- |||||||||| fentanyl citrate / Generic mfg., oxycodone controlled release / Generic mfg.
Journal: Synthetic opioids in Poland-A cause for concern or a media distraction? (Pubmed Central) - Sep 21, 2024
Poland currently does not seem to be in a position that resembles an early stage of an opioid crisis. With this article we want to calm a heated public debate that is currently taking place in Poland, and redirect attention to a much more substantial problem of synthetic cathinones.
- |||||||||| fentanyl citrate / Generic mfg., oxycodone controlled release / Generic mfg.
Journal: The Imperative of Regulation: The Co-creation of a Medical and Non-medical US Opioid Crisis. (Pubmed Central) - Sep 19, 2024
In the first opioid crisis wave (1998-2010), opioid-related deaths were mainly associated with prescription opioids such as Oxycontin (oxycodone hydrochloride)...Ironically, this turned the most powerful geopolitical force in the war against drugs into its greatest victim. Due to formulary availability and regulatory barriers to accessibility European countries have been relatively protected against following suit the US opioid crisis.
- |||||||||| sildenafil / Generic mfg., oxycodone controlled release / Generic mfg.
Review, Journal: Radio frequency identification technology; A method of analysis of falsified pharmaceutical products: Literature review. (Pubmed Central) - Sep 3, 2024
The authenticated Radio Frequency Identification devices model is used for pharmaceutical products' authentication from origin of pharmaceutical industry to the pharmacy at any point along the chain of the distribution. Popular pharmaceutical products, such as OxyContin and Sildenafil Citrate, which are particular targets of falsification have mandated the use of Radio Frequency Identification devices technology.
- |||||||||| ketamine / Generic mfg.
Journal, Adverse events: A replication study using the World Health Organization pharmacovigilance database (VigiBase (Pubmed Central) - Aug 22, 2024
Mixed results were observed with ketamine with some RORs increased and others decreased. Estimating RORs using a pharmacovigilance database does not establish causation in the case of elevated RORs and cannot be assumed to be a therapeutic effect when lower RORs were observed.
- |||||||||| Xtampza ER (oxycodone) / Collegium Pharma
Curbing Opioid Abuse: Real-World Evidence of Abuse-Deterrent Formulations (Exhibit Hall) - Jul 31, 2024 - Abstract #PAINWeek2024PAINWeek_161;
Estimating RORs using a pharmacovigilance database does not establish causation in the case of elevated RORs and cannot be assumed to be a therapeutic effect when lower RORs were observed. 3-4 To date, there are 4 opioids (1 immediate release [IR] and 3 extended release [ER]) with US Food and Drug Administration (FDA)
- |||||||||| MoxDuo IR (morphine + oxycodone) / QRxPharma, AbbVie
Restrictive Domains in Healthcare Opioid Legislation in Low- and Middle-Income Countries (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1524;
3-4 To date, there are 4 opioids (1 immediate release [IR] and 3 extended release [ER]) with US Food and Drug Administration (FDA) While analyses of associations of restrictive domains and HDI and QDI are ongoing and results are pending, this scoping review preliminarily calls attention to the specific restrictive domains of the legislative language that may negatively influence access to quality pain management.Individual models of success in facilitating access to opioids and developing palliative care programs were identified in Nepal, Mongolia, and Uganda.
- |||||||||| oxycodone controlled release / Generic mfg.
Journal: Inside "Operation Change Agent": Mallinckrodt's Plan for Capturing the Opioid Market. (Pubmed Central) - Jul 9, 2024
This research on internal corporate strategy joins the growing challenges to industry claims that opioid sales teams simply educated providers and helped fill existing demand for their products. It has important implications for regulatory policy and consumer protections that can better protect health in the face of competitive market forces.
- |||||||||| morphine sulphate / Generic mfg.
Symptomatic Catheter Tip Granuloma in a Patient With High Dose Intrathecal Morphine Therapy: To Explant or Not to Explant (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_3143;
Only three drugs (morphine, baclofen, and ziconotide) are approved by the US Food and Drug Administration (FDA) for use in intrathecal pain pump, but several drugs are used off-label, such as hydromorphone, fentanyl, sufentanyl, ketamine, clonidine, and bupivacaine...This case discusses the use of the combination of long- and short-acting oral opioids in the process of rapid weaning off intrathecal opioids in a patient with an IDDS.CASE HISTORYThe patient is a 66-year-old female with a past medical history significant for pulmonary embolism, deep venous thrombosis (on Xarelto), bipolar disorder, asthma, chronic obstructive pulmonary disease, and chronic low back pain...Her pain is well controlled with oxycontin 30 mg bid and oxycodone 15 mg tid...Will you agree?9)Why did this patient develop granuloma at the tip of intrathecal catheter in the first place? Does it relate to the content of drug or it can happen to anyone with intrathecal drug delivery?10)Your new pain fellow asked if there is anything you can do prevent formation of granuloma in other patients.1
- |||||||||| morphine sulphate / Generic mfg.
