Ventavis (iloprost) / Bayer, J&J, University of Copenhagen 
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27 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Ventavis (iloprost) / Bayer, J&J, University of Copenhagen
ChiCTR-TRC-08000242: The mechanisms and effects on organ protection of combination of nitric oxide gas and iloprost during cardiopulmonary bypass

Completed
4
60
 
routine CPB plus NO plus iloprost ;routine CPB plus iloprost ;routine CPB plus NO ;routine CPB not taking any drugs
Department of Thoracic and Cardiovascular Surgery, West China Hospital; The National Natural Science Fundation, The National Natural Science Funds
isolated atrial septal defects and/or ventricular septal defects with/without pulmonary hypertension
 
 
2014-000091-25: A single-centre, placebo-controlled, double-blinded, randomized, cross-over study of Iloprost (Ventavis®) in patients with Eisenmenger syndrome

Ongoing
4
15
Europe
Ventavis, Inhalation solution, Iloprost
Royal Brompton and Harefield NHS Foundation Trust, Bayer PLC
Pulmonary Arterial Hypertension Eisenmenger syndrome, PAH Eisenmenger, Diseases [C] - Respiratory Tract Diseases [C08]
 
 
2006-000905-41`ACTRN12621000227897: Offene, monozentrische, randomisierte, placebo-kontrollierte, einfach blinde und Observer-blinde klinische Studie bei PatientInnen mit Raynaud Syndrom mit / ohne progressiver systemischer Sklerodermie zur systemischen Therapie mit Iloprost versus Placebo

Ongoing
4
20
Europe
Ilomedin, 1-22460, Ilomedin, Ilomedin
ao. Univ. Prof. Dr. Elisabeth Aberer, Australia and New Zealand Urogenital and Prostate trials group (ANZUP), Below the Belt fund
Prostate cancer
 
 
2016-002984-32: ND ND

Ongoing
4
238
Europe
ENDOPROST, ND, Concentrate for solution for infusion, Solution for infusion, ENDOPROST - 0.05 MG/0.5 ML CONCENTRATO PER SOLUZIONE PER INFUSIONE 1 FIALA
UNIVERSITÀ CATTOLICA DEL SACRO CUORE- POLICLINICO A. GEMELLI, Azienda Farmaceutica: ITALFARMACO
SISTEMIC SCLEROSIS SCLEROSI SISTEMICA, NA NA, Diseases [C] - Musculoskeletal Diseases [C05]
 
 
2010-022660-12: A prospective, multi-center, randomized, double blinded, placebo-controlled study for the evaluation of Iloprost in the early postoperative period after liver transplantation Prospektive, multizentrische, randomisierte, doppelblinde, placebo-kontrollierte Studie zur Evaluation von Iloprost in der frühen postoperativen Phase nach Lebertransplantation (PRAISE-Studie)

Ongoing
3
430
Europe
Concentrate for solution for infusion, Ilomedin
Friedrich Schiller University, BAYER Vital GmbH, Astellas Pharma GmbH, SIRS-Lab GmbH
the early postoperative period after liver transplantation, the early postoperative period after liver transplantation frühe postoperative Periode nach Lebertransplantation, Body processes [G] - Physiological processes [G07]
 
 
2006-003957-25: Rare Diseases with microvascular involvement. High Dose Intravenous N-acetylcysteine versus Iloprost for early, rapidlyprogressive diffuse Systemic Sclerosis (Scleroderma)

Ongoing
3
45
Europe
HIDONAC*EV 1FL 5G 25ML, ENDOPROST 50*INFUS 1F 0,050MG/, HIDONAC*EV 1FL 5G 25ML, ENDOPROST 50*INFUS 1F 0,050MG/
AZIENDA OSPEDALIERO UNIVERSITARIA OSPEDALI RIUNITI UMBERTO I - G.M.LANCISI - G.SALESI
Systemic Scleroderma
 
 
2018-001709-10: Ilomedin for treatment of septic shock with persistent microperfusion defects Ilomédine dans le traitement du choc septique avec persistence de troubles de la microperfusion

