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- || ivermectin oral / Generic mfg.
Review, Journal: Paediatrics: how to manage scabies. (Pubmed Central) - Apr 10, 2021
Oral ivermectin, where available, is reserved for use in high-risk cases in children or in mass drug administration programmes in endemic communities...Although time consuming and labour intensive for caregivers, the implementation of appropriate treatment strategies usually results in prompt cure for the child and their contacts. Here, we provide a summary of treatments and recommendations for the management of paediatric scabies.
- ||| ivermectin oral / Generic mfg.
RT Two-doses of oral #Ivermectin (300 μg/kg given 72 hours apart) as chemoprophylaxis among Health Care Workers reduces the risk of COVID-19 infection by 83% in the following month. 3,500 participants. Indian study. Surprise-surprise: No US-based ones. https://t.co/NVaYbqzL2b (Twitter) - Apr 9, 2021
- | ivermectin oral / Generic mfg.
New trial: SARS-CoV-2 Pre-exposure Prophylaxis With Ivermectin Retrospective Cohort Study (clinicaltrials.gov) - Apr 5, 2021
P, N=713, Completed, Sponsor: Grupo Rescue S.A.S Rep
- | ivermectin oral / Generic mfg.
New P3 trial: Efficacy of Ivermectin in Outpatients With Non-severe COVID-19 (clinicaltrials.gov) - Apr 5, 2021
P3, N=400, Recruiting, Sponsor: Universidad Nacional de Asunci
- | Journal: The American Heartworm Society and Association of Shelter Veterinarians' 2019 Shelter Heartworm Management Practices Survey. (Pubmed Central) - Mar 25, 2021
Most respondents provided monthly heartworm preventives for dogs (81.1%) and used oral ivermectin products per product labels (67.2%) to do so...Protocols typically included adjunctive treatment with doxycycline or minocycline (92.3%), prednisone (71.3%), and macrocyclic lactones (58.6%)...Heartworm prevention was provided by 29.9% of respondents that admitted cats and 9.9% of those that admitted ferrets. These results can be used to identify challenges to meeting recommended practices regarding prevention, diagnosis, and treatment of heartworm disease in the animal shelter setting and to target operational and educational resources toward the areas of greatest need.
- | ivermectin oral / Generic mfg.
Enrollment change, Trial completion date, Trial primary completion date: SAINT-PERU: Randomized Phase IIA Clinical Trial to Evaluate the Efficacy of Ivermectin to Obtain Negative PCR Results in Patients With Early Phase COVID-19 (clinicaltrials.gov) - Mar 18, 2021
P2a, N=186, Recruiting, Sponsor: Universidad Peruana Cayetano Heredia
These results can be used to identify challenges to meeting recommended practices regarding prevention, diagnosis, and treatment of heartworm disease in the animal shelter setting and to target operational and educational resources toward the areas of greatest need. N=68 --> 186 | Trial completion date: Jan 2021 --> Apr 2021 | Trial primary completion date: Dec 2020 --> Apr 2021
- | albendazole / Generic mfg.
Trial completion, Trial completion date, Trial primary completion date: Efficacy and Safety of IVM/ALB Co-administration (clinicaltrials.gov) - Mar 17, 2021
P2/3, N=1673, Completed, Sponsor: Jennifer Keiser
N=68 --> 186 | Trial completion date: Jan 2021 --> Apr 2021 | Trial primary completion date: Dec 2020 --> Apr 2021 Active, not recruiting --> Completed | Trial completion date: Dec 2020 --> Jul 2020 | Trial primary completion date: Feb 2020 --> May 2020
- | tramadol hydrochloride / Generic mfg.
Journal: Tramadol Effects on Lameness Score After Inhibition of P-GP by Ivermectin Administration in Horses: Preliminary Results. (Pubmed Central) - Mar 16, 2021
We conclude that inhibition of enteric P-gp by ivermectin did not alter the effects of tramadol, suggesting that tramadol is not a substrate for P-gp. However, future studies should be conducted to assess the interaction between P-gp inhibitors on the pharmacokinetics of tramadol.
- | ivermectin oral / Generic mfg.
Trial completion date, Trial primary completion date: Study in COvid-19 Patients With iveRmectin (CORVETTE-01) (clinicaltrials.gov) - Mar 7, 2021
P2, N=240, Recruiting, Sponsor: Kitasato University
However, future studies should be conducted to assess the interaction between P-gp inhibitors on the pharmacokinetics of tramadol. Trial completion date: Mar 2021 --> Sep 2021 | Trial primary completion date: Mar 2021 --> Sep 2021
- | ivermectin oral / Generic mfg.
