loperamide / Generic mfg. 
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  • ||||||||||  loperamide / Generic mfg.
    Journal:  Gut-brain axis mediated by intestinal content microbiota was associated with Zhishi Daozhi decoction on constipation. (Pubmed Central) -  Feb 18, 2025   
    In this study, Kunming mice were administered a high-protein diet (HFHPD) and loperamide hydrochloride injections to induce constipation...ZDD appears to alleviate constipation, potentially through mechanisms linked to the brain-gut axis and its interaction with the intestinal microbiota. Among the treatment groups, the medium dose of ZDD demonstrated the most effective results.
  • ||||||||||  budesonide / Generic mfg., loperamide / Generic mfg.
    Review, Journal:  Update on the epidemiology and management of microscopic colitis. (Pubmed Central) -  Feb 13, 2025   
    There is an unmet need to further define the pathophysiology of microscopic colitis. Additionally, trials with novel therapies, particularly in patients with budesonide-refractory disease, are needed.
  • ||||||||||  loperamide / Generic mfg.
    Journal:  Yunweiling alleviates functional constipation: integrating network pharmacology and experimental study. (Pubmed Central) -  Feb 11, 2025   
    The effects of these extracts and solvent fractions on reducing/delaying diarrhea were compared with the impact of the solvent used for reconstitution and a standard drug (loperamide 3 The integration of network pharmacology and experimental investigations indicated the effectiveness of yunweiling in managing FC, offering essential theoretical support for clinical application.
  • ||||||||||  loperamide / Generic mfg.
    Preclinical, Journal:  Assessment of Antidiarrheal Effect of Oleuropein Through  (Pubmed Central) -  Feb 10, 2025   
    The standard drug, loperamide (LOP) at 3?mg/kg, was used for comparison...In conclusion, the findings suggest that OLP possesses significant antidiarrheal potential both in vivo and through receptor interaction, positioning it as a promising natural therapeutic agent for managing diarrhea. Further studies are warranted to fully elucidate its mechanisms of action and clinical applicability.
  • ||||||||||  loperamide / Generic mfg.
    Journal:  Spiked Systems for Colonic Drug Delivery: Architectural Opportunities and Quality Assurance of Selective Laser Sintering. (Pubmed Central) -  Feb 6, 2025   
    Poly(vinyl alcohol) (PVA) was used as the binding material and loperamide hydrochloride was incorporated as the active ingredient...No movement on the tissue was recorded for the spiked balls, and specimens with more spikes exhibited longer retention times and potentially, enhanced bioavailability. Our results suggest that SLS 3D printing is a versatile technology that holds the potential to revolutionize drug delivery systems by enabling the creation of complex geometries and medications with tunable properties.
  • ||||||||||  loperamide / Generic mfg.
    Clinical, Journal:  Evaluation of the Effect of Loperamide on the Cardiac Repolarization Interval Using Exposure-Response Analysis. (Pubmed Central) -  Jan 27, 2025   
    The sensitivity analysis considering loperamide concentrations in the effect compartment instead of M1 as input for the concentration-??QTcF analysis confirmed these findings. The data showed that loperamide or M1 does not have an effect on cardiac repolarization that exceeds the threshold of regulatory concern in healthy participants at doses of 8 and 48?mg.
  • ||||||||||  loperamide / Generic mfg.
    Trial completion date, Trial initiation date, Trial primary completion date:  A Bowel Management Program (Retrograde Rectal Enema) for the Treatment of Low Anterior Resection Syndrome in Rectal Cancer Patients (clinicaltrials.gov) -  Jan 4, 2025   
    P1,  N=80, Not yet recruiting, 
    Although DRE and ARM are commonly used diagnostic measures among women with FI, the weak correlations with patient-reported symptoms raises questions about their utility in clinical care. Trial completion date: Dec 2026 --> Dec 2028 | Initiation date: Oct 2024 --> Mar 2025 | Trial primary completion date: Dec 2025 --> Dec 2028
  • ||||||||||  loperamide / Generic mfg.
    Journal:  Effects of brown seaweed oligosaccharides on obesity and constipation managements. (Pubmed Central) -  Dec 30, 2024   
    Our results indicated that BSO intervention significantly increased fecal pallet output and fecal water content, as well as improved intestinal transit. In conclusion, this study lays the foundation for a deeper understanding of how BSO may influence obesity and constipation, offering novel insights into its potential safe and efficacious clinical applications.
  • ||||||||||  pazopanib / Generic mfg., loperamide / Generic mfg.
