| TNKASE (tenecteplase) / Roche, Boehringer Ingelheim |
NCT06498323: Intravenous TNK vs TPA for AIS Treatment on MSU,a Prospective Multicenter RCT |
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| Recruiting | 4 | 160 | RoW | tenecteplase | Mahidol University | Intravenous, Thrombosis, Acute Ischemic Stroke | 08/25 | 08/25 | | |
| Completed | 4 | 609 | Europe, Canada, RoW | Tenecteplase, TNKase, Metalyse, Clopidogrel, Coronary angiography, Primary PCI | KU Leuven, Boehringer Ingelheim, Life Sciences Research Partners, Fund for Clinical Cardiovascular Research at LRD | Myocardial Infarction | 10/22 | 09/23 | | |
ANGEL-TNK, NCT05624190: Intra-arterial Recombinant Human TNK Tissue-type Plasminogen Activator (rhTNK-tPA) Thrombolysis for Acute Large Vascular Occlusion After Successful Mechanical Thrombectomy Recanalization |
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| Recruiting | 4 | 256 | RoW | Recombinant Human tenecteplase Tissue-type Plasminogen Activator (rhTNK-tPA), IA rhTNK-tPA, Best Medical Management | Beijing Tiantan Hospital | Ischemic Stroke, Acute | 07/24 | 07/24 | | |
ChiCTR2100042450: Canceled by the investigator. Intravenous Tenecteplase Plus Endovascular Treatment Versus Endovascular Treatment Alone For Stroke Patient With Large Vessel Occlusion: a Multicenter, Double-Blind, Randomized Controlled Trial |
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| Recruiting | 4 | 542 | | Intravenous thrombolysis with tenecteplase combined with endovascular therapy ;Endovascular therapy | Xinqiao Hospital of the Army Medical University; Xinqiao Hospital of the Army Medical University, Self-financing | Acute ischemic stroke | | | | |
DO-IT, NCT06571149: Safety and Efficacy of Intravenous Thrombolysis in Patients With Ischemic Stroke and Direct Oral Anticoagulants Intake |
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| Not yet recruiting | 4 | 906 | Europe, Canada, Japan, RoW | Tenecteplase or Alteplase | Insel Gruppe AG, University Hospital Bern | Ischemic Stroke | 01/29 | 04/29 | | |
NCT06010628: Tenecteplase for Acute Ischemic Stroke Within 4.5 to 6 Hours of Onset (EXIT-BT2) |
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| Recruiting | 4 | 1440 | RoW | Tenecteplase | General Hospital of Shenyang Military Region | Stroke, Ischemic | 12/25 | 12/25 | | |
ATTIS, NCT05604638: Early Administration of Tirofiban in Patients Treated With Tenecteplase for Acute Ischemic Stroke |
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| Not yet recruiting | 4 | 600 | NA | Tenecteplase plus Tirofiban, Tenecteplase plus Placebo | Second Affiliated Hospital of Guangxi Medical University, CSPC Pharmaceutical Group Limited | Acute Ischemic Stroke | 03/25 | 12/25 | | |
TRICAS, ChiCTR2300073033: Tenecteplase for Thrombolysis Bridging Thrombectomy Combined with Remote Ischemia Conditioning in Acute Ischemic Stroke |
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| Not yet recruiting | 4 | 200 | | The patient received bilateral upper limb RIC (cuff pressure 180mmHg) twice a day for at least 7 consecutive days within 48 hours after operation. An entire intervention episode is composed of five cycles of 5min of ischemia followed by 3min of reperfusion. ;Accept standardized diagnosis and treatment plans recommended by the guidelines | the First Affiliated Hospital of Xi'an Jiaotong University; the First Affiliated Hospital of Xi'an Jiaotong University, China International Medical Foundation | Cerebrovascular diseases | | | | |
2004-002241-12: Ensayo clínico de fase IIIb - IV, aleatorizado y abierto, para evaluar la eficacia y seguridad de tenecteplasa junto con heparina no fraccionada administrada previo a la realización de PCI primaria, en comparación con la realización de PCI primaria convencional, en pacientes con infarto agudo de miocardio. |
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| Ongoing | 3/4 | 50 | Europe | Metalyse, Liquemin N 25 000, Metalyse, Liquemin, Metalyse, Liquemin | Boehringer Ingelheim España S.A | Fibrinolisis previa a la PCI primaria en infarto agudo de miocardio | | | | |
