||||||||||SH3765 / Nanjing Sanhome Pharma, EPZ015666 / GSK, Ipsen Journal: PRMT5 activates lipid metabolic reprogramming via MYC contributing to the growth and survival of mantle cell lymphoma. (Pubmed Central) - May 15, 2024 Furthermore, PRMT5 was significantly associated with MYC expression in 105 MCL samples and the GEO database (GSE93291). CRISPR MYC knockout indicated PRMT5 can promote MCL outgrowth by inducing SREBP1/2 and FASN expression through the MYC pathway.