hall A) -  Sep 29, 2024 - Abstract #ACAAI2024ACAAI_935;    
    Adjustments to treatment, including introduction of pimecrolimus and topical mupirocin ointment, also failed to produce any improvement...However, the patient showed improvement with the administration of oral prednisolone...Patch tests for triamcinolone acetonide, desonide, and fluocinolone acetonide were positive, showing localized inflammation and worsening of eczema at application sites...Early consideration and use of dupilumab can result in notable clinical benefits for such patients. Consent granted from patient's parents to present case.
  • ||||||||||  fluocinolone acetonide / Generic mfg.
    Retrospective data, Journal:  INTRAVITREAL 0.18-mg FLUOCINOLONE ACETONIDE IMPLANT FOR PEDIATRIC UVEITIS. (Pubmed Central) -  Sep 20, 2024   
    Consent granted from patient's parents to present case. The 0.18-mg fluocinolone acetonide implant has a similar efficacy for the treatment of pediatric uveitis, particularly pars planitis, as in the adult population, although with higher rates of ocular hypertension requiring intervention.
  • ||||||||||  Durezol (difluprednate ophthalmic emulsion) / Senju, Novartis
    Review, Journal:  Corticosteroids for the Management of Uveitic Macular Edema: A Comprehensive Review. (Pubmed Central) -  Sep 5, 2024   
    Emerging techniques, such as suprachoroidal space triamcinolone acetonide administration, offer promising alternatives for managing UME. Through a thorough examination of current evidence, this review provides valuable insights into optimizing the management of UME and improving visual outcomes in patients with uveitis.
  • ||||||||||  Remicade (infliximab) / J&J, Humira (adalimumab) / AbbVie
    Journal:  Subretinal Fibrosis Developing 10 Years After First Presentation with Chronic Ocular Sarcoidosis in a Child. (Pubmed Central) -  Jun 12, 2024   
    Ultimately, the patient's intraocular inflammation was successfully controlled by using intravitreal steroids (Triamcinolone and Fluocinolone acetonide implant)...The index case progressed to sight-robbing bilateral subretinal fibrosis, a rare complication of ocular sarcoidosis despite a combination of conventional and biologic anti-inflammatory therapies. There is a pressing need to develop new treatment agents for refractory non-infectious uveitis.
  • ||||||||||  Triesence (triamcinolone acetonide injectable suspension) / Novartis, Kenalog-40 (triamcinolone acetonide injection suspension) / BMS
    Review, Journal:  The Treatment of Diabetic Retinal Edema with Intravitreal Steroids: How and When. (Pubmed Central) -  Apr 9, 2024   
    They have been demonstrated to be effective in reducing macular edema and improving visual outcomes in DME patients but are associated with a high risk of intraocular pressure elevation and cataract development, so their use requires an accurate patient selection. This manuscript aims to provide a comprehensive overview of the pathology, epidemiology, risk factors, physiopathology, clinical features, treatment mechanisms of actions, treatment options, prognosis, and ongoing clinical studies related to the treatment of DME, with particular consideration of intravitreal steroids therapy.
  • ||||||||||  fluocinolone acetonide / Generic mfg., hydroquinone / Generic mfg.
    Journal:  Best Practices in the Treatment of Melasma with a Focus on Patients with Skin of Color. (Pubmed Central) -  Jan 15, 2024   
    Not yet recruiting --> Recruiting | Initiation date: Sep 2023 --> Jan 2024 Melasma can be challenging to treat, particularly in patients with skin of color, and our recommendations for best practices for patients in the United States are an important step toward standardizing care.
  • ||||||||||  fluocinolone acetonide / Generic mfg.
    Journal:  The Effects of Lumbricus rubellus Extract on Staphylococcus aureus Colonization and IL-31 Levels in Children with Atopic Dermatitis. (Pubmed Central) -  Nov 29, 2023   
    AD patients aged 8-16 who had a Scoring Atopic Dermatitis (SCORAD) index > 25, with total IgE serum level > 100 IU/mL, and had healthy weight were randomly assigned into two groups: one received fluocinolone acetonide 0.025% and placebo (control group) and one received fluocinolone acetonide 0.025% combined with L. rubellus extract (Vermint) (intervention group)...Moreover, fourteen AD patients in the intervention group showed an improvement in the SCORAD index of more than 35% (p = 0.057). L. rubellus extract significantly decreases S. aureus colonization and the IL-31 level in AD patients, suggesting its potential as an adjuvant therapy for children with AD.
  • ||||||||||  dexamethasone / Generic mfg., fluocinolone acetonide / Generic mfg.
    Journal:  Treatment of Intermediate Uveitis-associated Retinal Vasoproliferative Tumors: A Case Series. (Pubmed Central) -  Sep 27, 2023   
    This study found that treatment with FA led to an enhancement in the anterograde movement of mitochondria based on fluorescent imaging. Combination intravitreal anti-VEGF and corticosteroid implants may be a useful approach for the treatment of intermediate uveitis-associated VPTs and can lead to both functional and structural improvement.
  • ||||||||||  fluocinolone acetonide / Generic mfg.
