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- long-acting injectable ivermectin / MedinCell
Does Ivermectin impair Anopheles attractiveness toward treated hosts under fields and laboratory conditions? (Convention Center - Room 353 (3rd Floor); In-Person-Only) - Oct 11, 2024 - Abstract #ASTMH2024ASTMH_3372;
We showed an insecticidal effect for up to 3-4 months on major wild malaria vector, meeting the WHO target product profile for endectocide-based malaria control. Dual-choice experiments with wild mosquitoes may help concluding on potential attractiveness impairment by ivermectin treatments, from which disentangling parts of the princeps molecule and the vehicle will also be needed.
- long-acting injectable ivermectin / MedinCell
Pharmacokinetic properties and mosquito-lethal effects of a novel long-lasting formulation of ivermectin in cattle (Convention Center - Hall I-1 (1st Floor); In-Person-Only) - Oct 11, 2024 - Abstract #ASTMH2024ASTMH_3144;
Body weight-scaled doses used in cattle (0.6, 1, 1.5 mg/kg) were predicted to result in sustained ivermectin exposure and sustained dirus and minimus killing for >35 days and >90 days, respectively, after a single injection. This could be a promising novel tool for transmission blocking of malaria and for the treatment of NTDs in humans.
- long-acting injectable ivermectin / MedinCell
Long-acting formulation of Ivermectin for effective malaria control: insights from an age-structured modelling study. (Convention Center - Hall I-1 (1st Floor); In-Person-Only) - Oct 11, 2024 - Abstract #ASTMH2024ASTMH_2899;
This could be a promising novel tool for transmission blocking of malaria and for the treatment of NTDs in humans. Translated to entomological parameters, this corresponds to a 65% decrease of infectious Anopheles
- long-acting injectable ivermectin / MedinCell
Comparative susceptibility of wild-derived and laboratory-reared Aedes and Anopheles larvae to Ivermectin: a preliminary study toward experimental selection of larval ivermectin resistance mechanisms (Convention Center - Hall I-1 (1st Floor); In-Person-Only) - Oct 11, 2024 - Abstract #ASTMH2024ASTMH_1236;
Overall, these data showed how lab-raised and wild-derived Anopheles and Aedes larvae and females are affected differently by ivermectin, highlighting potential implications for vector control strategies. Further investigations are planned to understand potential existing mechanisms allowing wild-derived larvae to better survive than laboratory ones despite the presence of ivermectin in their breeding environment.
- long-acting injectable ivermectin / MedinCell
The SAIVE trial: post-exposure use of ivermectin in COVID-19 prevention, efficacy and safety results (C / 07) - Apr 2, 2023 - Abstract #ECCMID2023ECCMID_5765;
- ||||| ivermectin oral / Generic mfg., long-acting injectable ivermectin / MedinCell
Clinical: No new randomized trial assessing efficacy of ivermectin in prophylaxis was published since then. We have only press release from MedinCell confirming the huge efficacy (72% reduction of infections when treatment started in the 5 days after contact). https://t.co/cNJwlpypGq (Twitter) - Mar 14, 2023
- ||| long-acting injectable ivermectin / MedinCell
Clinical: 😃 Here, from MEDINCELL "After completion, the study confirms the safety of ivermectin up to a dose of 100 µg / kg / day in continuous administration over 1 month in healthy volunteers." https://t.co/vTfByEQKbs (Twitter) - Jan 27, 2023
- |||| long-acting injectable ivermectin / MedinCell
The ivermectin peddlers operate in such obvious bad faith that it's ridiculous. Them leaping on the MedinCell press release illustrates that. https://t.co/Qfs9vFi5yD https://t.co/BVXAfw1bZ9 https://t.co/2FgOE1l6Br https://t.co/CtzdiIIKjE https://t.co/r01aI5kDy2 (Twitter) - Jan 20, 2023
- |||| ivermectin oral / Generic mfg., long-acting injectable ivermectin / MedinCell
Clinical: Early treatment is key Medincell news “Study in 399 participants met its primary efficacy endpoint with a reduction of 72% of COVID-19 infection in the group treated with daily oral administration of IVERMECTIN compared to the placebo group” 💔 https://t.co/3vRJOEGtiP (Twitter) - Jan 10, 2023
- |||| long-acting injectable ivermectin / MedinCell
Trial completion: SAIVE: A Study to Evaluate the Efficacy and Safety of Ivermectin in COVID-19 Prevention (clinicaltrials.gov) - Jan 6, 2023
P2, N=400, Completed, Sponsor: MedinCell S.A
Further investigations are planned to understand potential existing mechanisms allowing wild-derived larvae to better survive than laboratory ones despite the presence of ivermectin in their breeding environment. Recruiting --> Completed
- |||| long-acting injectable ivermectin / MedinCell
Team IVERMANIA is always skeptical of press releases by pharma companies esp if funded by Bill Gates. They are always sure ivermectin was under-dosed if <500 mcg/kg Weird that they they don’t raise these criticisms about this press release from MedinCell pharma’s new study… (Twitter) - Jan 5, 2023
- long-acting injectable ivermectin / MedinCell
Drug repurposing for optimal use of Ivermectin against malaria: long lasting formulations allowing efficacy against wild-derived Anopheles for at least 2 months (Convention Center - Hall 4A (4th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_1397;
Discrepancies between both colonies pointed possible cross-resistance mechanisms displayed by field Anopheles. Further modeling at the epidemiological level and safety studies are ongoing towards human application in the future.