2010-022725-16: INTRACORONARY ADMINISTRATION OF TENECTEPLASE VERSUS ABCIXIMAB AS ADJUNCTIVE TREATMENT DURING PRIMARY ANGIOPLASTY IN ACUTE MYOCARDIAL INFARCTION OF ANTERIOR LOCATION ADMINISTRACION INTRACORONARIA DE TENECTEPLASA FRENTE A ABCIXIMAB COMO TRATAMIENTO ADJUNTO DURANTE ANGIOPLASTIA PRIMARIA EN INFARTO AGUDO DE MIOCARDIO DE LOCALIZACION ANTERIOR |
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| Ongoing | 3/4 | 60 | Europe | METALYSE, REOPRO, METALYSE, REOPRO | FRANCISCO JOSE MORALES PONCE, GRANT FROM: SUBVENCIONES PARA INVESTIGACION INDEPENDIENTE-DIRECCION GENERAL DE FARMACIA-ESPAÑA | ACUTE MYOCARDIAL INFARCTION INFARTO AGUDO DE MIOCARDIO | | | | |
2014-005369-64: Improve the myocardial reperfusion in ST elevation myocardial infarction: a randomized study between thrombectomy and pharmacological approach guided by the angiographic evidence of thrombus Mejoría de la reperfusión miocárdica en el infarto agudo de miocardio con elevación del segmento ST: estudio aleatorizado entre trombectomía versus el tratamiento farmacológico adyuvante guiado por la carga trombótica |
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| Ongoing | 3 | 170 | Europe | Powder and solution for solution for injection, Metalyse | Consorci MAr Parc de Salut de Barcelona, Parc de Salut MAR | ST elevation myocardial infarction Infarto agudo de miocardio con elevación de ST, Myocardial infarction Infarto agudo de miocardio, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
2015-002657-36: Evaluation of Tenecteplase versus Alteplase for Stroke Thrombolysis (TASTE) Trial |
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| Ongoing | 3 | 1024 | Europe | Actilyse, Metalyse, Powder and solvent for solution for injection/infusion, Powder and solvent for solution for injection, Actilyse (Alteplase), Metalyse | University of Newcastle, National Health and Medical Research Council, Boehringer Ingelheim | Acute Ischaemic Stroke, Stroke or 'brain attack' caused by a clot, Diseases [C] - Nervous System Diseases [C10] | | | | |
2015-005469-22: A randomised controlled trial of TNK-tPA versus standard of care for minor ischemic stroke with proven occlusion. |
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| Ongoing | 3 | 1274 | Europe | Metalyse 10,000 U, Powder and solvent for solution for injection, Metalyse 10, 000 U Powder and solvent for solution for injection Tenecteplase (TNK-tPA) | University of Calgary, University of Calgary | To demonstrate the efficacy of using TNK-tPA (tenecteplase), a thrombolytic agent that is relatively novel to the treatment ischemic stroke but well-established in the treatment of myocardial infarction, to treat minor ischemic stroke patients with proven acute symptomatic occlusions or perfusion abnormalities., To demonstrate the efficacy of using TNK-tPA to treat minor ischemic stroke with proven arterial occlusion., Diseases [C] - Nervous System Diseases [C10] | | | | |
2016-002075-10: ATTEST 2: A trial comparing the new "clot busting" drug treatment tenecteplase with standard "clot busting" treatment |
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| Ongoing | 3 | 1870 | Europe | Actilyse, Metalyse, Powder and solvent for solution for injection/infusion, Powder and solvent for solution for injection, Actilyse, Metalyse | NHS Greater Glasgow & Clyde, University of Glasgow, The Joint Stroke Association/ British Heart Foundation Award, Boehringer Ingelheim, | Acute ischaemic stroke, Stroke caused by a blood clot, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
2018-002546-36: TENECTEPLASE IN CENTRAL RETINAL ARTERY OCCLUSION STUDY (TenCRAOS): A RANDOMIZED CONTROLLED TRIAL OF ACUTE CLOTSOLVING MEDICATION IN CENTRAL RETINALY ARTERY OCCLUSION. |
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| Not yet recruiting | 3 | 78 | Europe | Metalyse, Concentrate and solvent for solution for injection, Capsule, Tenecteplase Metalyse, acetylsalisylic acid | Oslo University Hospital, Oslo University Hospital | Central retinal artery occlusion, Central retinal artery occlusion (CRAO) is an ophthalmologic emergency that, without prompt revascularization, bears high risk of permanent blindness., Diseases [C] - Eye Diseases [C11] | | | | |
