TNKASE (tenecteplase) / Roche, Boehringer Ingelheim 
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  • ||||||||||  TNKASE (tenecteplase) / Roche, Boehringer Ingelheim
    Journal:  Use of Tenecteplase in Acute Ischemic Stroke in the Time of SARS-CoV-2. (Pubmed Central) -  Jul 13, 2023   
    The easier administration of TNK has improved the accessibility of fibrinolytic therapy, even in adverse circumstances, such as the COVID-19 pandemic. Its use appears to be safe and effective, even in patients who are not candidates for mechanical thrombectomy.
  • ||||||||||  TNKASE (tenecteplase) / Roche, Boehringer Ingelheim, Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Review, Journal:  Evolving Thrombolytics: from Alteplase to Tenecteplase. (Pubmed Central) -  Jun 19, 2023   
    This paper provides an overview of completed and ongoing randomized trials and nonrandomized studies analyzing tenecteplase in the treatment of acute ischemic stroke. Results reviewed support the safe use of tenecteplase in clinical practice.
  • ||||||||||  TNKASE (tenecteplase) / Roche, Boehringer Ingelheim
    Review, Journal:  Tenecteplase: A Review of Its Pharmacology and Uses. (Pubmed Central) -  Jun 12, 2023   
    Intravenous thrombolysis therapy with TNK can not only increase the proportion of 90-day mRS 0-2 in BAD patients, but also reduce the incidence of END. No abstract available
  • ||||||||||  TNKASE (tenecteplase) / Roche, Boehringer Ingelheim, Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Journal:  Intravenous thrombolysis of ischemic stroke-Current status (Pubmed Central) -  Jun 12, 2023   
    The most recent guidelines indicate that TNK is particularly advantageous over rtPA in patients treated in combination with endovascular stroke therapy (EST). The combination of IVT and EST should primarily be performed in the 4.5?h time window in patients without contraindications; in the later time window EST alone is conceivable if it can be performed without delay.
  • ||||||||||  TNKASE (tenecteplase) / Roche, Boehringer Ingelheim, Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Journal:  Femoral Access-Site Complications with Tenecteplase versus Alteplase before Mechanical Thrombectomy for Large-Vessel-Occlusion Stroke. (Pubmed Central) -  Jun 12, 2023   
    The combination of IVT and EST should primarily be performed in the 4.5?h time window in patients without contraindications; in the later time window EST alone is conceivable if it can be performed without delay. Tenecteplase compared with alteplase before mechanical thrombectomy for large-vessel-occlusion stroke is not associated with an alteration in femoral access-site complication rates.
  • ||||||||||  TNKASE (tenecteplase) / Roche, Boehringer Ingelheim, Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Enrollment open:  DIVAr (clinicaltrials.gov) -  Jun 12, 2023   
    P=N/A,  N=300, Recruiting, 
    Tenecteplase compared with alteplase before mechanical thrombectomy for large-vessel-occlusion stroke is not associated with an alteration in femoral access-site complication rates. Not yet recruiting --> Recruiting
  • ||||||||||  TNKASE (tenecteplase) / Roche, Boehringer Ingelheim
    Review, Journal:  UpdatED: The emergency medicine pharmacotherapy literature of 2022. (Pubmed Central) -  Jun 5, 2023   
    Pharmacotherapy-related publications deemed to be GRADE 1A and 1B were reviewed by the group for inclusion in the review. In all, this article summarizes and provides commentary on the potential clinical impact of 13 articles, 4 guidelines, and 3 meta-analyses covering topics including anticoagulant reversal, tenecteplase in acute ischemic stroke, guideline updates for heart failure and aortic aneurysm, magnesium in atrial fibrillation, sedation in mechanically ventilated patients and pain management strategies in the Emergency Department (ED), and tranexamic acid use in epistaxis and GI bleed.
