ivermectin oral / Generic mfg. 
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  • ||||||||||  moxidectin / Generic mfg., albendazole / Generic mfg.
    Enrollment closed:  Efficacy and Safety of MOX/ALB Co-administration (clinicaltrials.gov) -  Aug 20, 2021   
    P3,  N=282, Active, not recruiting, 
    Consequently, the clinicians should be aware of this parasitosis among the travelers or immigrants coming from endemic regions in Africa. Recruiting --> Active, not recruiting
  • ||||||||||  ivermectin oral / Generic mfg., ivermectin topical / Generic mfg.
    Clinical, Journal:  Attenuation of clinical and immunological outcomes during SARS-CoV-2 infection by ivermectin. (Pubmed Central) -  Aug 19, 2021   
    In particular, IVM dramatically reduces the Il-6/Il-10 ratio in lung tissue and promotes macrophage M2 polarization, which might account for the more favorable clinical presentation of IVM-treated animals. Altogether, this study supports the use of immunomodulatory drugs such as IVM, to improve the clinical condition of SARS-CoV-2-infected patients.
  • ||||||||||  ivermectin oral / Generic mfg., ivermectin topical / Generic mfg.
    Clinical, Review, Journal:  Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19. (Pubmed Central) -  Aug 19, 2021   
    Furthermore, results from numerous controlled prophylaxis trials report significantly reduced risks of contracting COVID-19 with the regular use of ivermectin. Finally, the many examples of ivermectin distribution campaigns leading to rapid population-wide decreases in morbidity and mortality indicate that an oral agent effective in all phases of COVID-19 has been identified.
  • ||||||||||  ivermectin oral / Generic mfg.
    Journal:  CoViTris2020 and ChloViD2020: a striking new hope in COVID-19 therapy. (Pubmed Central) -  Aug 18, 2021   
    In this new research study, I succeeded to repurpose the two antioxidant polyhydroxy-1,3,4-oxadiazole compounds CoViTris2020 and ChloViD2020 as the first multitarget coronaviral protein blockers with extremely higher potencies (reach about 65 and 304 times, for CoViTris2020, and 20 and 93 times, for ChloViD2020, more potent than remdesivir and favipiravir, respectively)...CoViTris2020 and ChloViD2020 inhibit SARS-CoV-2 life cycle with surprising EC values of 0.31 and 1.01 μM, respectively. CoViTris2020 strongly inhibits coronaviral-2 RdRp with exceptionally lower inhibitory binding energy of - 12.00 kcal/mol.
  • ||||||||||  remdesivir / Generic mfg., ivermectin oral / Generic mfg.
    Preclinical, Journal:  Combination Treatment With Remdesivir and Ivermectin Exerts Highly Synergistic and Potent Antiviral Activity Against Murine Coronavirus Infection. (Pubmed Central) -  Aug 17, 2021   
    Using an in vitro model of MHV infection of RAW264.7 macrophages, the safety and efficacy of monotherapy of remdesivir, chloroquine, ivermectin, and doxycycline were investigated...The next best synergistic combination was remdesivir with doxycycline, which decreased levels of live virus by ~3-log and viral RNA by ~1.5-log. These results warrant further studies to explore the mechanisms of action of the combination therapy, as well as future in vivo experiments and clinical trials for the treatment of SARS-CoV-2 infection.
  • ||||||||||  ivermectin oral / Generic mfg., azithromycin / Generic mfg.
    Trial completion, Enrollment change:  Evaluation of Prognostic Modification in COVID-19 Patients in Early Intervention Treatment (clinicaltrials.gov) -  Aug 16, 2021   
    P3,  N=114, Completed, 
    These results warrant further studies to explore the mechanisms of action of the combination therapy, as well as future in vivo experiments and clinical trials for the treatment of SARS-CoV-2 infection. Recruiting --> Completed | N=62 --> 114