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- |||| diphenhydramine/lorazepam/zolpidem (SM-1) / Eusol Biotech
Trial completion date, Trial primary completion date: An Investigational Study to Assess Efficacy and Pattern of Use of SM-1 in Subjects With a History of Transient Insomnia (clinicaltrials.gov) - Jul 6, 2021
P3, N=220, Not yet recruiting, Sponsor: Sequential Medicine Ltd
Trial completion date: Dec 2021 --> Dec 2022 | Trial primary completion date: Dec 2021 --> Dec 2022
- Silenor (doxepin) / Currax
[VIRTUAL] Impact of sleep aid reduction strategies across a multi-hospital health system () - Dec 26, 2020 - Abstract #ASHP2020ASHP_2196;
The electronic medical record system will identify patients prescribed temazepam, alprazolam, lorazepam, zolpidem, diphenhydramine, trazodone, or doxepin (low dose) for insomnia during their admission at South Florida Baptist Hospital between April 2019 and October 2020...This data will be reviewed by clinical pharmacy personnel and health system leadership to determine whether medication-induced fall rates have decreased since initial evaluation one year ago. Results from the analysis will provide future direction to improving the utilization of sleep aid medications for our health system.
- | diphenhydramine/lorazepam/zolpidem (SM-1) / Eusol Biotech
Journal: Visible, Near-Infrared, and Dual-Range Luminescence Spanning the 4f Series Sensitized by a Gallium(III)/Lanthanide(III) Metallacrown Structure. (Pubmed Central) - Dec 3, 2020
In the case of Sm-1, the values of Q in CHOH and CDOD solutions are exceptionally high, that is, 10.1(5) and 83(1) %. Values obtained for Yb-1, that is, 0.78(4) % in CHOH and 8.4(1)% in CDOD, are among the highest ones reported today for Yb complexes formed with nondeuterated and nonhalogenated ligands.
- || Atarax (hydroxyzine hydrochloride) / Alliance, diphenhydramine/lorazepam/zolpidem (SM-1) / Eusol Biotech
Clinical, Journal: Prescription Medications for the Treatment of Insomnia and Risk of Suicide Attempt: a Comparative Safety Study. (Pubmed Central) - Nov 7, 2020
No significant differences in suicide attempt risk were identified between benzodiazepines or sedating antihistamines and zolpidem, respectively. These findings provide the first comparative effectiveness evidence against the use of trazodone for insomnia.
- |||| diphenhydramine/lorazepam/zolpidem (SM-1) / Eusol Biotech
Trial completion date, Trial primary completion date: An Investigational Study to Assess Efficacy and Pattern of Use of SM-1 in Subjects With a History of Transient Insomnia (clinicaltrials.gov) - Oct 22, 2020
P3, N=220, Not yet recruiting, Sponsor: Sequential Medicine Ltd
These findings provide the first comparative effectiveness evidence against the use of trazodone for insomnia. Trial completion date: Dec 2020 --> Dec 2021 | Trial primary completion date: Dec 2020 --> Dec 2021
- || diphenhydramine/lorazepam/zolpidem (SM-1) / Eusol Biotech
New P2 trial: SM-1 vs. an Active Comparator in A Model of Transient Insomnia (clinicaltrials.gov) - May 20, 2020
P2, N=14, Not yet recruiting, Sponsor: Sequential Medicine Ltd
- | diphenhydramine/lorazepam/zolpidem (SM-1) / Eusol Biotech
Trial completion date, Trial primary completion date: An Investigational Study to Assess Efficacy and Pattern of Use of SM-1 in Subjects With a History of Transient Insomnia (clinicaltrials.gov) - Oct 3, 2019
P3, N=220, Not yet recruiting, Sponsor: Sequential Medicine Ltd
Trial completion date: Dec 2020 --> Dec 2021 | Trial primary completion date: Dec 2020 --> Dec 2021 Trial completion date: Jun 2020 --> Dec 2020 | Trial primary completion date: Jun 2020 --> Dec 2020