2020-001982-36: Alteplase compared to tenecteplase in patients with acute ischemic stroke: Registry-based pragmatic randomized controlled trial Porovnánà alteplasy s tenecteplasou u pacientů s akutnà ischemià mozku: pragmatická randomizovaná kontrolovaná klinická studie založená na registru |
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| Ongoing | 3 | 500 | Europe | Powder and solution for solution for injection, Metalyse, Actilyse | Fakultnà nemocnice u sv. Anny, Fakultnà nemocnice u sv. Anny | Acute ischemic stroke Akutnà ischemická mozková pÅ™Ãhoda, Acute ischemic stroke Akutnà ischemická mozková pÅ™Ãhoda, Diseases [C] - Nervous System Diseases [C10] | | | | |
ACTRN12618000778280: A phase 3 study of low-dose intracoronary thrombolytic therapy in STEMI (heart attack) patients |
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| Completed | 3 | 50 | | | University of Sydney, National Health and Medical Research Council, Abbott Pty Ltd | ST elevation myocardial infarction | | | | |
2020-001599-13: Tenecteplase Compared to Alteplase for Large Vesel Oclusion patients before Thrombectomy Tenecteplasa en comparación con Alteplasa para pacientes con oclusión de gran vaso antes de la trombectomÃa. |
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| Ongoing | 3 | 500 | Europe | Tenecteplase, Alteplase, NA, Powder and solvent for solution for injection, Metalyse, Actilyse | Hospital Vall Hebron, Hospital Vall Hebron | Acute Ischaemic Stroke Ictus Isquémico Agudo, Acute Ischaemic Stroke Ictus Isquémico Agudo, Diseases [C] - Nervous System Diseases [C10] | | | | |
| Terminated | 3 | 201 | Europe | Tenecteplase, Metalyse, Alteplase, Actilyse | Haukeland University Hospital | Stroke, Acute, Cerebrovascular Disorders, Ischemic Stroke | 09/21 | 12/21 | | |
| Recruiting | 3 | 600 | Europe, US, RoW | Tenecteplase, Metalyse, Control | University Hospital of North Norway, UiT The Arctic University of Norway, The Royal Norwegian Ministry of Health, Norwegian Health Association | Ischemic Stroke, Stroke, Acute | 12/21 | 12/22 | | |
| Completed | 3 | 1600 | Canada | Tenecteplase, tNK, Alteplase, tPA | University of Calgary | Stroke, Acute, Thromboses, Intracranial | 04/22 | 04/23 | | |
| Completed | 3 | 458 | Canada, US | Tenecteplase, Placebo | Genentech, Inc. | THROMBOLYSIS | 02/23 | 02/23 | | |
TNK-CAT, NCT05626972: Tenecteplase Compared to Alteplase for Patients With Large Vesel Oclusion Suspicion Before Thrombectomy |
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| Recruiting | 3 | 500 | Europe | Tenecteplase | Hospital Universitari Vall d'Hebron Research Institute, Instituto de Salud Carlos III | Acute Ischemic Stroke | 05/23 | 05/24 | | |
| Completed | 3 | 516 | RoW | tenecteplase (0.25 mg/kg, Max 25 mg), standard medical treatment, Aspirin, Clopidogrel | Beijing Tiantan Hospital | Ischemic Stroke, Acute | 01/24 | 02/24 | | |
NCT05601999: Study of Efficacy and Safety of GNR-060 vs Metalyse in Patients With ST Elevation Myocardial Infarction |
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| Recruiting | 3 | 244 | RoW | GNR-060, Tenecteplase, Metalyse | AO GENERIUM | ST Elevation Myocardial Infarction | 10/24 | 10/24 | | |
ORIGINAL, NCT04915729: A Study in Chinese Patients to Compare How Tenecteplase and Alteplase Given After a Stroke Improve Recovering of Physical Activity |
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| Completed | 3 | 1490 | RoW | tenecteplase, alteplase | Boehringer Ingelheim | Stroke | 10/23 | 10/23 | | |
| Terminated | 3 | 832 | | | Acute Stroke Service, National Health and Medical Research Council (NHMRC) , Greater Charitable Foundation, National Heart Foundation of Australia | Acute ischaemic stroke | | | | |
NCT05745259: Thrombolysis Treated With TNK-tPA in Acute Ischemic Stroke Patients （3T Stroke-Ⅲ） |
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| Recruiting | 3 | 1630 | RoW | Alteplase, rt-PA, Tenecteplase, TNK-tPA | Beijing Tiantan Hospital, Jiangsu FENG HUA Biotech Pharmaceutical Co., Ltd, The Place Pharmaceutical(Jiangsu) Co., Ltd | Acute Ischemic Stroke | 11/23 | 03/24 | | |
TNK-PLUS, NCT06221371: Endovascular Treatment With or Without Preceding Intravenous Tenecteplase (TNK) in Patients With Late-window acUte Ischemic Stroke Due to Middle Cerebral Artery Occlusion |
