papaverine / Generic mfg. 
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  • ||||||||||  papaverine / Generic mfg.
    Review, Journal:  Symmetrical peripheral gangrene caused by urosepsis: Case reports and literature review. (Pubmed Central) -  Oct 28, 2024   
    Our cases and literature review demonstrate that timely and accurate diagnosis, effective infection control, correction of hypoperfusion, organ function support, early management of disseminated intravascular coagulation, avoidance of premature amputation, and multidisciplinary comprehensive treatment are crucial for the successful treatment of SPG caused by urosepsis.
  • ||||||||||  papaverine / Generic mfg.
    Journal:  Experience of vascular injuries at a military hospital in Korea. (Pubmed Central) -  Oct 21, 2024   
    Vascular repair should be performed without tension or spasm. Preservation of the harvested vein in papaverine solution and blood while using a temporary intravascular shunt is a method of eliminating spasms.
  • ||||||||||  papaverine / Generic mfg.
    Journal:  Effects of Papaverine on Experimentally Induced Myringosclerosis. (Pubmed Central) -  Oct 7, 2024   
    Vasodilation is thought to cause an increase in oxygen-derived free radicals, which may contribute to the pathogenesis of MS. The results suggest that the effects of papaverine on MS should be carefully evaluated.
  • ||||||||||  papaverine / Generic mfg.
    Journal:  The Effect of Local Papaverine Use in an Experimental High-Risk Colonic Anastomosis Model: Reduced Inflammatory Findings and Less Necrosis. (Pubmed Central) -  Sep 29, 2024   
    Additionally, the necrosis score of the ICA +P7 group was significantly lower than that of the ICA -P7 group (p = 0.014). Data from the current study reveal that, although topical papaverine seems to suppress inflammation in anastomosis tissue and reduce necrosis at 7 days, definite conclusions regarding its impact on anastomotic leak cannot be drawn without further studies investigating anastomotic wound healing and anastomotic leak, preferably with both shorter- and longer-term evaluations.
  • ||||||||||  papaverine / Generic mfg.
    Journal:  Structural analysis of a ligand-triggered intermolecular disulfide switch in a major latex protein from opium poppy. (Pubmed Central) -  Sep 13, 2024   
    Crystal structures of the Cys59Ser mutant were determined in the presence of papaverine and in the absence of exogenous BIA compounds...The analysis of conformational changes triggered by the binding of BIA compounds suggests a molecular mechanism coupling ligand binding to the disruption of an intermolecular disulfide bond. This mechanism may be involved in the regulation of biosynthetic reactions in plants and possibly other organisms.
  • ||||||||||  papaverine / Generic mfg.
    Journal:  Papaverine effect on superficial vein in thumb replantation procedure: A case study. (Pubmed Central) -  Sep 2, 2024   
    Papaverine is a vasodilator and facilitates venous anastomosis when veins and couplers are mismatched. This case demonstrates how papaverine, a vasodilator, may be used to improve surgical outcome during thumb replantation when small veins prevent venous coupler use.
  • ||||||||||  sildenafil / Generic mfg., papaverine / Generic mfg., paroxetine / Generic mfg.
    Journal:  Investigation of Cissus populnea as a Potential Therapeutic Agent for Erectile Dysfunction. (Pubmed Central) -  Sep 2, 2024   
    PDE5, Nitric oxide synthase (NOS) and androgen receptor (AR) genes were studied using RT-PCR on CP-treated paroxetine-induced ERDF-rats...Five (leading) compounds with induced-fit docking (IFD) scores in kcal/mol, namely, stigmasterol (-638.73), daucosterol (-644.73), furostanol (-639.29), papaverine (-639.03), and capsaicin (-642.88), had better docking scores of -9.936, -9.824, -9.064, -8.863, and -8.736?kcal/mol, respectively, compared with those of sildenafil (-8.611?kcal/mol)...The QSAR model revealed that lead compounds possess good pIC50 values. These results indicate that C. populnea is a more promising possible treatment for controlling EDRF and deserves further research.
  • ||||||||||  papaverine / Generic mfg.
    Journal:  Nonocclusive mesenteric ischemia after percutaneous kyphoplasty: A case report. (Pubmed Central) -  Aug 26, 2024   
    Yet, once it happens, delayed diagnosis or misdiagnosis can lead to serious consequences such as intestinal necrosis and abdominal infection, even endangering the patient's life. We currently lack experience in preventing this complication, but timely diagnosis and appropriate intervention are effective measures in treating such complications.
  • ||||||||||  verapamil / Generic mfg., nitroprusside / Generic mfg., papaverine / Generic mfg.
    Journal, Surgery:  Preventing sheep carotid artery spasm for vascular graft surgery and computed tomography angiography. (Pubmed Central) -  Aug 23, 2024   
    Conversely, ascending aortic arch access via the femoral artery for CT angiography did not cause CA spasm and maintained arterial flow. During CA graft surgery, surgical trauma induced CA spasm, which was prevented by localised intraarterial administration of vasodilators papaverine hydrochloride and verapamil prior to significant surgical manipulation.
  • ||||||||||  verapamil / Generic mfg., papaverine / Generic mfg., nitroglycerin / Generic mfg.
    Journal:  Difficult 6F Guiding Sheath Removal Using the Transradial Artery Approach: A Case Report. (Pubmed Central) -  Aug 21, 2024   
    Postoperatively, the patient experienced mild subcutaneous hematoma and pain. We consider reporting this case valuable because no previous studies have described similar difficulties in removing a 6F guiding sheath from the radial artery.
  • ||||||||||  morphine sulphate / Generic mfg., papaverine / Generic mfg.
