- |||||||||| fentanyl citrate / Generic mfg., Instanyl (fentanyl) / Takeda
Journal: Decreasing Door-to-Analgesia Time: Increasing Use of Sickle Cell Pain Management Pathway. (Pubmed Central) - Jan 14, 2026
This quality improvement initiative demonstrated that increased use of a pre-established intranasal fentaNYL protocol yielded a reduction in time to opioid administration for pediatric patients with sickle cell disease in vaso-occlusive crises. These results align with existing literature emphasizing the benefits of standardized pain pathways in improving efficiency and equity in practice.
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Journal: When Access Becomes Fatal: A Case Series of Anesthetic-Drug Suicides Among Anesthesiologists. (Pubmed Central) - Jan 14, 2026
Accurate interpretation requires integrated scene analysis, targeted toxicology, and awareness of the unique pharmacologic challenges associated with anesthetic agents. Enhanced drug-security measures, early mental-health intervention, and vigilance within anesthesiology departments are essential to reduce the occurrence of similar fatalities.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Trends in fentanyl-containing drug samples seized by law enforcement agencies across Canada. (Pubmed Central) - Jan 14, 2026
Enhanced drug-security measures, early mental-health intervention, and vigilance within anesthesiology departments are essential to reduce the occurrence of similar fatalities. Across Canada from 2020 to 2024, there has been a 24% increase in fentanyl-containing drug seizures in which multiple substances are detected, most notably benzodiazepines, xylazine and potent fentanyl analogues within a single sample.
- |||||||||| fentanyl citrate / Generic mfg.
Clinical, Journal: Clinical factors linked to xylazine exposure in emergency department patients with illicit opioid overdose. (Pubmed Central) - Jan 14, 2026
Across Canada from 2020 to 2024, there has been a 24% increase in fentanyl-containing drug seizures in which multiple substances are detected, most notably benzodiazepines, xylazine and potent fentanyl analogues within a single sample. Xylazine detection among emergency department opioid overdose patients appears to be more prevalent in the Northeast US and bradycardia appears to be a statistically significant clinical predictor.
- |||||||||| fentanyl citrate / Generic mfg.
Clinical, Journal: Comparative analysis of (Pubmed Central) - Jan 12, 2026
Findings may help inform the development of interventions to reduce barriers to treatment access and success within rural areas which may be slow to implement policy change. In hip-fracture patients, ultrasound-guided PENG and FNB improved the
- |||||||||| fentanyl citrate / Generic mfg.
Preclinical, Journal: Characterizing the in vitro metabolic features of nine alicyclic fentanyl-type new psychoactive substances. (Pubmed Central) - Jan 11, 2026
The monohydroxylation of the phenyl group adhered to an electrophilic substitution mechanism governed by the electron density and both the theoretical calculation results and mass spectrometric data consistently indicated that sp2-carbon monohydroxylation occurred exclusively at the phenethyl group in the tail. The findings provide data and analytical strategies for the development of a universal F-NPS metabolic prediction model.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Liquid chromatography-mass spectrometry quantitation and prevalence of medetomidine and xylazine in New Haven, Connecticut. (Pubmed Central) - Jan 11, 2026
Medetomidine, a potent alpha-2 adrenergic receptor agonist not approved for human use, has recently been detected in overdose cases, particularly in fentanyl-positive individuals...A subset of medetomidine-positive cases also tested positive for xylazine, indicating potential co-adulteration. This study highlights the value of expanded toxicological testing in identifying emerging adulterants that may otherwise go undetected by routine screening.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Modeling Supports Combinatorial Effects Between Pharmacological and Non-Pharmacological Interventions to Prevent Opioid-Induced Cardiac Arrest. (Pubmed Central) - Jan 11, 2026
We extended a previously validated model for opioid antagonists by incorporating the mechanism of rescue breathing, and quantified combinatorial effects between rescue breathing and various formulations of naloxone under different fentanyl overdose scenarios in a virtual patient population suffering from opioid-induced respiratory failure...Even in cases where virtual subjects survived without naloxone, 4?mg intranasal naloxone provided benefit by shortening the time to recovery of spontaneous. Our results highlight the importance of utilizing both pharmacological and non-pharmacological interventions in reversal of overdose.
- |||||||||| fentanyl citrate / Generic mfg., methamphetamine / Generic mfg.
Journal: Fentanyl test strip use and homelessness among people who use drugs in Rhode Island. (Pubmed Central) - Jan 10, 2026
We found that housing status was not independently and longitudinally associated with FTS use; however, people who used crystal methamphetamine were more than twice as likely to have used FTS in the past month. Future research exploring how differential housing situations may affect uptake of harm reduction services is needed to prevent fentanyl overdose.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Outpatient initiation of direct-to-inject buprenorphine. (Pubmed Central) - Jan 9, 2026
In this retrospective study, DTI buprenorphine initiation demonstrated favorable tolerability and retention in a high-risk population across diverse outpatient settings. This approach may offer a viable pathway to long-acting buprenorphine treatment for individuals using fentanyl who may not tolerate traditional initiation methods.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Exploring drug checking services for people who use drugs: Pre-implementation study. (Pubmed Central) - Jan 9, 2026
This approach may offer a viable pathway to long-acting buprenorphine treatment for individuals using fentanyl who may not tolerate traditional initiation methods. DCS can inform PWUD and the public of dangerous analogues in the drug supply, increase autonomy to make informed decisions, and reduce overdose risk.
