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  • ||||||||||  ivermectin topical / Generic mfg.
    Strongyloides Colitis: An Inflammatory Bowel Disease Imitator (Exhibit Hall) -  Jul 29, 2023 - Abstract #ACG2023ACG_797;    
    In cases where Strongyloidiasis is diagnosed, treatment with ivermectin shows effective results (9). Figure: Ulcerations in the cecum
  • ||||||||||  Journal:  The search for better treatment strategies for mansonellosis: An expert perspective. (Pubmed Central) -  Jul 21, 2023   
    We recommend that human infections with Mansonella species be treated, regardless of any apparent clinical manifestations. We argue that mansonellosis, despite being widely considered a benign infection, may represent a direct or indirect cause of significant morbidity that remains poorly characterized at present.
  • ||||||||||  ivermectin oral / Generic mfg.
    Phase classification:  Ivermectin Therapy for Scabies Infection in Children Younger Than 5 Years of Age (ITCHY Study) (clinicaltrials.gov) -  Jul 20, 2023   
    P2,  N=100, Recruiting, 
    We argue that mansonellosis, despite being widely considered a benign infection, may represent a direct or indirect cause of significant morbidity that remains poorly characterized at present. Phase classification: P4 --> P2
  • ||||||||||  ivermectin oral / Generic mfg., albendazole / Generic mfg., ivermectin topical / Generic mfg.
    Journal:  Albendazole - Ivermectin combination decreases inflammation in experimental neurocysticercosis. (Pubmed Central) -  Jul 17, 2023   
    The current treatment is performed with anthelminthic drugs - albendazole (ABZ) or praziquantel - associated with anti-inflammatory and corticosteroids in order to prevent the negative effects of the inflammatory reaction to the parasite's death...The IVM monotherapy and ABZ-IVM combination showed more degenerated cysticerci, less inflammatory infiltration, meningitis and hyperemia than the other groups. Therefore, it is possible to recommend the combination of albendazole and ivermectin as alternative chemotherapy for NCC due to its antiparasitic and anti-inflammatory effects, with potential to decrease the negative effects of the inflammatory burst when the parasite is killed within the CNS.
  • ||||||||||  metformin / Generic mfg., ivermectin oral / Generic mfg., fluvoxamine / Generic mfg.
    Trial completion date:  COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19) (clinicaltrials.gov) -  Jul 13, 2023   
    P3,  N=1323, Active, not recruiting, 
    Therefore, it is possible to recommend the combination of albendazole and ivermectin as alternative chemotherapy for NCC due to its antiparasitic and anti-inflammatory effects, with potential to decrease the negative effects of the inflammatory burst when the parasite is killed within the CNS. Trial completion date: Feb 2023 --> Feb 2024
  • ||||||||||  moxidectin / Generic mfg.
    Enrollment closed, Enrollment change, Trial primary completion date:  EOLoa: Clinical Trial Evaluating the Safety and Efficacy of Moxidectin 2 mg Ivermectin-controlled in Loa Loa Microfilaremic Patients (clinicaltrials.gov) -  Jul 12, 2023   
    P2,  N=72, Active, not recruiting, 
    Being potentially curative in one intervention round, this combination should be considered for population group faced with challenges of achieving adequate coverage and adhesion to ivm MDA over prolonged period (>10 years). Recruiting --> Active, not recruiting | N=220 --> 72 | Trial primary completion date: Feb 2023 --> Aug 2023
  • ||||||||||  ivermectin oral / Generic mfg.
    Journal:  COVID-19 pharmaceuticals in aquatic matrices: The threatening effects over cyanobacteria and microalgae. (Pubmed Central) -  Jul 10, 2023   
    This study examined the presence of three repositioned drugs used for COVID-19 treatment: azithromycin (AZI), ivermectin (IVE) and hydroxychloroquine (HCQ) in water samples collected from three urban rivers in Curitiba, Brazil, during August and September 2020...The use of AZI, IVE and HCQ for COVID-19 treatment may have generated surface water contamination, which could increased their potential ecotoxicological effects. This raises the need to further investigation into their effects on aquatic ecosystems.