Not yet recruiting
3
236
Europe
Ilomédine, B01AC11, Concentrate for solution for infusion, Ilomédine
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)
Ilomedin: Cardiology - Angeiology - Vasodilators and anti-ischemic drugs: Severe ischemia: route of injection (Prostaglandin analogs: iloprost) Ilomedine : Cardiologie - Angéiologie - Vasodilatateurs et anti-ischémiques : Ischémie sévère : voie injectable (Analogues de la prostaglandine : iloprost), Diseases [C] - Cardiovascular Diseases [C14]
 
 
2020-000624-20: Core decompression versus core decompression followed by infusion of Iloprost in thetreatment of idiopathic non-traumatic avascular necrosis of the femoral head

Ongoing
3
38
Europe
Concentrate for solution for infusion, Iloprost ratiopharm
Leipzig University, Deutsche Forschungsgemeinschaft (DFG)
idiopathic non-traumatic avascular necrosis of the femoral head (IN-ANFH), idiopathic non-traumatic avascular necrosis of the femoral head (IN-ANFH), Diseases [C] - Musculoskeletal Diseases [C05]
 
 
I-MICRO, NCT03788837: ILOPROST in Septic Shock With Persistent Microperfusion Defects

Completed
3
240
Europe
ILOPROST, 50 microgrammes /0,5 ml vials, NaCl, (Saline 0.9%)
Assistance Publique - Hôpitaux de Paris
Septic Shock Hyperdynamic
01/24
01/24
2019-001131-31: Efficacy and safety of 72-hours infusion of prostacyclin (1 ng/kg/min) in patients with septic shock suffering from organ failure caused by endothelial breakdown

Not yet recruiting
2/3
380
Europe
Ilomedin, Concentrate for solution for infusion, Ilomedin
Section for transfusion Medicines, Capital Region Blood Bank, Copenhagen University Hospital, Innovation Fund Denmark
Shock-induced endotheliopathy in patients with septic shock, Septic patients with shock and damage to the smallest blood vessels, Diseases [C] - Bacterial Infections and Mycoses [C01]
 
 
Bayer, J&J_COVID: Danish Team of Researchers to Test Treatment of Critically Ill Patients Suffering from COVID-19

Not yet recruiting
2
0
Danish
Ventavis (iloprost ) - Bayer, J&J, University of Copenhagen
Bayer, J&J, Copenhagen University, BioPorto
COVID-19
 
 
2011-004567-80: We think that the blood flow increases during intraarterial injection of a special drug, called iloprost, during surgical treatment in the distal limbs, because of the vasodilatation in diabetics and non diabetics in the same way. Wir glauben, dass sich ein verbesserter Blutfluss, durch die intraarterielle Injektion eines gefässerweiternden Medikamentes, im gleichen Ausmass bei zuckerkranken Patienten und nicht zuckerkranken Patienten zeigt, welche an den peripheren Gefässen operiert werden.

Ongoing
2
60
Europe
Ilomedin, 1-22460, Concentrate and solvent for injection, Ilomedin
Georg Hagmüller Institute for Vascular Research, Georg Hagmüller Institute for Vascular Research
We think that the blood flow increases during intraarterial injection of iloprost during surgical treatment in distal vessels in patients with arteriosclerosis and diabetes and non diabetes in the same way because of vasodilatation. So we investigate people with arteriosclerosis and diabetes and non diabetes which undergo surgical treatment. Wir untersuchen die Flowveränderung an den peripheren Gefässen bei Patienten mit Arteriosklerose, welche sich einer chirurgischen Behandlung unterziehen, und dabei intraarteriell Iloprostinjektionen erhalten. Dabei werden Diabetiker und Nicht-Diabetiker untersucht., We investigate patients with stenosis in distal vessels and diabetes or non diabetes which underwent surgical treatment in distal vessels. Wir untersuchen Patienten, welche unter Engstellen in den Gefässen leiden und welche Diabetiker und Nicht-Diabetiker sind und welche sich einer chirurgischen Sanierung an den Beingefässen unterziehen., Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Surgical Procedures, Operative [E04]
 
