| Bystolic (nebivolol) / Menarini, AbbVie |
2007-003549-33: Efectos de Nebivolol y Atenolol sobre la Presión Central Aórtica en Pacientes Hipertensos |
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| Completed | 4 | 152 | Europe | Capsule*, Tablet, Lovibon 5 mg, Blokium 50 mg y Blokium 100 mg, Hidrosaluretil | Laboratorios MENARINI, S. A. | Hipertensión esencial leve o moderada | | | | |
2004-004329-90: EARLY METABOLIC CHANGES WITH THIAZIDE OR BETA BLOCKER THERAPY FOR ESSENTIAL HYPERTENSION (MAIN STUDY). |
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| Completed | 4 | 66 | Europe | ATENOLOL, BENDROFLUMETHIAZIDE, Nebivolol Hydrochloride, Amiloride hydrochloride, Hydrochlorothiazide, N/A, PL 0289/0172, Film-coated tablet, Tablet, Nebilet, No trade name, Apo-Hydro | CAMBRIDGE UNIVERSITY HOSPITALS FOUNDATION NHS TRUST | ESSENTIAL HYPERTENSION | | | | |
2005-001214-40: A trial to compare the effects of nebivolol versus atenolol on various cardiovascular measurements including insulin sensitivity |
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| Ongoing | 4 | 50 | Europe | Atenolol, Atenolol, Nebliet, Atenolol, Nebliet | Imperial College London | Hypertension | | | | |
2007-006115-23: Effects of nebivolol on the cardiovascular functions, thermoregulation and blood flow during real and simulated conditions of microgravity |
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| Ongoing | 4 | 4 | Europe | Nebilet, Nebilet, Nebilet | Berlin-Chemie AG | Effects on the cardiovascular functions, thermoregulation and blood flow during microgravity | | | | |
2008-001509-40: Effects of beta blockers on central arterial pressure and vascular stiffness |
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| Ongoing | 4 | 60 | Europe | Nebilet, Talliton, Betaloc Zok, Nebilet, Talliton, Betaloc Zok | Hungarian Kidney Foundation | Patients with hypertension and/or ischemic heart disease | | | | |
2008-007516-15: Comparaison des effets du nébivolol et de l\'aténolol sur la fonction endothéliale vasomotrice des artères de conductance lors de l\'hypertension artérielle essentielle |
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| Ongoing | 4 | 100 | Europe | NEBILOX, ATENOLOL BIOGARAN 50 mg, NEBILOX, ATENOLOL BIOGARAN 50 mg | Laboratoires NEGMA | Hypertension artérielle | | | | |
2011-006090-25: The impact of heart rate on the effects of antihypertensive therapy on central and peripheral blood pressure Südame löögisageduse mõju vererõhuravimite mõjule tsentraalsele ja perifeersele vererõhule |
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| Completed | 4 | 100 | Europe | ivabradine, nebivolol, atenolol, Tablet, Procoralan, Nebilet, Atenolol-ratiopharm | Tartu Ülikooli kardioloogiakliinik, Eesti Teadusfond | Patients with dual chamber (atrium and ventricle) cardiac pacemaker placed due to sick sinus syndrome (at least 1 month after implantation) Patsiendid, kellele on siinussõlme nõrkuse sündroomi tõttu varasemalt paigaldatud koja ja vatsakese elektroodiga kardiostimulaator (vähemalt 1 kuu peale implantatsiooni), Patients who have been placed a permanent cardiac pacemaker due to heart rate problems (at least 1 month after implantation) Patsiendid, kellele on südame rütmihäire tõttu varasemalt paigaldatud püsikardiostimulaator (vähemalt 1 kuu pärast paigaldamist), Diseases [C] - Cardiovascular Diseases [C14] | | | | |
2020-002340-23: Effectiveness and safety of combination of nebivolol and zofenopril calcium in mild to moderate hypertensive patients Efficacia e sicurezza della combinazione di nebivololo e zofenopril calcio in pazienti affetti da ipertensione da lieve a moderata |
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| Not yet recruiting | 4 | 216 | Europe | Nebivolol, Zofenopril calcium, [na], Tablet, Film-coated tablet, LOBIVON - 28 COMPRESSE 5 MG, ZOPRANOL - 28 COMPRESSE RIVESTITE CON FILM 30 MG IN BLISTER (PVDC/PVC/AL) | MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG SA, Menarini International Operations Luxembourg SA | Grade 1 and 2 hypertension Ipertenzione di grado 1 e 2, Hypertension Ipertensione, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
