Ventavis (iloprost) / Bayer, J&J, University of Copenhagen 
Welcome,         Profile    Billing    Logout  
  Diseases    Trials    Trials    News 


«12345678910111213»
  • ||||||||||  Ventavis (iloprost) / Bayer, J&J, University of Copenhagen
    Journal:  Comparison of the Patency and Regenerative Potential of Biodegradable Vascular Prostheses of Different Polymer Compositions in an Ovine Model. (Pubmed Central) -  May 31, 2023   
    In this study, we fabricated an electrospun biodegradable poly(?-caprolactone) (PCL) prosthesis and poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/poly(?-caprolactone) (PHBV/PCL) prosthesis loaded with iloprost (a prostacyclin analog) as an antithrombotic drug and cationic amphiphile with antibacterial activity...The polymeric material of both prostheses degraded and was replaced with neotissue containing smooth-muscle cells; macrophages; proteins of the extracellular matrix such as type I, III, and IV collagens; and vasa vasorum. Thus, the biodegradable PCL/Ilo/A prostheses demonstrate better regenerative potential than PHBV/PCL-based implants and are more suitable for clinical use.
  • ||||||||||  Ventavis (iloprost) / Bayer, J&J, University of Copenhagen
    Retrospective data, Journal:  The effect of using iloprost on prognosis in COVID-19 patients with ARDS: a retrospective clinical study. (Pubmed Central) -  May 23, 2023   
    These findings suggest that DHEA could be an effective drug for pressure overload-induced left or right ventricular hypertrophy by regulating the shared hub differentially expressed genes associated with fibrosis. Iloprost improves oxygenation but has no effect on mortality in COVID-19 ARDS.
  • ||||||||||  Ventavis (iloprost) / Bayer, J&J, University of Copenhagen
    Journal:  Platelet phosphatidylserine is the critical mediator of thrombosis in heparin-induced thrombocytopenia. (Pubmed Central) -  Apr 27, 2023   
    These prothrombotic conditions were prevented via the upregulation of PLTs intracellular cAMP with Iloprost, a clinically approved prostacyclin analogue...Taken together, our findings indicate that procoagulant PLTs are critical mediators of prothrombotic conditions in HIT. Specific PS targeting could be a promising therapeutic approach to prevent thromboembolic events in HIT patients.
  • ||||||||||  Ventavis (iloprost) / Bayer, J&J, University of Copenhagen
    Review, Journal:  Iloprost for the treatment of frostbite: a scoping review. (Pubmed Central) -  Mar 30, 2023   
    Primary gaps in the literature include a paucity of randomised trials and relatively limited study populations to date. While the case evidence is promising, a multi-centre collaboration would be crucial to adequately power prospective randomised studies to definitively determine if iloprost has a role in the treatment of frostbite.
  • ||||||||||  Ventavis (iloprost) / Bayer, J&J, University of Copenhagen
    Trial initiation date:  Oral Iloprost for the Prevention of Lung Cancer In Former Smokers (clinicaltrials.gov) -  Mar 14, 2023   
    P2,  N=80, Not yet recruiting, 
    The clinical availability of almitrine is limited. Initiation date: Jan 2023 --> Dec 2023
  • ||||||||||  Ventavis (iloprost) / Bayer, J&J, University of Copenhagen
    Preclinical, Journal:  Precision cut lung slices as a preclinical model for non-small cell lung cancer chemoprevention. (Pubmed Central) -  Mar 9, 2023   
    agonizing chemoprevention agent iloprost produced similar effects on gene expression and downstream signaling as in vivo models...To demonstrate potential for drug screening, we treated PCLS with additional lung cancer chemoprevention agents and confirmed activity markers in culture. PCLS offers an intermediate step for chemoprevention research between in vitro and in vivo models that can facilitate drug screening prior to in vivo studies and support mechanistic studies with more relevant tissue environments and functions than in vitro models.
  • ||||||||||  sildenafil / Generic mfg., Ventavis (iloprost) / Bayer, J&J, University of Copenhagen
    Journal:  Treatment of gangrenous digit-threatening paraneoplastic acrocyanosis with vasodilator therapy. (Pubmed Central) -  Feb 27, 2023   
    In parallel to the chemotherapy, vasodilatory therapy was administered as two courses of intravenous synthetic prostacyclin analogue iloprost along with sildenafil. This resulted in a significant improvement in digital pain and gangrene with healing of ulceration.
  • ||||||||||  Ventavis (iloprost) / Bayer, J&J, University of Copenhagen
    Possible Immune Reaction to COVID-19 Vaccination - a Case Report (#12) (foyer) -  Feb 8, 2023 - Abstract #GTH2023GTH_323;    
    In the further course, the therapy regimen was changed to Ilomedin IV for 4 days once a month...Conclusion In summary, a circulatory perfusion disorder associated with microthrombotic events may be a possible side effect of SARS CoV-2 vaccination. A combination of Nifidipine, DOAC and pain therapy has been shown to be an effective treatment of "COVID-fingers" in this case report.
  • ||||||||||  Fragmin (dalteparin sodium) / Pfizer, Eisai, Ventavis (iloprost) / Bayer, J&J, University of Copenhagen, Opdivo (nivolumab) / Ono Pharma, BMS
    Immune Checkpoint Inhibitor Associated Vasculitis- A Limitation to Cancer Therapy () -  Feb 4, 2023 - Abstract #BSR2023BSR_470;    
    ICIs have revolutionised the management and outcomes across a range of malignancies. However, their mechanism can inadvertently induce undesired toxicity, the awareness of which is paramount.