- |||||||||| fentanyl citrate / Generic mfg.
Journal, HEOR: Micro-costing analysis of harm reduction services in office-based addiction treatment. (Pubmed Central) - Jan 9, 2026
We found that the estimated costs of HRS integration into OBAT sites was affordable and on par with other medical supplies kept in clinic spaces. More research needs to be done to assess HRS cost-effectiveness in reducing healthcare utilization and patient morbidity.
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., methamphetamine / Generic mfg.
Preclinical, Journal: Impact of morphine dependence and withdrawal on economic demand for fentanyl, cocaine, and methamphetamine in rats. (Pubmed Central) - Jan 9, 2026
These results demonstrate that opioid withdrawal increases motivation for opioid use while reducing motivation for stimulants, particularly at higher costs. Understanding these dynamics is crucial for developing effective polysubstance treatments addressing both opioid dependence and stimulant co-use.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Inadvertent Administration of Oxytocin via Epidural. (Pubmed Central) - Jan 9, 2026
The anesthesia team placed an epidural catheter and initiated an infusion of bupivacaine with fentanyl for pain management...We summarize the literature on inadvertent neuraxial medication infusions, which can lead to devastating consequences. While this patient experienced no adverse effects, we present this case as a cautionary case study to highlight the need for system-level interventions to enhance patient safety.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Did the illicit fentanyl trade experience a supply shock? (Pubmed Central) - Jan 8, 2026
Supplemental oxygen should be available whenever fentanyl is administered. A synthesis of government and social media data suggests a disruption, possibly tied to events in China.
- |||||||||| fentanyl citrate / Generic mfg.
PK/PD data, Journal: Pharmacokinetics and analgesic efficacy of fentanyl and buprenorphine in chicken embryos. (Pubmed Central) - Jan 8, 2026
A significant reduction in wide beak opening, a nociceptive behavioral parameter, was observed 15?min after administration of fentanyl. In conclusion, both opioids may have potential as safe analgesic options for the use during potentially painful procedures in chicken embryos, although further research is needed to fully demonstrate their clinical efficacy.
- |||||||||| fentanyl citrate / Generic mfg., methamphetamine / Generic mfg.
Journal: Refining cause of death attribution among opioid, opioid-stimulant and stimulant acute toxicity deaths. (Pubmed Central) - Jan 7, 2026
In San Francisco, USA, causes of death and other significant condition characteristics among deaths attributed to fentanyl appear to be similar regardless of the involvement of stimulants, but are markedly different from deaths involving stimulants without opioids. When reporting on drug-related mortality and developing interventions, deaths attributed to a combination of fentanyl and stimulants may be appropriately considered in the context of opioid overdose prevention, while deaths attributed to stimulants without opioids may require a response focused on preventing and treating underlying chronic medical conditions.
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Journal: Inclusion of "palliative care pharmacology" as a new chapter in the pharmacology textbook for medical undergraduate students: A strength, weakness, opportunity, and threat analysis. (Pubmed Central) - Jan 7, 2026
We also explored its current relevance and future potential. In addition, we analyzed the internal and external factors influencing this approach, including its strengths, weaknesses, opportunities, and threats.
- |||||||||| fentanyl citrate / Generic mfg.
Review, Journal: Fentanyl's Deadly Footprint: A New Framework for Predicting Overdose Hotspots. (Pubmed Central) - Jan 6, 2026
However, external validation, calibration reporting, uncertainty characterization, and equity-sensitive performance metrics are uncommon. This review organizes these strands into a three-tier framework--mortality-only, EMS and emergency department, and multi-stream environments--that links mapping, forecasting, and spike detection to operational response while embedding explicit equity and governance safeguards.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Barriers to Buprenorphine Initiation in Patients Using Fentanyl. (Pubmed Central) - Jan 6, 2026
In this survey study of clinician-reported problems initiating BUP treatment, clinicians working in high-volume noninpatient settings reported more problems initiating BUP in patients using fentanyl, and many reported changing their clinical practices in response to these problems. Further research is warranted to match alternate BUP induction strategies by clinical settings.
- |||||||||| fentanyl citrate / Generic mfg., oxycodone/acetaminophen / Generic mfg.
