- |||||||||| ivermectin oral / Generic mfg.
Trial completion date, Trial primary completion date: ISSC: Ivermectin Safety in Small Children (clinicaltrials.gov) - Sep 8, 2023
P2, N=398, Not yet recruiting,
These findings highlight Ivermectin as a novel antiviral agent with potential for the development of drugs against PEDV infection. Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Jun 2023 --> Apr 2024
- |||||||||| ivermectin oral / Generic mfg.
Review, Journal: The Penn Medicine COVID-19 Therapeutics Committee-Reflections on a Model for Rapid Evidence Review and Dynamic Practice Recommendations During a Public Health Emergency. (Pubmed Central) - Sep 7, 2023
Our objectives are to discuss the logistics and challenges of forming an effective committee, undertaking a rapid evidence review process, aligning evidence-based guidelines with operational realities, and iteratively revising recommendations in response to changing pandemic data. We specifically discuss the arc of evidence for corticosteroids; the noble beginnings and dangerous misinformation end of hydroxychloroquine and ivermectin; monoclonal antibodies and emerging viral variants; and patient screening and safety processes for tocilizumab, baricitinib, and nirmatrelvir-ritonavir.
- |||||||||| ivermectin oral / Generic mfg.
Journal: Post-Covid condition and clinic characteristics associated with SARS-CoV-2 infection: a 2-year follow-up to Brazilian cases. (Pubmed Central) - Aug 31, 2023
The first wave of SARS-CoV-2 infection in Brazil featured extensive drug misuse, notably the ineffective COVID kit comprised of ivermectin, antimalarials and azithromycin, and elevated in-hospital mortality...Long haulers are more likely to be women, previously hospitalized, and reported a range of symptoms from muscle pain to cognitive deficit. Our longitudinal study is essential to inform public health authorities to develop strategies and policies to control the spread of the virus and mitigate its impacts on society.
- |||||||||| ivermectin oral / Generic mfg.
Journal: Post-COVID-19 cryptosporidiosis: A serious risk or mere association? (Pubmed Central) - Aug 31, 2023
Administering azithromycin, hydroxychloroquine, and ivermectin was significantly related to an increased risk of Cryptosporidium infection in group 1, whereas only azithromycin was more frequently recorded in group 2...Cryptosporidium genotype 1 was the most commonly occurring subset in individuals with post-COVID-19. The findings demonstrated that aggravating gastrointestinal manifestations, increased fecal biomarkers and anti-COVID-19 therapeutic interventions are significantly related to the existence of Cryptosporidium oocysts in patients with post-COVID-19, indicating the predominance of.
- |||||||||| metronidazole topical / Generic mfg., ivermectin oral / Generic mfg.
Demodicidosis diagnosis made easier by dermoscopy (e-Poster Hall) - Aug 30, 2023 - Abstract #EADV2023EADV_3686;
Furthermore, the IC value of ivermectin against the SARS-CoV-2 main protease was revealed to be 42.39 Various therapeutic regimens have been proposed to treat DD, including acaricides
- |||||||||| Demodicosis mimetizing GVHD ( graft versus host disease), in a bone marrow transplanted man (e-Poster Hall) - Aug 30, 2023 - Abstract #EADV2023EADV_3533;
Various therapeutic regimens have been proposed to treat DD, including acaricides Introduction & Objectives: Materials & A 50-year-old white man came to the clinic on the 123rd day after bone marrow transplantation for the treatment of myelofibrosis in the use of :prednison 40 mg every other day, sirolimus , sulfametaxol trimetropin , amoxicilin, pozaconazol , valaciclovir, pentoxifilina, deferasirox , vitamin E, calcium, vitamin D, pyridoxine...In the dermis there is a sparse lymphomononuclear infiltrate
- |||||||||| ivermectin oral / Generic mfg., ivermectin topical / Generic mfg.
Imported Tungiasis: A case report from Greece (e-Poster Hall) - Aug 30, 2023 - Abstract #EADV2023EADV_3083;
It affects the plantar surface of the feet and is endemic in many countries, with an epidemic prevalence in sub-Saharan Africa. The parasitic infection should be considered a transborder infection and included in the differential diagnosis for patients with a history of travel to endemic areas.
- |||||||||| ivermectin oral / Generic mfg.
An unusual case of crusted scabies in erythrodermic mycosis fungoides. (e-Poster Hall) - Aug 30, 2023 - Abstract #EADV2023EADV_3027;
The preserved cellular immune response would be responsible for mounting a reply against the salivary antigens generated by the mite during its feeding, thus controlling the infection. Therefore, factors that lead to a reduction in the cellular immune response make the individual more susceptible to massive infestations by Sarcoptes.
