- |||||||||| alendronate / Generic mfg.
Journal: Magnesium-Organic Framework-Loaded Bisphosphonate-Functionalized Gel Scaffolds for Enhanced Bone Regeneration. (Pubmed Central) - Nov 9, 2023
It is noteworthy that the continuous slow release of Mg and alendronate could induce the macrophage switch to the M2 phenotype and promote osteogenic differentiation in the early stage, resulting in improved bone regeneration during implanting the scaffolds into the distal femoral. In summary, Mg-MOFs-loaded alendronate-modified gelatin gel scaffolds have been developed, exhibiting great potential for bone regenerative.
- |||||||||| 5-fluorouracil / Generic mfg., temozolomide / Generic mfg., alendronate / Generic mfg.
Journal: Elucidating anticancer drugs release from UiO-66 as a carrier through the computational approaches. (Pubmed Central) - Nov 5, 2023
It provides insights into the complex dynamics of drug release and the factors influencing it, thereby emphasizing the promise of UiO-66 as a viable candidate for drug delivery. This work contributes to our understanding of UiO-66's role and sets the stage for improved performance optimization in the cancer treatment.
- |||||||||| zoledronic acid / Generic mfg., alendronate / Generic mfg.
Journal, HEOR, Cost-effectiveness, Cost effectiveness: Cost-Effectiveness Analysis of CT-Based Finite Element Modeling for Osteoporosis Screening in Secondary Fracture Prevention: An Early Health Technology Assessment in the Netherlands. (Pubmed Central) - Oct 30, 2023
For postmenopausal Dutch women who have been referred to the FLS, direct access to CT2S may be cost-effective compared with DXA for age groups 70s and 80s, when considering the ICER threshold of the Netherlands. This study positions CT2S as a potential novel osteoporosis-screening tool for secondary fracture prevention in the clinical setting.A shorter screening interval of 2 y increases the effectiveness of both screening strategies, but the ICER of CT2S compared with DXA also increased substantially, which made CT2S no longer cost-effective for the 70s age group; however, it remains cost-effective for individuals in their 80s.Annual zoledronic acid treatment with better adherence may contribute to a lower cost-effectiveness ratio when comparing CT2S to DXA screening and the treat all strategies for all age groups.
- |||||||||| alendronate / Generic mfg.
Journal: A Comparative Study of Ultrasmall Calcium Carbonate Nanoparticles for Targeting and Imaging Atherosclerotic Plaque. (Pubmed Central) - Oct 22, 2023
In an animal model of atherosclerosis, we compare the imaging performance of three types of nanoparticles: bare amorphous calcium carbonate and those functionalized with the ligands alendronate (for microcalcification targeting) and trimannose (for inflammation targeting). Our study provides useful insights into ligand-mediated targeted imaging of atherosclerosis through a combination of in vivo imaging, ex vivo tissue analysis, and in vitro targeting experiments.
- |||||||||| Prolia (denosumab) / Amgen, Daiichi Sankyo, raloxifene hydrochloride / Generic mfg., alendronate / Generic mfg.
Clinical, Retrospective data, Review, Journal: Efficacy and safety of medications for osteoporosis in kidney transplant recipients or patients with chronic kidney disease: a meta-analysis. (Pubmed Central) - Oct 22, 2023
In patients at stage 5 CKD and undergoing hemodialysis, alendronate and raloxifene increased lumbar spine BMD...These medications may increase the incidence of adverse events and their safety needs to be further evaluated. Therefore, we cannot draw a definitive conclusion about the efficacy and safety of osteoporosis medications in the above group of patients.
- |||||||||| alendronate / Generic mfg.
Journal: A Dual Reversible Cross-Linked Hydrogel with Enhanced Mechanical Property And Capable of Proangiogenic and Osteogenic Activities for Bone Defect Repair. (Pubmed Central) - Oct 8, 2023
To address these limitations, our study aimed to develop a novel hydrogel, termed dual cross-linked alendronate (ALN)-Ca /Mg -doped sulfated hyaluronic acid (SHA@CM) hydrogel, using a one-step mixing injection molding in situ method known as the "three-in-one" approach...These findings were supported by an in vivo study using a rat cranial defect model, wherein the SHA@CM hydrogel demonstrated enhanced therapeutic efficacy in bone defect repair. Overall, our results indicate that the SHA@CM hydrogel holds significant potential as a platform for the clinical translation of BTE.