Journal: Identification of N-pyrrolidino protonitazene in suspect tablets encountered at an international mail facility. (Pubmed Central) - Jan 5, 2026
One of the United States Food and Drug Administration's (FDA) National Forensic Chemistry Center (NFCC) international mail facility (IMF) satellite laboratories received suspect light blue, round tablets debossed with "PERCOCET 5" on one side and half score on the other side...This finding is alarming considering that this compound reportedly has 25 times the potency of fentanyl...Since first being identified in these tablets, N-pyrrolidino protonitazene has been encountered with increasing regularity by this laboratory in other tablets with different colors, shapes, and markings. This compound has also been identified in tablets containing other drug substances.
- |||||||||| Review, Journal: Neuraxial anesthesia and pain management for cesarean delivery. (Pubmed Central) - Jan 4, 2026
We propose several important considerations for the management of anesthesia and analgesia for cesarean delivery, focusing on patient-reported outcomes related to intraoperative and postoperative pain. Considerations include: (1) understanding the innervation of the uterus, peritoneum and abdominal wall, and the pain pathways involved with sensations and pain during and after cesarean delivery (eg, visceral sensations such as occurs with uterine manipulation may be very uncomfortable for some patients); (2) understanding the different neuraxial anesthetic and analgesic approaches (eg, epidural, spinal, combined spinal-epidural) with their specific advantages, limitations, and indications (eg, spinal anesthesia provides the most reliable neuraxial block, with the fastest onset but a limited duration, though it can be extended by the addition of adjuvants); (3) selecting the most appropriate anesthetic technique and neuraxial medications (eg, local anesthetics, opioids, adjuvants including alpha2-adrenergic agonists) to prevent, mitigate, manage intraoperative discomfort, and optimize postoperative analgesia; (4) recognizing that intraoperative pain during cesarean delivery occurs in approximately 15% of cesarean deliveries and shivering in up to 50% of cesarean delivery (from a complex interplay of heat loss, disrupted thermoregulation, psychological stress, and surgical factors), necessitating multifaceted prevention approaches; (5) preoperatively identifying patient-specific risk factors for intraoperative pain (eg, opioid use disorder, chronic pain, previous traumatic childbirth experience, anxiety) to promote thorough counseling (eg, setting expectations, avoiding traumatizing circumstances, incorporating shared decision-making, offering general anesthesia if neuraxial block is inadequate) and tailored strategies; (6) optimizing interdisciplinary communication to identify inadequate labor epidural analgesia and allow replacement if intrapartum cesarean delivery becomes indicated, as well as adequate testing of neuraxial block by the anesthesia team and the obstetricians before proceeding with skin incision constitutes best practices; (7) recognizing the obstetric, surgical, and anesthesia-related factors associated with increased intraoperative and postoperative pain (eg, uterine exteriorization, intrapartum cesarean delivery, repeat cesarean delivery, use of an epidural anesthetic rather than a spinal or combined spinal-epidural anesthetic) should prompt specific approaches to enhance anesthesia and postoperative analgesia (eg, enhanced doses of neuraxial opioid, prolonged use of epidural analgesia with local anesthetic solutions or repeated doses of epidural morphine, abdominal wall blocks, particularly if neuraxial morphine could not be used); and (8) implementing stepwise opioid-sparing multimodal analgesia (eg, acetaminophen and nonsteroidal antiinflammatory drugs taken together) and personalized protocols for opioid prescriptions after cesarean delivery, since these have been shown to significantly reduce in-hospital opioid consumption and unnecessary opioid prescription without increasing postoperative pain.
- |||||||||| fentanyl citrate / Generic mfg., methadone / Generic mfg.
Journal: Harm reduction engagement and ongoing opioid use among adults receiving methadone or buprenorphine in Philadelphia. (Pubmed Central) - Jan 4, 2026
More favorable attitudes and higher HRS utilization among buprenorphine recipients suggest that MOUD setting and structure may influence harm reduction engagement. These findings add quantitative evidence describing HRS use among MOUD populations and suggests that tailoring harm-reduction supports to these contextual factors may be an important consideration for MOUD programs.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Investigation of 3D structural specificities between neurotransmitters and receptors using the TSR-based computational method. (Pubmed Central) - Jan 2, 2026
(iii) Complementary structural features between fentanyl and its biosensor were identified, providing insights into binding specificity...In conclusion, this study establishes an advanced computational framework for representing and quantifying neurotransmitter structures. The TSR-based approach provides a powerful tool for dissecting structural specificity in ligand-receptor interactions and lays a solid foundation for deeper mechanistic insight and more effective rational drug design.
- |||||||||| fentanyl citrate / Generic mfg., methamphetamine / Generic mfg.
Journal: Cocaine-Induced Cardiovascular and Immune Dysfunction: Emerging Mechanisms. (Pubmed Central) - Jan 2, 2026
However, the underlying mechanisms remain incompletely understood. Recently, emerging mechanisms of drug action, independent of neurotransmitter dysregulation, have been described in non-neuronal cells, helping to explain the significant burden of cardiovascular disease, immune compromise, and sudden death in the drug user population.
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