 
2013-004596-12: Infusion at home ,using a pump device, of a drug that dilates peripheral blood vessels to treat patients affected by a disease named Systemic sclerosis, with manifestations caused by a reduced blood flow in hands and feet. Infusione a casa di un farmaco per dilatare i vasi periferici in pazienti affetti da una malattia chiamata sclerosi sistemica che si manifesta con fenomeni causati da una riduzione del flusso di sangue a mani e piedi.

Ongoing
2
20
Europe
Endoprost, Concentrate for solution for infusion, Endoprost
Azienda ospedaliera universitaria Ospedali Riuniti, OO. RR. Torrette di Ancona
Raynaud's phenomenon and acral ulcers in systemic sclerosis Fenomeno di raynaud e ulcere acrali secondarie a sclerosi sistemica, Manifestations caused by a low blood flow in hands and feet in patients affected by fibrosis of various tissues. Manifestazioni dovute a basso flusso sanguigno in pazienti affetti da fibrosi dei tessuti, Diseases [C] - Skin and Connective Tissue Diseases [C17]
 
 
2009-015828-28: Iloprost in der Behandlung der Präeklampsie – klinische Pilotstudieengl.: oral Iloprost in pre-eclampsia treatment - a pilot study

Ongoing
2
10
Europe
Ilomedin Infusionslösung 10 mcg/0,5ml, Ilomedin 10 microgramm / 0,5ml Infusionslösungskonzentrat, Ilomedin 10 microgramm / 0,5ml Infusionslösungskonzentrat
Medizinische Universität Wien
early- onset Pre-eclampsia
 
 
2019-000936-24: Efficacy and safety of 72-hour infusion of Prostacyclin (1 ng/kg/min) in trauma patients with haemorrhagic shock suffering from organ failure caused by endothelial breakdown

Not yet recruiting
2
220
Europe
Ilomedin (2,5 ml vial), Concentrate for solution for infusion, Ilomedin
Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Novo Nordisk Foundation
Shock-induced endotheliopathy in trauma patients, Severely bleeding trauma patients with shock and damage to the smallest blood vessels, Diseases [C] - Injuries, poisonings, and occupational diseases [C21]
 
 
2016-003168-37: New therapy for patients suffering Acute Respiratory Distress Syndrome

Not yet recruiting
2
150
Europe
Ventavis, Nebulisation solution, Ventavis
University Tuebingen, Department of Aneshesia and intensive care University Hospital Tuebingen
Acute respiratory distress syndrome requiring mechanical ventilation, Patients with pulmonary insufficiency requiring mechanical ventilation, Diseases [C] - Symptoms and general pathology [C23]
 
 
2022-004079-17: Efficacy and safety of 72-hour infusion of Prostacyclin (1 ng/kg/min) in mechanically ventilated patients with infectious respiratory failure

Ongoing
2
450
Europe
Ilomedin, Concentrate and solvent for concentrate for solution for infusion, Ilomedin
Rigshospitalet, None
Infectious pulmonary endotheliopathy, Infectious respiratory failure, Diseases [C] - Respiratory Tract Diseases [C08]
 
 
2022-003725-22: Acute effect of iloprost inhalation on pulmonary hypertension developed during exercise in Post-COVID-19 patients Akute Wirkung der Inhalation mit Iloprost bei Lungenhochdruck unter Belastung nach einer COVID-19-Infektion

Not yet recruiting
2
120
Europe
Nebulisation solution, Ventavis
Justus-Liebig-University Gießen, BMBF
Exercise-induced pulmonary hypertension after a COVID-19 infection Belastungsinduzierte pulmonale Hypertonie nach einer COVID-19-Infektion, Pulmonary hypertension developed during exercise by patient with a Long-COVID-19 infection Lungenhochdruck unter Belastung nach einer Long-COVID-19-Infektion, Diseases [C] - Respiratory Tract Diseases [C08]
 