- ||||| long-acting injectable ivermectin / MedinCell
New P2 trial: SAIVE: A Study to Evaluate the Efficacy and Safety of Ivermectin in COVID-19 Prevention (clinicaltrials.gov) - Mar 31, 2022
P2, N=400, Recruiting, Sponsor: MedinCell S.A
- |||| long-acting injectable ivermectin / MedinCell, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
De toute façon entre le pot de terre (Medincell & ses recherches sur l'ivermectine en traitement et prophylaxie) & le pot de fer (Merck qui voulait imposer rapidement le molnupiravir testé à grande échelle dans le monde y compris à Bordeaux), on sait qui est le plus fort, non? 1/ (Twitter) - Mar 28, 2022
- |||| long-acting injectable ivermectin / MedinCell
Clinical, Adverse events: Clinical trial conducted by @MedinCell confirms the #safety of continuous administration of #Ivermectin (April 19, 2021) "No side effects were observed with the three doses of ivermectin tested up to 100 μg / kg." https://t.co/U1LdHfaF0g (Twitter) - Oct 14, 2021
- | long-acting injectable ivermectin / MedinCell
Journal: BEPO®: Bioresorbable diblock mPEG-PDLLA and triblock PDLLA-PEG-PDLLA based in situ forming depots with flexible drug delivery kinetics modulation. (Pubmed Central) - Jun 22, 2021
This has been demonstrated studying the in vitro release of two model molecules: bupivacaine and ivermectin. Formulations releasing these drugs have been administered to animal models to show the possibility of delivering therapeutics from weeks to months by using BEPO® technology.
- || long-acting injectable ivermectin / MedinCell
Trial completion: Exploratory Ph I Trial of the Active IMP in Healthy Volunteers in Relation to COVID-19 (clinicaltrials.gov) - Jun 22, 2021
P1, N=24, Completed, Sponsor: MedinCell S.A
Formulations releasing these drugs have been administered to animal models to show the possibility of delivering therapeutics from weeks to months by using BEPO® technology. Recruiting --> Completed
- ||| long-acting injectable ivermectin / MedinCell
This is not a club of conspirationists, this is a workshop on ivermectin organised by @Medincell, which is a French biotech company funded by UNITAID and Gates fundation. Collaborative Workshop • Ivermectin Against Covid-19 https://t.co/MUjjdeJklW (Twitter) - May 13, 2021
- |||| long-acting injectable ivermectin / MedinCell
MedinCell : "pas d'obstacle à la prescription de l'ivermectine contre la Covid-19" https://t.co/cZq0QFdQW7 via @boursedirect @drkronbernard @philippefroguel @gkierzek @EChabriere @raoult_didier @BrouquiPhilippe @EdoajoEric @boulware_dr @DrSamuelBrown @stkirsch @NicoleDelepine (Twitter) - Apr 23, 2021
- |||| long-acting injectable ivermectin / MedinCell
Pour le cours de rattrapage sur l'#ivermectine et la #covid19, c'est ici : Workshop de @MedinCell en ligne: https://t.co/MUjjdeJklW (Vous savez, cette biotech française qui finira bouffée par les Américains ou qui vendra son futur brevet à l'étranger, faute d'intérêt national?) (Twitter) - Mar 17, 2021
- | long-acting injectable ivermectin / MedinCell
New P1 trial: Exploratory Ph I Trial of the Active IMP in Healthy Volunteers in Relation to COVID-19 (clinicaltrials.gov) - Nov 17, 2020
P1, N=24, Recruiting, Sponsor: MedinCell S.A