- |||||||||| ivermectin oral / Generic mfg.
Localized genital crusted lesions in an immunocompetent patient : Think about scabies. (e-Poster Hall) - Aug 30, 2023 - Abstract #EADV2023EADV_3001;
It most commonly occurs in individuals with severe immunosuppressive diseases or those who use systemic or topical immunosuppressants, which can explain the inability of the immune system to prevent an overwhelming scabies reproduction. Our patient
- |||||||||| methotrexate / Generic mfg.
Scabies in a Patient with hydatidiform mole treated with Methotrexate (e-Poster Hall) - Aug 30, 2023 - Abstract #EADV2023EADV_2969;
Our patient In conclusion, this case report highlights the challenges of managing infectious dermatological conditions in oncologic patients, particularly when methotrexate must be administered as a mandatory regimen.
- |||||||||| ivermectin oral / Generic mfg., ivermectin topical / Generic mfg.
Benzyl benzoate induced contact dermatitis complicated by a necrotizing fasciitis of the perineum (e-Poster Hall) - Aug 30, 2023 - Abstract #EADV2023EADV_2576;
Benzyl benzoate, a topical insecticide for scabies, is applied in a diluted solution with a concentration between 10% and 25% and is known to cause skin irritation and contact dermatitis. Contact dermatitis may lead to skin barrier damage and provide an ideal environment for bacteria or fungi to develop.
- |||||||||| ivermectin oral / Generic mfg., albendazole / Generic mfg.
Monitoring impact of three rounds of mass drug administration in eight high-risk villages using a three-drug regimen on lymphatic filariasis in American Samoa (5 Grand Hall K - Ballroom Level (East Tower); In-Person) - Aug 25, 2023 - Abstract #ASTMH2023ASTMH_243;
In 2018, 2019 and 2021, the American Samoa Department of Health (DOH) conducted mass drug administration (MDA) for lymphatic filariasis (LF) with ivermectin, diethylcarbamazine and albendazole (IDA) and conducted impact surveys after each MDA...DOH followed up and treated 46/48 CFA positive persons, including the 8 never treated.High MDA coverage (?65%) and a low proportion of never treated led to a decline in Mf prevalence in the defined villages. Despite Mf prevalence meeting the stop MDA target (<0.5%), high CFA prevalence, vector efficiency and frequent movement between American Samoa and LF-endemic Samoa, supports the need for another MDA, including social mobilization targeting men.
- |||||||||| ivermectin oral / Generic mfg.
Spatial analysis of the relationship of Onchocerca volvulus exposure between humans and black flies in Ethiopia (5 Grand Hall K - Ballroom Level (East Tower); In-Person) - Aug 25, 2023 - Abstract #ASTMH2023ASTMH_241;
Similarly, examination of residual spatial autocorrelation showed that incorporating fly site positivity to the model began to lower residual clustering at the 33km threshold. These findings will direct the collection and testing of flies to better elucidate the relationship between parasite prevalence in flies and humans across diverse geographies, informing cost-effective surveillance.
- |||||||||| ivermectin oral / Generic mfg., albendazole / Generic mfg.
Animals as reservoir of Brugia malayi in Belitung District, Indonesia, as a potential thread for the elimination of lymphatic filariasis in humans (5 Grand Hall K - Ballroom Level (East Tower); In-Person) - Aug 25, 2023 - Abstract #ASTMH2023ASTMH_240;
Belitung district was known to be endemic for zoophilic B. malayi but received 5 rounds of mass drug administration (MDA) with DEC and albendazole between 2006 and 2010 at high coverage, passed 3 transmission assessment surveys (TAS) and was assumed to be free of infection in 2017...Further studies have to demonstrate gene flow between the B. malayi populations in animals and humans to confirm the role of an animal reservoir. For the elimination of lymphatic filariasis, B. malayi areas with an animal reservoir may need to be declared as special zones with intensified intervention and surveillance.
- |||||||||| Veramyst (fluticasone furoate nasal spray) / GSK
Enrollment closed: ACTIV-6: COVID-19 Study of Repurposed Medications (clinicaltrials.gov) - Aug 18, 2023
P3, N=15000, Active, not recruiting,
The primary outcome and select secondary outcome data will be presented. Recruiting --> Active, not recruiting
- |||||||||| ivermectin oral / Generic mfg., ivermectin topical / Generic mfg.
Journal: Computational Prediction of the Interaction of Ivermectin with Fibrinogen. (Pubmed Central) - Aug 2, 2023
Taken together, our in silico results suggest that IVM may interfere with SP-fibrinogen binding and, potentially, decrease the formation of fibrin clots resistant to degradation. Additional in vitro studies are warranted to validate whether IVM binding to fibrinogen is sufficiently stable to prevent interaction with the SP, and potentially reduce its thrombo-inflammatory effect in vivo.