    Review, Journal, Adverse events:  Optimizing glucocorticoid therapy for Beh (Pubmed Central) -  Sep 26, 2023   
    Moreover, we underscore the importance of combining GCS with immunosuppressive drugs and biological agents to minimize adverse reactions and optimize therapeutic outcomes. The review concludes that, while GCS remain a crucial component of BU treatment, careful consideration of their administration and combination with other therapies is essential to achieve long-term remission and improved visual outcomes for patients with BU.
  • ||||||||||  fluocinolone acetonide / Generic mfg.
    Peanut Allergy Puzzle: Unexpected Response To Topical Fluocinolone (Monitor 08) -  Sep 14, 2023 - Abstract #ACAAI2023ACAAI_782;    
    Case Description A 17-month-old female with atopic dermatitis and multiple food allergies including egg, peanut, and tree nuts developed a diffusely erythematous, pruritic morbilliform rash across the trunk, extremities, hands, and groin about 5-7 hours after applying Fluocinolone acetonide 0.01% oil for the first time on the hands, arms, and legs...Hence, when treating patients with food allergies, the food content of topical treatments should be considered as possible triggers for reactions. Further investigation into non-oral exposure to food allergens is warranted.
  • ||||||||||  fluocinolone acetonide / Generic mfg.
    Review, Journal:  Corticosteroid implants for chronic non-infectious uveitis. (Pubmed Central) -  Sep 2, 2023   
    To better understand the efficacy and safety profiles of corticosteroid implants, we need future trials that examine implants of different doses, used for different durations. The trials should measure core standard outcomes that are universally defined, and measured at comparable follow-up time points.
  • ||||||||||  risperidone / Generic mfg., fluocinolone acetonide / Generic mfg.
    Morgellons Disease with Neurotic Excoriation: A Little-Known Disorder of Psychodermatology (e-Poster Hall) -  Aug 30, 2023 - Abstract #EADV2023EADV_4334;    
    In approaching psychodermatology patients, dermatologists need to build good patient-doctor rapport since these patients often deny the psychiatry problem as the cause of their skin condition. Collaborative management with the psychiatry department is essential in managing psychodermatology patients.
  • ||||||||||  fluocinolone acetonide / Generic mfg.
    Journal:  REDD1 (regulated in development and DNA damage (Pubmed Central) -  Jul 24, 2023   
    We found large differences in transcriptome of REDD1 KO and control Cas9 cells in response to glucocorticoid fluocinolone acetonide (FA): both the scope and amplitude of response were significantly decreased in REDD1 KO...We found the increased expression and abnormal nuclear translocation of FKBP51 in both untreated and FA-treated REDD1 KO cells. Overall, our results suggest the existence of a feed-forward loop in GR signalling mediated by its target gene REDD1, which has translational potential for the development of safer GR-targeted therapies.
  • ||||||||||  tacrolimus topical / Generic mfg., fluocinolone acetonide / Generic mfg., acyclovir / Generic mfg.
    Study of post herpetic leukoderma-clinical significance and therapeutic challenge () -  Jul 3, 2023 - Abstract #WCD2023WCD_6668;    
    Topical tacrolimus 0.1% cream, fluocinolone acetonide cream and decapeptide(BFGF lotion) were given in combination... Combination of medical, surgical, and micropigmentation yielded better results, along with either continuous or episodic antiviral treatment
  • ||||||||||  fluocinolone acetonide / Generic mfg.
    Trial completion date, Trial primary completion date:  PANTHER: Imaging of Uveitis Patients Receiving Injectable Fluocinolone Acetonide Implant (clinicaltrials.gov) -  Feb 8, 2023   
    P=N/A,  N=30, Recruiting, 
    The method greenness was evaluated using GAPI, AGREE, and analytical eco scale and found that the method is green. Trial completion date: Mar 2023 --> Mar 2024 | Trial primary completion date: Jan 2023 --> Jan 2024
  • ||||||||||  fluocinolone acetonide / Generic mfg.
    Journal:  Identification of Two Novel Hydroperoxide Impurities in Fluocinolone Acetonide Topical Solution by Liquid Chromatography Mass Spectrometry. (Pubmed Central) -  Jan 23, 2023   
    A possible mechanism for the formation of these two novel hydroperoxide impurities is based on the neighboring group participation effect of adjacent hydroxyl group (Internal SN2) which results in the loss of fluorine atom and formation of epoxide intermediate followed by the addition of the HOOH group. Since most of the hydroperoxide impurities are genotoxic in nature, one should eliminate these impurities from Active Pharmaceutical Ingredient (API) or protect the formulation product from these oxidative impurities.
  • ||||||||||  fluocinolone acetonide / Generic mfg.
    Review, Journal:  Corticosteroid implants for chronic non-infectious uveitis. (Pubmed Central) -  Jan 17, 2023   
    We searched CENTRAL (which contains the Cochrane Eyes and Vision Trials Register), MEDLINE Ovid, Embase, PubMed, LILACS, and three trials registries to November 2021.  SELECTION CRITERIA: We included randomized controlled trials comparing either fluocinolone acetonide (FA) or dexamethasone (DEX) intravitreal implants with standard-of-care therapy or sham procedures, with at least six months of follow-up after treatment...Nevertheless, the evidence suggests that these implants may increase the risk of cataract progression and IOP elevation, which will require interventions over time.  To better understand the efficacy and safety profiles of corticosteroid implants, we need future trials that examine implants of different doses, used for different durations. The trials should measure core standard outcomes that are universally defined, and measured at comparable follow-up time points.