- |||||||||| Prolia (denosumab) / Amgen, Daiichi Sankyo
Trial completion date, Trial primary completion date: Denosumab Safety Assessment in Multiple Observational Databases (clinicaltrials.gov) - Oct 3, 2023
P=N/A, N=508215, Active, not recruiting,
Overall, these in vitro results illustrate the potential of the targeted NPs as an effective therapeutic system towards bone metastasized breast cancer. Trial completion date: Sep 2023 --> Jun 2024 | Trial primary completion date: Sep 2023 --> Jun 2024
- |||||||||| Evenity (romosozumab-aqqg) / Astellas, Amgen, UCB
Enrollment closed, Trial completion date, Trial primary completion date: Effects of Romosozumab on Bone Density in Women With Anorexia Nervosa (clinicaltrials.gov) - Oct 3, 2023
P3, N=30, Active, not recruiting,
Trial completion date: Sep 2023 --> Jun 2024 | Trial primary completion date: Sep 2023 --> Jun 2024 Recruiting --> Active, not recruiting | Trial completion date: Jan 2025 --> Sep 2025 | Trial primary completion date: Jan 2025 --> Sep 2024
- |||||||||| Prolia (denosumab) / Amgen, Daiichi Sankyo
Enrollment closed, Trial primary completion date: BAD: Alendronate in an Weekly Effervescent Tablet Formulation Following Denosumab Discontinuation (clinicaltrials.gov) - Sep 30, 2023
P=N/A, N=92, Active, not recruiting,
Recruiting --> Active, not recruiting | Trial completion date: Jan 2025 --> Sep 2025 | Trial primary completion date: Jan 2025 --> Sep 2024 Recruiting --> Active, not recruiting | Trial primary completion date: Oct 2023 --> Sep 2024
- |||||||||| zoledronic acid / Generic mfg., alendronate / Generic mfg., pamidronate disodium / Generic mfg.
Journal: Aminobisphosphonates reactivate the latent reservoir in people living with HIV-1. (Pubmed Central) - Sep 25, 2023
Our results demonstrate the novel use of N-BPs to reverse HIV-1 latency while inducing immune effector functions. This preliminary evidence merits further investigation in a controlled clinical setting possibly in combination with therapeutic vaccination.
- |||||||||| alendronate / Generic mfg.
Cost-Effectiveness Analysis of Sequential Treatment with Abaloparatide Followed by Alendronate in US Women and Men with Multiple Previous Fractures (Poster Hall; in person) - Sep 23, 2023 - Abstract #ACRConvergence2023ACR_Convergence_3971;
M. Hiligsmann: Amgen, 5, IBSA, 6, Mylan Pharmaceuticals, 6, Radius Health, Inc., 5, UCB, 2; S. Silverman: Amgen, 2, 5, Radius Health, Inc, 2, 5; A. Singer: Agnovos, 2, Amgen, 2, 6, Radius Health, Inc, 2, 6, Radius Health, Inc., 5, UCB, 2, 5; Y. Wang: Radius Health, Inc, 3; L. Pearman: Radius Health, Inc, 3; J. Caminis: Radius Health, Inc, 12, Former Employee; J. Reginster: CNIEL, 5, 6, Dairy Research Council, 6, IBSA-Genevrier, 2, 5, 6, Mylan, 5, 6, Pierre Fabre, 1, Radius Health, Inc, 2, 5, 5, Teva, 2, 6.
- |||||||||| Prolia (denosumab) / Amgen, Daiichi Sankyo
Soluble Buffered Alendronate After Denosumab Discontinuation in Erosive Hand OA Patients (Poster Hall; in person) - Sep 23, 2023 - Abstract #ACRConvergence2023ACR_Convergence_3304;
Clinical implications of the increase of bone turnover markers in this non osteoporotic remain doubtful, since BMD values did not change over time, except at the lumbar spine in the 24 weeks alendronate group. Longer follow-up is warranted to evaluate clinical consequences on long term.
