ZT-01 / Zucara Therap 
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  • ||||||||||  ZT-01 / Zucara Therap
    Trial completion date, Trial primary completion date:  ZONE: A Study of the Effect of ZT-01 on Night-time Hypoglycemia in Type 1 Diabetes (clinicaltrials.gov) -  Apr 11, 2024   
    P2,  N=168, Recruiting, 
    We observed apparent sex-related differences to the hormonal responses to hyper- and hypoglycemia, and SSTR2a may increase glucagon responses more so in F rats with T2D. Trial completion date: Jul 2024 --> Jul 2025 | Trial primary completion date: Jul 2024 --> Jun 2025
  • ||||||||||  ZT-01 / Zucara Therap
    Trial termination:  Effect of ZT-01 on Glucagon During Hypoglycemia in Type 1 Diabetes Mellitus (clinicaltrials.gov) -  May 18, 2022   
    P1,  N=24, Terminated, 
    SSTR2a treatment increases glucagon responsiveness and delays the onset of insulin-induced hypoglycaemia in this rat model of pre-T2D where only a modest deficiency in glucagon counterregulation exists. Recruiting --> Terminated; The study was completed following review of the assumptions underlying the power calculation and it was deemed that enough subjects had been recruited to complete enrollment