  • ||||||||||  Tracleer (bosentan) / J&J, Roche
    Audit of Bosentan use in Rapid Access to Digital Ulcer Clinic (RADUC) in systemic sclerosis: a single-centre experience () -  Feb 4, 2023 - Abstract #BSR2023BSR_466;    
    Our data suggest that bosentan is well-tolerated and effective in reducing the overall DU burden and improving some of the patient-reported outcomes at 6-months. To date, most patients had already received both sildenafil and IV-prostanoids; however, an increasing number of patients are now initiated on bosentan prior to IV-prostanoids, and this will be audited in the future.
  • ||||||||||  Ventavis (iloprost) / Bayer, J&J, University of Copenhagen
    Inpatient Admission pathway For Patients With Rheumatological Disorders () -  Feb 4, 2023 - Abstract #BSR2023BSR_356;    
    This pathway allowed safe and prompt treatment, prognosis and excellent experience for acutely ill patients with rheumatological disorders. This additionally enabled reduced length of stay supporting financial sustainability of the Trust.
  • ||||||||||  Ventavis (iloprost) / Bayer, J&J, University of Copenhagen
    Journal:  Tracing G-Protein-Mediated Contraction and Relaxation in Vascular Smooth Muscle Cell Spheroids. (Pubmed Central) -  Jan 9, 2023   
    Under these conditions, mouse and human VSMC spheroids contracted upon treatment with ET-1 and potassium chloride or relaxed in response to caffeine and the prostacyclin analogue Iloprost...In summary, culture of VSMCs in three-dimensional spheroids lowers baseline G-protein activity and enables analyses of both contraction and relaxation of mouse and human VSMCs. This model serves as a simple and versatile tool for drug testing and investigating G-protein-depending signaling.
  • ||||||||||  nitroprusside / Generic mfg.
    DELAYED PULMONARY VASODILATOR RESPONSE TO SODIUM NITROPRUSSIDE (Poster Hall_Hall F) -  Jan 4, 2023 - Abstract #ACCWCC2023ACC_WCC_6332;    
    Background: The 2022 ESC pulmonary hypertension (PH) guidelines describe acute vasoreactivity as a drop of >10 mmHg in mean pulmonary artery pressure (PAP) to <40 mmHg with an increase or no change in cardiac output (CO) on right heart catheterization (RHC) in response to inhaled nitrous oxide, inhaled iloprost, or intravenous (IV) epoprostenol...For this reason, we describe a case of vasodilatory challenge (VDC) with SNP in which there was a delayed response in PAP.Case: 45-year-old male with a history of severe Group I pulmonary arterial hypertension on home Ambrisentan 5 mg daily, and Tadalafil 40 mg daily, presented with worsening shortness of breath... Prolonged exposure to vasodilator therapy may be required to diagnose delayed responders to vasodilator therapies and to identify an important patient population which may gain benefit from ALR in treatment of their mixed pre- and post-capillary PH.
  • ||||||||||  Ventavis (iloprost) / Bayer, J&J, University of Copenhagen
    RNA POLYMERASE III ASSOCIATED MYOCARDITIS IN A PATIENT WITH COVID VIREMIA (Poster Hall_Hall F) -  Jan 4, 2023 - Abstract #ACCWCC2023ACC_WCC_1692;    
    Identification of this high-risk feature allowed for timely admission to the cardiac ICU for management of cardiogenic shock with dobutamine, norepinephrine and vasopressin. Patients with detectable RNA-Polymerase-III antibodies may be at an increased risk for severe viral myocarditis and cardiogenic shock when infected with COVID-19.
  • ||||||||||  dasatinib / Generic mfg.
    DASATINIB INDUCED RIGHT VENTRICULAR FAILURE IN A PATIENT WITH CHRONIC MYELOID LEUKEMIA (Poster Hall_Hall F) -  Jan 4, 2023 - Abstract #ACCWCC2023ACC_WCC_984;    
    There are no current monitoring guidelines for patients on Dasatinib for Chronic Myeloid Leukemia. Non-invasive monitoring via echocardiography can potentially reduce the risk of adverse effects linked to Dasatinib as early detection of pulmonary arterial hypertension and right heart failure can be reversed with early cessation of the medication.
  • ||||||||||  Ventavis (iloprost) / Bayer, J&J, University of Copenhagen, Reasanz (serelaxin) / Novartis
    Preclinical, Journal:  In vitro effect of relaxin in the rat corpus cavernosum under hyperglycemic and normoglycemic conditions. (Pubmed Central) -  Dec 13, 2022   
    Prostacyclin-mediated relaxation was evaluated by cumulative administration of iloprost (10-10M), a prostacyclin analog...Serelaxin exerts different effects via different mechanism on endothelium-dependent responses depending on the dose and duration of exposure. Therefore, proper timing and dosing of serelaxin administration in the penile tissue need to be investigated in further studies in diabetic animal models.
  • ||||||||||  Ventavis (iloprost) / Bayer, J&J, University of Copenhagen, Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Journal:  Livid Fingers after Respiratory Infection (Pubmed Central) -  Dec 8, 2022   
    In addition to short-term lysis therapy with alteplase, the patient was therapeutically anticoagulated and received aspirin. An ilomedin (iloprost) therapy was carried out.
  • ||||||||||  Ventavis (iloprost) / Bayer, J&J, University of Copenhagen
    Journal:  Metabolism Characteristics of Mycoplasma pneumoniae Infection in Asthmatic Children. (Pubmed Central) -  Nov 26, 2022   
    Mp infection in asthmatic children can cause changes in the levels of various amino acids in the body, which were enriched in the pathways such as valine, leucine and isoleucine biosynthesis. Palmitic acid can activate TLR2, and iloprost reduces IL-10 levels, ultimately leading to the increased airway inflammation.