- |||||||||| Prolia (denosumab) / Amgen, Daiichi Sankyo, Evenity (romosozumab-aqqg) / Astellas, Amgen, UCB
Clinical, Review, Journal: Pharmacological agents for bone fracture healing: talking points from recent clinical trials. (Pubmed Central) - Sep 23, 2023
Concerning the effect of parathormone, current level I evidence is controversial, and additional studies are required. Level I, systematic review of RCTs.
- |||||||||| alendronate / Generic mfg.
Preclinical, Journal: Administration of alendronate exacerbates ammonium chloride-induced acidosis in mice. (Pubmed Central) - Sep 19, 2023
Overall, we discovered that BPPs may exacerbate acidosis symptoms by inhibiting the release of buffering ions from bone. Therefore, we propose that BPP administration should be carefully considered for those with CKD and that alkali supplementation could help minimize acidifying effects.
- |||||||||| alendronate / Generic mfg.
Journal: Alendronate induces skeletal alterations in the chicken embryonic development model. (Pubmed Central) - Sep 18, 2023
An increased inflammatory activation may contribute, at least in part, to the attained outcomes. Overall present findings suggest a negative influence of alendronate on the embryonic bone development process in a dose-dependent manner, highlighting the potential risk of alendronate use during embryonic development.
- |||||||||| risedronate / Generic mfg., alendronate / Generic mfg.
Journal, HEOR, Cost-effectiveness, Cost effectiveness: Cost-effectiveness of weekly gastro-resistant risedronate 35 (Pubmed Central) - Sep 15, 2023
The scenario analyses confirmed the stability of the base case results. According to this study, RIS-GR would be the dominant treatment (lower costs with QALY gain) compared with ALN.
- |||||||||| Livial (tibolone) / Organon
Review, Journal: Oral Therapeutics Post Menopausal Osteoporosis. (Pubmed Central) - Sep 7, 2023
According to this study, RIS-GR would be the dominant treatment (lower costs with QALY gain) compared with ALN. Oral therapy is indicated to prevent pathologic fractures in those deemed at increased risk following screening.
- |||||||||| Review, Journal: Comparative Analysis of Various Forms of Local Drug Delivery Systems on a Class 2 Furcation - A Systematic Review. (Pubmed Central) - Sep 1, 2023
Local drug deliveries such as Boric acid, alendronate gel, and other drugs exhibited anti-inflammatory, antibacterial & osteoblastic differentiation activity...A search was conducted using PubMed, Google scholar, science direct, and Pub Med central using MeSH terms - local drug delivery in periodontics, boric acid in the management of class II mandibular furcation, simvastatin in the treatment of furcation...The various local drugs used in treating class II mandibular furcation defects are effective in the prevention of bleeding on probing, bone resorption, gingival bleeding index and increase in the bone fill, and microbial deposit removal. The managing of class II mandibular furcation defect with the drugs mentioned in this review can be effective by reducing several clinical parameters such as bleeding on probing, gingival indices, osteoblastic differentiation, bone fill, etc., Considering the results of the studies, it can be concluded that it can be used as a therapeutic therapy against class II furcation defects with positive outcomes.
- |||||||||| alendronate / Generic mfg.
Review, Journal: Role of Bisphosphonates in Periodontal Diseases: Systematic Review. (Pubmed Central) - Sep 1, 2023
Alendronate was utilized as a supplement to SRP in seven studies, four of which employed topical administration and three of which used oral alendronate...In comparison to SRP alone, SRP with bisphosphonate treatment significantly reduced PD (P = 0.002), increased CAL (P = 0.008), and filled BD (P < 0.001). Although BT as an adjunct appears to be successful in treating periodontitis, its practical applicability is questionable due to the possibility of developing jaw osteonecrosis and the short-range follow-up of the research.
- |||||||||| alendronate / Generic mfg.
