Mental Retardation
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  • ||||||||||  Journal:  Risk Factors for Psychiatric Disorders in Pediatric Patients with Tuberous Sclerosis Complex. (Pubmed Central) -  May 12, 2025   
    2 years; OR?=?56.200, P?=?0.036) and seizure frequency (>1/month; OR?=?25.855, P?=?0.027) were closely related to occurrence of anxiety and/or depression disorders in pediatric patients with TSC.The study results showed that psychiatric comorbidities of children with TSC had a high incidence and risk factors. The study provides new insights into the diagnosis and treatment of comorbid psychiatric disorders in pediatric patients with TSC.
  • ||||||||||  Aybintio (bevacizumab biosimilar) / Samsung, Mundipharma
    Journal:  Mental Distress Among Females Following 2021 Abortion Restrictions in Texas. (Pubmed Central) -  May 12, 2025   
    To quantify changes in frequent mental distress among females in Texas, following implementation of the 2021 Texas Heartbeat Act Senate Bill 8 (SB8), which banned abortions upon detection of embryonic cardiac activity...Disproportionately higher increases among younger people could be associated with higher levels of anticipated or actual need for abortion care or less ability to overcome barriers to care, including travel. These findings signal that state abortion policy may negatively affect mental health.
  • ||||||||||  Review, Journal:  Autism spectrum disorder and inherited metabolic diseases: are there any common features? (Pubmed Central) -  May 12, 2025   
    A total of 9 cross-sectional studies reporting children diagnosed with ASD, who were subsequently screened for IMD, were identified. There is no cause-effect relationship be-tween autism spectrum disorders and inherited metabolic diseases; however, all neurometabolic diseases presenting with intellectual disability may meet the criteria for ASD diagnosis.
  • ||||||||||  Journal:  Siblings with a Homozygous Variant in the NHP2 Gene: A Case Report and Review of Literature. (Pubmed Central) -  May 12, 2025   
    Genome sequencing revealed a c.415T>C (p.Tyr139His) disease-causing variant in the NHP2 gene in the index case that was heterozygous in the parents and homozygous in the index case and her older brother. In cases of multisystem involvement, consanguineous marriage, and multiple affected family members, patients may develop very rare diseases, such as dyskeratosis congenita, and physicians should be aware that new clinical findings may emerge during long-term follow-up, the diagnosis of which may count on genome sequencing.
  • ||||||||||  Journal:  Modeling of demoralization in breast cancer. (Pubmed Central) -  May 12, 2025   
    Early detection of demoralization and of the co-occurrence of depression and demoralization are essential for promoting the well-being of patients with breast cancer. Psychotherapy should focus on strengthening the modifiable negative correlates of demoralization, countering the modifiable positive correlates, and preventing the co-occurrence of demoralization and depression.
  • ||||||||||  Journal:  Complex medical conditions and health risk behaviors among homeless males with schizophrenia. (Pubmed Central) -  May 12, 2025   
    The study highlights that the substantial burden of complex medical conditions and health risk behaviors in this population underscores the need for a healthcare system that is not only reactive but also proactive. Such a system should prioritize health promotion and disease prevention to effectively safeguard the well-being of these vulnerable individuals.
  • ||||||||||  Review, Journal:  Biological Susceptibility of Patients with Schizophrenia to Metabolic Syndrome: A Review. (Pubmed Central) -  May 12, 2025   
    Therefore, further studies are warranted to enhance our comprehension of the intricate mechanisms underlying the susceptibility of patients with SCZ to MetS. These studies will be crucial in developing effective, targeted therapeutic strategies to treat MetS in this vulnerable population.
  • ||||||||||  Journal:  The modular mind and psychiatry: toward clinical integration with a focus on self-disorders. (Pubmed Central) -  May 12, 2025   
    Next, we will explore how the modular perspective can illuminate the nature of intrapsychic conflicts. Finally, we will discuss how evidence from neuropsychiatric syndromes supports the modular view of the mind and, in turn, how this perspective can provide a basis for classifying mental disorders.
  • ||||||||||  Journal:  Investigating causal networks of dementia using causal discovery and natural language processing models. (Pubmed Central) -  May 12, 2025   
    Although evidence for the direct link between biological age and dementia was less pronounced, its potential value in dementia management remains non-negligible. This study advances our understanding of dementia mechanisms and highlights the potential of NLP and machine learning for the causal discovery of complex diseases from high-dimensional data.
  • ||||||||||  Review, Journal:  Trace amine-associated receptors as potential targets for the treatment of anxiety and depression. (Pubmed Central) -  May 12, 2025   
    Despite our limited understanding of the underlying mechanisms through which TAARs regulates stress-related disorders, current evidence strongly suggests that TAAR ligands could represent novel pharmacotherapy for treating psychiatric disorders such as depression, bipolar disorder, and anxiety disorders like post-traumatic stress disorder (PTSD). This offers hope for more effective and safer treatment options in the field of mental health.
  • ||||||||||  Observational data, Journal:  The Impact of Cataract Surgery Refusal on Depressive Symptoms and Cognitive Function. (Pubmed Central) -  May 12, 2025   
    Refusal of cataract surgery is significantly associated with more depressive symptoms but does not appear to be linked to cognitive function. These findings highlight the importance of addressing psychological factors when discussing surgical options with older adults and emphasise the need for a multidisciplinary approach to improve both visual and mental health outcomes.
  • ||||||||||  Review, Journal:  Epilepsy: Genetic Insights and Advances in Gene Therapies (Pubmed Central) -  May 12, 2025   
    In this review, I further discuss the results of studies on patients, mouse models of epilepsy, and neurodevelopmental disorder-related SCN1A, SCN2A, and STXBP1 genes, which encode voltage-gated sodium channel alpha subunits Nav1.1 and Nav1.2, as well as the synaptic protein Munc18-1. These studies suggest pathological mechanisms, including a novel cortico-striatal circuit, and trials aimed at developing gene therapies.
  • ||||||||||  Journal:  Lifetime history of depression and eating behaviours: a co-twin control study of the TwinsUK registry. (Pubmed Central) -  May 12, 2025   
    Our findings suggest the association between depression and eating can be partly explained by pre-existing genetic and environmental vulnerabilities. Understanding the mechanisms underlying this relationship could guide the development of effective management strategies, including personalized nutrition plans, integrated mental and dietary care, and regular monitoring to mitigate the risk of maladaptive eating behaviours and eating disorders.
  • ||||||||||  Journal:  Exploring mental health literacy on twitter: A machine learning approach. (Pubmed Central) -  May 12, 2025   
    This findings suggest that recognizing mental disorders influences help-seeking attitudes through mediators like help-seeking efficacy and positive mental health maintenance. These results provide valuable insights for future interventions and policies aimed at promoting help-seeking behaviors and advancing mental health literacy.