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| Recruiting | 3 | 390 | RoW | rhTNK-tPA, Tenecteplase, direct EVT | Beijing Tiantan Hospital, Linyi People's Hospital | Ischemic Stroke, Acute, Thrombolysis, Endovascular Treatment | 12/24 | 05/25 | | |
DIRECT-TNK, NCT05199194: Randomization to Endovascular Treatment Alone or Preceded by Systemic Thrombolysis With Tenecteplase in Ischemic Stroke |
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| Recruiting | 3 | 390 | RoW | Tenecteplase, TNK, Placebo | Hospital Moinhos de Vento, Ministry of Health, Brazil, Boehringer Ingelheim, Medtronic | Stroke, Ischemic, Stroke, Acute | 07/26 | 07/27 | | |
| Recruiting | 3 | 452 | RoW | Tenecteplase, rhTNK-tPA, TNK-tPA, Best Practice (which may include intravenous Alteplase), rt-PA | Beijing Tiantan Hospital | Ischemic Stroke, Acute | 02/26 | 05/26 | | |
| Recruiting | 3 | 78 | Europe, RoW | Intravenous injection of Tenecteplase and one dose of placebo tablet, Metalyse, One tablet of Acetylsalicylic Acid and one dose of IV placebo, Aspirin | Oslo University Hospital | Central Retinal Artery Occlusion | 10/24 | 01/25 | | |
ChiCTR2200064809: Safety and efficacy of adjunctive intra-arterial Tenecteplase after successful endovascular thrombectomy in patients with large vessel occlusion stroke |
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| Completed | 3 | 498 | | Intraarterial TNK; Standard treatment | The Second Affiliated Hospital of Chongqing Medical University; The Second Affiliated Hospital of Chongqing Medical University, Project funding | Acute ischemic stroke | | | | |
| Not yet recruiting | 3 | 20000 | NA | Standard-dose intravenous tenecteplase, Low-dose intravenous tenecteplase, No intravenous tenecteplase, Conservative Blood Pressure Control, Moderate Blood Pressure Control, Intensive Blood Pressure Control, Placebo, NoNO-42 | The George Institute, University of Calgary, Berry Consultants | Stroke | 05/34 | 05/34 | | |
NCT06414499: Teneteplase Reperfusion Therapy in Acute Ischemic Cerebrovascular Events-Ⅳ(TRACE Ⅳ) |
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| Recruiting | 3 | 1394 | RoW | rhTNK-tPA, Control group | Beijing Tiantan Hospital | Tenecteplase, Minor Ischemic Stroke | 07/25 | 12/25 | | |
ACT-WHEN, NCT06320431: ACT-GLOBAL THROMBOLYSIS (-001) Domain Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632 |
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| Recruiting | 3 | 4000 | Canada, RoW | Tenecteplase, TNKase, Metalyse | University of Calgary, The George Institute for Global Health, Australia | Acute Ischemic Stroke AIS, Stroke Acute, Stroke, Acute, Stroke Ischemic | 09/30 | 12/30 | | |
TEMPO-2, NCT02398656: A Randomized Controlled Trial of TNK-tPA Versus Standard of Care for Minor Ischemic Stroke With Proven Occlusion |
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| Completed | 3 | 886 | Europe, Canada, RoW | Tenecteplase, TNK-tPA, Antiplatelet treatment, ASA, Clopidogrel | University of Calgary | Stroke, Acute | 01/24 | 04/24 | | |
NCT05701956: Intravenous Tenecteplase Plus EVT Versus EVT Alone on 4.5 to 24 Hours After Basilar Artery Occlusion |
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| Recruiting | 3 | 332 | RoW | Tenecteplase, TNK, TNK-tPA, TNKase, rhTNK-tPA, Endovascular thrombectomy, thrombectomy | The First Affiliated Hospital of University of Science and Technology of China | Basilar Artery Occlusion, Acute Cerebrovascular Accident, Stroke Due to Basilar Artery Occlusion | 12/25 | 03/26 | | |
TNK-LVO, NCT06658197: Efficacy and Safety of Tenecteplase Bridging Mechanical Thrombectomy for Acute Large Vessel Occlusion Stroke |
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| Not yet recruiting | 3 | 850 | RoW | Tenecteplase, TNK, Alteplase, recombinant tissue plasminogen activator (rtPA) | Xuanwu Hospital, Beijing | Stroke, Ischemic, Stroke, Acute, Thrombosis, Brain, Drug Effect | 12/26 | 06/27 | | |
| Recruiting | 3 | 445 | RoW | Tenecteplase (1/3 systemic weight based dose), TNKase, Sterile water for injection (WFI) | University of Sydney, Genentech, Inc. | STEMI, Elevated IMR (>32) | 12/24 | 12/26 | | |