    Journal:  Genomic and Cell-Specific Regulation of Benzylisoquinoline Alkaloid Biosynthesis in Opium Poppy. (Pubmed Central) -  Jul 24, 2024   
    In this review, we highlight recent advances in genome sequencing and single cell and spatial transcriptomics with a focus on how these efforts can improve our understanding of the genomic and cell-specific regulation of BIA biosynthesis. Such knowledge is vital for opium poppy genetic improvement and metabolic engineering efforts targeting the modulation of alkaloid yield and composition.
  • ||||||||||  Zyesami inhalation (aviptadil) / Relief Therap, United Therapeutics Corp, Seren Clinical, NRx Pharma, Invicorp (aviptadil/phentolamine mesilate) / Regent Pacific Group
    Journal:  A comprehensive history of injection therapy for erectile dysfunction, 1982-2023. (Pubmed Central) -  Jun 30, 2024   
    Papaverine administration before Foley catheter balloon insertion for cervical ripening resulted in improved Bishop scores and shorter catheter balloon insertion-to-delivery intervals. After 40
  • ||||||||||  trodulamine (MSI-1436) / Novo Biosci
    Review, Journal:  A Review of the Protective Effects of Alkaloids Against Alpha-synuclein toxicity in Parkinson's disease. (Pubmed Central) -  Jun 14, 2024   
    The findings of the present study highlight the inhibitory activities of alkaloids against synucleinopathy. However, no clinical data supports the reported activities in humans, which calls attention to the need for conducting clinical trials to elucidate the efficacy, safety, proper dosage, unwanted effects and pharmacokinetics aspects of alkaloids in humans.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Source Apportionment of Morphine in Wastewater (Pubmed Central) -  Apr 21, 2024   
    The different sources varied in these months due to the COVID-19 and influenza A outbreaks, in which the use of drugs containing poppy straws and codeine was the main source, whereas the use of morphine analgesics remained relatively stable. Inventory analysis further demonstrated the reliability of the source contributions from the PMF model, and morphine was not abused in this city.
  • ||||||||||  papaverine / Generic mfg.
    Role of Papaverine in Salvaging Torsion Testis: An Innovative Study (304B) -  Mar 12, 2024 - Abstract #AUA2024AUA_3406;    
    Our study is a pioneer study showing this unique effect of papaverine. Papaverine seems to have a promising effect in prolonging the critical time interval in which the testis can be salvaged.
  • ||||||||||  papaverine / Generic mfg.
    Adherence to Intracavernosal Injection Relative to Prescriber Choices and Patient Income (304A) -  Mar 12, 2024 - Abstract #AUA2024AUA_3179;    
    Less than a third of men who obtain an IRx for ICI will refill the prescription at the same formulation, and higher concentration of PGE1 may be relevant. Future work should investigate the role of standardization of ICI prescribing and titration, as well as patient and provider education.
  • ||||||||||  sildenafil / Generic mfg., pentoxifylline / Generic mfg., papaverine / Generic mfg.
    Horizontal Plication and Reduction Corporoplasty for Penile Girth Discrepancy (Chritmas Tree Deformity) (Video Abstract Theater) -  Mar 12, 2024 - Abstract #AUA2024AUA_1887;    
    Attempts at treatment, including pentoxifylline, traction devices, and collagenase injections, yielded no improvement...During surgery, papaverine-induced artificial erections were utilized without a tourniquet... The successful outcome, evidenced by the patient's ability to engage in satisfactory sexual intercourse and maintain good erections with pharmacological support, demonstrates the potential of this technique in enhancing the quality of life for patients suffering from similar conditions.
  • ||||||||||  papaverine / Generic mfg.
    Trial completion date, Trial primary completion date, Combination therapy:  Papaverine in Combination With Chemoradiation for the Treatment of Stage II-III Non-small Cell Lung Cancer (clinicaltrials.gov) -  Dec 20, 2023   
    P1,  N=28, Recruiting, 
    These findings revealed that papaverine protects against ANIT-induced Cholestasis. Trial completion date: Dec 2024 --> Dec 2025 | Trial primary completion date: Dec 2023 --> Dec 2024
  • ||||||||||  papaverine / Generic mfg.
    Rotationplasty: Technique for Osteosarcoma of the Distal Femur in a Young Child (OrthoLive, West Hall) -  Dec 19, 2023 - Abstract #AAOS2024AAOS_3726;    
    Papaverine is used to help with vasospasm, and pulses are confirmed after closure of the skin with the use of nylon suture. Postoperatively, the patient has done well, restarted chemotherapy, and begun fitting for a prosthesis for ambulation.
  • ||||||||||  papaverine / Generic mfg.
    Trial completion date, Trial suspension, Trial primary completion date:  Papaverine and Stereotactic Body Radiotherapy (SBRT) for Non Small Cell Lung Cancer (NSCLC) or Lung Metastases (clinicaltrials.gov) -  Nov 26, 2023   
    P1,  N=24, Suspended, 
    Postoperatively, the patient has done well, restarted chemotherapy, and begun fitting for a prosthesis for ambulation. Trial completion date: Dec 2023 --> Dec 2024 | Recruiting --> Suspended | Trial primary completion date: Dec 2022 --> Dec 2024
  • ||||||||||  Stendra (avanafil) / IEH Biopharma, Menarini, Endo
    Journal:  Oral phosphodiesterase type 5 inhibitors and priapism: A VigiBase analysis. (Pubmed Central) -  Nov 4, 2023   
    Severe toxicity, including acute kidney injury, metabolic acidosis, and cardiac arrest, appears dose-dependent. PDE5i use shows disproportionate priapism signals which are higher in young patients.