New P2 trial: Alendronate for Hip Osteonecrosis in Adults With Sickle Cell Disease (clinicaltrials.gov) - Aug 30, 2023
P2, N=24, Not yet recruiting,
Although BT as an adjunct appears to be successful in treating periodontitis, its practical applicability is questionable due to the possibility of developing jaw osteonecrosis and the short-range follow-up of the research. .
- |||||||||| losartan / Generic mfg., doxycycline / Generic mfg., alendronate / Generic mfg.
A rare case of an ulcer chronified by iatrogenic calcinosis cutis with good response to sodium thiosulfate occlusive dressings. (e-Poster Hall) - Aug 30, 2023 - Abstract #EADV2023EADV_3763;
There are few cases reported and the therapeutic is tailor made depending on the patient and the type. This is a case in which it is exhaustively demonstrated how important it is to apply adequate care to our wounds, making the right diagnosis first, treating the underlying causes that chronifies the wound and going through with the most appropriate advanced therapy products at the precise moment using TIME clinical decision support tool.
- |||||||||| alendronate / Generic mfg.
Journal: A Bone Targeting Nanoparticle Loaded Ogp to Restore Bone Homeostasis for Osteoporosis Therapy. (Pubmed Central) - Aug 10, 2023
We designed poly(lactic-co-glycolic acid) (PLGA) nanoparticles modified by alendronate (AL) to transport osteogenic peptides (OGP) (AL-PLGA@P NPs)...With AL-PLGA@P NPs, bone microarchitecture and bone mass were improved in ovariectomized osteoporosis rats. Therefore, this study proposes a novel osteoporosis-based drug system that effectively improves bone density.
- |||||||||| cyclosporin A microemulsion / Generic mfg., alendronate / Generic mfg.
Journal: Myricitrin: A promising herbal therapy for periodontitis in immunosuppressed status. (Pubmed Central) - Jul 31, 2023
Myricitrin showed beneficial effects in counteracting bone resorption in subjects with immunosuppression-associated periodontitis. Its efficacy in slowing down disease progression was comparable to that of alendronate.
- |||||||||| zoledronic acid / Generic mfg., alendronate / Generic mfg.
Bone, Prayers and Trabecular Layer: Where Is the Gluten? (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_4633;
Alendronate treatment improved her L1-L4 bone mineral density (BMD) from a t-score of -2.0 in 2017 to -1.6 in 2018, but despite the same treatment regimen, her right hip BMD reduced from a t-score of -1.2 in 2018 to -2.1 in 2022...Her treatment was changed to zoledronic acid and she was referred to GI...C. Graph of patient
- |||||||||| dexamethasone / Generic mfg., alendronate / Generic mfg.
Preclinical, Journal: Effects of Eleutherine bulbosa (mill.) urb. bulb extract on mice glucocorticoid-induced osteoporosis models. (Pubmed Central) - Jul 26, 2023
Glucocorticoid (Dexamethasone) 0.1015 mg/kg BW/day induction was given to all groups except the healthy group to create osteoporosis rats for approximately four weeks...The result showed that E. bulbosa bulbs extract could raise blood calcium levels and bone density percentage at doses of 60 and 120 mg/kg BW, as well as raise osteoblast cell levels at doses of 120 mg/kg BW. The findings indicate that E.bulbosa bulb extract is a potential complementary medicine for osteoporosis.
- |||||||||| alendronate / Generic mfg.
Journal: Novel one-pot strategy for fabrication of a pH-Responsive bone-targeted drug self-frame delivery system for treatment of osteoporosis. (Pubmed Central) - Jul 13, 2023
In this work, a novel bone-targeting drug self-frame delivery system (DSFDS) with high drug loading efficiency and pH responsive drug release was fabricated by condensation of curcumin (Cur), amino group terminated polyethylene glycol (NH-PEG), and alendronate (ALN) using hexachlorocyclotriphosphonitrile (HCCP) as the linker...The above results clearly demonstrated that HCPA NPs are promising for OP treatment. Given the simplicity and well designability of fabrication strategy, explicit therapy efficacy and low toxicity of HCPA NPs, we believe that this work should be of great interest for fabrication of various DSFDS to deal with many diseases.
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