- ||||| diphenhydramine/lorazepam/zolpidem (SM-1) / Eusol Biotech
Trial completion date, Trial initiation date, Trial primary completion date: An Investigational Study to Assess Efficacy and Pattern of Use of SM-1 in Subjects With a History of Transient Insomnia (clinicaltrials.gov) - Mar 20, 2019
P3, N=220, Not yet recruiting, Sponsor: Sequential Medicine Ltd
Trial completion date: Jun 2020 --> Dec 2020 | Trial primary completion date: Jun 2020 --> Dec 2020 Trial completion date: Jan 2020 --> Jun 2020 | Initiation date: Jun 2019 --> Oct 2019 | Trial primary completion date: Jan 2020 --> Jun 2020
- | diphenhydramine/lorazepam/zolpidem (SM-1) / Eusol Biotech
Trial completion date, Trial initiation date, Trial primary completion date: An Investigational Study to Assess Efficacy and Pattern of Use of SM-1 in Subjects With a History of Transient Insomnia (clinicaltrials.gov) - Nov 26, 2018
P3, N=220, Not yet recruiting, Sponsor: Sequential Medicine Ltd
Trial completion date: Jan 2020 --> Jun 2020 | Initiation date: Jun 2019 --> Oct 2019 | Trial primary completion date: Jan 2020 --> Jun 2020 Trial completion date: Jan 2019 --> Jan 2020 | Initiation date: Sep 2018 --> Jun 2019 | Trial primary completion date: Jan 2019 --> Jan 2020
- ||||||| diphenhydramine/lorazepam/zolpidem (SM-1) / Eusol Biotech
Trial completion: SM-1 vs 2 Comparators and Placebo in Participants With a History of Transient Insomnia. (clinicaltrials.gov) - Mar 30, 2018
P3, N=85, Completed, Sponsor: Sequential Medicine Ltd
Trial completion date: Jan 2019 --> Jan 2020 | Initiation date: Sep 2018 --> Jun 2019 | Trial primary completion date: Jan 2019 --> Jan 2020 Active, not recruiting --> Completed
- ||||| diphenhydramine/lorazepam/zolpidem (SM-1) / Eusol Biotech
Enrollment closed: SM-1 vs 2 Comparators and Placebo in Participants With a History of Transient Insomnia. (clinicaltrials.gov) - Mar 6, 2018
P3, N=84, Active, not recruiting, Sponsor: Sequential Medicine Ltd
Active, not recruiting --> Completed Recruiting --> Active, not recruiting
- |||| diphenhydramine/lorazepam/zolpidem (SM-1) / Eusol Biotech
Trial completion date, Trial primary completion date: SM-1 vs 2 Comparators and Placebo in Participants With a History of Transient Insomnia. (clinicaltrials.gov) - Mar 3, 2018
P3, N=84, Recruiting, Sponsor: Sequential Medicine Ltd
Recruiting --> Active, not recruiting Trial completion date: May 2018 --> May 2018 | Trial primary completion date: May 2018 --> May 2018
- |||||||||| diphenhydramine/lorazepam/zolpidem (SM-1) / Eusol Biotech
New P3 trial: An Investigational Study to Assess Efficacy and Pattern of Use of SM-1 in Subjects With a History of Transient Insomnia (clinicaltrials.gov) - Nov 9, 2017
P3, N=220, Not yet recruiting, Sponsor: Sequential Medicine Ltd
- |||||||||| diphenhydramine/lorazepam/zolpidem (SM-1) / Eusol Biotech
New P3 trial: SM-1 vs 2 Comparators and Placebo in Participants With a History of Transient Insomnia. (clinicaltrials.gov) - Nov 6, 2017
P3, N=68, Recruiting, Sponsor: Sequential Medicine Ltd
- | diphenhydramine/lorazepam/zolpidem (SM-1) / Eusol Biotech
Trial completion: Pilot Study of a Combination Drug Product for Treatment of Short-term Insomnia (clinicaltrials.gov) - Sep 14, 2016
P2, N=39, Completed, Sponsor: Sequential Medicine Ltd
Trial completion date: May 2018 --> May 2018 | Trial primary completion date: May 2018 --> May 2018 Not yet recruiting --> Completed
- diphenhydramine/lorazepam/zolpidem (SM-1) / Eusol Biotech
New P2 trial: Pilot Study of a Combination Drug Product for Treatment of Short-term Insomnia (clinicaltrials.gov) - Feb 2, 2016
P2, N=39, Not yet recruiting, Sponsor: Sequential Medicine Ltd