Lexiscan (regadenoson) / GE Healthcare, Astellas, Gilead 
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 50 Diseases   11 Trials   11 Trials   833 News 


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  • ||||||||||  Lexiscan (regadenoson) / GE Healthcare, Astellas, Gilead
    Journal:  F-Sodium fluoride uptake is associated with severity of atherosclerotic stenosis in stable ischemic heart disease. (Pubmed Central) -  Mar 25, 2022   
    We retrospectively identified 114 patients who received both regadenoson stress Rb myocardial perfusion PET and F-NaF PET study with an average interval of 5 months...There was poor correlation between calcification and F-NaF uptake in coronary arteries (r = 0.41) Coronary arterial F-NaF uptake is associated with coronary stenosis severity in patients with stable coronary artery disease. F-NaF PET studies may be useful for characterizing coronary atherosclerotic plaques.
  • ||||||||||  Lexiscan (regadenoson) / GE Healthcare, Astellas, Gilead
    Clinical, Review, Journal:  Asystole following Regadenoson administration: Review of literature, risk factors and management. (Pubmed Central) -  Mar 23, 2022   
    In this article, we report a case of asystole following Regadenoson administration, evaluate mechanisms and risk factors for Regadenoson induced bradyarrhythmias to better identify patients at risk. We also review the available treatment options and propose recommendations for limiting its risk.
  • ||||||||||  Lexiscan (regadenoson) / GE Healthcare, Astellas, Gilead
    Preclinical, Journal:  Quantitative myocardial first-pass perfusion imaging of CO -induced vasodilation in rats. (Pubmed Central) -  Mar 8, 2022   
    The current study aimed to quantify the pharmacokinetic effect of a CO gas challenge on myocardial perfusion in rats using high-resolution, first-pass perfusion CMR and compared it with pharmacologically induced hyperemia using regadenoson...It was concluded that hypercapnia leads to significantly increased coronary flow and yields similar myocardial flow reserves in healthy rats as compared with pharmacological stimulation. Accordingly, inducible hypercapnia can be selected as an alternative stressor in CMR studies of myocardial blood flow in small animals.
  • ||||||||||  Lexiscan (regadenoson) / GE Healthcare, Astellas, Gilead
    Clinical, Journal:  Early onset of left ventricular regional asynchrony in arteries with sub-clinical stenosis. (Pubmed Central) -  Feb 8, 2022   
    No abstract available A subgroup of coronary territories with normal relative perfusion and normal or non-obstructive coronary disease may have reduced MFR, which is signaled physiologically by a mild degree of left ventricular asynchrony.
  • ||||||||||  Lexiscan (regadenoson) / GE Healthcare, Astellas, Gilead
    Trial termination:  Simultaneous Assessment of FFR and SPECT (clinicaltrials.gov) -  Feb 2, 2022   
    P=N/A,  N=27, Terminated, 
    A subgroup of coronary territories with normal relative perfusion and normal or non-obstructive coronary disease may have reduced MFR, which is signaled physiologically by a mild degree of left ventricular asynchrony. Completed --> Terminated; Slow recruitment, funding period ended
  • ||||||||||  Lexiscan (regadenoson) / GE Healthcare, Astellas, Gilead
    REGADENOSON-INDUCED TAKOTSUBO CARDIOMYOPATHY (Poster Hall_Hall C) -  Jan 28, 2022 - Abstract #ACC2022ACC_6097;    
    Regadenoson has rarely been described as a potential trigger for TC. This case highlights this possibility, as well as abnormal perfusion in the dyskinetic segments during the immediate onset of a TC episode.
  • ||||||||||  Lexiscan (regadenoson) / GE Healthcare, Astellas, Gilead
    RARE SINGLE CORONARY ARTERY CASE DISCOVERED AFTER A FALSE POSITIVE STRESS TEST (eAbstract site) -  Jan 28, 2022 - Abstract #ACC2022ACC_5143;    
    A Lexiscan stress test showed a small in size, moderate in intensity reversible anterior wall defect that did not improve with prone imaging, consistent with myocardial ischemia... This case is worth presenting to add to the number of rare cases that exist for SCA Left Type I anomalies.
  • ||||||||||  Lexiscan (regadenoson) / GE Healthcare, Astellas, Gilead
    CLINICAL AND ECONOMIC OUTCOMES OF PHARMACOLOGICAL STRESS TESTS IN PATIENTS WITH A HISTORY OF COVID-19 (eAbstract site) -  Jan 28, 2022 - Abstract #ACC2022ACC_5049;    
    Patients with prior COVID-19 undergoing pharm MPI were slightly more likely to use a reversal agent, without a clinically significant increase in subsequent resource use or costs. Long-term concerns for pharm MPI in patients with COVID-19 history may not be warranted.