 
COMBAT-ARF, NCT06319274: Infusion of Prostacyclin Vs Placebo for 72-hours in Mechanically Ventilated Patients with Acute Respiratory Failure

Recruiting
2
450
Europe
Iloprost, Ilomedin, Isotonic saline
Pär Johansson
Acute Respiratory Failure, Endothelial Dysfunction, Pulmonary Infection
12/26
12/26
NCT05411107: Oral Iloprost for the Prevention of Lung Cancer In Former Smokers

Withdrawn
2
80
NA
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Bronchial Brush Biopsy, bronchial brushing, Bronchoscopy, Iloprost, Ciloprost, Iloprost Clathrate, Ventavis, ZK 36374, Placebo Administration, Questionnaire Administration
National Cancer Institute (NCI)
Bronchial Epithelial Dysplasia, Chronic Obstructive Pulmonary Disease, Lung Carcinoma, Stage I Lung Cancer AJCC v8, Stage II Lung Cancer AJCC v8, Tobacco-Related Carcinoma
12/26
06/27
2017-003813-24: A clinical trial investigating Iloprost as medication to improve bone healing in patients with upper arm bone fracture. Eine klinische Studie, welche Iloprost als Medikament für die Verbesserung der Knochenheilung bei Patienten mit Brüchen des Oberarmknochens verbessern möchte.

Not yet recruiting
1/2
30
Europe
Concentrate for solution for infusion, Ilomedin
Charité-Universitätsmedizin Berlin, BMBF, BCRT
Proximal humeral fracture Proximale Humerusfraktur, Fractures of the upper part of the upper arm Knochenbruch des Oberarmknochens, Body processes [G] - Bones and nerves physological processes [G11]
 
 
Ilobone, NCT04543682: A Clinical Trial Investigating Iloprost as Medication to Improve Bone Healing in Patients With Proximal Humeral Fracture

Recruiting
1/2
30
Europe
0.125 ng/kg/min Iloprost, Ilomedin, SUB08136MIG, CAS (Chemical Abstracts Service) number 78919-13-8, 0.25 ng/kg/min Iloprost, CAS number 78919-13-8, open reduction and internal fixation with an angular stable plate (PHILOS), humerus surgery, Open Reduction and Internal fixation of proximal humeral fracture using Philos plate, PHILOS Plating
Charite University, Berlin, Germany
Proximal Humeral Fracture
05/24
12/24
NCT02237183: Iloprost in Preventing Lung Cancer in Former Smokers

Completed
1
34
US
Iloprost, Ciloprost, Iloprost Clathrate, Ventavis, ZK 36374, Placebo Administration, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration
National Cancer Institute (NCI)
Lung Carcinoma
03/20
08/23
NCT04583046: Effects of Iloprost on Pulmonary Oxygenation in Obese Patients During One-lung Ventilation

Not yet recruiting
N/A
78
NA
normal saline inhalation, iloprost inhalation
Yonsei University
Lung Cancer (Including Metastatic Cancer), Pulmonary Infection
08/22
08/22
NCT04598191: Effect of Intraoperative Iloprost Inhalant on Hemodynamic Stability in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery

Recruiting
N/A
100
RoW
Iloprost, Control (Normal saline)
Yonsei University
Coronary Artery Occlusive Disease
12/22
12/22
NCT02825160: Non-interventional, Postauthorization Safety Study of Ventavis for Pulmonary Arterial Hypertension (PAH)

Completed
N/A
282
Japan
Ventavis (Iloprost, BAYQ6256)
Bayer
Hypertension, Pulmonary
03/23
09/23
NCT04927039: Effects of Iloprost on Oxygenation During One-lung Ventilation in Supine-positioned Patients

