- |||||||||| ivermectin oral / Generic mfg., albendazole / Generic mfg., tetracycline / Generic mfg.
Journal: Veterinary Drug Prescribing Practices at Selected District Veterinary Clinics of Rift Valley Areas of Ethiopia. (Pubmed Central) - Nov 21, 2021 Among the total drugs, oxytetracycline, ivermectin, penstrep, sulfa drugs, and albendazole were the most leading prescribed drugs with a frequency of 43.0%, 17.6%, 10.2%, 6.5%, and 1.3%, respectively...In conclusion, this study revealed problems in antibiotics and anthelmintics use, description of routes of administration and length of treatment, and shortage of laboratory diagnostic facilities. Therefore, veterinary drugs, particularly antibiotics and anthelmintics, should be used appropriately to safeguard the public from residual drug impacts and resistance development.
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Journal: Lack of detectable short-term effects of a single dose of ivermectin on the human immune system. (Pubmed Central) - Nov 21, 2021 P1 Overall, our data do not support a direct effect of ivermectin, when given at the dose used in current filarial elimination programmes, on the human immune system. Trial registration ClinicalTrials.gov NCT03459794 Registered 9th March 2018, Retrospectively registered https://clinicaltrials.gov/ct2/show/NCT03459794?term=NCT03459794&draw=2&rank=1 .
- |||||||||| hydroxychloroquine / Generic mfg., ivermectin oral / Generic mfg., ibuprofen / Generic mfg.
Review, Journal: Self-medication practices to prevent or manage COVID-19: A systematic review. (Pubmed Central) - Nov 17, 2021 Studies that assessed self-medication for COVID-19 found heterogeneous results regarding self-medication prevalence and medications used. More well-designed and adequately reported studies are warranted to assess this topic.
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Journal: Identification of the metabolites of ivermectin in humans. (Pubmed Central) - Nov 16, 2021 Human liver microsomes, primary human hepatocytes, and whole blood from healthy volunteers given oral ivermectin were used to identify ivermectin metabolites by ultra-high performance liquid chromatography coupled with high-resolution mass spectrometry...Demethylated (M1) and hydroxylated (M3) ivermectin were the main human in vivo metabolites. Further studies are needed to characterize the pharmacokinetic properties and mosquito-lethal activity of these metabolites.
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Enrollment open: A Phase III Confirmatory Study of K-237 (clinicaltrials.gov) - Nov 14, 2021 P3, N=1000, Recruiting, No abstract available Not yet recruiting --> Recruiting
- |||||||||| ivermectin long-acting injectable / Monash University, The Peter Doherty Institute for Infection and Immunity
New P3 trial: Ivermectin to prevent Coronavirus (EUDRACT) - Nov 12, 2021 P3, N=1000, Not yet recruiting,
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma
Clinical, Journal: Successful treatment of tocilizumab and ivermectin for a patient with ARDS due to COVID-19. (Pubmed Central) - Nov 12, 2021 These findings confirm transcriptional alterations in importins and Rho GTPases upon SARS-CoV-2 infection and point to IVM and ATV as valid drugs to impair nuclear localization of importin α when used at clinically-relevant concentrations. No abstract available
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