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Enrollment closed: ORIGINAL: A Study in Chinese Patients to Compare How Tenecteplase and Alteplase Given After a Stroke Improve Recovering of Physical Activity (clinicaltrials.gov) - Jul 27, 2023 P3, N=1490, Active, not recruiting, Recruiting --> Active, not recruiting
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Clinical, Retrospective data, Journal, HEOR: Symptomatic Intracranial Hemorrhage With Tenecteplase vs Alteplase in Patients With Acute Ischemic Stroke: The Comparative Effectiveness of Routine Tenecteplase vs Alteplase in Acute Ischemic Stroke (CERTAIN) Collaboration. (Pubmed Central) - Jul 14, 2023 In this large study, ischemic stroke treatment with 0.25-mg/kg tenecteplase was associated with lower odds of sICH than treatment with alteplase. The results provide evidence supporting the safety of tenecteplase for stroke thrombolysis in real-world clinical practice.
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Journal: Use of Tenecteplase in Acute Ischemic Stroke in the Time of SARS-CoV-2. (Pubmed Central) - Jul 13, 2023 The easier administration of TNK has improved the accessibility of fibrinolytic therapy, even in adverse circumstances, such as the COVID-19 pandemic. Its use appears to be safe and effective, even in patients who are not candidates for mechanical thrombectomy.
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Review, Journal: Evolving Thrombolytics: from Alteplase to Tenecteplase. (Pubmed Central) - Jun 19, 2023 This paper provides an overview of completed and ongoing randomized trials and nonrandomized studies analyzing tenecteplase in the treatment of acute ischemic stroke. Results reviewed support the safe use of tenecteplase in clinical practice.
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Review, Journal: Tenecteplase: A Review of Its Pharmacology and Uses. (Pubmed Central) - Jun 12, 2023 Intravenous thrombolysis therapy with TNK can not only increase the proportion of 90-day mRS 0-2 in BAD patients, but also reduce the incidence of END. No abstract available
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Journal: Intravenous thrombolysis of ischemic stroke-Current status (Pubmed Central) - Jun 12, 2023 The most recent guidelines indicate that TNK is particularly advantageous over rtPA in patients treated in combination with endovascular stroke therapy (EST). The combination of IVT and EST should primarily be performed in the 4.5?h time window in patients without contraindications; in the later time window EST alone is conceivable if it can be performed without delay.
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Journal: Femoral Access-Site Complications with Tenecteplase versus Alteplase before Mechanical Thrombectomy for Large-Vessel-Occlusion Stroke. (Pubmed Central) - Jun 12, 2023 The combination of IVT and EST should primarily be performed in the 4.5?h time window in patients without contraindications; in the later time window EST alone is conceivable if it can be performed without delay. Tenecteplase compared with alteplase before mechanical thrombectomy for large-vessel-occlusion stroke is not associated with an alteration in femoral access-site complication rates.
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Enrollment open: DIVAr (clinicaltrials.gov) - Jun 12, 2023 P=N/A, N=300, Recruiting, Tenecteplase compared with alteplase before mechanical thrombectomy for large-vessel-occlusion stroke is not associated with an alteration in femoral access-site complication rates. Not yet recruiting --> Recruiting
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Review, Journal: UpdatED: The emergency medicine pharmacotherapy literature of 2022. (Pubmed Central) - Jun 5, 2023 Pharmacotherapy-related publications deemed to be GRADE 1A and 1B were reviewed by the group for inclusion in the review. In all, this article summarizes and provides commentary on the potential clinical impact of 13 articles, 4 guidelines, and 3 meta-analyses covering topics including anticoagulant reversal, tenecteplase in acute ischemic stroke, guideline updates for heart failure and aortic aneurysm, magnesium in atrial fibrillation, sedation in mechanically ventilated patients and pain management strategies in the Emergency Department (ED), and tranexamic acid use in epistaxis and GI bleed.