  • ||||||||||  TNKASE (tenecteplase) / Roche, Boehringer Ingelheim, Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Journal, Head-to-Head:  Tenecteplase versus alteplase in treatment of acute ST-segment elevation myocardial infarction: a randomized non-inferiority trial. (Pubmed Central) -  Jun 2, 2023   
    P4
    In all, this article summarizes and provides commentary on the potential clinical impact of 13 articles, 4 guidelines, and 3 meta-analyses covering topics including anticoagulant reversal, tenecteplase in acute ischemic stroke, guideline updates for heart failure and aortic aneurysm, magnesium in atrial fibrillation, sedation in mechanically ventilated patients and pain management strategies in the Emergency Department (ED), and tranexamic acid use in epistaxis and GI bleed. rhTNK-tPA was non-inferior to rt-PA in the effect of improving recanalization of the infarct-related artery, a validated surrogate of clinical outcomes, among Chinese patients with acute STEMI.
  • ||||||||||  TNKASE (tenecteplase) / Roche, Boehringer Ingelheim, Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Journal, HEOR, Cost-effectiveness, Cost effectiveness:  Cost-effectiveness of tenecteplase versus alteplase for stroke thrombolysis evaluation trial in the ambulance. (Pubmed Central) -  May 30, 2023   
    Treatment of ischaemic stroke patients with tenecteplase appeared to be cost-effective and improve QALYs in the MSU setting based on Phase II data. The reduced total cost from tenecteplase was driven by savings from acute hospitalisation and reduce need for nursing home care.
  • ||||||||||  TNKASE (tenecteplase) / Roche, Boehringer Ingelheim
    Review, Journal:  Tenecteplase in Acute Stroke: What About the Children? (Pubmed Central) -  May 25, 2023   
    Changes in fibrinolytic capacity over childhood, pediatric pharmacological considerations such as age-specific differences in drug clearance and volume of distribution, and practical aspects of drug delivery such as availability in children's hospitals may impact decisions about transitioning from alteplase to tenecteplase for acute pediatric stroke treatment. Pediatric and adult neurologists should prepare institution-specific guidelines and organize prospective data collection.
  • ||||||||||  TNKASE (tenecteplase) / Roche, Boehringer Ingelheim, Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Journal:  Follow-up Imaging After Thrombolysis: FIAT, A Randomized Trial. (Pubmed Central) -  May 15, 2023   
    Trial completion date: Dec 2022 --> Dec 2023 | Trial primary completion date: Dec 2022 --> Dec 2023 It is likely safe to forgo follow up imaging after thrombolysis in the absence of clinical decompensation.
  • ||||||||||  TNKASE (tenecteplase) / Roche, Boehringer Ingelheim, Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Trial completion, Trial completion date:  AcTQuICR: Alteplase Compared to Tenecteplase in Patients With Acute Ischemic Stroke (clinicaltrials.gov) -  May 12, 2023   
    P3,  N=1600, Completed, 
    It is likely safe to forgo follow up imaging after thrombolysis in the absence of clinical decompensation. Active, not recruiting --> Completed | Trial completion date: Dec 2022 --> Apr 2023
  • ||||||||||  TNKASE (tenecteplase) / Roche, Boehringer Ingelheim
    Enrollment open, Trial completion date, Trial primary completion date:  ALLY: Adjunctive Intra-arterial Tenecteplase Following Mechanical Thrombectomy Pilot Trial (clinicaltrials.gov) -  Apr 21, 2023   
    P2,  N=20, Recruiting, 
    This is the first study to report that intra-arterial TNK during the first pass of EVT seems safe and feasible in AIS-LVO patients. Not yet recruiting --> Recruiting | Trial completion date: Jun 2023 --> Dec 2024 | Trial primary completion date: Dec 2022 --> Dec 2024
  • ||||||||||  TNKASE (tenecteplase) / Roche, Boehringer Ingelheim
    TENECTEPLASE IN CENTRAL (Paper Poster Area) -  Apr 19, 2023 - Abstract #ESOC2023ESOC_1452;    
    P3