- |||||||||| Ventavis (iloprost) / Bayer, J&J, University of Copenhagen
Journal: Oral Pulmonary Arterial Hypertension-Targeted Therapy in Patients With Pulmonary Hypertension due to Interstitial Lung Disease. (Pubmed Central) - Mar 21, 2025
Exclusion criteria included: enrollment in PH-related clinical trials, use of inhaled treprostinil or iloprost and prior PAH-targeted therapy initiated before consenting to registry enrollment, thus precluding baseline data...In patients with measurements both before and after treatment with PAH-targeted therapy, there was a decrease in PVR (n = 13, 8 vs. 5 WU, P < 0.001), an increase in cardiac output (n = 13, 4 vs. 5 L/min, P = 0.014), and a decrease in NT-proBNP levels (n = 26, 1,421 vs. 842 ng/dL, P = 0.045). In this study, use of PAH-targeted therapy in patients with PH-ILD was associated with statistically significant and clinically meaningful improvements in NT-proBNP and pulmonary hemodynamics.
- |||||||||| Prolia (denosumab) / Amgen, Ventavis (iloprost) / Bayer, J&J, University of Copenhagen
Review, Journal: Pharmacological therapy for subchondral pathologies of the knee joint (Pubmed Central) - Mar 19, 2025
In osteonecrosis and bone marrow edema of the knee joint, complementary drug therapy may be beneficial. However, the available data is not yet sufficiently robust for general treatment recommendations.
- |||||||||| Ventavis (iloprost) / Bayer, J&J, University of Copenhagen
Review, Journal: Treatment of freezing cold injuries (Pubmed Central) - Feb 26, 2025
This mechanism explains why more severe frostbite injuries can be successfully treated with thrombolytic therapy and drugs such as iloprost and NSAID...Imaging methods such as angiography, CT or bone scintigraphy give valuable added information to complement clinical examination after thawing. Proper wound care is of essence and aggressive surgery, such as amputation, should be postponed until definite clinical demarcation of necrosis is established.
- |||||||||| Ventavis (iloprost) / Bayer, J&J, University of Copenhagen, Tracleer (bosentan) / J&J, Roche
Journal: Systemic Sclerosis Complicated by Rapidly Progressive Osteomyelitis: A Case Report. (Pubmed Central) - Feb 12, 2025
This case highlights the critical need for vigilant radiographic monitoring and timely antibiotic intervention in patients with SSc who develop vascular complications. Early diagnosis and treatment are crucial for optimizing patient outcomes and preventing severe bone damage.
- |||||||||| Ventavis (iloprost) / Bayer, J&J, University of Copenhagen, Keytruda (pembrolizumab) / Merck (MSD)
Review, Journal, Adverse events, Checkpoint inhibition: Digital ischemia: a rare immune-related adverse event of immune checkpoint inhibitors-case report and review of the literature. (Pubmed Central) - Dec 4, 2024
We collaborated with our rheumatology department to initiate treatment, including corticosteroids, iloprost, and mycophenolate mofetil...IrAEs are becoming more common due to the widespread use of ICIs. For this reason, it is crucial to diagnose and treat rare IrAEs, such as digital ischemia, as early as possible to improve outcomes.
- |||||||||| Ventavis (iloprost) / Bayer, J&J, University of Copenhagen
Journal: Stable measurement of chemistry, immunochemistry, and hematology analytes in a heparin-based anticoagulant with iloprost additive: A promising candidate for the polyvalent blood collection tube. (Pubmed Central) - Nov 19, 2024
The analysis highlights the RTMD risks of ERAs and PRDs in treating PH and underscores the need for careful monitoring of ADEs to ensure their safe and effective use in clinical practice. Our novel dry-sprayed anticoagulant formulation, HEP-ILOP, is a promising candidate for a polyvalent blood collection tube, enabling the analysis of hematology, chemistry, and immunochemistry analytes in the same tube.
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma
A case of worsening scleroderma-associated interstitial lung disease in pregnancy () - Nov 8, 2024 - Abstract #BSRCBC2024BSR_CBC_67;
She was managed with mycophenolate mofetil, hydroxychloroquine, prednisolone, sildenafil, omeprazole, and vitamin D. During active disease phases with digital ulcerations, she received iloprost and bosentan.She had her first child aged 30 without complications while off mycophenolate mofetil...Her echocardiogram was normal with no evidence of pulmonary hypertension.Despite the increase in her prednisolone to 10 mg and the initiation of azathioprine, she continued to experience dyspnoea at rest...This suggests that tocilizumab may help stabilise inflammatory lung disease during pregnancy, indicating its potential use in managing severe maternal disease if other pregnancy-compatible drugs are not suitable. The decision to use tocilizumab in pregnancy involves careful consideration of the risks and benefits, with input from a multidisciplinary team to ensure comprehensive patient care.