Symptomatic Catheter Tip Granuloma in a Patient With High Dose Intrathecal Morphine Therapy: To Explant or Not to Explant (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_3028;
Only three drugs (morphine, baclofen, and ziconotide) are approved by the US Food and Drug Administration (FDA) for use in intrathecal pain pump, but several drugs are used off-label, such as hydromorphone, fentanyl, sufentanyl, ketamine, clonidine, and bupivacaine...This case discusses the use of the combination of long- and short-acting oral opioids in the process of rapid weaning off intrathecal opioids in a patient with an IDDS.CASE HISTORYThe patient is a 66-year-old female with a past medical history significant for pulmonary embolism, deep venous thrombosis (on Xarelto), bipolar disorder, asthma, chronic obstructive pulmonary disease, and chronic low back pain...Her pain is well controlled with oxycontin 30 mg bid and oxycodone 15 mg tid...Will you agree?9)Why did this patient develop granuloma at the tip of intrathecal catheter in the first place? Does it relate to the content of drug or it can happen to anyone with intrathecal drug delivery?10)Your new pain fellow asked if there is anything you can do prevent formation of granuloma in other patients.1
- |||||||||| fentanyl citrate / Generic mfg., oxycodone controlled release / Generic mfg.
Journal: The effect of opioid use on traffic fatalities. (Pubmed Central) - Apr 29, 2024
The effect is mainly concentrated in fatal crashes with drug involvement of drivers ages between 25 and 44. Our results highlight additional long-term detrimental consequences of the introduction and marketing of OxyContin.
- |||||||||| OxiFast (oxycodone immediate release) / Purdue, Shionogi, Mundipharma
Enrollment open, Trial initiation date, Surgery: 5x-Multiplier vs 3-Tier Model for Discharge Opioid Prescriptions After Intra-abdominal Cancer Surgery: A Randomized Clinical Trial (clinicaltrials.gov) - Mar 29, 2024
P2, N=150, Recruiting,
Compared with oral oxycontin tablet, the use of PCSA with hydromorphone achieved a shorter titration duration for patients with cancer pain (p<0.001), without significantly increasing adverse events (p=0.32). Not yet recruiting --> Recruiting | Initiation date: Jun 2024 --> Mar 2024
- |||||||||| fentanyl citrate / Generic mfg.
A Rare Case of Alcoholic hepatitis/ Fentanyl-induced Renal TMA () - Mar 23, 2024 - Abstract #NKFSCM2024NKF_SCM_574;
INTRODUCTION: Thrombotic Microangiopathy (TMA) represents a pathologic diagnosis in which abnormalities in the microvasculature lead to thrombosis that can affect multiple organs including the kidneys. It is important to recognize these substances, including opioid derived or synthetic formulations, as possible triggers for TMA.
- |||||||||| fentanyl citrate / Generic mfg., oxycodone/acetaminophen / Generic mfg., oxycodone controlled release / Generic mfg.
Outcomes of an Opioid Education and Naloxone Distribution Program in Juvenile Hall in San Diego (Convention Center Exhibit Hall) - Mar 16, 2024 - Abstract #PAS2024PAS_2755;
Of all 49 individuals who participated, there was a statistically significant increase in the number who, after training, correctly identified heroin, oxycontin and fentanyl as opioids (p < 0.010), correctly identified trouble breathing as a sign of opioid overdose (p < 0.004), wanted to help someone who overdosed (p < 0.017), felt they would know how to help someone who overdosed (p < 0.001), and reported not needing additional training in order to feel confident helping someone who overdosed (p < 0.007). All participants successfully completed simulation of nasal injection.
- |||||||||| pethidine / Samaritan Pharma
Patterns of Outpatient Opioid Prescriptions in Yinzhou, China: A Decade-Long Study (2011-2021) () - Mar 8, 2024 - Abstract #ISPOR2024ISPOR_238;
This is the first report detailing outpatient opioid prescription duration, daily OME, and initial user patterns in China, revealing lower opioid use rates, average durations, and doses compared to North America, UK, and Australia, suggesting relatively safe opioid use in China. However, the presence of high-risk prescriptions highlights the need for enhanced monitoring of adverse events and pain assessment in outpatient settings.
- |||||||||| Palexia RP (tapentadol extended release) / Assertio, J&J, Grunenthal, Collegium Pharma
Journal: Comparison of the effects of OPRM1 A118G polymorphism using different opioids: A prospective study. (Pubmed Central) - Jan 15, 2024
However, the presence of high-risk prescriptions highlights the need for enhanced monitoring of adverse events and pain assessment in outpatient settings. Tapentadol and methadone may be more suitable than hydromorphone, oxycodone, and fentanyl for G-allele carriers due to their dual mechanism of action and low susceptibility to OPRM1 A118G polymorphism.
