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- Undisclosed CAB-HER2-CAR-T / BioAtla, Exuma Biotech
mRNA encoding a CAR specific stimulating protein (CSSP) mediates tumor metabolism regulated (TMR) CAR signaling for CAR-T expansion beyond the tumor microenvironment (Section 2) - Mar 5, 2024 - Abstract #AACR2024AACR_6978;
TMR-CAR-T cells can achieve proliferative capacity outside the tumor microenvironment using synthetic mRNA encoding CAR Specific Stimulatory Proteins. This novel mRNA approach may provide additional tools to promote the proliferation and/or persistence of solid tumor targeted CAR-T cells outside the tumor environment.