NCT04845061: Evaluating the Outcome of Cardio Selective beta1- Blockers Use in Patients With Copd |
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| Recruiting | 4 | 30 | RoW | Nebivolol Tablets | Ain Shams University | Copd | 12/21 | 01/22 | | |
NCT04767061: Impact of Beta-blockers on Physical Function in HFpEF |
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| Completed | 4 | 9 | US | Beta blockers, atenolol, betaxolol, bisoprolol, metoprolol, nebivolol, nadolol, propranolol, acebutolol, penbutolol, pindolol, carvedilol, labetalol, sotalol, metoprolol succinate, metoprolol tartrate | Weill Medical College of Cornell University, The New York Community Trust | Heart Failure, Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction, Cardiac Failure, Heart Disease | 04/22 | 04/23 | | |
2021-005077-10: Study on the effectiveness and safety of combined treatment with nebivolol and amlodipine in mild to moderate hypertensive patients. |
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| Not yet recruiting | 4 | 302 | Europe | Nebivolol, Amlodipine, Tablet, LOBIVON 5 mg tablets, AMLODIPINE EUROGENERIC 5 mg tablets, AMLODIPINE EUROGENERIC 10 mg tablets | Menarini International Operations Luxembourg SA, Menarini International Operations Luxembourg SA | Grade 1-2 hypertension, Hypertension, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
| Completed | 4 | 301 | Europe | Nebivolol, Amlodipine | Menarini International Operations Luxembourg SA, Menarini International Operations Luxembourg SA | Hypertension | 11/22 | 11/22 | | |
2022-003060-25: Study on the effectiveness and safety of combined treatment with Nebivolol and Ramipril in hypertensive patients |
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| Ongoing | 4 | 270 | Europe | Nebivolol, Ramipril, Tablet, LOBIVON 5 mg tablets, Ramipril Zentiva 2.5 mg, Ramipril Zentiva 5 mg, Ramipril Zentiva 10 mg | Menarini International Operations Luxembourg SA, Menarini International Operations Luxembourg SA | Cardiovascular DiseaseHypertensive patients, Hypertension, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
NCT04757584: Pilot Deprescribing N-of-1 Trials for Beta-blockers in HFpEF |
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| Completed | 4 | 9 | US | Beta blockers, atenolol, betaxolol, bisoprolol, metoprolol, nebivolol, nadolol, propranolol, acebutolol, penbutolol, pindolol, carvedilol, labetalol, sotalol, metoprolol succinate, metoprolol tartrate | Weill Medical College of Cornell University, National Institute on Aging (NIA) | Heart Failure, Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction, Cardiac Failure, Heart Disease | 04/23 | 04/23 | | |
| Active, not recruiting | 4 | 2760 | Europe | Metoprolol Succinate, Bisoprolol, Carvedilol, Nebivolol | Bispebjerg Hospital, Amager Hospital, University Hospital Bispebjerg and Frederiksberg, Bornholm Hospital, Gentofte Hospital, Glostrup University Hospital, Copenhagen, Herlev Hospital, Hvidovre University Hospital, Nordsjaelland Hospital, Holbaek Hospital, Nykoebing Hospital, Naestved Hospital, Nordsjaellands Hospital, Zealand University Hospital, Slagelse Hospital, Odense University Hospital, Svendborg Hospital, Sydvestjysk Sygehus, Hospital of Southern Jutland, Sygehus Lillebaelt (Vejle and Kolding), Aarhus University Hospital, Hospitalsenheden Midt, Hospitalsenheden Vest, Regionshospitalet Horsens, Silkeborg Sygehus, Aalborg University Hospital | Acute Myocardial Infarction, Non-ST Elevation Myocardial Infarction (nSTEMI), ST Elevation Myocardial Infarction | 04/25 | 12/35 | | |
| Completed | 4 | 266 | Europe | Nebivolol 5 mg, Ramipril 2.5/5/10 mg | Menarini International Operations Luxembourg SA, Menarini International Operations Luxembourg SA | Hypertension | 02/24 | 02/24 | | |
| Not yet recruiting | 4 | 100 | Europe | Nebivolol, Placebo | Jagiellonian University, University Hospital in Krakow | Intracranial Aneurysm | 01/29 | 01/30 | | |
NCT02817360: NT-proBNP Selected Prevention of Cardiac Events in Diabetic Patients |