NCT05657457: Improving Neurological Outcome for Acute Basilar Artery Occlusion With Sufficient Recanalization After Thrombectomy by Intraarterial Tenecteplase (INSIST-IT) |
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| Recruiting | 3 | 228 | RoW | Tenecteplase | General Hospital of Shenyang Military Region, Cerebrovascular Disease Collaboration & Innovation Alliance of Liaoning | Stroke, Ischemic | 03/25 | 03/25 | | |
NCT05657444: Intra-arterial Tenecteplase During First Thrombectomy Attempt for Acute Stroke (BRETIS-TNK II) |
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| Recruiting | 3 | 372 | RoW | Tenecteplase | General Hospital of Shenyang Military Region, Cerebrovascular Disease Collaboration & Innovation Alliance of Liaoning | Stroke, Ischemic | 12/25 | 12/25 | | |
ETERNAL-LVO, NCT04454788: Extending the Time Window for Tenecteplase by Effective Reperfusion in Patients With Large Vessel Occlusion |
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| Recruiting | 3 | 740 | RoW | Tenecteplase, Standard Care (which may include intravenous Alteplase) | University of Melbourne, Professor Mark Parsons | Ischemic Stroke | 06/25 | 12/25 | | |
TECNO, NCT05499832: Safety and Efficacy of Intra-arterial Tenecteplase for Noncomplete Reperfusion of Intracranial Occlusions |
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| Recruiting | 3 | 156 | Europe | Tenecteplase | Insel Gruppe AG, University Hospital Bern | Ischemic Stroke | 07/25 | 10/25 | | |
NCT05827042: Endovascular Thrombectomy Alone Versus Intravenous Thrombolysis Plus Thrombectomy on Acute Basilar Artery Occlusion |
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| Recruiting | 3 | 338 | RoW | Intravenous thrombolysis, Alteplase or Tenecteplase, Endovascular thrombectomy | The First Affiliated Hospital of University of Science and Technology of China | Basilar Artery Occlusion, Acute Cerebrovascular Accident, Stroke Due to Basilar Artery Occlusion | 12/25 | 03/26 | | |
EXTEND-IV, NCT05199662: Randomization to Extend Stroke Intravenous ThromboLysis In Evolving Non-Large Vessel Occlusion With TNK (RESILIENT |
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| Recruiting | 3 | 360 | RoW | Intravenous tenecteplase, TNK, Metalyse, Placebo | Hospital Moinhos de Vento, Ministry of Health, Brazil, Boehringer Ingelheim, Brainomix Limited, iSchemaView, Inc | Ischemic Stroke, Acute | 07/26 | 07/27 | | |
NCT05684172: Intra-arterial TNK Following Endovascular Thrombectomy in Patients With Large Vessel Occlusion of Posterior Circulation |
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| Completed | 2/3 | 208 | RoW | Tenecteplase, endovascular thrombectomy alone | The First Affiliated Hospital of University of Science and Technology of China | Acute Ischemic Stroke, Intracranial Artery Occlusion, Endovascular Thrombectomy | 08/23 | 11/23 | | |
NCT05657470: Rescue Thrombolysis for Medium Vessel Occlusion (RESCUE-TNK) |
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| Recruiting | 2/3 | 80 | RoW | Tenecteplase | General Hospital of Shenyang Military Region, Cerebrovascular Disease Collaboration & Innovation Alliance of Liaoning | Stroke, Ischemic | 09/25 | 09/25 | | |
| Recruiting | 2/3 | 544 | RoW | rhTNK-tPA, TNKase, TNK-tPA, Endovascular treatment, intra-arterial treatment, interventional therapy | Xinqiao Hospital of Chongqing, CSPC RECOMGEN PHARMACEUTICAL (GUANGZHOU) CO.,LTD | Stroke, Acute, Stroke, Ischemic | 12/25 | 03/26 | | |
POST-ETERNAL, NCT05105633: Extending the Time Window for Tenecteplase by Recanalization of Basilar Artery Occlusion in Posterior Circulation Stroke |
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| Recruiting | 2/3 | 688 | RoW | Tenecteplase, Standard Care (which may include intravenous Alteplase) | University of Melbourne | Basilar Artery Occlusion | 08/26 | 12/26 | | |
NCT05892510: Post-thrombectomy Intra-arterial Tenecteplase for Acute manaGement of Non-retrievable Thrombus and No-reflow in Emergent Stroke |
