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- | Tagrisso (osimertinib) / AstraZeneca, 14aj / Nankai University School of medicine
Journal: Discovery and structural optimization of potent epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M/C797S resistance mutation for lung cancer treatment. (Pubmed Central) - May 27, 2022
In vivo xenograft mouse model, oral administration of compound 14aj led to significant tumor regression without obvious toxicity. In addition, this compound showed good pharmacokinetics.