- |||||||||| Combination therapy as treatment for resistant Evans syndrome in a systemic lupus erythematosus patient () - Nov 8, 2024 - Abstract #BSRCBC2024BSR_CBC_32;
Unfortunately, she later suffered from bilateral pulmonary emboli requiring initiation of warfarin...Treatment has involved glucocorticoids, hydroxychloroquine, MMF, cyclophosphamide, B cell depletion [rituximab, then later ofatumumab], belimumab, IVIG and eltrombopag...Treatments include that of csDMARDS (such as MMF or azathioprine), IVIG, B-cell depletion, belimumab and cyclophosphamide...for ITP in a phase IIb trial on the basis that B-cell activating factor could be implicated in the failure of B-cell depletion treatment for encouraging the development of long-lasting splenic plasma cells. This trial demonstrated a reduction in circulating T-follicular helper cells with combination therapy with improved treatment response and acceptable safety.
- |||||||||| Ventavis (iloprost) / Bayer, J&J, University of Copenhagen, Tracleer (bosentan) / J&J, Roche, Rituxan (rituximab) / Roche
Echoes of Hope: Navigating Pregnancy post heart transplant in the context of systemic sclerosis () - Nov 8, 2024 - Abstract #BSRCBC2024BSR_CBC_11;
Previously, she was on Sildenafil, but this was discontinued due to developing non-ischemic optic neuritis and retinal vein thrombosis.Other complications secondary to SSc include oesophageal dysmotility, dyspepsia, and mild interstitial lung disease. Her medication history includes Bosentan, Losartan, Aspirin, Clopidogrel, Sertraline, Esomeprazole and multivitamins...MMF was switched to Azathioprine as part of her pregnancy planning...Patients should be monitored for arrhythmia and graft dysfunction due to postpartum volume shifts, although these changes are usually well tolerated.
- |||||||||| CS585 / Cereno Scientific, Ventavis (iloprost) / Bayer, J&J, University of Copenhagen, Uptravi (selexipag) / J&J
Selectivity and Long Action of In Vivo Efficacy of CS585, a Novel Prostacyclin Receptor Agonist, Compared to FDA-Approved Prostacyclin Agonists Iloprost and Selexipag in the Prevention of Thrombosis (Halls G-H (San Diego Convention Center)) - Nov 6, 2024 - Abstract #ASH2024ASH_6468;
In both in vivo and ex vivo models, we observe non-selective effects of iloprost and selexipag, in addition to confirming the limitations of length of effect in the blood previously reported in the literature. In overcoming the concerns of sustained efficacy in the blood while maintaining high selectivity for the IP receptor, CS585 represents a novel approach for the anti-platelet treatment of thrombotic diseases, with the potential to augment the therapeutic options for patients suffering from diseases like thrombosis, VTE, MI, stroke, and PAH.
- |||||||||| Review, Journal: New and Emerging Therapeutic Drugs for the Treatment of Pulmonary Arterial Hypertension: A Systematic Review. (Pubmed Central) - Sep 30, 2024
Conversely, udenafil, racecadotril, sotatercept, anastrozole, riociguat, tacrolimus, and ralinepag were found to be safe, well-tolerated, and effective in improving hemodynamic measures and 6-MWDs. This study aims to summarize the developing treatment options currently under clinical trials, highlighting the need for further trials before their application in clinical practice.
- |||||||||| Ventavis (iloprost) / Bayer, J&J, University of Copenhagen
Journal: A Case of Interstitial Lung Disease-Related Pulmonary Hypertension Successfully Treated with Inhaled Iloprost. (Pubmed Central) - Sep 29, 2024
The patient, a 68-year-old female, was diagnosed with IPF in 2018 and was maintained on pirfenidone...Due to the ineffectiveness of sildenafil and a CT scan indicating stable IPF, a repeat RHC was performed, which showed a worsening of PH (mPAP 62 mmHg)...This case suggests that inhaled iloprost may be beneficial for managing PH-ILD. Further research is needed to confirm the efficacy of iloprost in PH-ILD treatment.
- |||||||||| Retrospective data, Review, Journal: Pulmonary artery denervation versus conventional therapies for PAH: a systematic review and updated network meta-analysis. (Pubmed Central) - Sep 25, 2024
Compared with 16 types of conventional therapies and Placebo, PADN has advantage over nine single therapies and Placebo in improving 6MWD and appears to be better than two types of dual-drug combined therapies while with no statistical significance. PADN shows a favourable antihypertensive effect on mPAP and has a lower risk to trigger clinical worsening or hospitalization, while its risk on mortality and severe adverse events is still inconclusive.
- |||||||||| Ventavis (iloprost) / Bayer, J&J, University of Copenhagen, VentaProst (epoprostenol inhalation) / Aerogen Pharma
Review, Journal: The Influence of Pulmonary Arterial Hypertension In Pregnancy: A Review. (Pubmed Central) - Sep 10, 2024
Managing PAH in pregnancy requires careful planning, continuous monitoring, and tailored therapeutic strategies to navigate the complex interplay of physiological changes and mitigate risks. Future research should focus on elucidating the pathophysiology of PAH during pregnancy and developing safer, more effective treatments to improve maternal and fetal outcomes.