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| Not yet recruiting | 2/3 | 462 | RoW | Intra-arterial tenecteplase injection at the completion of thrombectomy, Placebo | University of Melbourne | Ischemic Stroke, Acute, Cerebrovascular Disorders, Brain Disorder, Central Nervous System Diseases | 08/27 | 11/27 | | |
ACTRN12608000466347: Low-dose tenecteplase versus standard-dose alteplase for acute ischaemic stroke: an Imaging-Based Efficacy Trial. |
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| Recruiting | 2 | 75 | | | John Hunter Hospital, University of Newcastle, National Health and Medical Research Council (NHMRC) Project Grant: ID 510722 | Ischaemic stroke | | | | |
NCT05281549: Thrombolysis Treated With TNK-tPA in Acute Ischemic Stroke Patients （3T Stroke-II） |
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| Active, not recruiting | 2 | 225 | RoW | Alteplase, rt-PA, Tenecteplase, TNK-tPA | Beijing Tiantan Hospital, Jiangsu FENG HUA Biotech Pharmaceutical Co., Ltd, The Place Pharmaceutical(Jiangsu) Co., Ltd | Acute Ischemic Stroke | 01/22 | 05/22 | | |
ACTRN12621000696897: To assess if the administration of a clot busting medication (Tenecteplase) administered at the site of the clot in the brain following intravenous administration of the clot busting medication is safe and feasible in patients with acute ischaemic stroke within 4.5 hours of symptom onset. |
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| Terminated | 2 | 18 | | | Northern Sydney Local Health District, Royal North Shore Hospital | Ischaemic stroke | | | | |
| Completed | 2 | 224 | RoW | Tenecteplase, The best treatment selected by local doctors(Aspirin, Recombinant Tissue Plasminogen Activator, Urokinase, Thrombectomy) | Huashan Hospital, Puer People's Hospital, Shanghai 6th People's Hospital, Hexigten Traditional Chinese and Mongolian Medicine Hospital, Yangpu Hospital, School of Medicine, Tongji University, The First Affiliated Hospital of Shanxi Medical University, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Linyi People's Hospital, Shanghai 10th People's Hospital, Nanshi Hospital of Nanyang, Shanghai Fifth People's Hospital,Fudan University, Xuzhou Medical University Affiliated Hospital of Huaian, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, The First Affiliated Hospital of Soochow Medical University, Affiliated Haian People's Hospital of Nantong University, First Affiliated Hospital of Harbin Medical University, the Third Hospital of Mianyang, Zhejiang Province People's Hospital, Shanghai East Hospital, The Central Hospital of Jiaozuo Coal Group, Huizhou Municipal Central Hospital, Zhejiang University, The Second Affiliated Hospital of Chongqing Medical University, Ningbo No. 1 Hospital | Stroke | 09/23 | 09/23 | | |
ALLY, NCT05172934: Adjunctive Intra-arterial Tenecteplase Following Mechanical Thrombectomy Pilot Trial |
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| Completed | 2 | 20 | US | intra-arterial tenecteplase | ProMedica Health System, Genentech, Inc. | Ischemic Stroke | 09/23 | 11/23 | | |
NCT05580822: Additive Effects of Intra-arterial Tenecteplase for Successful Thrombectomy Due to Acute Basilar Artery Occlusion |
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| Not yet recruiting | 2 | 520 | NA | Tenecteplase for Injection, Saline | First Hospital of China Medical University | Basilar Artery Occlusion, Thrombectomy, Tenecteplase | 12/24 | 12/25 | | |
DATE IIa Trial, ChiCTR2400080624: Safety and efficacy pilot study of adjunctive intra-arterial tenecteplase after successful endovascular thrombectomy in patients with large vessel occlusion stroke (DATE): A prospective, multicenter, randomized controlled, open-label, end-point, blinded Phase IIa clinical trial |
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| Not yet recruiting | 2 | 157 | | Intra-arterial Tenecteplase thrombolysis (dose A: 0.03125mg/kg) in occluded arteries after successful endovascular treatment.; Intra-arterial Tenecteplase thrombolysis (dose B: 0.0625mg/kg) in occluded arteries after successful endovascular treatment.; Endovascular treatment | The First Affiliated Hospital of the Army Medical University; The First Affiliated Hospital of the Army Medical University, Key Project of Chongqing Science (2023ZDXM025) and Health Joint Medical Research Project and Major Project of Clinical Research Incubation at the First Affiliated Hospital of Army Medical University (2023IITZD01) | Acute ischemic stroke | | | | |
