- |||||||||| remifentanil / Generic mfg., morphine sulphate / Generic mfg.
Trial completion date, Trial primary completion date: Comparison of Postoperative Analgesic Efficacy of the Erector Spina Plane Block and Quadratus Lumborum Block in Open Nephrectomy: a Prospective Randomized Clinical Study (clinicaltrials.gov) - Oct 15, 2024 P=N/A, N=60, Active, not recruiting, While our findings should be interpreted with caution owing to the small number of studies and substantial heterogeneity, proactive prevention, recognition, and management of inappropriate drug dosing in this population is warranted. Trial completion date: Apr 2024 --> Jan 2026 | Trial primary completion date: Jan 2024 --> Jan 2026
- |||||||||| clonidine / Generic mfg.
Clinical, Journal, Monotherapy: Clonidine as Monotherapy for Neonatal Opioid Withdrawal Syndrome: A Randomized Trial. (Pubmed Central) - Oct 15, 2024 Adding ketamine to TPVB resulted in better analgesia as demonstrated by significantly delayed time to first rescue analgesia, lower total amount of consumed opioid, and pain score without considerable effect on chronic pain and complications in patients undergoing thoracotomy. Of 155 infants, 120 required treatment and were randomized to receive oral clonidine (n = 60) at 1
- |||||||||| morphine sulphate / Generic mfg.
Journal: Comparison of fascial plane blocks (ESPB vs. TPVB) for pain relief following modified radical mastectomy. (Pubmed Central) - Oct 11, 2024 Morphine consumption and Visual Analog Score (VAS) for pain were recorded at 3, 6, 12, and 24 h postoperatively...The mean age and body mass index (BMI) of patients and length of hospital stay in both the groups were similar. Both ESPB and TPVB provided adequate analgesia in patients undergoing MRM; however, TPVB had better efficacy and opioid-sparing effect when compared to ESPB.
- |||||||||| Retrospective data, Journal: Feasibility of opioid-free anesthesia in laparoscopic radical prostatectomy: A retrospective, quasi-experimental study. (Pubmed Central) - Oct 11, 2024
Predefined protocols for either opioid-based anesthesia (OBA; with continuous remifentanil infusion) or OFA (continuous lidocaine, dexmedetomidine, and ketamine infusion) were followed...Lower morphine requirements were recorded in the first 18 and 24 postoperative hours, that is, 0 (IQR 0-0) versus 1 (IQR 0-2.75) mg, P = 0.028 and 0 (IQR 0-2) versus 1.5 (IQR 0-3) mg, P = 0.012, respectively...There was no difference in total complications or the length of stay. In this study, OFA strategy was found to be safe, feasible, and provided adequate analgesia, minimizing the use of postoperative opioids, and was independently associated with earlier ambulation.
- |||||||||| morphine sulphate / Generic mfg., amitriptyline / Generic mfg., methadone / Generic mfg.
CASE REPORT: KETAMINE USE IN REFRACTORY NEUROPATHIC PAIN OF MALIGNANT PERIPHERAL NERVE SHEATH TUMOUR () - Oct 11, 2024 - Abstract #ASCOMOS2024ASCOMOS_303; CONCLUSION Parenteral burst ketamine and oral ketamine are effective adjuncts in managing refractory cancer-related neuropathic pain, especially in patients intolerant to opioids and methadone. Further research is necessary to understand the efficacy and safety of ketamine in this context.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Comparison of Awake Respiratory Control Versus Sleep Obstructive Sleep Apnea Endotypes. (Pubmed Central) - Oct 10, 2024 In conclusion, awake measures of respiratory control are related to physiological endotypes such as airway collapsibility and arousal threshold during sleep and OSA severity. Awake ventilatory chemosensitivity has the best potential to predict changes in OSA severity with morphine.
- |||||||||| morphine sulphate / Generic mfg.
Preclinical, Journal: A multi-target ligand (JM-20) prevents morphine-induced hyperalgesia in na (Pubmed Central) - Oct 9, 2024 Even in the absence of nerve injury, JM-20 attenuated the peripheral neuroinflammatory response observed in morphine-treated sham-operated animals (0% vs. 1-25%). These findings suggest that JM-20 could prevent morphine-induced hyperalgesia by anti-inflammatory and antioxidant mechanisms.
- |||||||||| morphine sulphate / Generic mfg.
Journal, Surgery: Enhanced recovery after adolescent idiopathic scoliosis surgery care pathway: Perioperative strategy to improve outcome. (Pubmed Central) - Oct 9, 2024 Our ERAS care pathway for AIS surgery lead to consequently improve the outcome regarding the VAS scores, the morphine consumption, the LOS and the complication and re hospitalisation rates. Regarding our results, ERAS care pathway for AIS surgery appears to be efficient in terms of benefits on complications rates, LOS and opioid consumption.Intrathecal morphine and "anti-inflammatory" anaesthesia provides a good quality of pain management and allows the patient to get up early.A superiority trial might be interesting to highlight the role of the ERAS pathway in AIS surgery.
- |||||||||| morphine sulphate / Generic mfg.
Journal, Surgery: Opioid Prescribing Trends Among Workers' Compensation Patients Undergoing Foot and Ankle Surgery. (Pubmed Central) - Oct 9, 2024 It is important for treating physicians to be aware of these trends, and discussions with patients regarding expected opioid use when planning surgical intervention may be beneficial. Physicians may need to set expectations preoperatively and suggest there are limits on the amount of opioids that can safely be prescribed.
- |||||||||| Prialt (ziconotide) / Jazz
Journal: Physicochemical Stability Study of the Morphine-Bupivacaine-Ziconotide Association. (Pubmed Central) - Oct 6, 2024 However, AKI remained a risk following these surgeries, regardless of NSAID use, likely owing to underlying disease, longer operations, and fluid shifts. All results are in favor with a physicochemical stable preparation for six mixture profiles when stored in polypropylene syringes at 5
- |||||||||| metamizole / Generic mfg., morphine sulphate / Generic mfg.
Clinical, Retrospective data, Journal, Surgery: Pain after laparoscopic endometriosis-specific vs. hysterectomy surgeries: A retrospective cohort analysis. (Pubmed Central) - Oct 4, 2024 Increased post-operative morphine use was observed in patients with endometriosis following laparoscopic surgery, despite no significant difference in mean VAS scores during the post-operative days. These findings suggest that personalized pain relief protocols should be adjusted for women with endometriosis.
- |||||||||| lignocaine / Generic mfg.
Retrospective data, Review, Journal: Perioperative intravenous lignocaine for pediatric postoperative pain-A systematic review and meta-analysis. (Pubmed Central) - Oct 4, 2024 There is low quality evidence to suggest that perioperative intravenous lignocaine bolus followed by an infusion significantly reduced the opioid consumption on the first postoperative day in pediatric surgical patients. The effects of perioperative lignocaine on postoperative pain scores and the need for rescue analgesia are uncertain.
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Clinical, Review, Journal: Effect of Neurostimulation on Chronic Pancreatic Pain: A Systematic Review. (Pubmed Central) - Oct 4, 2024 Another important insight was that opioid intake decrease is a common trend among most studies included and that adverse effects were rarely reported. To further elucidate the potential of these neurostimulation techniques, we suggest the development of new clinical trials with larger samples and adequate sham controls.
|