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Trial completion date, Trial primary completion date: ZONE: A Study of the Effect of ZT-01 on Night-time Hypoglycemia in Type 1 Diabetes (clinicaltrials.gov) - Apr 11, 2024 P2, N=168, Recruiting, We observed apparent sex-related differences to the hormonal responses to hyper- and hypoglycemia, and SSTR2a may increase glucagon responses more so in F rats with T2D. Trial completion date: Jul 2024 --> Jul 2025 | Trial primary completion date: Jul 2024 --> Jun 2025
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Trial termination: Effect of ZT-01 on Glucagon During Hypoglycemia in Type 1 Diabetes Mellitus (clinicaltrials.gov) - May 18, 2022 P1, N=24, Terminated, SSTR2a treatment increases glucagon responsiveness and delays the onset of insulin-induced hypoglycaemia in this rat model of pre-T2D where only a modest deficiency in glucagon counterregulation exists. Recruiting --> Terminated; The study was completed following review of the assumptions underlying the power calculation and it was deemed that enough subjects had been recruited to complete enrollment
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