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- || ivermectin oral / Generic mfg.
Clinical, Review, Journal: The mechanisms of action of Ivermectin against SARS-CoV-2: An evidence-based clinical review article. (Pubmed Central) - Jun 16, 2021
This evidence-based review article aims to discuss the mechanism of action of ivermectin against SARS-CoV-2 and summarizing the available literature over the years. A schematic of the key cellular and biomolecular interactions between Ivermectin, host cell, and SARS-CoV-2 in COVID-19 pathogenesis and prevention of complications have been proposed.
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Clinical, Review: Today the prestigious Nature magazine published an article about Covid and Ivermectin. Your opinion please The mechanisms of action of Ivermectin against SARS-CoV-2: An evidence-based clinical review article https://t.co/UCGXqId2R7 (Twitter) - Jun 15, 2021
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Clinical, Review: A Must Read to YOU all @doctorsoumya @mvankerkhove @DrTedros @who @DrEricDing mechanisms of action of Ivermectin against SARS-CoV-2: An evidence-based clinical review article https://t.co/Pai50sDN6w (Twitter) - Jun 15, 2021
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How about you push for Ivermectin to be licensed for covid treatment as is? Instead of non big issue exhausting 🌈 propoganada (Twitter) - Jun 15, 2021
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Clinical: #ivermectin #IvermectinSavesLives #ivermectine ... what's been generally bizarre is that Governments worldwide relied on health bureaucrats, most notably #DrFauci #Fauci, rather than doctors actually treating #covid19 patients like @McCulloughBHVH #sankaranchetty (Twitter) - Jun 15, 2021
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Retrospective data, Review: Ivermectin for Prevention and Treatment of COVID-19 Infection: a Systematic Review and Meta-analysis https://t.co/pkSkAMEBNz https://t.co/33BO00ukQW (Twitter) - Jun 14, 2021
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Clinical: It’s funny, supposedly ivermectin is being used all over South America and Mexico. Supposedly ivermectin would have cured covid 6 months ago, funny those countries still have covid…such a vast conspiracy theory. Every doctor, every researcher, every hospital..all in on it! (Twitter) - Jun 14, 2021
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Clinical: No data available to suggest a link between India’s reduction of COVID-19 cases and the use of ivermectin https://t.co/7tOo0OyZ8D (Twitter) - Jun 14, 2021
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Clinical: I used ivermectin on a single 🐈 patient with feline covid- we've studied for decades. My N=1 didn't respond. I believe Gilead has a more effective drug it didn't push for EUA because of you'll never guess...patents & $ But ivermectin has a long history of safe use in people. (Twitter) - Jun 14, 2021
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Preclinical: Vinay, @MonicaGandhi9 and @ZDoggMD are by far the three biggest arrogant morons in the Covid space. They sound sane until you listen closely. Prasad’s going to look like a dumpster rat after crapping on Ivermectin (Twitter) - Jun 13, 2021
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Clinical: Merck which manufactures the brand name version of Ivermectin has said there is "no meaningful evidence of its efficacy in Covid-19 treatment". Its good that TN government stayed away from recommending Ivermectin in its covid protocol. Link: https://t.co/bYOnY3AiO4 (Twitter) - Jun 13, 2021
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Clinical: Baseless & offense to all docs who work their a**es off using Ivermectin to save ppl from covid AND an experimental vaccine. (Twitter) - Jun 13, 2021
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Let's say Ivermectin does show promising results in COVID, does anyone have a link or paper to the proposed possible mechanism? (Twitter) - Jun 13, 2021
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Clinical: Dr Nyjon Eccles describes how #ivermectin saved his mother’s life —rapidly — when hospitalized (and not improving) with #COVID19. But how many millions have died, without having a doctor for a son able to especially organise Ivermectin to be administered? https://t.co/gN8q0yPlu7 (Twitter) - Jun 13, 2021
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Clinical: You disagree with using Ivermectin ? How are you treating your covid patients ? Have you taken the time to look at Dr Tess Lawrie’s work? She is a research expert. Her company is @EvidenceLimited Take a look @BIRDGroupUK (Twitter) - Jun 13, 2021
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Only the #CovidCult are against Ivermectin (Twitter) - Jun 13, 2021
- ||| hydroxychloroquine / Generic mfg., ivermectin oral / Generic mfg.