ChiCTR2300073787: A pilot dose-escalation safety study of adjunctive intra-arterial tenecteplase after successful endovascular thrombectomy in patients with large vessel occlusion stroke |
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| Recruiting | 1 | 88 | | Intra-arterial Tenecteplase thrombolysis in occluded arteries after successful endovascular treatment. The dose gradient of Tenecteplase is set as 1/8, 1/4, 1/2, 3/4 of the intravenous thrombolytic dose (0.25 mg/kg), which are respectively drug dose A (0.03125 mg/kg), drug dose B (0.0625 mg/kg), drug dose C (0.125 mg/kg), and drug dose D (0.1875 mg/kg). Proceed sequentially from the low-dose group to the high-dose group. | The First Affiliated Hospital of the Army Medical University; The First Affiliated Hospital of the Army Medical University, Key Project of Chongqing Science and Health Joint Medical Research Project and Major Project of Clinical Research Incubation at the First Affiliated Hospital of Army Medical University | Acute ischemic stroke | | | | |
NCT06696131: Tenecteplase (TNK) in the Treatment of Intracerebral Hemorrhage(ICH) |
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| Not yet recruiting | 1 | 5 | NA | TNK | Gaurav Gupta, MD | Intracerebral Hemorrhage, Intracranial Hemorrhages, Hemorrhagic Strokes | 01/27 | 12/27 | | |
DISTAL-IVT, NCT05635786: Early Recanalization After Intravenous Thrombolysis with Tenecteplase Versus Alteplase in Distal Vessel Occlusion Strokes |
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| Recruiting | N/A | 320 | Europe | Alteplase (0.9mg/kg), Tenecteplase (0.25mg/kg) | Centre Hospitalier Sud Francilien | Acute Distal Vessel Occlusion Stroke | 12/24 | 12/24 | | |
TITACIPPI, NCT05733507: Tirofiban Plus Intravenous Thrombolysis in Acute Anterior Choroidal Infarction or Paramedian Pontine Infarction |
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| Completed | N/A | 48 | Europe | IVT with tenecteplase or alteplase, Intervention Name : Tirofiban and IVT with tenecteplase or alteplase | Centre Hospitalier Sud Francilien | Acute Anterior Choroidal Infarction (ACI), Paramedian Pontine Infarction (IPP) | 09/23 | 09/23 | | |
DIVArétro, NCT05809921: Dual IntraVenous Thrombolysis Approach (DIVA) in Patients With Medium-vessel-occlusion Strokes: a Retrospective Study |
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| Completed | N/A | 294 | Europe | alteplase, Alteplase + possible complementary IVT with tenecteplase | Centre Hospitalier Sud Francilien | Acute Ischemic Stroke Due to Medium-vessel-occlusion | 09/23 | 09/23 | | |
| Recruiting | N/A | 1200 | RoW | Tenecteplase, rhTNK-tPA, Alteplase, rt-PA | Huashan Hospital, Keshiketeng Banner Traditional Chinese Medicine Mongolian Medicine Hospitalorem Ipsum, Nanshi Hospital of Nanyang, The First Affiliated Hospital of Ningbo University, Jilin Liuhe Hospital, Shenyang Fifth People's hospital, Shanghai East Hospita, Shanghai 10th People's Hospital, Shanghai Fifth People's Hospital, Shanghai Pudong Gongli hospital, Shanghai Neuromedical Center, Shanghai Fourth People's Hospital, Shanghai Pudong People's Hospital, Shanghai Putuo Liqun Hospital, Shenyang Fushun general hospital of mining bureau, Yantai Affliated Hosiptal of Binzhou Medical University, Shanghai Ninth People's Hospital Huangpu Branch, Shanghai Deji Hospital, Ruijin Hospital Luwan Branch | Ischemic Stroke | 12/23 | 05/24 | | |
NCT04201964: Improving Neuroprotective Strategy for Ischemic Stroke With Poor Recanalization After Thrombectomy by Intra-arterial TNK (INSIST-TNK) |
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| Recruiting | N/A | 30 | RoW | Intra-arterial administration of tenecteplase | Hui-Sheng Chen | Ischemic Stroke | 06/25 | 06/25 | | |
DO-IT Cohort, NCT06556446: Intravenous Thrombolysis in Patients With Ischemic Stroke and Recent Ingestion of Direct Oral Anticoagulants |
