- |||||||||| Review, Journal: A Review of Clinical Trials of Cancer and Its Treatment as a Vaccine. (Pubmed Central) - Nov 13, 2023
This brief discussion of vaccines and their varieties with examples also discusses vaccine clinical trials in relation to cancer diseases in this DNA and RNA-based cancer vaccine that has had successful clinical trials like the cervical cancer drug VGX-3100, the kidney cancer drug Pembrolizumab, MGN-1601, the prostate cancer drug pTVG-HP with rhGM-CSF, the melanoma cancer drug proteasome siRNA, and the lung cancer drug FRAME-001.
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Development of whole Framome personalized cancer vaccines () - May 9, 2022 - Abstract #CIMT2022CIMT_107;
P2
Mouse immunogenicity studies with synthetic long peptides showed that Frame neoantigens are immunogenic and induce both CD8+ and CD4+ T cell responses. We have designed and received authorities approval for the first clinical trial with personalized FRAME-001 peptide cancer vaccine for patients with advanced non-small cell lung cancer with unsatisfactory response to the immune checkpoint inhibition.
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