@PierreKory @EdoajoEric @Covid19Critical @Covid19Crusher @McCulloughBHVH #ivermectin #HydroxyChloroquine (Twitter) - Jun 13, 2021
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Clinical: Small RCT of #ivermectin in a symptomatic #SARSCoV2 + pts showing benefits. https://t.co/L35p8YX9Nr @Medscape @NYTScience @JAMA_current (Twitter) - Jun 12, 2021
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Clinical: I use to have this view. But now its quite obvious this is very naive POV. In today’s world, disinformation, that spreads rapidly and rampantly online leads to ppl dying. If even 1 person dies of covid bc they thought ivermectin was equal to a vaccine, that enough for me. (Twitter) - Jun 12, 2021
- || ivermectin oral / Generic mfg.
There is fuck all risk. It's all a complete fraud. It's practically common knowledge. #covidfraud #ivermectinworks (Twitter) - Jun 12, 2021
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Journal: Drugs that target early stages of Onchocerca volvulus: A revisited means to facilitate the elimination goals for onchocerciasis. (Pubmed Central) - Jun 12, 2021
Prophylaxis of onchocerciasis is not a new concept. We present new data showing that these drugs can inhibit L3 molting and/or inhibit motility of L4 at IC50 and IC90 that are covered by the concentration of these drugs in plasma based on the corresponding pharmacological profiles obtained in human clinical trials when these drugs were tested using various doses for the therapeutic treatments of various helminth infections.
- || chloroquine phosphate / Generic mfg., hydroxychloroquine / Generic mfg., ivermectin oral / Generic mfg.
Clinical, P2 data, Journal: Phase 2 randomized study on chloroquine, hydroxychloroquine or ivermectin in hospitalized patients with severe manifestations of SARS-CoV-2 infection. (Pubmed Central) - Jun 12, 2021
To be older than 60 years of age, obesity, diabetes, extensive pulmonary involvement and low SaO at hospital admission due to independent risk factors for mortality. Although CQ, HCQ or ivermectin revealed a favorable safety profile, the tested drugs do not reduce the need for supplemental oxygen, ICU admission, invasive ventilation or death, in patients hospitalized with a severe form of COVID-19.
- || ivermectin oral / Generic mfg.
Use Ivermectine in early stage Covid-19: cheap, very safe and good results. Listen to Pierre Kory (Twitter) - Jun 11, 2021
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Clinical, Clinical data, Journal: Effects of a Single Dose of Ivermectin on Viral and Clinical Outcomes in Asymptomatic SARS-CoV-2 Infected Subjects: A Pilot Clinical Trial in Lebanon. (Pubmed Central) - Jun 11, 2021
Ivermectin appears to be efficacious in providing clinical benefits in a randomized treatment of asymptomatic SARS-CoV-2-positive subjects, effectively resulting in fewer symptoms, lower viral load and reduced hospital admissions. However, larger-scale trials are warranted for this conclusion to be further cemented.
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Review, Journal: Ivermectin gegen Hakenwurm - und Coronavirus? (Pubmed Central) - Jun 11, 2021
However, larger-scale trials are warranted for this conclusion to be further cemented. No abstract available
- ||||| hydroxychloroquine / Generic mfg., ivermectin oral / Generic mfg.
Clinical: Now we need the data from a large multicentre study on the role of HCQ in the treatment of COVID. If ICMR hasn't initiated the study, we need to. We also need prophylaxis and treatment studies on ivermectin. @doctorsoumya @PrinSciAdvGoI (Twitter) - Jun 11, 2021
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Clinical: AIIMS should conduct clinical study on Ivermectin prophylaxis. Every bit of armour against Covid shud be deployed. Ivermectin is proven safe, inexpensive, AIIMS BBS studies showed effective prophylaxis. Low risk-High reward potential. @aiims_newdelhi @ProfBhargava @MoHFW_INDIA (Twitter) - Jun 11, 2021
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From what I see in this trial as well, Ivermectine reduces symptomatic COVID and ARS by 50%, and it’s significant. Any weird IRB here ? @boulware_dr (Twitter) - Jun 10, 2021
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Clinical: WARNING WARNING #ivermectin MUST BE ADMINISTERED TO CHILDREN NOT VACCINES. #ivermectinworks #IvermectinSavesLives @drharshvardhan @MoHFW_INDIA @Drs4CovidEthics @ICMRDELHI @IMAIndiaOrg @ProfBhargava @yogrishiramdev @amitabhk87 @adgpi @GitaGopinath @WHO @CDCgov @BBCWorld @CNN (Twitter) - Jun 10, 2021
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Clinical: WARNING WARNING #ivermectin MUST BE ADMINISTERED TO CHILDREN NOT VACCINES. #ivermectinworks #IvermectinSavesLives @drharshvardhan @MoHFW_INDIA @Drs4CovidEthics @ICMRDELHI @IMAIndiaOrg @ProfBhargava @yogrishiramdev @amitabhk87 @adgpi @GitaGopinath @WHO @CDCgov @BBCWorld @CNN (Twitter) - Jun 10, 2021
- | ivermectin oral / Generic mfg.
