NUV-868 / Nuvation Bio 
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  • ||||||||||  NUV-868 / Nuvation Bio, Lynparza (olaparib) / Merck (MSD), AstraZeneca
    NUV-868, a novel BD2-selective BET inhibitor, in combination with enzalutamide or olaparib, inhibits growth of solid tumor xenografts (Section 20; Poster Board #2) -  Mar 14, 2023 - Abstract #AACR2023AACR_8408;    
    P1/2
    Our preclinical data demonstrate that NUV-868, a BD2-selective BET inhibitor, inhibits growth of tumor xenografts in combination with enzalutamide or olaparib and provides rationale for examination of these combinations in the clinic. An ongoing, phase 1 clinical study (NCT05252390) is evaluating NUV-868 as a monotherapy and in combination with olaparib or enzalutamide in patients with advanced solid tumors.