    Journal:  Case 332: Tyrosine Kinase Inhibitor-induced Intestinal Lymphangiectasia. (Pubmed Central) -  Dec 24, 2024   
    A comprehensive metabolic panel was performed, indicating a serum chloride level of 98 mmol/L (reference range, 100-108 mmol/L) and an alkaline phosphatase level of 121 U/L (2.02 ?kat/L) (reference range, 45-115 U/L [0.75-1.92 ?kat/L]). The patient underwent surveillance imaging with contrast-enhanced CT of the abdomen and pelvis in the venous phase.
  • ||||||||||  loperamide / Generic mfg.
    Journal:  Cistanche deserticola polysaccharide alleviates constipation by regulating intestinal barrier function and intestinal microbiota and their metabolites. (Pubmed Central) -  Dec 16, 2024   
    In this study, we established a loperamide-induced constipation model in mice to investigate the effects of Cistanche polysaccharides (CDPS) and to explore its underlying pharmacological mechanism...Notably, CDPS increased the abundance of beneficial bacteria, including Prevotellaceae UCG-001, Odoribacter, Clostridiales vadin BB60 group, Alistipes, Lactobacillaceae, and Rikenellaceae, while decreasing the abundance of harmful bacteria such as Parabacteroides and Proteobacteria. In summary, CDPS may prevent and treat constipation by modulating intestinal flora composition, influencing metabolite profiles, and reinforcing mucosal barrier function.
  • ||||||||||  loperamide / Generic mfg.
    Journal:  Ligustilide improves functional constipation by non-covalently activating TRPA1 in colon tissue. (Pubmed Central) -  Dec 7, 2024   
    Our findings demonstrate that Lig, the API in AS for constipation treatment, activates TRPA1 through non-covalent interactions, increasing mucus secretion and improving functional constipation. These findings advance our understanding of the therapeutic mechanism of AS and Lig on constipation and suggest a new approach for developing TRPA1 agonists.
  • ||||||||||  thapsigargin / University of Nottingham, Pirbright Institute
    Journal:  Zuojin Pill enhances gastrointestinal motility by modulating the pacemaker potentials in interstitial cells of Cajal through multiple signaling pathways. (Pubmed Central) -  Dec 4, 2024   
    Furthermore, ZJP reversed the reduction of ITR caused by loperamide (Imodium) and normalized the ITR abnormality of two etiologically distinct GI motility disorder (GMD) mouse models. Finally, ZJP increased serum concentrations of the pro-peristalsis factors motilin and substance P. Our results suggest that ZJP depolarizes ICCs via 5-HT4 or muscarinic M3 receptor activation and G-protein dependent calcium-, PLC-, inositol triphosphate-, and MAPK signaling pathways (but not PKC-dependent pathways), leading to enhanced GI motility.
  • ||||||||||  loperamide / Generic mfg.
    Journal, IO biomarker:  Integrated gut microbiota and serum pharmacochemistry reveal the mechanisms of wine steaming in alleviating rhubarb diarrhea. (Pubmed Central) -  Nov 30, 2024   
    Overall, PRH can alleviate RH-induced diarrhea by recovering the GM imbalance and abnormal levels of GM-mediated SCFAs, alleviating the decrease in cellular immune function and abnormal expression of TLR4/NF-?B, thereby suppressing the release of inflammatory factors, possibly, through its lower content of anthraquinones. This study explored for the first time the processing mechanism of wine steaming in alleviating RH-induced diarrhea from the aspects of small intestinal flora and small intestinal immune function.
  • ||||||||||  loperamide / Generic mfg.
    Preclinical, Journal:  Effects of Saccharomyces boulardii on microbiota composition and metabolite levels in the small intestine of constipated mice. (Pubmed Central) -  Nov 23, 2024   
    Here, we aimed to explore the effects of S. boulardii on the small intestine and the underlying mechanisms in mice with loperamide-induced constipation...While not fully reversing defecation changes, Saccharomyces boulardii alters intestinal flora, up-regulates key proteins affecting water reabsorption and inflammation, and positively influences metabolic pathways. Our study provides serves as a basis for further studies on the application of S. boulardii in the treatment of intestinal disorders.
  • ||||||||||  loperamide / Generic mfg.
    Journal:  What Do Travelers Know about Traveler's Diarrhea? Impact of a Pre-Travel Consultation in the Lisbon Area, Portugal. (Pubmed Central) -  Oct 25, 2024   
    However, knowledge gaps persisted: over 50% were unaware of TD's self-limited nature, 30% did not recognize loperamide as a symptom reliever, and 36% believed all travelers should take antibiotics to prevent TD...Thus, a pre-travel consultation effectively increased travelers' TD knowledge. However, post-consultation knowledge levels remained suboptimal, indicating the need for targeted interventions to increase travelers' literacy and optimize pre-travel consultations.