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Journal: Effects of second litter syndrome on reproductive performance in sows. (Pubmed Central) - Sep 27, 2024
Only APBA1-2 was significantly decreased by SLS...Therefore, SLS sows do not necessarily have future low reproductive performance or be culled. Future investigations should explore the mechanism of alternate decrease/increase patterns in PBA.
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Journal: Replicating the Association of Variants in BSN and APBA1 with Obesity in Diverse Populations. (Pubmed Central) - Sep 4, 2024
Specifically, BSN pLoF variants were associated with pulmonary hypertension, atrial fibrillation, and anticoagulant use, while APBA1 pLoF variants were linked to disorders of the temporomandibular joint. These findings underscore the potential of large-scale biobanks in advancing genetic discovery.
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Journal: Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease. (Pubmed Central) - Apr 17, 2024
We identified rare loss-of-function variants in two genes (BSN and APBA1) with effects substantially larger than those of well-established obesity genes such as MC4R...Finally, we explored the plasma proteomic signatures of BSN PTV carriers as well as the functional consequences of BSN deletion in human induced pluripotent stem cell-derived hypothalamic neurons. Collectively, our findings implicate degenerative processes in synaptic function in the etiology of adult-onset obesity.
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Trial completion: A Study Investigating Lu AG22515 in Healthy Adults (clinicaltrials.gov) - Aug 28, 2023
P1, N=58, Completed,
Collectively, our findings implicate degenerative processes in synaptic function in the etiology of adult-onset obesity. Active, not recruiting --> Completed
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Journal: Evaluation of the Genetic Diversity, Population Structure and Selection Signatures of Three Native Chinese Pig Populations. (Pubmed Central) - Jun 28, 2023
A total of 359 candidate genes were identified, and some genes may affect characteristics such as immunity (IL-2, IL-21 and ZFYVE16), adaptability (APBA1), reproduction (FGF2, RNF17, ADAD1 and HIPK4), meat quality (ABCA1, ADIG, TLE4 and IRX5), and heat tolerance (VPS13A, HSPA4). Overall, the findings of this study will provide some valuable insights for the future breeding, conservation and utilization of these three Chinese indigenous pig populations.
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Enrollment closed, Enrollment change: A Study Investigating Lu AG22515 in Healthy Adults (clinicaltrials.gov) - May 15, 2023
P1, N=58, Active, not recruiting,
Overall, the findings of this study will provide some valuable insights for the future breeding, conservation and utilization of these three Chinese indigenous pig populations. Recruiting --> Active, not recruiting | N=43 --> 58
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Trial completion date, Trial primary completion date: A Study Investigating Lu AG22515 in Healthy Adults (clinicaltrials.gov) - Nov 9, 2022
P1, N=43, Recruiting,
Recruiting --> Active, not recruiting | N=43 --> 58 Trial completion date: Jan 2023 --> Jun 2023 | Trial primary completion date: Dec 2022 --> Jun 2023
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Enrollment open, Trial initiation date: A Study Investigating Lu AG22515 in Healthy Adults (clinicaltrials.gov) - Apr 4, 2022
P1, N=43, Recruiting,
The results highlight the needs for more effective management of T2DM and for tobacco smoking cessation interventions in this community, and further research on the associations of T2DM with other disease processes, including cancer and neurobehavioral pathways. Not yet recruiting --> Recruiting | Initiation date: Dec 2021 --> Mar 2022
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