- |||||||||| Humira (adalimumab) / Eisai, AbbVie
[VIRTUAL] Immune reconstitution syndrome following discontinuation of long-term azathioprine for ulcerative colitis () - Jul 5, 2021 - Abstract #BAD2021BAD_328; His skin eruption and eosinophilia improved transiently with courses of itraconazole and ivermectin. We describe a rare case of IRIS following discontinuation of long-term azathioprine use and suspect that this entity is not well recognized...Commonly seen in the context of HIV, there have been an increasing number of reports of IRIS occurring following the withdrawal of immunosuppressive therapy such as methotrexate and adalimumab...In this subset of patients who present with skin eruptions following the cessation of immunosuppressive therapy, IRIS should be considered in the differential. The diagnosis and management, as demonstrated in our case, is challenging, requiring a multidisciplinary approach.
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[VIRTUAL] Intravenous cidofovir treatment of severe giant molluscum contagiosum presenting with myiasis () - Jul 5, 2021 - Abstract #BAD2021BAD_299; An individual funding request to commence IV cidofovir for our patient was approved based on the severity of her condition. To date, she has had 10 infusions with subjective evidence of clinical improvement and is due another four infusions. This case highlights the use of IV cidofovir in patients with refractory MC, and presents the first case of using IV cidofovir in an immunocompromised, HIV-negative woman with severe and recalcitrant MC.
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Journal: Electron Donor-Acceptor Capacity of Selected Pharmaceuticals against COVID-19. (Pubmed Central) - Jul 4, 2021 The results I present here show Valrubicin as the best electron acceptor (an anticancer drug with three F atoms in its structure) and elbasvir as the best electron donor (antiviral for chronic hepatitis C)...Ivermectin and Molnupiravir are two powerful COVID-19 drugs that are not good electron acceptors, and the fact that they are not as effective oxidants as other molecules may be an advantage...These results represent a further advance on the road towards understanding the action mechanisms of drugs used as possible treatments for COVID-19. Looking ahead, clinical studies are needed to define the importance of antioxidants in treating COVID-19.
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Clinical, Review, Journal: Evidence-based approach to early outpatient treatment of SARS-CoV-2 (COVID-19) infection. (Pubmed Central) - Jul 3, 2021 Clinicians should mindfully identify and avoid commission bias during this pandemic, especially as more data have accumulated to assist with clinically sound decision-making. We describe a more evidence-based approach to treatment of early outpatient COVID-19, stressing the availability of Food and Drug Administration emergency use authorization therapies and considering plausibly beneficial, nonprescription supplements that are generally regarded as safe.
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Review, Journal: Mass drug administration for endemic scabies: a systematic review. (Pubmed Central) - Jul 2, 2021 Further evidence is needed surrounding MDA use in urban areas with increased levels of migration. Importantly, MDA should not substitute the tackling of socioeconomic factors which contribute to endemic disease such as good sanitation and hygiene.
- |||||||||| ivermectin oral / Generic mfg., albendazole / Generic mfg.
Journal: Utilization of droplet digital PCR to survey resistance associated polymorphisms in the β tubulin gene of Haemonchus contortus in sheep flocks in Sweden. (Pubmed Central) - Jul 1, 2021 Furthermore, after establishing a mixed model and fitting our data, we found a significant (p < 0.01) difference in the average frequency of the mutation F200Y between paired, pre- and post-treatment with albendazole, samples. Although the frequency difference in samples treated with albendazole was relatively minor (88.5% in pre- and 95.6% in post-treatment), no significant (p = 0.15) change in F200Y mutation frequency was observed between the samples from the flocks treated with ivermectin (90.8% and 92.6 %, respectively).
- |||||||||| hydroxychloroquine / Generic mfg., ivermectin oral / Generic mfg.
Journal: SARS CoV-2 (COVID-19) Current Pharmacotherapy for Mother and Infant. (Pubmed Central) - Jun 30, 2021 It has led to a worldwide effort to find effective treatments, from repurposed medications to new discoveries, as well as the push to develop effective vaccines. As the race to fight this pandemic unfolds, this column provides what is currently available to combat this virus, how it has been utilized in the pregnant population, and what data have been made available about how these treatments affect fetal development and the neonate.
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