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| Recruiting | 4 | 2400 | Europe, RoW | RAS-antagonist and beta-blocker up-to maximal dosages, Enalapril 40mg/d, Ramipril 10mg/d, Lisinopril 40mg/d, Cilazapril 5mg/d, Perindopril 8mg/d, Captopril 150mg/d, Spirapril 24mg/d, Quinapril 40mg/d, Trandolapril 4mg/d, Zofenopril 60mg/d, Fosinopril 40mg/d, Candesartan 32mg/d, Valsartan 320mg/d, Irbesartan 300mg/d, Losartan 150mg/d, Eprosartan 800mg/d, Bisoprolol 10mg/d, Metoprololsuccinat 200mg/d, Carvedilol 50mg/d (100mg/d if weight is > 85kg), Nebivolol 10mg/d, RAS-antagonist and beta-blocker none or at stable dose | Martin Huelsmann | Heart Diseases, Diabetes Mellitus, Type 2 | 12/25 | 12/26 | | |
NCT06035978: Determination of Drug Levels for Pharmacotherapy of Heart Failure |
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| Not yet recruiting | 4 | 100 | RoW | Nebivolol, Nebilet, anatomical-therapeutic-chemical code (ATC) C07AB12, Valsartan and Sacubitril, Entresto, ATC C09DX04, Carvedilol, Dilatrend, ATC C07AG02, Bisoprolol, Concor, ATC C07AB07, Metoprolol, Betaloc ZOK, ATC C07AB02, Spironolactone, Verospiron, ATC C03DA01 | University Hospital Ostrava | Cardiovascular Diseases, Heart Failure With Reduced Ejection Fraction | 04/26 | 04/26 | | |
2020-003881-38: ESONIA - The evaluation of Efficacy and Safety Of Nebivolol in the treatment of arterial hypertension In Adolescents ESONIA - Ocena skuteczności i bezpieczeństwa nebiwololu w leczeniu nadciśnienia tętniczego u nastolatków. |
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| Not yet recruiting | 3 | 150 | Europe | Nebivolol 5 mg, Tablet, Nebilenin | Warszawski Uniwersytet Medyczny, Agencja Badań Medycznych | Arterial hypertension in adolescents Nadciśnienie tętnicze u nastolatków, Arterial hypertension in adolescents Nadciśnienie tętnicze u nastolatków, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
| Active, not recruiting | 3 | 42 | RoW | Atorvastatin + L-arginine + Folic acid + Nicorandil + Nebivolol, Nicorandil, L-arginine, Folic acid, Nebivolol, Placebo | Lebanese American University Medical Center | Covid19 | 03/22 | 07/22 | | |
CONTROL, NCT05728632: Cardioprotective Effects of Nebivolol Versus Placebo in Patients Undergoing Chemotherapy With Anthracyclines |
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| Active, not recruiting | 3 | 80 | Europe | Nebivolol, Lobivon, Placebo | Giulio Stefanini, Agenzia Italiana del Farmaco | Breast Cancer, Lymphoma, Large B-Cell, Diffuse, Cardiotoxicity, Left Ventricular Dysfunction, Chemotherapy Effect | 02/23 | 02/23 | | |
2021-002487-46: Prophylactic frequent premature ventricular complexeS sUPPression on left ventriculaR function impairmEnt in aSymptomatic patientSSUPPRESS Traitement prophylactique des extrasystoles ventriculaires fréquentes sur l’incidence de la cardiomyopathie rythmique induite chez les patients asymptomatiques |
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| Not yet recruiting | 3 | 298 | Europe | Bisoprolol, Nebivolol, Flécaïnide, Verapamil, Diltiazem, Amiodarone, Sotalol, PROPAFENONE, C01BC03 | Assistance Publique - Hôpitaux de Paris, PHRC | Premature ventricular contractions (PVCs) Contractions ventriculaires prématurées (PVC), Premature ventricular contractions (PVCs) Contractions ventriculaires prématurées (PVC), Diseases [C] - Cardiovascular Diseases [C14] | | | | |
2017-004618-24: Evaluation of the protective effect on the heart of a betablocker drug, nebivolol, in patients with breast cancer or diffuse B-cell lymphoma for which anthracyclinic chemotherapy has been planned Valutazione dell'effetto di protezione sul cuore di un farmaco betabloccante, nebivololo, in pazienti con tumore della mammella o linfoma diffuso a cellule B per i quali è stata pianificata chemioterapia con antracicline |
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| Completed | 3 | 80 | Europe | NEBIVOLOLO, NEBIVOLOLO, Capsule, hard, NEBIVOLOLO DOC GENERICI - 5 MG COMPRESSE "" 28 COMPRESSE IN BLISTER PVDC/PVC/AL | IRCCS ISTITUTO CLINICO HUMANITAS | To prevent cardiotoxicity of chemotherapeutic agents (anthracyclines) Prevenzione della cardiotossicità da chemioterapia (antracicline), To prevent cardiotoxicity of chemotherapeutic agents (anthracyclines) Prevenire la cardiotossicità da chemioterapia (antracicline), Diseases [C] - Cardiovascular Diseases [C14] | | | | |