New P1/2 trial: IVER-Leve: Ivermectin Reproposing for Mild Stage COVID-19 Outpatients (clinicaltrials.gov) - Mar 4, 2021
P1/2, N=240, Completed, Sponsor: Ministry of Public Health, Argentina
- |||| ivermectin oral / Generic mfg.
New P2 trial: A randomized, double-blind, placebo-controlled study to assess the safety and efficacy of ivermectin in asymptomatic and mild severity COVID-19 patients A randomized, double-blind, placebo-controlled study to assess the safety and efficacy of ivermectin in asymptomatic and mild severity COVID-19 patients (EUDRACT) - Mar 4, 2021
P2, N=70, Ongoing, Sponsor: Meditop Gy
- | moxidectin / Generic mfg., albendazole / Generic mfg.
Trial completion date, Trial initiation date, Trial primary completion date: Safety of a Single Dose of Moxidectin Compared With Ivermectin in Individuals Living in Onchocerciasis Endemic Areas and in Individuals Living in Onchocerciasis Endemic Areas With High Levels of Lymphatic Filariasis Co-endemicity Receiving Concomitant Albendazole (clinicaltrials.gov) - Mar 3, 2021
P3, N=12500, Not yet recruiting, Sponsor: Medicines Development for Global Health
Trial completion date: Mar 2021 --> Sep 2021 | Trial primary completion date: Mar 2021 --> Sep 2021 Trial completion date: Jan 2022 --> Mar 2023 | Initiation date: Nov 2020 --> Mar 2021 | Trial primary completion date: Jan 2022 --> Mar 2023
- |||| ivermectin oral / Generic mfg.
Clinical: Even toddlers, children and pregnant women can be safely protected against a #Covid19 infection #Ivermectin safety in infants and children under 15 kg https://t.co/xYsJmIlRjF Safety of oral #Ivermectin during pregnancy https://t.co/q9E5uKoaw6 https://t.co/uNLrIDEqvh (Twitter) - Feb 26, 2021
- |||| ivermectin oral / Generic mfg.
Clinical: Even toddlers, children and pregnant women can be safely protected against a #Covid19 infection #Ivermectin safety in infants and children under 15 kg https://t.co/xYsJmIlRjF Safety of oral #Ivermectin during pregnancy https://t.co/q9E5uKoaw6 https://t.co/yOtNBoFVCE (Twitter) - Feb 24, 2021
- | ivermectin oral / Generic mfg.
Enrollment open: Inhaled Ivermectin and COVID-19 (clinicaltrials.gov) - Feb 23, 2021
P3, N=80, Recruiting, Sponsor: Mansoura University
Trial completion date: Jan 2022 --> Mar 2023 | Initiation date: Nov 2020 --> Mar 2021 | Trial primary completion date: Jan 2022 --> Mar 2023 Not yet recruiting --> Recruiting
- || ivermectin oral / Generic mfg.
Clinical, Journal: Crusted scabies; a 2-year prospective study from the Northern Territory of Australia. (Pubmed Central) - Feb 23, 2021
Crusted scabies can be successfully treated with aggressive guideline-based therapy, but high mortality remains from underlying comorbidities. Reinfection on return to community is common while scabies remains endemic.
- ||||| ivermectin oral / Generic mfg.
Clinical: Even toddlers, children and pregnant women can be safely protected against a #Covid19 infection #Ivermectin safety in infants and children under 15 kg https://t.co/xYsJmIlRjF Safety of oral #Ivermectin during pregnancy https://t.co/q9E5uKoaw6 https://t.co/yOtNBoFVCE (Twitter) - Feb 22, 2021
- |||| ivermectin oral / Generic mfg.
Clinical: Even toddlers, children and pregnant women can be safely protected against a #Covid19 infection #Ivermectin safety in infants and children under 15 kg https://t.co/xYsJmIlRjF Safety of oral #Ivermectin during pregnancy https://t.co/q9E5uKoaw6 https://t.co/yOtNBoFVCE (Twitter) - Feb 22, 2021
- ||||| metformin / Generic mfg., ivermectin oral / Generic mfg., fluvoxamine / Generic mfg.