  • ||||||||||  ivermectin oral / Generic mfg.
    Journal:  Reliability evaluation in rural Congo of the calibrated blood smear technique to assess Loa loa microfilaremia level (Pubmed Central) -  Jul 4, 2023   
    All estimated coefficients of variability were lower than the calculated acceptable coefficients suggesting reliability of the technique, although the lack of laboratory references precludes any conclusion on the quality of this diagnosis. It is imperative to implement a quality system and standardization of procedures for the diagnosis of L. loo microfilaremia, both in endemic countries and in the rest of the world, where the demand for diagnosis has been increasing for years.
  • ||||||||||  albendazole / Generic mfg.
    Successfully Cured of Cutaneous Larva Migrans with Oral Albendazole on unsual site: A Case Report () -  Jul 3, 2023 - Abstract #WCD2023WCD_7615;    
    In addition, mometasone furoate 0.1% topically twice daily was applied on the hyperpigmentation and serpiginous erythematous lesions...KEY MESSAGE: CLM is a skin infestation caused by penetration and migration in the epidermis of larvae of nematodes. Oral albendazole has an important role to against infections caused by nematodes and leads to rapid resolution of the lesions confirmed the initial diagnosis of cutaneous larva migrans.
  • ||||||||||  ivermectin oral / Generic mfg.
    Scabies: a confusing simulator () -  Jul 3, 2023 - Abstract #WCD2023WCD_7590;    
    Dermoscopic examination as well as parasitological study of sub-nail samples are keys for positive diagnosis. It is also necessary to make patients aware of the dangers of self-medication with corticosteroids
  • ||||||||||  ivermectin oral / Generic mfg.
    Good Efficacy And Safety Of Seven Consecutive Days Of 5% Permethrin Cream For Crusted Scabies () -  Jul 3, 2023 - Abstract #WCD2023WCD_7490;    
    When oral ivermectin is not available, repeated use of topical scabicides can be used as an alternative treatment...KEY MESSAGE: Permethrin cream is the gold standard for the treatment of scabies, because the therapeutic success rate reaches 90% with a very good safety level. Repeated single therapy of 5% permethrin cream without systemic therapy gives a good result and safety for crusted scabies
  • ||||||||||  ivermectin oral / Generic mfg.
    Erythroderma secondary to crusted scabies in immunocompromised patient () -  Jul 3, 2023 - Abstract #WCD2023WCD_7473;    
    He was treated with oral ivermectin 200mcg/kg/dose given on day 1,2,8,9 and 15 and 25% benzoyl benzoate applied daily for 7 days, then twice weekly for 5 weeks and keratolytic...This case indicates that crusted scabies is associated with HIV infection and that it can result in erythroderma. And since typical symptoms of scabies are usually absent, high index of suspicion is necessary to reach to diagnosis
  • ||||||||||  Cutaneous Larva Migrans In Infancy () -  Jul 3, 2023 - Abstract #WCD2023WCD_7434;    
    The child has a history of using oral Mebendazole 2.5 mls for 3 days during the course of this illness with no improvement...The use of oral Ivermectin to children and infants <15kg is off label and there is still limited data of its benefits that are available. Above, is a case of an infant who has a clinical response to cutaneous larva migrans with oral Ivermectin
  • ||||||||||  ivermectin oral / Generic mfg.
    Crusted Scabies In An Elderly Patient With Diabetes Mellitus: A Case Report () -  Jul 3, 2023 - Abstract #WCD2023WCD_7429;    
    His lesions were completely resolved after being treated with topical sulphur ointment and oral ivermectin for 2 weeks...KEY MESSAGE: Crusted scabies is a severe form of scabies presenting with hyperkeratotic plaques and erythema that contain numerous scabies mites and eggs, and it mostly occurs in people who have a weakened immune system or a neurological disease, the elderly, and the disabled. We would like to present this case in order to show a special picture of crusted scabies on the palms which is impressive and educational, and to emphasize the importance of considering Crusted scabies in the diagnosis of dermatological diseases presenting with hyperkeratotic plaques and erythema combined with immunocompromised condition and neuropathy due old age, long history of diabetes and long-term misuse of topical steroids.
