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ENCHANCEMENT OF MITOPHAGY VIA USP30 INHIBITION AS A THERAPEUTIC STRATEGY FOR ACUTE KIDNEY INJURY (SAT-025; Exhibition Hall and Main Foyer) - Mar 8, 2024 - Abstract #ISNWCN2024ISN_WCN_620;
These findings highlight Vincere's USP30 inhibitor molecules potential in AKI treatment and as a prophylactic measure against CKD progression. The mitophagy-enhancing ability, coupled with selectivity and favorable pharmacological profile present a promising therapeutic approach in AKI management and CKD prevention.
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VB-08: A SMALL MOLECULE INHIBITOR OF USP30 THAT ENHANCES MITOPHAGY (On-Demand Oral Gallery D) - Dec 23, 2022 - Abstract #ADPD2023ADPD_791;
Here, we report a novel USP30 inhibitor, VB - 08... VB-08 presents a useful tool to test the effect of increased mitophag y in rodent models of neurodegeneration and sets the stage for translational development of a new and promising class of compounds for PD.
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