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A targeted masked ImmunoCytokine for CD138 expressing cancers (Exhibit Hall B) - Sep 27, 2023 - Abstract #SITC2023SITC_1461;
QXL138AM is a masked immunocytokine comprised of an anti-CD138 antibody fused to a masked IFN?2a via a cleavable linker...Finally, the peptide mask slightly altered its efficacy in a human xenograft tumor model compared to an analogous control lacking the mask. Together these data suggested that tumor targeting of IFNA, combined with selective mask removal in the tumor environment could maximize potency while minimizing IFNA receptor activation in normal tissues.
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