  • ||||||||||  cetirizine oral / Generic mfg., ivermectin oral / Generic mfg., gentamicin sulfate / Generic mfg.
    Combination Therapy Permethrin 5% Cream With Soap And Cream Tea Tree Oil 5% In A Scabies Patient: A Case Report () -  Jul 3, 2023 - Abstract #WCD2023WCD_7415;    
    Treatment consists of topical agents containing acaricides (5% permethrin, 10%-25% benzyl benzoate, 10% crotamiton) and oral ivermectin...The patient was treated with 10 mg cetirizine tablets once-a-day at night, 5% permethrin cream once-a-week, cream gentamicin twice-a-day on the erosion area and education to prevent transmission and re-infection...KEY MESSAGE: One of the new additional therapy that have a good effect on scabies is TTO. In this case, administration of creams and soaps containing 5% TTO could significantly reduce pruritus in the patient
  • ||||||||||  ivermectin oral / Generic mfg.
    Disseminated lichen planus after SARS-CoV-2 infection: a new trigger to be considered? () -  Jul 3, 2023 - Abstract #WCD2023WCD_5178;    
    She had previously been prescribed many different therapies: corticosteroids, antihistamines and oral ivermectin without improvement...A new course of treatment was then started, with prednisone 1 mg/kg for 30 days, leading to complete remission of lesions...LP cases following SARS-CoV-2 vaccination also develop a few lesions, with only one report of widespread skin lesions after first dose of Pfizer-BioNTech COVID-19 vaccine. Immune system dysregulation triggered by SARS-CoV-2 is similar to that observed on LP pathogenesis and may therefore act as a precipitating factor
  • ||||||||||  ivermectin oral / Generic mfg.
    Review, Journal:  A Comprehensive Update of Various Attempts by Medicinal Chemists to Combat COVID-19 through Natural Products. (Pubmed Central) -  Jul 2, 2023   
    Despite trying to handle the pandemic with the repurposing of some drugs, such as chloroquine, hydroxychloroquine, remdesivir, lopinavir, ivermectin, etc., against COVID-19, the SARS-CoV-2 virus continues its out-of-control spread...This article deals with the literature reports to date of natural products showing inhibitory activity towards SARS-CoV-2 through different approaches, such as in vivo, in vitro, and in silico studies. Natural compounds targeting the proteins of SARS-CoV-2-the main protease (M), papain-like protease (PL), spike proteins, RNA-dependent RNA polymerase (RdRp), endoribonuclease, exoribonuclease, helicase, nucleocapsid, methyltransferase, adeno diphosphate (ADP) phosphatase, other nonstructural proteins, and envelope proteins-were extracted mainly from plants, and some were isolated from bacteria, algae, fungi, and a few marine organisms.
  • ||||||||||  ivermectin oral / Generic mfg.
    Journal:  Theoretical study of chemical reactivity descriptors of some repurposed drugs for COVID-19. (Pubmed Central) -  Jun 26, 2023   
    The HOMO and LUMO orbital energies were calculated to obtain the energy gap of the studied drugs, which is in the following order: Favipiravir?<?Hydroxychloroquine, Remdesivir?<?Ivermectin?<?Artesunate?<?Artemether?<?Artemisinin. Generally, molecules with a larger energy gap have lower chemical reactivity and higher kinetic stability.
  • ||||||||||  ivermectin oral / Generic mfg., ivermectin topical / Generic mfg.
    Journal:  In brief: OTC ivermectin for head lice. (Pubmed Central) -  Jun 24, 2023   
    All therapies showed similar low efficacy in treating trichuriasis in C No abstract available