New P4 trial: I-TECH: Ivermectin Treatment Efficacy in Covid-19 High Risk Patients (clinicaltrials.gov) - Jun 10, 2021
P4, N=500, Not yet recruiting, Sponsor: Clinical Research Centre, Malaysia
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PK/PD data, Journal: The effect of food on the pharmacokinetics of oral ivermectin. (Pubmed Central) - Jun 10, 2021
No abstract available In this analysis, the effect of a high-fat breakfast compared with a fasted-state administration of a single oral dose of 12 mg ivermectin was minimal.
- | ivermectin oral / Generic mfg.
Journal: Scabies. (Pubmed Central) - Jun 10, 2021
Repeated therapeutic failure when permethrin was used under controlled conditions and documented mechanisms for increased tolerance may indicate the last possibility. We therefore call for additional research on this topic.
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Journal: Oral ivermectin for a scabies outbreak in a long-term-care facility: Potential value in preventing COVID-19 and associated mortality? (Pubmed Central) - Jun 10, 2021
COVID-19 therapeutic agents remain sparce and ivermectin, an antiparasitic showed anti-SARS-CoV-2 activity in vitro. Moxidectin, another macrocyclic lactone, with a longer plasma half-life, could be considered too.
- | Veramyst (fluticasone furoate nasal spray) / GSK
Enrollment open: ACTIV-6: COVID-19 Study of Repurposed Medications (clinicaltrials.gov) - Jun 10, 2021
P3, N=15000, Recruiting, Sponsor: Susanna Naggie, MD
Moxidectin, another macrocyclic lactone, with a longer plasma half-life, could be considered too. Not yet recruiting --> Recruiting
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Clinical: Ivermectin can also be used to prevent covid or during covid safely. The evil kosher vaccine lobby who holds world health org ( WHO ) and US CDC by their short curlies, runs down ivermectin. https://t.co/Rc4vUr3tJI (Twitter) - Jun 9, 2021
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@doctorsoumya @PSampathkumarMD @celinegounder Madam,I need to clarify How effective is Ivermectin? Is there any relationship between Ivermectin and morality due to Covid-19? Thanks in advance. (Twitter) - Jun 9, 2021
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@drbeen_medical has been following all the studies for over a year. Bangladesh has used Ivermectin since may 2020. With 78 deaths per million compared to Average of 1800 in UK. What was the harm done, nothing. Where is the covid emergency? https://t.co/tEoQqGtSmV (Twitter) - Jun 9, 2021
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Clinical: Hi Bret, Can you please have @VPrasadMDMPH on your show to discuss Ivermectin.Vinay, like yourself, has been a rare source of commonsense on all things Covid and he has valid doubts on Ivermectin and he has expertise in public health policy. (Twitter) - Jun 9, 2021
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Clinical: Can ivermectin, fluvoxamine, or metformin reduce the risk of clinical deterioration? reduce hospitalization? reduce #LongCovid symptoms? when started early for #COVID19? Lots of promising data, but large nationwide trial seeks definitive answers. https://t.co/JqAM3WDyyI (Twitter) - Jun 9, 2021
- ||||| metformin / Generic mfg., ivermectin oral / Generic mfg., fluvoxamine / Generic mfg.
