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Journal: Toxic responses of blue orchard mason bees (Osmia lignaria) following contact exposure to neonicotinoids, macrocyclic lactones, and pyrethroids. (Pubmed Central) - Jan 30, 2021 Macrocyclic lactones (abamectin and ivermectin) were also highly toxic to O. lignaria with LD estimates of 5.51-32.86 ng/bee...Additionally, three of seven pesticides (43%) resulted in significantly different mass normalized LD values for male and female O. lignaria. These results indicate that non-Apis pollinators may be highly susceptible to pesticides originating from beef cattle feed yards, necessitating consideration of more stringent regulatory protections than those based on A. mellifera pesticide sensitivity.
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Try Ivermectin. (Twitter) - Jan 30, 2021
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Ivermectin (Twitter) - Jan 29, 2021
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Ivermectin (Twitter) - Jan 29, 2021
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Journal: Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents. (Pubmed Central) - Jan 29, 2021 The 100 ns molecular dynamics simulation studies showed that ivermectin may require homodimeric form of 3CLpro enzyme for its inhibitory activity. In summary, these molecules could be useful to develop highly specific therapeutically viable drugs to inhibit the SARS-CoV-2 replication either alone or in combination with drugs specific for other SARS-CoV-2 viral targets.
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Journal: Computational Design and Preliminary Serological Analysis of a Novel Multi-Epitope Vaccine Candidate against Onchocerciasis and Related Filarial Diseases. (Pubmed Central) - Jan 27, 2021 The elimination plan for the disease is currently challenged by many factors including amongst others; the potential emergence of resistance to the main chemotherapeutic agent, ivermectin (IVM)...Preliminary immunological analyses revealed that the multi-epitope vaccine candidate reacted with antibodies in sera from both onchocerciasis-infected individuals, endemic normals as well as loiasis-infected persons but not with the control sera from European individuals. These results support the premise for further characterisation of the engineered protein as a vaccine candidate for onchocerciasis.
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Ivermectin? (Twitter) - Jan 27, 2021
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