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| Recruiting | N/A | 2800 | Europe, Canada, RoW | Tenecteplase and Alteplase | Insel Gruppe AG, University Hospital Bern, Swiss Stroke Trialist Association, Swiss Stroke Registry | Ischemic Stroke | 03/26 | 12/26 | | |
| Recruiting | N/A | 260 | NA | alteplase or tenecteplase, tPA or TNK | Chinese University of Hong Kong, Pamela Youde Nethersole Eastern Hospital, Queen Mary Hospital, Hong Kong, Princess Margaret Hospital, Canada, Tuen Mun Hospital, The Queen Elizabeth Hospital, United Christian Hospital | CVA (Cerebrovascular Accident) | 12/28 | 03/29 | | |
NCT05724342: Tenecteplase REperfusion in Acute Ischemic sTroke Registry（TREAT） |
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| Recruiting | N/A | 1600 | RoW | rhTNK-tPA Thrombolysis | Beijing Tiantan Hospital, National Natural Science Foundation of China, Beijing Municipal Science & Technology Commission, Beijing Municipal Administration of Hospitals | Stroke, Ischemic | 09/24 | 12/24 | | |
NCT06559436: Extending the Time Window for Intravenous Tenecteplase in Patients With Distal Medium Vessel Occlusions Stroke |
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| Recruiting | N/A | 560 | RoW | Intravenous thrombolysis, Standard medical management | The First Affiliated Hospital of University of Science and Technology of China | Acute Ischemic Stroke | 09/26 | 12/26 | | |
TRANSIT, NCT06621121: A Real-world Study of Tenecteplase Versus Alteplase for Thrombolysis in Patients Within 4.5 H of Onset of Ischemic Stroke |
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| Recruiting | N/A | 6000 | RoW | Tenecteplase, Alteplase | Tianjin Huanhu Hospital | Stroke Acute, Tenecteplase, Alteplase | 10/25 | 10/26 | | |
ChiCTR2300067439: Tenecteplase intravenous thrombolysis in the treatment of acute ischemic non-macrovascular occlusive stroke at 4.5 to 9 hours of onset：A multicenter randomized controlled study |
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| Not yet recruiting | N/A | 870 | | TNK thrombolysis ;Non-thrombolytic therapy | Mianyang central hospital; Mianyang central hospital, CSPC Pharmaceutical Group Co., Ltd. | Acute ischemic non-macrovascular occlusive stroke | | | | |
NCT06018181: Outcomes After Intravenous Alteplase / Tenecteplase With or Without Shuxuetong Injection in Routine Clinical Practice |
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| Not yet recruiting | N/A | 2008 | NA | Shuxuetong Injection | Dongzhimen Hospital, Beijing | Ischemic Stroke, Acute | 04/25 | 12/25 | | |
ChiCTR2400084840: Intracoronary administration of Tenecteplase to prevent PCI-related myocardial infarction in patients enriched with attenuated signal coronary plaques |
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| Not yet recruiting | N/A | 864 | | Immediate intracoronary injection of 4mL of 0.9% NaCl solution containing 4mg of TNK following balloon angioplasty (dilation).; Immediate intracoronary injection of 4mL of 0.9% NaCl solution following balloon angioplasty (dilation). | Sir Run Run Shaw Hospital, Zhejiang University School of Medicine; Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, NONE | coronary heart disease | | | | |
ChiCTR2400089572: Efficacy and safety of tirofiban after intravenous thrombolysis with tenecteplase in acute ischemic stroke: a multicenter randomized controlled trial |
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| Not yet recruiting | N/A | 310 | | Teneplase thrombolysis was followed by intravenous tirofiban antiplatelet therapy; Patients in this group received intravenous placebo | ganzhou people's hospital; ganzhou people's hospital, no funding | acute ischemic stroke | | | | |
ChiCTR2400091196: Chinese Cohort of Tenecteplase Thrombolysis for Acute Ischemic Stroke |
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| Not yet recruiting | N/A | 10000 | | | Second Affiliated Hospital of Army Medical University, PLA; Second Affiliated Hospital of Army Medical University, PLA, Optimization of endovascular treatment strategy for acute massive cerebral infarction | Lschemic stroke | | | | |
| Not yet recruiting | N/A | 5000 | Europe | | Assistance Publique - Hôpitaux de Paris | Stroke, Acute | 03/28 | 03/28 | | |