Enrollment change, Trial primary completion date: COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19) (clinicaltrials.gov) - Feb 21, 2021
P2/3, N=750, Recruiting, Sponsor: University of Minnesota
Reinfection on return to community is common while scabies remains endemic. N=70 --> 750 | Trial primary completion date: Sep 2021 --> Jun 2021
- || ivermectin oral / Generic mfg., doxycycline / Generic mfg., Pierre Fabre
Clinical, Journal: A five day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness. (Pubmed Central) - Feb 17, 2021
A 5-day course of ivermectin was found to be safe and effective in treating mild COVID-19 adult patients. Larger trials will be needed to confirm these preliminary findings.
- | ivermectin oral / Generic mfg.
Enrollment change, Combination therapy: SINZ-COVID-PK: Efficacy of Subcutaneous Ivermectin With or Without Zinc in COVID-19 Patients (clinicaltrials.gov) - Feb 16, 2021
P1/2, N=180, Recruiting, Sponsor: Sohaib Ashraf
Larger trials will be needed to confirm these preliminary findings. N=60 --> 180
- ||||| ivermectin oral / Generic mfg.
Clinical: Even toddlers, children and pregnant women can be safely protected against a #Covid19 infection #Ivermectin safety in infants and children under 15 kg https://t.co/xYsJmIlRjF Safety of oral #Ivermectin during pregnancy https://t.co/q9E5uKoaw6 https://t.co/yOtNBoFVCE (Twitter) - Feb 16, 2021
- | doxycycline / Generic mfg.
Trial completion: Efficacy and Safety of Ivermectin and Doxycycline in Combination or IVE Alone in Patients With COVID-19 Infection. (clinicaltrials.gov) - Feb 3, 2021
P2, N=72, Completed, Sponsor: International Centre for Diarrhoeal Disease Research, Bangladesh
N=60 --> 180 Enrolling by invitation --> Completed
- || hydroxychloroquine / Generic mfg., ivermectin oral / Generic mfg.
Facebook gave permission to talk about Hydroxychloroquine. This and Ivermectin have been shown to be very effective when given early. Now that we all have permission from one of the world's rulers to mention it, let's spread the word! (Twitter) - Jan 31, 2021
- ||| Aplidin (plitidepsin) / PharmaMar, Roche
Clinical: Vaccines is all we hear about from you. What about the very important role of antivirals? Ivermectin and Plitidepsin are looking extremely promising. Can help the burden on hospitals! Need to move quickly on these! (Twitter) - Jan 31, 2021
- || ivermectin / Generic mfg.
#ivermectin es una solucion q no les guste xq es barata @Minsa_Peru Mazzetti o Dr. Huertas es su problema. @FDA @FDA_Drug_Info dieron un paso. (Twitter) - Jan 31, 2021
- || ivermectin / Generic mfg.
If they want to save POC live why didn't they tell them to take vitamin D? There's also evidence for low cost drugs like Ivermectin. Furthermore, Rapid Antigen tests would've let people know their status. (Twitter) - Jan 31, 2021
- || ivermectin / Generic mfg.
If they wanted to save POC lives they should've approved Ivermectin and Rapid Antigen tests. I don't think Fauci cares. (Twitter) - Jan 31, 2021
- || ivermectin / Generic mfg.
On vaccines: there are alternatives. And vaccines are only defense. A complementary approach & good offense would consist of widely distributing and using the #IVERMECTIN Kills C19 in 6 days. See my tweet to President Biden https://t.co/kCf0RmE3mp and pls RT widely (Twitter) - Jan 31, 2021
- ||| ivermectin / Generic mfg.
Clinical: RT @CDCDirector It would be best to involve the army in a very speedy distribution of #Ivermectin to retirement homes, hospitals, schools, work groups, etc. It should be ingested as soon as any person becomes positive, in which case the cure is usually speedy, under 6 days. (Twitter) - Jan 31, 2021
- ||| ivermectin / Generic mfg.
Clinical: RT @CDCDirector It would be best to involve the army in a very speedy distribution of #Ivermectin to retirement homes, hospitals, schools, work groups, etc. It should be ingested as soon as any person becomes positive, in which case the cure is usually speedy, under 6 days. (Twitter) - Jan 31, 2021
- |||| ivermectin / Generic mfg.
Clinical: RT BTW, in today's news "Slovakia Becomes the First EU Nation to Formally Approve Ivermectin for Both Prophylaxis and Treatment for COVID-19 Patients." How about US? (Twitter) - Jan 31, 2021
- || ivermectin / Generic mfg.