  • ||||||||||  Lexiscan (regadenoson) / GE Healthcare, Astellas, Gilead
    LEFT MAIN CORONARY ARTERY VASOSPASM: A MISDIAGNOSED CASE OF SEVERE CORONARY ARTERY DISEASE (eAbstract site) -  Jan 28, 2022 - Abstract #ACC2022ACC_3983;    
    CCTA is a non-invasive tool that can unmask LMCA spasm and help prevent unnecessary surgery in such cases. Physicians should have a high suspicion for CAS especially in patients with anginal chest pain who lack CAD risk factors.
  • ||||||||||  Lexiscan (regadenoson) / GE Healthcare, Astellas, Gilead
    A RARE CASE OF DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS) SYNDROME INDUCED BY REGADENOSON (Poster Hall_Hall C) -  Jan 28, 2022 - Abstract #ACC2022ACC_25;    
    It is imperative to have a high clinical suspicion and use multi-modality imaging to rule out an interarterial course which can cause myocardial ischemia and sudden death. Extra caution should be considered in patients who develop reactions after Lexiscan study, DRESS syndrome should be suspected, investigated and treated appropriately to avoid any serious and fatal outcomes.
  • ||||||||||  Lexiscan (regadenoson) / GE Healthcare, Astellas, Gilead
    Trial completion date, Trial primary completion date:  Treat COVID-19 Patients With Regadenoson (clinicaltrials.gov) -  Jan 24, 2022   
    P1/2,  N=40, Recruiting, 
    In patients with LBBB undergoing regadenoson PET stress imaging, artifactual septal perfusion defects are rare. Trial completion date: Jan 2022 --> Dec 2023 | Trial primary completion date: Nov 2021 --> Jan 2023
  • ||||||||||  Lexiscan (regadenoson) / GE Healthcare, Astellas, Gilead
    Journal:  The Impact of Ischemia Assessed by Magnetic Resonance on Functional, Arrhythmic, and Imaging Features of Hypertrophic Cardiomyopathy. (Pubmed Central) -  Jan 4, 2022   
    Each patient underwent cardiovascular magnetic resonance (CMR) including parametric mapping, perfusion imaging during regadenoson-induced hyperemia, late gadolinium enhancement (LGE) and three-dimensional longitudinal, circumferential, and radial strains analysis...Ischemia was associated with shorter time to anaerobic threshold (β-estimate: -0.442, 95% CI: -0.860; -0.023, p = 0.039). In HCM, ischemia associates with morphological markers of severity of disease, fibrosis, arrhythmia, and functional capacity.
  • ||||||||||  Lexiscan (regadenoson) / GE Healthcare, Astellas, Gilead
    Preclinical, Journal:  MRI-based in vivo detection of coronary microvascular dysfunction before alterations in cardiac function induced by short-term high-fat diet in mice. (Pubmed Central) -  Dec 29, 2021   
    Basal coronary flow and coronary reserve, as assessed using the A adenosine receptor agonist regadenoson, were also not altered in HFD-fed mice...Multiparametric cardiac MRI revealed a reduction in systolic heart function, including decreased ejection rate, increased end-systolic volume and decreased myocardial strain in diastole with impaired ejection fraction, but not until 4 weeks of HFD. Short-term feeding with HFD resulted in early endothelial dysfunction in coronary microcirculation that preceded alteration in cardiac function and systemic insulin resistance.
  • ||||||||||  Lexiscan (regadenoson) / GE Healthcare, Astellas, Gilead
    APICAL HYPERTROPHIC CARDIOMYOPATHY MIMICKING AS MYOCARDIAL INFARCTION. (Promenade Lobby (Sunset Center)) -  Dec 20, 2021 - Abstract #WSMRF2022WSMRF_107;    
    Nuclear Lexiscan stress test at that time showed ?reversible defect of the cardiac apex suggestive of ischemia?, cardiac catheterization was negative, and transthoracic echocardiogram (TTE) showed preserved left ventricular function and mild mitral regurgitation...This case illustrates the importance of understanding and diagnosing patients with ApHCM since patient symptoms mimicked a myocardial infarction. The accurate and timely diagnosis may highly improve the clinical outcome and overall well-being of the patient.
  • ||||||||||  donepezil / Generic mfg.
