fentanyl citrate / Generic mfg. 
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  • ||||||||||  fentanyl citrate / Generic mfg., methamphetamine / Generic mfg.
    Journal:  Refining cause of death attribution among opioid, opioid-stimulant and stimulant acute toxicity deaths. (Pubmed Central) -  Sep 17, 2025   
    In San Francisco, USA, causes of death and other significant condition characteristics among deaths attributed to fentanyl appear to be similar regardless of the involvement of stimulants, but are markedly different from deaths involving stimulants without opioids. When reporting on drug-related mortality and developing interventions, deaths attributed to a combination of fentanyl and stimulants may be appropriately considered in the context of opioid overdose prevention, while deaths attributed to stimulants without opioids may require a response focused on preventing and treating underlying chronic medical conditions.
  • ||||||||||  fentanyl citrate / Generic mfg., oxycodone/acetaminophen / Generic mfg.
    Journal:  Identification of N-pyrrolidino protonitazene in suspect tablets encountered at an international mail facility. (Pubmed Central) -  Sep 17, 2025   
    One of the United States Food and Drug Administration's (FDA) National Forensic Chemistry Center (NFCC) international mail facility (IMF) satellite laboratories received suspect light blue, round tablets debossed with "PERCOCET 5" on one side and half score on the other side...This finding is alarming considering that this compound reportedly has 25 times the potency of fentanyl...Since first being identified in these tablets, N-pyrrolidino protonitazene has been encountered with increasing regularity by this laboratory in other tablets with different colors, shapes, and markings. This compound has also been identified in tablets containing other drug substances.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Adsorptive Cathodic Stripping Analysis of Xylazine Within Fouling-Resistant and Nanomaterial-Enhanced Modified Electrode Sensors. (Pubmed Central) -  Sep 17, 2025   
    The impact of congestion on intranasal medication absorption is likely dependent on each drug's properties, mode of action, and formulation. Given its now nearly ubiquitous use with fentanyl and fentanyl derivatives across the globe, XYL has become a primary target for researchers seeking to develop portable and cost-effective sensors for its detection...When used in this manner, the modified electrodes exhibited an overall average sensitivity of ~35 (
  • ||||||||||  fentanyl citrate / Generic mfg.
    Review, Journal:  Modern Methods for Detection of Fentanyl and Its Analogues: A Comprehensive Review of Technologies and Applications. (Pubmed Central) -  Sep 17, 2025   
    We highlight how integration of advanced sensors with machine learning is enhancing detection accuracy in complex field environments. Challenges such as operational constraints and the ever-evolving variety of fentanyl analogues are discussed, and future directions are recommended to improve field-deployable detection tools for safety and security applications.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Trends in United States Adolescent and Young Adult Overdose Fatalities, 1999-2023. (Pubmed Central) -  Sep 16, 2025   
    Claims for outpatient antibiotics are increasing, which is of significant concern, given renewed focus on antibiotic stewardship. This study extends previous research regarding long-term US AYA overdose fatality trends by demonstrating trends through 2023 and including understudied subgroups, underscoring IMF-related overdose burden in US AYA and inequities between subgroups, and debuting a data visualization application.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Improving Transdermal Fentanyl Prescribing Practices Using Electronic Medical Record. (Pubmed Central) -  Sep 16, 2025   
    Outcomes: After the intervention, a review of TD fentanyl orders over five months showed a reduction in inappropriate ordering from 42.5% to 15.2%. Standardized EMR order sets, combined with provider education, hold promise for enhancing the quality and safety of chronic pain management with TD fentanyl.
  • ||||||||||  Gazyva (obinutuzumab) / Roche, Biogen
    Journal:  Feasibility of pulsed field ablation for atrial fibrillation under mild conscious sedation. (Pubmed Central) -  Sep 16, 2025   
    Standardized EMR order sets, combined with provider education, hold promise for enhancing the quality and safety of chronic pain management with TD fentanyl. PFA under MCS is feasible in selected patients but pain and tolerance may be suboptimal, and high sedative doses are required.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Gender-based differences in harm reduction practices among people who use drugs in Rhode island: a latent class analysis. (Pubmed Central) -  Sep 14, 2025   
    We found that harm reduction practices and group membership in latent classes were largely comparable between men and women; however, men who use drugs are significantly less likely to keep naloxone nearby. Gender-attentive strategies to increase naloxone carriage and usage among men and enhanced outreach to persons characterized by no or low harm reduction practice utilization, including people who are single and those with a history of incarceration, may be warranted to mitigate overdose risk.
  • ||||||||||  Review, Journal:  Sedation in Critically Ill Children. (Pubmed Central) -  Sep 13, 2025   
    Further research is needed to optimize sedation and analgesia practices in critically ill children. By adopting evidence-based guidelines and incorporating non-pharmacological interventions, clinicians may be able to improve patient outcomes and also reduce the incidence of adverse events.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Exploring disparities in overdose fatalities and naloxone administration. (Pubmed Central) -  Sep 10, 2025   
    Findings point to racial disparities in emergency overdose response and the moderating role of stimulant involvement. Public health strategies should address how drug combinations and racialized patterns of overdose shape naloxone access in order to ensure more equitable responses.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Mu-opioid mediated discriminative stimulus effects of fentanyl and xylazine: Dose-response and time-course studies. (Pubmed Central) -  Sep 10, 2025   
    In drug combination tests, xylazine did not influence the acute effects of fentanyl; however, xylazine dose-dependently increased the duration of fentanyl's stimulus effects. These data indicate that xylazine does not produce discriminative stimulus effects like prototypical mu-opioid agonists but prolongs the mu-opioid mediated discriminative stimulus effects of fentanyl, which may partially explain its use in some populations who misuse opioids.