- |||||||||| Ventavis (iloprost) / Bayer, J&J, University of Copenhagen
Journal: Integrated-omics analysis with explainable deep networks on pathobiology of infant bronchiolitis. (Pubmed Central) - Aug 23, 2024
The network analyses identified eight modules and 50 existing drug candidates for repurposing, including prostaglandin I2 analogs (e.g., iloprost), which promote anti-inflammatory effects through TLR signaling. Our approach facilitates not only the identification of molecular networks underlying infant bronchiolitis but the development of pioneering treatment strategies.
- |||||||||| Ventavis (iloprost) / Bayer, J&J, University of Copenhagen
Spontaneous cholesterol crystal embolism (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_3275;
Our approach facilitates not only the identification of molecular networks underlying infant bronchiolitis but the development of pioneering treatment strategies. We proceeded to Iloprost perfusions, necrosis mummification and we intoduced Aspirin and Rosuvastatin which helped halt the disease
- |||||||||| Ventavis (iloprost) / Bayer, J&J, University of Copenhagen
COUGH ASSOCIATED SYNCOPE: A CASE OF COR PULMONALE (Convention Center Exhibit Hall: Poster Area 4) - Jul 31, 2024 - Abstract #CHEST2024CHEST_3046;
Our case highlights the importance of identifying unusual presentations of CLD-associated PH, emphasizing the necessity for thorough evaluation and personalized management strategies. Further research is warranted to improve our understanding of similar cases.
- |||||||||| Ventavis (iloprost) / Bayer, J&J, University of Copenhagen, Aurlumyn (iloprost intravenous) / CiVi Biopharma
Journal: Iloprost (Aurlumyn) for frostbite. (Pubmed Central) - Jul 15, 2024
It is inevitable to avoid the loss of patients with major abnormalities, severe comorbidities, and unpreventable organ dysfunctions. No abstract available
- |||||||||| Ventavis (iloprost) / Bayer, J&J, University of Copenhagen
Preclinical, Journal: BK Channels in Tail Artery Vascular Smooth Muscle Cells of Normotensive (WKY) and Hypertensive (SHR) Rats Possess Similar Calcium Sensitivity But Different Responses to the Vasodilator Iloprost. (Pubmed Central) - Jul 13, 2024
It was observed that: (1) single BK channels have similar current-voltage relationships, voltage-dependence and calcium sensitivity; (2) BK currents in cells with a strong buffering of the BK channel activator calcium have similar current-voltage relationships; (3) the iloprost-induced concentration-dependent increase of the BK current is larger in WKY compared to SHR; (4) the effects of activators of the PKA pathway, the catalytic subunit of PKA and the potent and selective cAMP-analogue Sp-5,6-DCl-cBIMPS on BK currents are similar. Thus, our data suggest that the lower iloprost-induced stimulation of the BK current in freshly isolated rat tail artery smooth muscle cells from SHR compared with WKY is due to the lower efficacy of upstream elements of the G-Protein/AC/BK channel pathway.
- |||||||||| Ventavis (iloprost) / Bayer, J&J, University of Copenhagen, Uptravi (selexipag) / J&J
Assessment of Group 1 PAH patients on triple therapy clinical four risk strata outcome in a UAE centre (PS-29; Poster board no. 18) - May 31, 2024 - Abstract #ERS2024ERS_4269;
All patients escalated to triple combination therapy by Prostacyclin analogues (Treprostinil IV/SQ, selexipag/iloprost inhaled) as third agent for atleast 3 months as best available therapy.1-,3-,5-year cumulative survival probability for Idiopathic was 95%(95%CI,75-92%),CTD 83%(95%CI,54-80%),CHD100%(95 CI,54-80%). Many patients remain in intermediate-high and high-risk category despite optimal triple therapy.Novel therapy pathway is needed for optimal clinical target.
- |||||||||| Ventavis (iloprost) / Bayer, J&J, University of Copenhagen
Journal: Establishment of the deuterium oxide dilution method as a new possibility for determining the transendothelial water permeability. (Pubmed Central) - May 30, 2024
The barrier-promoting substances cyclic adenosine monophosphate and iloprost reduced TEER and electrical capacity and increased permeability...This newly established in vitro method for direct measurement of transendothelial water permeability was verified as a highly precise technique in various assays. The use of patient-specific endothelial cells enables individualized precision medicine in the context of basic edema research, for example regarding the development of barrier-protective pharmaceuticals.
- |||||||||| Ventavis (iloprost) / Bayer, J&J, University of Copenhagen
Clinical guideline, Journal: American Burn Association Clinical Practice Guidelines on the Treatment of Severe Frostbite. (Pubmed Central) - May 6, 2024
No recommendation could be formed on the use of iloprost resulting in fewer amputations and/or more distal levels of amputation. No recommendation could be formed on the use of diagnostic imaging modalities for surgical planning on fewer amputations, a more distal level of amputation, or earlier timing of amputation.
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