- |||||||||| Enrollment open: No-PAIN: NSAID Use After Robotic Partial Nephrectomy (clinicaltrials.gov) - Sep 6, 2023
P2, N=110, Recruiting,
Trial completion date: Sep 2024 --> Sep 2025 | Trial primary completion date: Jun 2024 --> Jun 2025 Not yet recruiting --> Recruiting
- |||||||||| Decadron (dexamethasone) / Merck (MSD), Ozurdex (dexamethasone intravitreal implant) / AbbVie, Exparel (bupivacaine liposome injectable suspension) / Pacira
Trial completion, Trial completion date: Efficacy of Opioid-limiting Pain Management Protocol in Men Undergoing Urethroplasty (clinicaltrials.gov) - Aug 1, 2023
P4, N=60, Completed,
It also might be used for appropriate education and dissemination of information to persons engaged in drug use content on Twitter. Recruiting --> Completed | Trial completion date: Oct 2023 --> Jun 2023
- |||||||||| Prialt (ziconotide) / Jazz
Lost In Conversion: Intrathecal Opioids To Equivalent Oral Opioids In Chronic Pain Patients (South: Hall D-7) - Jul 20, 2023 - Abstract #ASA2023ASA_2332;
Only three drugs (morphine, baclofen, and ziconotide) are approved by the US Food and Drug Administration (FDA) for use in intrathecal pain pump, but several drugs are used off-label, such as hydromorphone, fentanyl, sufentanyl, ketamine, clonidine, and bupivacaine...This case discusses the use of the combination of long- and short-acting oral opioids in the process of rapid weaning off intrathecal opioids in a patient with an IDDS.CASE HISTORYThe patient is a 66-year-old female with a past medical history significant for pulmonary embolism, deep venous thrombosis (on Xarelto), bipolar disorder, asthma, chronic obstructive pulmonary disease, and chronic low back pain...Her pain is well controlled with oxycontin 30 mg bid and oxycodone 15 mg tid...Will you agree?9)Why did this patient develop granuloma at the tip of intrathecal catheter in the first place? Does it relate to the content of drug or it can happen to anyone with intrathecal drug delivery?10)Your new pain fellow asked if there is anything you can do prevent formation of granuloma in other patients.
- |||||||||| Prialt (ziconotide) / Jazz
Lost In Conversion: Intrathecal Opioids To Equivalent Oral Opioids In Chronic Pain Patients (South: Hall D-7) - Jul 20, 2023 - Abstract #ASA2023ASA_368;
Only three drugs (morphine, baclofen, and ziconotide) are approved by the US Food and Drug Administration (FDA) for use in intrathecal pain pump, but several drugs are used off-label, such as hydromorphone, fentanyl, sufentanyl, ketamine, clonidine, and bupivacaine...This case discusses the use of the combination of long- and short-acting oral opioids in the process of rapid weaning off intrathecal opioids in a patient with an IDDS.CASE HISTORYThe patient is a 66-year-old female with a past medical history significant for pulmonary embolism, deep venous thrombosis (on Xarelto), bipolar disorder, asthma, chronic obstructive pulmonary disease, and chronic low back pain...Her pain is well controlled with oxycontin 30 mg bid and oxycodone 15 mg tid...Will you agree?9)Why did this patient develop granuloma at the tip of intrathecal catheter in the first place? Does it relate to the content of drug or it can happen to anyone with intrathecal drug delivery?10)Your new pain fellow asked if there is anything you can do prevent formation of granuloma in other patients.
- |||||||||| morphine sulphate / Generic mfg., oxycodone controlled release / Generic mfg.
OPIOID USE REDUCTION BY OXYCODONE MORPHINE FORMULARY SWITCH () - May 12, 2023 - Abstract #EHA2023EHA_3151;
Switching from oxycodone to morphine as the preferred oral opioid for hemato-oncology patients with pain reduces both the oral opioid use during admission and the number of patients with an oral opioid prescription at discharge. Since the reduction in opioid use resulted in no differences in overall pain control, the oxycodone morphine switch warrants further implementation.Figure 1: number of clinical prescriptions for opioids at the hematology ward Drug interaction, Side effects, Quality of life
- |||||||||| Decadron (dexamethasone) / Merck (MSD), Ozurdex (dexamethasone intravitreal implant) / AbbVie, Exparel (bupivacaine liposome injectable suspension) / Pacira
Trial primary completion date: Efficacy of Opioid-limiting Pain Management Protocol in Men Undergoing Urethroplasty (clinicaltrials.gov) - Mar 20, 2023
P4, N=60, Recruiting,
Patients in the non-opioid placebo group spent more time mobilized the first week after surgery than those in the tapentadol ER and the oxycodone CR groups, while the number of steps was not different between the groups. Trial primary completion date: Oct 2022 --> Apr 2023
- |||||||||| Rapinyl (fentanyl) / Kyowa Kirin, Orexo, Zydus Cadila, OxiFast (oxycodone immediate release) / Purdue, Shionogi, Mundipharma
Journal: Medical opioid disposal in Fukuoka and Kumamoto cities. (Pubmed Central) - Mar 9, 2023
Trial primary completion date: Oct 2022 --> Apr 2023 In Fukuoka city, the most disposed opioid was 20 mg Oxycontin, worth approximately 940,000
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