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Antibody targeting NKG2D ligands MICA/B to unleash anti-tumor immunity of NK and ILC1 cells (Hall C) - Oct 6, 2022 - Abstract #SITC2022SITC_1320;
Conclusions Our data elucidated the functional heterogeneity of type I ILCs in prostate tumor microenvironment in a murine model, which has not been previously characterized. Moreover, we showed that targeting MIC with B10G5 could increase heterogeneity of type I innate lymphoid cells in vivo , which potentially contribute to better overall anti-tumor responses.
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[VIRTUAL] Selective inhibition of tyrosine kinase 2 prevents and restores interleukin-12- induced hair follicle immune privilege collapse: a novel approach to alopecia areata therapy? () - Aug 23, 2021 - Abstract #ESDR2021ESDR_226;
By quantitative immunohistomorphometry, we showed that ex vivo treatment of microdissected HFs with IL-12 (3 ng/mL) + IL-18 (20 ng/mL) upregulated MHC-I and II as well as MICA/B expression in the hair bulb (cardinal features of IP collapse), increased the numbers of CD3+ or CD56+ cells in HF epithelium and mesenchyme, and selectively enriched IFNginducible genes...Therefore, our data demonstrate that local IL-12 directly promotes perifollicular immune cell expansion, IFNg secretion, and HF-IP collapse. These findings support a potential role of IL12 signaling in AA pathogenesis and highlight IL-12 as a potential new target for pharmacologic AA therapy
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