- |||||||||| fentanyl citrate / Generic mfg., methamphetamine / Generic mfg.
Journal: New psychoactive substances in roadway crash victims in California. (Pubmed Central) - Jul 10, 2025
NPS were detected in polypharmacy use, with traditional recreational drugs such as fentanyl, methamphetamine, and delta-9 THC most frequently co-detected. The serum geometric means detected for bromazolam (5.41
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Clinical data, Journal, Adverse events: Association of morphine vs. fentanyl prescription dispensation with adverse clinical outcomes. (Pubmed Central) - Jul 10, 2025
Among outpatients, a new prescription dispensation of fentanyl, compared with morphine, was associated with a higher risk of fractures. The findings should be interpreted cautiously given the potential for residual confounding.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Three Candidates, Two Peaks: Addressing Conflicting Assignments of Fentanyl Protomers with DMS-UVPD. (Pubmed Central) - Jul 8, 2025
Collision cross section (CCS) measurements further corroborate these assignments, with calculated CCSs matching experimental values within 1% (on average) for both the N- and O-protomers, while calculated CCSs for the amide-N protomers deviate by an average of 7%. Microsolvation studies reveal that serial solvation progressively narrows the energy gap between the piperidine-N and O-protomers via the formation of a solvent bridge between the two sites, suggesting that rapid desolvation during electrospray ionization can kinetically trap a fraction of the ensemble in the higher-energy O-protonated form.
- |||||||||| ByFavo (remimazolam) / PAION, Cosmo Pharma, Mundipharma, Pharmascience, Eagle Pharma
PK/PD data, Journal: Pharmacokinetics and pharmacodynamics of remimazolam for procedural sedation in children and adolescents. (Pubmed Central) - Jul 8, 2025
This study has shown that the pharmacokinetics of remimazolam are likely different between children 6 yr or older and adults (after correcting for size). In addition, the exposure-response relationship shows that to effectively use remimazolam for procedural sedation in children 6 yr or older, the dosing regimen should be modified to allow for higher remimazolam exposures.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: The impact of chronic pain on brain gene expression. (Pubmed Central) - Jul 7, 2025
We tested for differentially expressed genes (DEGs) in chronic pain, migraine, lifetime fentanyl and oxymorphone use, and with chronic pain genetic risk in 4 brain regions (dorsal anterior cingulate cortex [dACC], dorsolateral prefrontal cortex [DLPFC], medial amygdala [MeA], and basolateral amygdala [BLA]) and imputed cell type expression data from 304 deeply phenotyped postmortem donors, potentially highlighting variation relevant to factors such as predisposition to chronic pain development, mechanisms of chronic pain development and persistence, and indirect effects of chronic pain and associated treatment or medication, and substance use...Chronic pain differential gene expression was not significantly different between men and women. Overall, chronic pain-associated gene expression is heterogeneous across region and cell type, is largely distinct from that in pain-related factors and migraine, and our results highlight BLA microglia as a key brain cell type in chronic pain.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Prescription Opioid Medication Survey: A Tool to Collect Deep Phenotypic Data on the Multifactorial Pathways to Opioid Use Disorder in Clinical and Population-Based Cohorts. (Pubmed Central) - Jul 7, 2025
Prescription opioids (e.g., oxycodone, hydrocodone, and fentanyl) are commonly used and misused, and it has been estimated that approximately 8-12% of individuals who misuse opioids will subsequently develop an opioid use disorder (OUD)...POMS is intended to be administered in clinical settings and large population-based cohorts, facilitating data collection that can enable discoveries to inform better prevention and intervention strategies for OUD. POMS offers a comprehensive tool for systematically capturing the multifactorial risk factors associated with opioid misuse and OUD, providing insights that can inform prevention and intervention strategies.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: First reports of illegal fentanyl sales in Peru: the beginning of a crisis? (Pubmed Central) - Jul 7, 2025
POMS offers a comprehensive tool for systematically capturing the multifactorial risk factors associated with opioid misuse and OUD, providing insights that can inform prevention and intervention strategies. No abstract available
- |||||||||| fentanyl citrate / Generic mfg., ketamine / Generic mfg., haloperidol / Generic mfg.
Journal: Ketamine treatment for buprenorphine-precipitated opioid withdrawal: a case report. (Pubmed Central) - Jul 7, 2025
The presence of fentanyl in the drug supply is thought to contribute to the incidence of buprenorphine-precipitated opioid withdrawal (BPOW) during initiation...An IV ketamine 27mg bolus was then administered, with an initial improvement followed by subsequent emergence delirium, which was addressed with IV haloperidol...Usually restricted to the intensive care unit and emergency department, this case report highlights both the potential and risks of IV ketamine on the general hospital floors. Further research is needed to better understand the safety of using ketamine to manage opioid withdrawal.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: New opioid use and mortality in older people with dementia. (Pubmed Central) - Jul 7, 2025
Transdermal fentanyl use was associated with an 8-fold excess mortality risk (8.26 (7.18-9.51)).ConclusionsOpioid use was associated with excess mortality, which may be due to the opioid, the indication or both. This observation calls for further research into the links between opioid use and excess mortality in elderly with dementia as it could have important implications for patient safety.