  • ||||||||||  Sublocade (buprenorphine once-monthly depot) / Indivior
    Journal:  Extended-release injectable buprenorphine for the treatment of opioid use disorder among individuals at high risk of overdose: The FASTER-BUP udy. (Pubmed Central) -  Sep 10, 2025   
    These data indicate that xylazine does not produce discriminative stimulus effects like prototypical mu-opioid agonists but prolongs the mu-opioid mediated discriminative stimulus effects of fentanyl, which may partially explain its use in some populations who misuse opioids. While XR-BUP was well tolerated in this sample of people with OUD at high risk of overdose, six-month retention rates were low and most continued to use illicit opioids while on treatment.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Complementary Separation of Novel Synthetic Opioids. (Pubmed Central) -  Sep 10, 2025   
    80-120). The added mobility separation resulted in the separation of isomeric compounds without compromising the sensitivity of the LC-q-TOF MS/MS analysis; that is, a good linear dynamic and (R2 > 0.98) and low limits of detection (LOD) in the 0.08-4 ng/mL range were observed for all synthetic analogues (?100 analogues can be observed with LOD < 1 ng/mL).
  • ||||||||||  fentanyl citrate / Generic mfg., naltrexone / Generic mfg.
    Journal:  Fentanyl-blocking effects of extended-release naltrexone in humans: Three case reports. (Pubmed Central) -  Sep 5, 2025   
    This paper presents three case histories of clinically necessary opiate challenges in opiate-abusing patients implanted with extended-release NTX (ER-NTX). It also reviews the sparse literature and is the first evidence that antagonist blood levels from ER-NTX preparations can completely block the lethal
  • ||||||||||  fentanyl citrate / Generic mfg., Alfenta (alfentanil) / Abbott
    Journal:  Expanding Fentanyl Analog Testing to Include Brain Specimens: Method Validation and Homogenate Stability Assessment. (Pubmed Central) -  Sep 5, 2025   
    Brain homogenate stability was improved when frozen and was not impacted by the addition of 1% sodium fluoride. The study herein provides insight into the feasibility of testing brain for fentanyl analogs and their stability under various storage conditions, contributing valuable data to the limited literature on brain toxicology testing.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Review, Journal:  Fentanyl (Pubmed Central) -  Sep 5, 2025   
    The risk of severe side effects increases in sleep; delayed side effects may present several hours after administration. This review finds that there is a need for clinical guidelines on the monitoring of patients after treatment with fentanyl.
  • ||||||||||  fentanyl citrate / Generic mfg.
    PK/PD data, Preclinical, Journal:  [11C]Fentanyl: Radiosynthesis and Preclinical PET Imaging for Its Pharmacokinetics. (Pubmed Central) -  Sep 5, 2025   
    Prolonged retention in adipose tissue may delay brain clearance, potentially increasing the risk of re-narcotization (as has been reported in clinical cases after naloxone reversal). These findings advance our ability to quantify fentanyl tissue distribution and pharmacokinetics in the brain and body and provide a valuable tool for further studies in preclinical and clinical settings.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Effects of Peer-to-Peer Opioid Overdose and Naloxone Training in Adolescents. (Pubmed Central) -  Sep 4, 2025   
    Topics covered included trends in overdose deaths particularly in adolescents, defining opioids including fentanyl, recognizing overdose, and responding with naloxone...Peer-to-peer overdose and naloxone training significantly increases knowledge, improves attitudes, and raises confidence in adolescents. There is a clear need to increase overdose awareness in adolescents and peers should be incorporated into prevention efforts.
  • ||||||||||  methamphetamine / Generic mfg.
    Journal:  Methamphetamine and Cocaine Overdose Deaths in the United States, 1999-2023. (Pubmed Central) -  Sep 4, 2025   
    Methamphetamine-involved overdose deaths were highest among American Indian/Alaska Native individuals, accounting for 44.50% of overdose deaths, while cocaine-involved overdose deaths were highest among Black individuals, comprising 48.47% of overdose deaths. Rising stimulant mortality, particularly in racial and ethnic minoritized populations, underscores the need for expanding access to harm reduction resources, greater funding for stimulant use disorder research, and targeted public health interventions.
  • ||||||||||  fentanyl citrate / Generic mfg., epinephrine / Generic mfg.
    Journal:  Cocaine induced first-degree and high-grade second-degree atrioventricular block in a dog: a case report. (Pubmed Central) -  Sep 4, 2025   
    Normal sinus rhythm returned after administration of atropine and epinephrine...Urine toxicology was positive for cocaine, cocaine metabolites, norfentanyl and trace amounts of fentanyl...Cocaine-induced AV block in canines is an unusual presentation in a clinical setting, given the sympathetic stimulation this drug commonly causes. Emergency veterinary clinicians should be aware of this rare but important electrocardiographic abnormality following cocaine toxicosis.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
    Journal:  Trends in prescription opioid use in Europe: A DARWIN EU (Pubmed Central) -  Sep 4, 2025   
    However, the prevalence of oxycodone, morphine, and fentanyl increased...Despite a decrease in new opioid prescriptions in many European countries, the prevalence of opioid use remained largely stable over the last decade. More data are needed to monitor evolving opioid prescription patterns in Europe, particularly in the post-pandemic era.