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Journal: Why onchocerciasis transmission persists after 15 annual ivermectin mass drug administrations in South-West Cameroon. (Pubmed Central) - Jun 26, 2021 Such persisting historical memories and fear of ivermectin might impact adherence to CDTI also in areas with historical presence but current absence of loiasis. Because such issues are unlikely to be tackled by CDTI adaptive measures, alternative strategies are needed for onchocerciasis elimination where negative perception of ivermectin is an entrenched barrier to community participation in programmes.
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Clinical, Journal: Reply to "Ivermectin Treatment May Improve the Prognosis of Patients With COVID-19". (Pubmed Central) - Jun 26, 2021 Because such issues are unlikely to be tackled by CDTI adaptive measures, alternative strategies are needed for onchocerciasis elimination where negative perception of ivermectin is an entrenched barrier to community participation in programmes. No abstract available
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Clinical, Review, Journal: A narrative review of pharmacologic treatments for COVID-19: safety considerations and ototoxicity. (Pubmed Central) - Jun 26, 2021 Recognition of hearing loss, tinnitus or imbalance/vertigo is therefore crucial to facilitate early intervention and prevent long-term damage. Hospitals should consider the inclusion of audiologic monitoring protocols for patients receiving COVID-19 therapeutics with known ototoxicity, especially in high risk patient groups such as the elderly and hearing impaired.
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From each flock, 36 adult sheep were selected and divided into five groups (G1 (0.08% ivermectin), G2 (10% albendazole), G3 (5% levamisole), G4 (1% moxidectin), G5 (10% closantel) and one control group, G6)...The variables irrigated area (P = 0.002), intensive breeding (P = 0.018), uncovered enclosures (P = 0.05), cultivated (P = 0.043) and native/cultivated (P = 0.007) pastures, and rotational grazing (P = 0.013) were significantly associated with GIN infection; irrigated area (P = 0.009), semi-intensive breeding (P = 0.05), rotational grazing (P = 0.045), cultivated (P = 0.021) and native/cultivated (P = 0.04) pastures, and estimated weighing of animals (P = 0.002) were significantly associated with AR. Therefore, improved management practices and strategic deworming must be implemented to prevent the development of AR.
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Review, Journal: Familiar dermatologic drugs as therapies for COVID-19. (Pubmed Central) - Jun 26, 2021 These and other agents, some of which have proven controversial, are being scrutinized by the scientific community. We briefly review the aforementioned dermatologic drugs and describe the most recent findings relevant to their use against COVID-19.
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Clinical, Review, Journal: A fatal case of COVID-19-associated invasive pulmonary aspergillosis. (Pubmed Central) - Jun 25, 2021 On admission, he was treated with ciclesonide inhalation, ivermectin, and meropenem...However, chest computed tomography showed bilateral ground-glass attenuations, multiple nodules, and consolidation. Aspergillus fumigatus was cultured from the tracheal aspirate and he was diagnosed with COVID-19-associated invasive pulmonary aspergillosis (CAPA) and treated with liposomal amphotericin B. However, he died 28 days after admission.
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Clinical, Journal: Is there autochthonous strongyloidiasis in Spanish children? (Pubmed Central) - Jun 24, 2021 First-line treatment was ivermectin in all but one, who was treated with albendazole...• Strongyloidiasis can be life-threatening in immunosuppressed patients What is New: • Spanish children can be affected by autochthonous strongyloidiasis. • Screening for strongiloidiasis should be performed in all candidates to immunosuppresive therapies, including children.
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Journal: The Time to Offer Treatments for COVID-19. (Pubmed Central) - Jun 24, 2021 Remdesivir and high titer convalescent plasma have emergency use authorization for hospitalized patients in the U.S.A...There is a need for treatment of outpatients who contract the disease, in addition to mass immunization. We call on public health authorities to authorize treatments with known low risk and potential benefit for use in parallel with mass immunization.
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Trial completion date: Study in COvid-19 Patients With iveRmectin (CORVETTE-01) (clinicaltrials.gov) - Jun 24, 2021 P2, N=240, Recruiting, We call on public health authorities to authorize treatments with known low risk and potential benefit for use in parallel with mass immunization. Trial completion date: Sep 2021 --> May 2022
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Journal: Progress towards onchocerciasis elimination in Côte d'Ivoire: A geospatial modelling study. (Pubmed Central) - Jun 23, 2021 Maps produced predict areas at risk for ongoing infection and transmission. Onchocerciasis might be eliminated in Côte d'Ivoire in the future with a combination of sustained CDTi with high coverage, active surveillance, and close monitoring for persistent infection in previously hyper-endemic areas.
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Trial termination: COVidIVERmectin: Ivermectin for Treatment of Covid-19 (clinicaltrials.gov) - Jun 23, 2021 P2, N=93, Terminated, Gene silencing of importin-α1, a cellular target of ivermectin and a key member of the host nuclear transport complex, inhibited viral replication and largely abolished the anti-HEV effect of ivermectin. Recruiting --> Terminated; Incidence has dramatically dropped and there is lack of eligible patients
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Journal: Transition from endemic behavior to eradication of malaria due to combined drug therapies: an agent-model approach. (Pubmed Central) - Jun 22, 2021 In the agent model, the main properties of human-mosquito interactions are implemented as parameters and the model is validated by comparing simulations with real data of malaria incidence collected in the endemic malaria region of Chimoio in Mozambique. Finally, we discuss our findings in light of current drug administration strategies for malaria prevention, which may interfere with human-to-mosquito transmission process.
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