- |||||||||| naloxone injection / Generic mfg., fentanyl citrate / Generic mfg.
Journal: Lessons Learned from a Grassroots Harm Reduction Effort to Prevent Drug Overdose Deaths. (Pubmed Central) - Jul 6, 2025
In Wichita and Sedgwick County, the epicenter of the opioid epidemic in Kansas, Safe Streets Wichita, a grassroots prevention and harm reduction coalition, started Project Wichita Overdose Recovery Kit Expedited Delivery (WORKED), a free volunteer-led intramuscular naloxone and FTS program...These findings help serve as the foundation by which interviewees envision a more holistic and comprehensive approach to harm reduction. Findings will be used to inform the fidelity, efficiency, accessibility, and longevity of community-based naloxone and FTS distribution and the implementation of harm reduction strategies in general across the state of Kansas.
- |||||||||| fentanyl citrate / Generic mfg., pregabalin / Generic mfg., methamphetamine / Generic mfg.
Journal: The first report from Ankara on the presence of xylazine abuse in blood and urine samples using a validated LC-HRMS method. (Pubmed Central) - Jul 5, 2025
Xylazine, an alpha-2 adrenergic receptor agonist approved for veterinary use, has emerged as a significant adulterant in illicit drugs, particularly synthetic opioids like fentanyl, contributing to a rise in fatal overdoses...Polysubstance use was common, with pregabalin (50%) and methamphetamine (28%) being the most frequently co-detected substances...The findings underscore the need for routine xylazine screening in forensic toxicology to monitor its prevalence and mitigate its impact as an emerging public health threat. The developed LC-HRMS method offers a rapid, sensitive, and reliable tool for detecting xylazine and its metabolites, supporting efforts to address this growing concern.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Structural Characterization of Nitazene Analogs Using Electrospray Ionization-Tandem Mass Spectrometry (ESI-MS/MS). (Pubmed Central) - Jul 4, 2025
Nitazene analogs are potent novel synthetic opioids (NSOs) that are becoming increasingly common and pose a threat to the public because of their fentanyl-like effects...Therefore, modification to the core nitazene structure produces different diagnostic product ions, which can be used to identify existing and novel analogs. This study provides a comprehensive assessment of the fragmentation behavior of nitazene analogs under ESI-MS/MS conditions, which provides the basis for identifying new structural modifications in novel nitazene analogs.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Stalled Improvements? Youth Opioid Misuse 2015-2022. (Pubmed Central) - Jul 2, 2025
One explanation is that by 2020 youth opioid misuse rates had already reached very low rates-the prevalence of misuse was less than 5% in all age groups in the 12-25 years range. Since opioid misuse rates are naturally bound below by zero, the converging and flattening of youth opioid misuse rates suggest little room for further reductions despite increasing mortality rates.
- |||||||||| fentanyl citrate / Generic mfg., dexmedetomidine / Generic mfg.
Journal, Intubation: Fentanyl versus dexmedetomidine during awake-fibreoptic intubation. (Pubmed Central) - Jul 2, 2025
Further, the efficacy of dexmedetomidine in reducing diastolic blood pressure is more pronounced; however, following intubation, the disparities between the two groups diminish and it is not statistically significant. Thus, in comparison to fentanyl, dexmedetomidine demonstrates superior efficacy in the management of heart rate both during and immediately following intubation.
- |||||||||| fentanyl citrate / Generic mfg., Chirocaine (levobupivacaine) / Purdue, AbbVie, dexmedetomidine / Generic mfg.
Journal: Intravenous dexmedetomidine versus levobupivacaine for hemodynamic response towards skull pin insertion. (Pubmed Central) - Jul 2, 2025
Likewise, during induction and at subsequent intervals (1 minute before and after skull pin placement, as well as at 3, 5, and 10 minutes thereafter), Spo2 levels were similar across the two groups (all p > 0.05). We concluded that the scalp block using fentanyl-levobupivacaine and intravenous dexmedetomidine has comparable efficacy in diminishing the hemodynamic response associated with the skull pin head.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Pain relief for femur fractures using Fascia Iliaca Block and IV fentanyl. (Pubmed Central) - Jul 2, 2025
Bupivacaine has a faster onset and longer duration of sensory block and motor block, providing better early pain alleviation than ropivacaine. Visual analog scale (VAS) scores were similar at baseline but significantly lower in Fascia Iliaca Compartment Block group during positioning (2.38
- |||||||||| fentanyl citrate / Generic mfg., hydromorphone hydrochloride / Generic mfg., methadone / Generic mfg.