Clinical: US Nationwide trial for #COVID19 testing #ivermectin vs. #fluvoxamine vs. +/- Metformin for outpatient, early #coronavirus with <7days of symptoms. Participate from home - remote trial by phone/internet. No in-person visits needed. https://t.co/ALcoIdBbqn (Twitter) - Jun 9, 2021
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Clinical: @boulware_dr any thoughts on India taking ivermectin out of the covid protocol despite evidence that providences that used it earlier had a much lower death rate? (Twitter) - Jun 9, 2021
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My entire family Covid 3/2020 I never got it - actively drank from sick friends glass all night - finally got it - 2 days with ivermectin , got my antibodies and stayed in for 2 weeks even though I was only sick 48 hours (Twitter) - Jun 9, 2021
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Critical!! @PMOIndia @narendramodi @drharshvardhan @MoHFW_INDIA @ICMRDELHI @icmr_niv @IMAIndiaOrg @CDSCO_INDIA_INF @drvgsomani @ProfBhargava @NITIAayog @amitabhk87 @RajivKumar1 @jayalal10 Only #ivermectin can prevent 3rd wave of #COVID19 which will destroy India's economy (Twitter) - Jun 9, 2021
- || Actemra IV (tocilizumab) / Roche, JW Pharma, Soliris (eculizumab) / Alexion Pharma
Biomarker, Clinical, Review, Journal: Pharmacogenomics and COVID-19: clinical implications of human genome interactions with repurposed drugs. (Pubmed Central) - Jun 9, 2021
These drugs include chloroquine (CQ), hydroxychloroquine (HCQ), azithromycin, lopinavir/ritonavir (LPV/r), atazanavir (ATV), favipiravir (FVP), nevirapine (NVP), efavirenz (EFV), oseltamivir, remdesivir, anakinra, tocilizumab (TCZ), eculizumab, heme oxygenase 1 (HO-1) regulators, renin-angiotensin-aldosterone system (RAAS) inhibitors, ivermectin, and nitazoxanide...The major drug variant pairs that associated with variations in clinical efficacy include CQ/HCQ (CYP2C8, CYP2D6, ACE2, and HO-1); azithromycin (ABCB1); LPV/r (SLCO1B1, ABCB1, ABCC2 and CYP3A); NVP (ABCC10); oseltamivir (CES1 and ABCB1); remdesivir (CYP2C8, CYP2D6, CYP3A4, and OATP1B1); anakinra (IL-1a); and TCZ (IL6R and FCGR3A). The major drug variant pairs that associated with variations in adverse effects include CQ/HCQ (G6PD; hemolysis and ABCA4; retinopathy), ATV (MDR1 and UGT1A1*28; hyperbilirubinemia; and APOA5; dyslipidemia), NVP (HLA-DRB1*01, HLA-B*3505 and CYP2B6; skin rash and MDR1; hepatotoxicity), and EFV (CYP2B6; depression and suicidal tendencies).
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Preclinical, Journal: Establishment of an in vitro culture system to study the developmental biology of Onchocerca volvulus with implications for anti-Onchocerca drug discovery and screening. (Pubmed Central) - Jun 9, 2021
The present study describes an in vitro system in which O. volvulus L3 larvae can be maintained in culture leading to the development of adult stages. Thus, this in vitro system may provide a platform to investigate mating behaviour and early stage of nodulogenesis of O. volvulus adult worms that can be used as additional targets for macrofilaricidal drug screening.
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Journal: Ivermectin as a potential treatment for COVID-19? (Pubmed Central) - Jun 9, 2021
Thus, this in vitro system may provide a platform to investigate mating behaviour and early stage of nodulogenesis of O. volvulus adult worms that can be used as additional targets for macrofilaricidal drug screening. No abstract available
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Clinical: Ivermectin is a broad spectrum antihelminthic. To survive in our body, helminths tweak our immune system. So there are no obvious symptoms or pathology in most cases. In other words, it becomes a 'comorbidity' in COVID-19. (Twitter) - Jun 9, 2021
- || hydroxychloroquine / Generic mfg., ivermectin oral / Generic mfg.
I wish @TGAgovau would look at HydroxyChloroquine and ivermectin in regards to covid…. (Twitter) - Jun 9, 2021
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Clinical: Huge success in #Delhi over #C19Deaths, #C19prevalence 📉 >96% within days🎉👏👏 Coincided with adoption of #AIIMS (All India Institute of Medical Sciences Covid )protocol, incldg #ivermectin kits for #c19Early outpatients & #C19prophylaxis @aiims_newdelhi @Covid19Critical (Twitter) - Jun 8, 2021