Not yet recruiting
N/A
60
RoW
5ml of inhaled normal saline, 20μg (2ml) of inhaled iloprost (Ventavis®) and 3ml of inhaled normal saline
Yonsei University
Mediastinal Mass
06/23
06/23
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Ventavis (iloprost) / Bayer, J&J, University of Copenhagen
ChiCTR-TRC-08000242: The mechanisms and effects on organ protection of combination of nitric oxide gas and iloprost during cardiopulmonary bypass

Completed
4
60
 
routine CPB plus NO plus iloprost ;routine CPB plus iloprost ;routine CPB plus NO ;routine CPB not taking any drugs
Department of Thoracic and Cardiovascular Surgery, West China Hospital; The National Natural Science Fundation, The National Natural Science Funds
isolated atrial septal defects and/or ventricular septal defects with/without pulmonary hypertension
 
 
2014-000091-25: A single-centre, placebo-controlled, double-blinded, randomized, cross-over study of Iloprost (Ventavis®) in patients with Eisenmenger syndrome

Ongoing
4
15
Europe
Ventavis, Inhalation solution, Iloprost
Royal Brompton and Harefield NHS Foundation Trust, Bayer PLC
Pulmonary Arterial Hypertension Eisenmenger syndrome, PAH Eisenmenger, Diseases [C] - Respiratory Tract Diseases [C08]
 
 
2006-000905-41`ACTRN12621000227897: Offene, monozentrische, randomisierte, placebo-kontrollierte, einfach blinde und Observer-blinde klinische Studie bei PatientInnen mit Raynaud Syndrom mit / ohne progressiver systemischer Sklerodermie zur systemischen Therapie mit Iloprost versus Placebo

Ongoing
4
20
Europe
Ilomedin, 1-22460, Ilomedin, Ilomedin
ao. Univ. Prof. Dr. Elisabeth Aberer, Australia and New Zealand Urogenital and Prostate trials group (ANZUP), Below the Belt fund
Prostate cancer
 
 
2016-002984-32: ND ND

Ongoing
4
238
Europe
ENDOPROST, ND, Concentrate for solution for infusion, Solution for infusion, ENDOPROST - 0.05 MG/0.5 ML CONCENTRATO PER SOLUZIONE PER INFUSIONE 1 FIALA
UNIVERSITÀ CATTOLICA DEL SACRO CUORE- POLICLINICO A. GEMELLI, Azienda Farmaceutica: ITALFARMACO
SISTEMIC SCLEROSIS SCLEROSI SISTEMICA, NA NA, Diseases [C] - Musculoskeletal Diseases [C05]
 
 
2010-022660-12: A prospective, multi-center, randomized, double blinded, placebo-controlled study for the evaluation of Iloprost in the early postoperative period after liver transplantation Prospektive, multizentrische, randomisierte, doppelblinde, placebo-kontrollierte Studie zur Evaluation von Iloprost in der frühen postoperativen Phase nach Lebertransplantation (PRAISE-Studie)

Ongoing
3
430
Europe
Concentrate for solution for infusion, Ilomedin
Friedrich Schiller University, BAYER Vital GmbH, Astellas Pharma GmbH, SIRS-Lab GmbH
the early postoperative period after liver transplantation, the early postoperative period after liver transplantation frühe postoperative Periode nach Lebertransplantation, Body processes [G] - Physiological processes [G07]
 
 
2006-003957-25: Rare Diseases with microvascular involvement. High Dose Intravenous N-acetylcysteine versus Iloprost for early, rapidlyprogressive diffuse Systemic Sclerosis (Scleroderma)

Ongoing
3
45
Europe
HIDONAC*EV 1FL 5G 25ML, ENDOPROST 50*INFUS 1F 0,050MG/, HIDONAC*EV 1FL 5G 25ML, ENDOPROST 50*INFUS 1F 0,050MG/
AZIENDA OSPEDALIERO UNIVERSITARIA OSPEDALI RIUNITI UMBERTO I - G.M.LANCISI - G.SALESI
Systemic Scleroderma
 
 
2018-001709-10: Ilomedin for treatment of septic shock with persistent microperfusion defects Ilomédine dans le traitement du choc septique avec persistence de troubles de la microperfusion