Tweet salvo on Ivermectin to President Biden https://t.co/kCf0RmE3mp (Twitter) - Jan 31, 2021
- || ivermectin / Generic mfg.
They're using Ivermectin (Stramectol) which we have readily available here. (Twitter) - Jan 31, 2021
- |||| ivermectin / Generic mfg.
Retrospective data: @DrAndrewHill Has shown you a remarkable meta analysis on IVERMECTIN and it’s proven use in treating and preventing Covid. Why is this not being rolled out along with the vaccine? 85% reduction in mortality! @DrTedros Why not? https://t.co/JJwdrOGayS (Twitter) - Jan 31, 2021
- || ivermectin / Generic mfg.
Okay but why the silence on Ivermectin as a mass preventative treatment? (Twitter) - Jan 30, 2021
- || ivermectin / Generic mfg.
ivermectin (Twitter) - Jan 30, 2021
- || ivermectin / Generic mfg.
Any idea how much ivermectin is being used in Canada ? (Twitter) - Jan 30, 2021
- || ivermectin / Generic mfg.
Baseline prescriptions for Ivermectin is 5,000 prescriptions per week for at least the last 5 years. Currently the use is over 55,000 per week. I would expect that off label use is now 10 times FDA indicated use. (Twitter) - Jan 30, 2021
- || ivermectin / Generic mfg., favipiravir / Generic mfg.
That’s good to hear... I live In Canada and none of the doctors I know have heard that ivermectin helps with covid, and have never even heard of avigan (Twitter) - Jan 30, 2021
- || ivermectin / Generic mfg.
We use Ivermectin too off label all the time. But Ivermectin is used off label in other situations as well. https://t.co/uTX2GDesgS (Twitter) - Jan 30, 2021
- || ivermectin / Generic mfg., favipiravir / Generic mfg.
US has been using ivermectin off label commonly? And Avigan is not available in the Us it is not produced or sold for any other use (Twitter) - Jan 30, 2021
- ||| ivermectin / Generic mfg., colchicine / Generic mfg., favipiravir / Generic mfg.
Clinical, FDA event: Yet they banned off label use for hcq. How many doctors are prescribing ivermectin or colchicine? And Avigan Has been proven to reduce stay in hospitals by 30%, plus likely reduced rates of infection, yet still hasn’t been approved by fda, so is not available in USA (Twitter) - Jan 30, 2021
- ||| ivermectin / Generic mfg.
Clinical: I've had C19, but if I needed anything, I want the alternative therapy protocol Ivermectin. That is my choice, (Twitter) - Jan 30, 2021
- | ivermectin / Generic mfg.
The jury is still out on the Ivermectin as the data for humans is all over the place. (Twitter) - Jan 30, 2021
- || ivermectin / Generic mfg.
The anti science movement that banned lifesaving meds like #Ivermectin and #hcq, not treating the sick early, shoving them on ventilators, and diagnosing solely using worthless #pcrtest (Twitter) - Jan 30, 2021
- || ivermectin / Generic mfg.
Spend lots of money making sophisticated videos of microscopic scary stuff, creating a spectacle of shock and horror. But don't authorise the off-label use of #Ivermectin which can prevent and cure it? (Twitter) - Jan 30, 2021
- || ivermectin / Generic mfg.
Ivermectin is your Achilles heel. (Twitter) - Jan 30, 2021
- || ivermectin / Generic mfg.
Clinical, Journal: Individuals living in an onchocerciasis focus and treated three-monthly with ivermectin develop fewer new onchocercal nodules than individuals treated annually. (Pubmed Central) - Jan 30, 2021
To our knowledge, these results suggest for the first time in humans, that ivermectin has a partial prophylactic effect on O. volvulus. Three-monthly treatment seems more effective than annual treatment to prevent the appearance of nodules.
- | ivermectin / Generic mfg., rifampicin / Generic mfg.
Journal: Efficient degradation of ivermectin by newly isolated Aeromonas taiwanensis ZJB-18,044. (Pubmed Central) - Jan 30, 2021
Therefore, the IVM tolerance of strain ZJB-18,044 may be due to the regulation of the intracellular IVM concentration by the activated macrolide efflux pump(s). With the high IVM degradation efficiency, A. taiwanensis ZJB-18,044 may serve as a bioremediation agent for IVM and other macrolides in the environment.