- |||||||||| ivermectin oral / Generic mfg., ivermectin topical / Generic mfg.
Preclinical, Journal: Ivermectin modulated cerebral ?-aminobutyric acid (GABA) and reduced the number of chronic Toxoplasma gondii cysts significantly in the brains of immunocompromised mice. (Pubmed Central) - Jul 31, 2023
The current study aimed to evaluate the efficacy of ivermectin (IVM) in treating latent cerebral toxoplasmosis and define its role in the neuromodulation of cerebral tissue GABA expression, conducted in an immunocompromised dexamethasone-treated mouse model infected with the ME49 Toxoplasma strain...IVM is shown in this work, not only to reduce the size and the number of Toxoplasma cystic lesions within the brain significantly with a reduction rate of 68.85% but to also increase the level of GABA local expression significantly in addition to improving cerebral histopathology. Thus, IVM by its ability to modulate GABA expression may improve such clinical situations, if used as a treatment either exclusively or in combination with other medications.
- |||||||||| Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
Baffling Presentation of Terminal Ileitis Mimicking Crohn (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_4149;
In 2019, during admission for central venous catheter-related fungal sepsis, the initiation of a gluten-free diet along with fluconazole resulted in improved symptoms, weight gain of 24 kg, and increased albumin levels (3.4 gm/dL)...Anti-parasitic therapy with ivermectin and albendazole, along with rapid tapering of previously initiated steroids, resulted in a decrease in stool frequency to 3-4/day, an increase in albumin to 3.2 gm/dL, and a weight gain of 6 kg...Strongyloidiasis often associated as a mimic of acute diseases or as a superinfection may also present as a chronic infection with a disease duration span of 3 years as witnessed in this case. Figure: A: Nematode fragments on HPE slide B: Capsule Endoscopy demonstrating significantly friable mucosa with loss of villi and ulcers C: Significantly friable mucosa with loss of villi and ulcers on retrograde spiral enteroscopy
- |||||||||| prednisone / Generic mfg., ivermectin oral / Generic mfg., ivermectin topical / Generic mfg.
The Stealthy Invader Unveiled: Duodenal Biopsy Discovers Strongyloides Stercoralis in an Immunosuppressed Patient (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_3886;
Infectious Disease was consulted and patient was started on ivermectin 200mcg/kg daily for 2 days, and prednisone dosage was lowered to 20mg once daily...Endoscopic findings of strongyloidiasis such as erythema, mucosal edema, ulcers, or friability can be nonspecific, making biopsy a valuable diagnostic tool that enables direct visualization of the Strongyloides within the affected mucosa. Figure: Image 1: EGD view of the duodenum Image 2: 10X view of the duodenum mucosa with mild active inflammation and worms consistent with Strongyloides stercoralis (black arrow) Image 3: 20X view
- |||||||||| The Taming of the Shrewd Helminth: Diagnosing Severe Colonic Trichuriasis (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_3571;
Good hygiene and proper food preparation practices are also very important in interrupting the cycle of transmission and should be stressed to patients traveling to endemic areas. Figure: Copious collection of worms burrowing into the colonic mucosa in the transverse colon with associated inflammation
- |||||||||| Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma, Creon (pancrelipase delayed-release) / AbbVie, Eisai
Pancreatic Elastase Deficiency in Gastrointestinal Strongyloidiasis (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_3119;
He was treated with neomycin, rifaximin, and creon...The lamina propria contains abundant eosinophils (>100 per high-power field). Focally, within crypts there are parasitic organisms consistent with Strongyloides stercoralis.
- |||||||||| ivermectin oral / Generic mfg.
Strongyloidiasis Causing Hemorrhagic Shock (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_2579;
Early diagnosis and treatment are imperative given the high mortality rates in patients who develop hyperinfection syndrome. Figure: Figure 1
- |||||||||| ivermectin oral / Generic mfg., albendazole / Generic mfg.
A Case of Strongyloidiasis Diagnosed by a Screening Colonoscopy (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_2185;
Strongyloides should be considered in patients with chronic gastrointestinal symptoms and eosinophilia, especially from subtropical areas and areas with poor sanitation. Figure: Eosinophilic microabscess and parasites visualized on histology
- |||||||||| ivermectin oral / Generic mfg.
Treatment with Ivermectin Increases the Population of Bifidobacterium in the Gut (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_2072;
The changes in bacterial relative abundance in individual subjects for bacteria of high physiological importance, namely the genera Bifidobacterium. Of note, the relative abundance of Bifidobacterium increased in most subjects.
|