Not yet recruiting
3
236
Europe
Ilomédine, B01AC11, Concentrate for solution for infusion, Ilomédine
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)
Ilomedin: Cardiology - Angeiology - Vasodilators and anti-ischemic drugs: Severe ischemia: route of injection (Prostaglandin analogs: iloprost) Ilomedine : Cardiologie - Angéiologie - Vasodilatateurs et anti-ischémiques : Ischémie sévère : voie injectable (Analogues de la prostaglandine : iloprost), Diseases [C] - Cardiovascular Diseases [C14]
 
 
2020-000624-20: Core decompression versus core decompression followed by infusion of Iloprost in thetreatment of idiopathic non-traumatic avascular necrosis of the femoral head

Ongoing
3
38
Europe
Concentrate for solution for infusion, Iloprost ratiopharm
Leipzig University, Deutsche Forschungsgemeinschaft (DFG)
idiopathic non-traumatic avascular necrosis of the femoral head (IN-ANFH), idiopathic non-traumatic avascular necrosis of the femoral head (IN-ANFH), Diseases [C] - Musculoskeletal Diseases [C05]
 
 
I-MICRO, NCT03788837: ILOPROST in Septic Shock With Persistent Microperfusion Defects

Completed
3
240
Europe
ILOPROST, 50 microgrammes /0,5 ml vials, NaCl, (Saline 0.9%)
Assistance Publique - Hôpitaux de Paris
Septic Shock Hyperdynamic
01/24
01/24
2019-001131-31: Efficacy and safety of 72-hours infusion of prostacyclin (1 ng/kg/min) in patients with septic shock suffering from organ failure caused by endothelial breakdown

Not yet recruiting
2/3
380
Europe
Ilomedin, Concentrate for solution for infusion, Ilomedin
Section for transfusion Medicines, Capital Region Blood Bank, Copenhagen University Hospital, Innovation Fund Denmark
Shock-induced endotheliopathy in patients with septic shock, Septic patients with shock and damage to the smallest blood vessels, Diseases [C] - Bacterial Infections and Mycoses [C01]
 
 
Bayer, J&J_COVID: Danish Team of Researchers to Test Treatment of Critically Ill Patients Suffering from COVID-19

Not yet recruiting
2
0
Danish
Ventavis (iloprost ) - Bayer, J&J, University of Copenhagen
Bayer, J&J, Copenhagen University, BioPorto
COVID-19
 
 
2011-004567-80: We think that the blood flow increases during intraarterial injection of a special drug, called iloprost, during surgical treatment in the distal limbs, because of the vasodilatation in diabetics and non diabetics in the same way. Wir glauben, dass sich ein verbesserter Blutfluss, durch die intraarterielle Injektion eines gefässerweiternden Medikamentes, im gleichen Ausmass bei zuckerkranken Patienten und nicht zuckerkranken Patienten zeigt, welche an den peripheren Gefässen operiert werden.

Ongoing
2
60
Europe
Ilomedin, 1-22460, Concentrate and solvent for injection, Ilomedin
Georg Hagmüller Institute for Vascular Research, Georg Hagmüller Institute for Vascular Research
We think that the blood flow increases during intraarterial injection of iloprost during surgical treatment in distal vessels in patients with arteriosclerosis and diabetes and non diabetes in the same way because of vasodilatation. So we investigate people with arteriosclerosis and diabetes and non diabetes which undergo surgical treatment. Wir untersuchen die Flowveränderung an den peripheren Gefässen bei Patienten mit Arteriosklerose, welche sich einer chirurgischen Behandlung unterziehen, und dabei intraarteriell Iloprostinjektionen erhalten. Dabei werden Diabetiker und Nicht-Diabetiker untersucht., We investigate patients with stenosis in distal vessels and diabetes or non diabetes which underwent surgical treatment in distal vessels. Wir untersuchen Patienten, welche unter Engstellen in den Gefässen leiden und welche Diabetiker und Nicht-Diabetiker sind und welche sich einer chirurgischen Sanierung an den Beingefässen unterziehen., Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Surgical Procedures, Operative [E04]
 
 
2013-004596-12: Infusion at home ,using a pump device, of a drug that dilates peripheral blood vessels to treat patients affected by a disease named Systemic sclerosis, with manifestations caused by a reduced blood flow in hands and feet. Infusione a casa di un farmaco per dilatare i vasi periferici in pazienti affetti da una malattia chiamata sclerosi sistemica che si manifesta con fenomeni causati da una riduzione del flusso di sangue a mani e piedi.