Journal: Opioid deaths in children in Ontario: A province-wide study. (Pubmed Central) - Jul 2, 2025
Fentanyl was the primary substance involved in 80% of deaths. Several potential areas of system change include education on fentanyl risk to young children, careful storage of illicit substances, and implications for how the child protection system intervenes in homes where the use of opioids and illicit substance use is reported to occur.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: The promotion of liver vitamin metabolism is of great significance for laying hens during fasting. (Pubmed Central) - Jul 2, 2025
In addition, through association analysis, we constructed a data platform for vitamin metabolism-related pathway genes and cecal metabolites, laying a foundation for future research. However, whether the relationship between gene expression in the liver and metabolites in the cecum is bidirectional or unidirectional is still unclear and needs to be further studied.
- |||||||||| fentanyl citrate / Generic mfg.
P1 data, Journal: [11C]Carfentanil PET Whole-Body Imaging of ?-Opioid Receptors: A First in-Human Study. (Pubmed Central) - Jul 1, 2025
MORs have a high affinity for both endogenous opioids such as ?-endorphins and exogenous opioids such as fentanyl...The long axial field of view was useful for measuring changes in the short-lived radiotracer [11C]carfentanil, with and without naloxone blocking. Further research is needed to evaluate the behavioral and clinical relevance of sex differences in naloxone-MOR interactions.
- |||||||||| fentanyl citrate / Generic mfg., Remitch (nalfurafine) / Toray, Mitsubishi Tanabe, morphine sulphate / Generic mfg.
Review, Journal: KOR agonists for the treatment and/or prevention of opioid use disorder and cocaine use disorder. (Pubmed Central) - Jul 1, 2025
Subsequently, nalfurafine and recently triazole 1.1 and oxa-noribogaine, three centrally acting KOR agonists devoid of such side effects, have been studied in animal models of OUD and CUD...Oxa-noribogaine suppressed cue-induced reinstatement of morphine and fentanyl seeking...Therefore, a combination of a KOR agonist and a MOR agonist or a compound with dual KOR/MOR agonist activities when used as analgesics will deter escalation use of MOR agonists, thus prevent OUD, and KOR agonists may be useful for treatment of cocaine abuse and relapse. Importantly, KOR agonists with no or fewer side effects of typical KOR agonists should be further investigated in animal models of OUD and CUD, particularly those that simulate stress-, cue- and drug priming-induced relapse for potential clinical development.
- |||||||||| fentanyl citrate / Generic mfg.
Retrospective data, Journal: Initiation of extended-release buprenorphine in emergency department patients: A retrospective cohort study. (Pubmed Central) - Jun 30, 2025
Study findings underscore the need for comprehensive research to inform interventions, focusing on racial and socioeconomic inequities. In patients with OUD presenting to a community ED, a treatment regimen of high dose SL bup and ER bup, and admission to a designated unit resulted in significantly reduced nonfatal overdoses, ED visits, and hospitalizations at one year.
- |||||||||| fentanyl citrate / Generic mfg., fluconazole oral / Generic mfg., midazolam hydrochloride / Generic mfg.
Journal: Clearance of Amlodipine, Fentanyl, Fluconazole, Methylprednisolone, and Midazolam by Continuous Renal Replacement Circuits. (Pubmed Central) - Jun 30, 2025
For drugs coadministered into a circuit, significant decreases in extraction and increases in drug recovery (2.5-109%) were found, suggesting dosing adjustments may be needed. This study highlights the need for additional studies of drug coadministration within CRRT circuits to describe complex drug-circuit and drug-drug interactions to provide dosing guidance in pediatric CRRT patients.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: The Diagnosis of Fentanyl-Induced Chest Wall Rigidity: A Case Report. (Pubmed Central) - Jun 27, 2025
Our case reveals that fentanyl-induced chest rigidity is a rare but important adverse event that can potentially occur to any patient. An understanding and awareness of this phenomenon is necessary for all health care providers who may utilize fentanyl for procedural sedation in their practices.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Descending Necrotizing Mediastinitis as a Deadly Complication Following Laparoscopic Sleeve Gastrectomy: A Case Report. (Pubmed Central) - Jun 27, 2025
This is the 1st reported case of descending necrotizing mediastinitis as a fatal complication of laparoscopic sleeve gastrectomy, which was identified and treated successfully owing to the timely and expanded use of an enhanced CT scan that included the cervical region. Traditionally, the cervical area has not been routinely examined when diagnosing complications following abdominal surgery, underscoring the importance of a comprehensive imaging approach from the neck to the abdomen to detect complications after sleeve gastrectomy.
- |||||||||| fentanyl citrate / Generic mfg., Olinvyk (oliceridine) / Trevena
Review, Journal: Opioid analgesics for sedation-based gastrointestinal endoscopy. (Pubmed Central) - Jun 27, 2025
Newly approved oliceridine is promising to render ideal analgesic effects for gastrointestinal endoscopy. Clinical studies on oliceridine in endoscopic procedures are urgently needed.
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