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Journal, Head-to-Head: Tenecteplase versus alteplase in treatment of acute ST-segment elevation myocardial infarction: a randomized non-inferiority trial. (Pubmed Central) - Jun 2, 2023 P4 In all, this article summarizes and provides commentary on the potential clinical impact of 13 articles, 4 guidelines, and 3 meta-analyses covering topics including anticoagulant reversal, tenecteplase in acute ischemic stroke, guideline updates for heart failure and aortic aneurysm, magnesium in atrial fibrillation, sedation in mechanically ventilated patients and pain management strategies in the Emergency Department (ED), and tranexamic acid use in epistaxis and GI bleed. rhTNK-tPA was non-inferior to rt-PA in the effect of improving recanalization of the infarct-related artery, a validated surrogate of clinical outcomes, among Chinese patients with acute STEMI.
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Journal: Improving neurological outcome for acute basilar artery occlusion with sufficient recanalization after thrombectomy by intraarterial tenecteplase (INSIST-IT): Rationale and design. (Pubmed Central) - May 30, 2023 Subgroup analysis of the primary outcome will be performed by age, gender, baseline NIHSS score, baseline pc-ASPECTS, intravenous thrombolysis, time from estimated symptom onset to treatment, mTICI, blood glucose, and stroke etiology. The results of this study will provide evidence of whether adjunct use of intraarterial tenecteplase after successful reperfusion with EVT is associated with better outcomes for acute BAO patients.
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Journal, HEOR, Cost-effectiveness, Cost effectiveness: Cost-effectiveness of tenecteplase versus alteplase for stroke thrombolysis evaluation trial in the ambulance. (Pubmed Central) - May 30, 2023 Treatment of ischaemic stroke patients with tenecteplase appeared to be cost-effective and improve QALYs in the MSU setting based on Phase II data. The reduced total cost from tenecteplase was driven by savings from acute hospitalisation and reduce need for nursing home care.
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Review, Journal: Tenecteplase in Acute Stroke: What About the Children? (Pubmed Central) - May 25, 2023 Changes in fibrinolytic capacity over childhood, pediatric pharmacological considerations such as age-specific differences in drug clearance and volume of distribution, and practical aspects of drug delivery such as availability in children's hospitals may impact decisions about transitioning from alteplase to tenecteplase for acute pediatric stroke treatment. Pediatric and adult neurologists should prepare institution-specific guidelines and organize prospective data collection.
- |||||||||| TNKASE (tenecteplase) / Roche, Boehringer Ingelheim, Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
Journal: Follow-up Imaging After Thrombolysis: FIAT, A Randomized Trial. (Pubmed Central) - May 15, 2023 Trial completion date: Dec 2022 --> Dec 2023 | Trial primary completion date: Dec 2022 --> Dec 2023 It is likely safe to forgo follow up imaging after thrombolysis in the absence of clinical decompensation.
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Trial completion, Trial completion date: AcTQuICR: Alteplase Compared to Tenecteplase in Patients With Acute Ischemic Stroke (clinicaltrials.gov) - May 12, 2023 P3, N=1600, Completed, It is likely safe to forgo follow up imaging after thrombolysis in the absence of clinical decompensation. Active, not recruiting --> Completed | Trial completion date: Dec 2022 --> Apr 2023
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Enrollment open, Trial completion date, Trial primary completion date: ALLY: Adjunctive Intra-arterial Tenecteplase Following Mechanical Thrombectomy Pilot Trial (clinicaltrials.gov) - Apr 21, 2023 P2, N=20, Recruiting, This is the first study to report that intra-arterial TNK during the first pass of EVT seems safe and feasible in AIS-LVO patients. Not yet recruiting --> Recruiting | Trial completion date: Jun 2023 --> Dec 2024 | Trial primary completion date: Dec 2022 --> Dec 2024
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TENECTEPLASE IN CENTRAL (Paper Poster Area) - Apr 19, 2023 - Abstract #ESOC2023ESOC_1452; P3
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