Ongoing
2
20
Europe
Endoprost, Concentrate for solution for infusion, Endoprost
Azienda ospedaliera universitaria Ospedali Riuniti, OO. RR. Torrette di Ancona
Raynaud's phenomenon and acral ulcers in systemic sclerosis Fenomeno di raynaud e ulcere acrali secondarie a sclerosi sistemica, Manifestations caused by a low blood flow in hands and feet in patients affected by fibrosis of various tissues. Manifestazioni dovute a basso flusso sanguigno in pazienti affetti da fibrosi dei tessuti, Diseases [C] - Skin and Connective Tissue Diseases [C17]
 
 
2009-015828-28: Iloprost in der Behandlung der Präeklampsie – klinische Pilotstudieengl.: oral Iloprost in pre-eclampsia treatment - a pilot study

Ongoing
2
10
Europe
Ilomedin Infusionslösung 10 mcg/0,5ml, Ilomedin 10 microgramm / 0,5ml Infusionslösungskonzentrat, Ilomedin 10 microgramm / 0,5ml Infusionslösungskonzentrat
Medizinische Universität Wien
early- onset Pre-eclampsia
 
 
2019-000936-24: Efficacy and safety of 72-hour infusion of Prostacyclin (1 ng/kg/min) in trauma patients with haemorrhagic shock suffering from organ failure caused by endothelial breakdown

Not yet recruiting
2
220
Europe
Ilomedin (2,5 ml vial), Concentrate for solution for infusion, Ilomedin
Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Novo Nordisk Foundation
Shock-induced endotheliopathy in trauma patients, Severely bleeding trauma patients with shock and damage to the smallest blood vessels, Diseases [C] - Injuries, poisonings, and occupational diseases [C21]
 
 
2016-003168-37: New therapy for patients suffering Acute Respiratory Distress Syndrome

Not yet recruiting
2
150
Europe
Ventavis, Nebulisation solution, Ventavis
University Tuebingen, Department of Aneshesia and intensive care University Hospital Tuebingen
Acute respiratory distress syndrome requiring mechanical ventilation, Patients with pulmonary insufficiency requiring mechanical ventilation, Diseases [C] - Symptoms and general pathology [C23]
 
 
2022-004079-17: Efficacy and safety of 72-hour infusion of Prostacyclin (1 ng/kg/min) in mechanically ventilated patients with infectious respiratory failure

Ongoing
2
450
Europe
Ilomedin, Concentrate and solvent for concentrate for solution for infusion, Ilomedin
Rigshospitalet, None
Infectious pulmonary endotheliopathy, Infectious respiratory failure, Diseases [C] - Respiratory Tract Diseases [C08]
 
 
2022-003725-22: Acute effect of iloprost inhalation on pulmonary hypertension developed during exercise in Post-COVID-19 patients Akute Wirkung der Inhalation mit Iloprost bei Lungenhochdruck unter Belastung nach einer COVID-19-Infektion

Not yet recruiting
2
120
Europe
Nebulisation solution, Ventavis
Justus-Liebig-University Gießen, BMBF
Exercise-induced pulmonary hypertension after a COVID-19 infection Belastungsinduzierte pulmonale Hypertonie nach einer COVID-19-Infektion, Pulmonary hypertension developed during exercise by patient with a Long-COVID-19 infection Lungenhochdruck unter Belastung nach einer Long-COVID-19-Infektion, Diseases [C] - Respiratory Tract Diseases [C08]
 