| Not yet recruiting | 3 | 150 | NA | Nevibolol, Placebo | Spanish Society of Cardiology | ANOCA - Angina With Non-obstructive Coronary Arteries, Coronary Microvascular Dysfunction (CMD) | 03/26 | 09/26 | | |
| Recruiting | 2/3 | 150 | US | Amlodipine, Norvasc, Katerzia, Norliqva, Nebivolol, Bystolic, Placebo | Stanford University, American Heart Association | Angina Pectoris, Microvascular Angina, Vasospastic Angina, Myocardial Bridge of Coronary Artery | 12/26 | 12/26 | | |
| Recruiting | 2/3 | 120 | RoW | Nebivolol+ Standard care arm, Epalrestat + Alpha Lipoic Acid +Standard care, Standard care alone | St. John's Research Institute | Diabetic Neuropathy Peripheral | 12/25 | 03/26 | | |
2012-002877-71: cGMP Enhancing Therapeutic Strategy for HFpEF: The cGETS Study An interventional, single blind, multicentre study. cGMP verhogende strategieën bij HFpEF: De cGETS Studie. Een interventionele, enkelblinde, multicentre studie. |
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| Ongoing | 2 | 25 | Europe | Tritace, Tablet, Film-coated tablet, Capsule, Januvia, Cialis, Lipitor, Zestril, Crestor, Zocor, Coversyl, Tritace, Atacand, Nebilet | European Commission FP7 Health 2010, European Commission FP7 Health 2010 | HFpEF patients over 18 years old and concomitant arterial hypertension, overweight or obesity and pulmonary hypertension. Patiënten met HFpEF die ouder zijn dan 18 jaar en tevens lijden aan arteriële hypertensie, overgewicht of obesitas en pulmonale hypertensie., Heart Failure with preserved Ejection Fraction in combination with a high blood pressure, high pulmonary blood pressure and overweight or obesity. Hartfalen met een bewaarde ejectiefractie met daarnaast een hoge bloeddruk, hoge longbloeddruk en overgewicht of zwaarlijvigheid., Diseases [C] - Cardiovascular Diseases [C14] | | | | |
NCT07233499: Evaluation of the Cardioprotective Effect of Nebivolol on Trastuzumab-Induced Cardiotoxicity in Breast Cancer Patients |
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| Recruiting | 2 | 56 | RoW | Nebivolol 5 mg | Ain Shams University, National Cancer Institute, Egypt | HER2-positive Breast Cancer | 02/27 | 02/27 | | |
NCT04130438: Efficacy of Medical Therapy in Women and Men With Angina and Myocardial Bridging |
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| Terminated | 2 | 5 | US | Nebivolol, Diltiazem, Placebo | Stanford University | Myocardial Bridging | 03/22 | 10/24 | | |
NCT06248099: Nebivolol Tablets 5 mg Relative to Nebilet Tablets 5 mg |
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| Not yet recruiting | 1 | 46 | NA | Nebivolol-Test product, Nebivolol-Reference product | Bio-innova Co., Ltd | Healthy Subjects | 08/24 | 09/24 | | |
NCT04962841: Nutraceuticals and Drug Treatment in Frail Older Adults |
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| Recruiting | N/A | 485 | Europe | Nutraceuticals, empaglifozin, nebivolol, sertraline, rivastigmine, metformin, ramipril, amlodipine | University of Campania "Luigi Vanvitelli" | Frailty | 07/21 | 04/23 | | |
| Completed | N/A | 13 | RoW | Atenolol, Bisoprolol, Metoprolol, Nebivolol, Propranolol, Diltiazem, Verapamil, digoxin | National Taiwan University Hospital | Atrial Fibrillation, Rate Control, Cardiopulmonary Exercise Test | 06/22 | 07/22 | | |
NCT05328310: Effect of Different Antihypertensive Drugs on Central Blood Pressure |
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| Active, not recruiting | N/A | 110 | RoW | Nebivolol | Korea University Anam Hospital | Hypertension | 12/22 | 03/26 | | |
HYIMPACT, NCT06938516: Prospective Observational Study On The Impact Of Nebilet In Blood Pressure Control In Hypertensive Patients |
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| Recruiting | N/A | 4537 | RoW | | A.Menarini Asia-Pacific Holdings Pte Ltd | Hypertension | 11/28 | 03/29 | | |