    Journal:  Blood-Brain Barrier Permeable and NO-Releasing Multifunctional Nanoparticles for Alzheimer's Disease Treatment: Targeting NO/cGMP/CREB Signaling Pathways. (Pubmed Central) -  Dec 16, 2021   
    The Reg moiety enabled the Reg-NPs to effectively regulate tight junction-associated proteins in the blood-brain barrier, thus facilitating the permeation of donepezil through the barrier and its accumulation in the brain. Moreover, the released NO and YC-1 activated the NO/cGMP/CREB signaling pathway by stimulating soluble guanylyl cyclase and inhibiting phosphodiesterase activity, which finally reduced cytotoxicity induced by aggregated Aβ in the neurons and was beneficial for synaptic plasticity and memory formation.
  • ||||||||||  Lexiscan (regadenoson) / GE Healthcare, Astellas, Gilead
    Journal:  Measuring myocardial blood flow with rubidium using Gjedde-Patlak-Rutland graphical analysis. (Pubmed Central) -  Nov 29, 2021   
    CT-MPI has the benefit of providing both complete anatomic coronary evaluation and assessment of myocardial perfusion. GPR analysis offers promise as a valid and analytically simpler technique for measuring myocardial blood flow, which, as with any clearance measured from GPR analysis, has units of ml/min/ml total tissue volume, and merits development as a polar map display.
  • ||||||||||  Lexiscan (regadenoson) / GE Healthcare, Astellas, Gilead
    Clinical, Journal, Heterogeneity:  Regadenoson-induced T-wave heterogeneity complements coronary stenosis detection by myocardial perfusion imaging in men and women. (Pubmed Central) -  Nov 21, 2021   
    Adding TWHV4-6 to MPI determinations reduced false-positive results by 70%, more than doubled true-negative results, and improved adjusted odds ratio to 6.8 (95% CI: 2.2-21.4, P = 0.001) with specificity of 78% in men and 86% in women. This observational study is the first to demonstrate the benefit of combining TWHV4-6 with MPI to enhance FLL detection during MPI with regadenoson in both men and women.
  • ||||||||||  Lexiscan (regadenoson) / GE Healthcare, Astellas, Gilead
    Transient Opening of the Blood-Brain Barrier by Vasoactive Peptides to Increase CNS Drug Delivery: Reality Versus Wishful Thinking? (Exhibit Hall D) -  Nov 16, 2021 - Abstract #SNO2021SNO_427;    
    Vasoactive peptides (VAPs) such as regadenoson, adenosine, and labradimil have been shown in animal studies to transiently open the BBB, and regadenoson is currently under investigation in humans to determine if it might improve CNS drug delivery...Dozens of VAPs have yet to be formally evaluated for this important clinical effect. This retrospective review summarizes the available data on VAPs highlighting agents that deserve further in vitro and in vivo investigations.
  • ||||||||||  Lexiscan (regadenoson) / GE Healthcare, Astellas, Gilead
    Journal:  Cardiac stress T1-mapping response and extracellular volume stability of MOLLI-based T1-mapping methods. (Pubmed Central) -  Nov 10, 2021   
    Power calculations indicate up to a fourfold (stress T1) and 7.5-fold (ECV) advantage in sample-size reduction using ShMOLLI. Our results indicate that ShMOLLI correlates strongly with increased MBF during regadenoson stress and achieves a significantly higher stress T1 response, greater effect size, and greater ECV measurement stability compared with the MOLLI variants tested.
  • ||||||||||  Lexiscan (regadenoson) / GE Healthcare, Astellas, Gilead
    Clinical, Journal:  Myocardial Perfusion Reserve in Children with Friedreich Ataxia. (Pubmed Central) -  Nov 4, 2021   
    In total, seven children with genetically confirmed FA, ages 8-17 years, underwent MPR stress testing using regadenoson...This retrospective study shows that children with FA develop MPR defects early in the disease process. It also suggests MPR may be a sensitive tool to evaluate underlying cardiac compromise and could be of use in directing surgical management decisions in children with FA.
  • ||||||||||  Lexiscan (regadenoson) / GE Healthcare, Astellas, Gilead
    Journal:  Large-scale evaluation of ion mobility spectrometry for the rapid detection of synthetic cannabinoid receptor agonists in infused papers in prisons. (Pubmed Central) -  Oct 30, 2021   
    The selectivity and sensitivity of Rapiscan Itemiser 3E and Itemiser 4DN Ion Trap Mobility Spectroscopy™ (ITMS™) systems were evaluated using 21 SCRA reference standards...Used effectively and with up to date substance libraries, they will help reduce the supply of SCRAs into prisons and identify emerging threats as they arise. Several emerging SCRAs (5F-MPP-PICA, 5F-EMB-PICA, and 4F-MDMB-BICA) were detected for the first time in Scottish prisons between May and August 2020 as a result of routine monitoring and all were detected using the ITMS systems tested.