 
COMBAT-ARF, NCT06319274: Infusion of Prostacyclin Vs Placebo for 72-hours in Mechanically Ventilated Patients with Acute Respiratory Failure

Recruiting
2
450
Europe
Iloprost, Ilomedin, Isotonic saline
Pär Johansson
Acute Respiratory Failure, Endothelial Dysfunction, Pulmonary Infection
12/26
12/26
NCT05411107: Oral Iloprost for the Prevention of Lung Cancer In Former Smokers

Withdrawn
2
80
NA
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Bronchial Brush Biopsy, bronchial brushing, Bronchoscopy, Iloprost, Ciloprost, Iloprost Clathrate, Ventavis, ZK 36374, Placebo Administration, Questionnaire Administration
National Cancer Institute (NCI)
Bronchial Epithelial Dysplasia, Chronic Obstructive Pulmonary Disease, Lung Carcinoma, Stage I Lung Cancer AJCC v8, Stage II Lung Cancer AJCC v8, Tobacco-Related Carcinoma
12/26
06/27
2017-003813-24: A clinical trial investigating Iloprost as medication to improve bone healing in patients with upper arm bone fracture. Eine klinische Studie, welche Iloprost als Medikament für die Verbesserung der Knochenheilung bei Patienten mit Brüchen des Oberarmknochens verbessern möchte.

Not yet recruiting
1/2
30
Europe
Concentrate for solution for infusion, Ilomedin
Charité-Universitätsmedizin Berlin, BMBF, BCRT
Proximal humeral fracture Proximale Humerusfraktur, Fractures of the upper part of the upper arm Knochenbruch des Oberarmknochens, Body processes [G] - Bones and nerves physological processes [G11]
 
 
Ilobone, NCT04543682: A Clinical Trial Investigating Iloprost as Medication to Improve Bone Healing in Patients With Proximal Humeral Fracture

Recruiting
1/2
30
Europe
0.125 ng/kg/min Iloprost, Ilomedin, SUB08136MIG, CAS (Chemical Abstracts Service) number 78919-13-8, 0.25 ng/kg/min Iloprost, CAS number 78919-13-8, open reduction and internal fixation with an angular stable plate (PHILOS), humerus surgery, Open Reduction and Internal fixation of proximal humeral fracture using Philos plate, PHILOS Plating
Charite University, Berlin, Germany
Proximal Humeral Fracture
05/24
12/24
NCT02237183: Iloprost in Preventing Lung Cancer in Former Smokers

Completed
1
34
US
Iloprost, Ciloprost, Iloprost Clathrate, Ventavis, ZK 36374, Placebo Administration, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration
National Cancer Institute (NCI)
Lung Carcinoma
03/20
08/23
NCT04583046: Effects of Iloprost on Pulmonary Oxygenation in Obese Patients During One-lung Ventilation

Not yet recruiting
N/A
78
NA
normal saline inhalation, iloprost inhalation
Yonsei University
Lung Cancer (Including Metastatic Cancer), Pulmonary Infection
08/22
08/22
NCT04598191: Effect of Intraoperative Iloprost Inhalant on Hemodynamic Stability in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery

Recruiting
N/A
100
RoW
Iloprost, Control (Normal saline)
Yonsei University
Coronary Artery Occlusive Disease
12/22
12/22
NCT02825160: Non-interventional, Postauthorization Safety Study of Ventavis for Pulmonary Arterial Hypertension (PAH)

Completed
N/A
282
Japan
Ventavis (Iloprost, BAYQ6256)
Bayer
Hypertension, Pulmonary
03/23
09/23
NCT04927039: Effects of Iloprost on Oxygenation During One-lung Ventilation in Supine-positioned Patients

Not yet recruiting
N/A
60
RoW
5ml of inhaled normal saline, 20μg (2ml) of inhaled iloprost (Ventavis®) and 3ml of inhaled normal saline
Yonsei University
Mediastinal Mass
06/23
06/23

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