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Journal: Drug repurposing against SARS-CoV-1, SARS-CoV-2 and MERS-CoV. (Pubmed Central) - Dec 2, 2021 Herein, we aim to review drugs with in vitro antiviral activity against SARS-CoV-2, combined with molecular docking data and results from preliminary clinical studies. Finally, when considering all these previous findings, as well as the possibility of oral administration, 11 molecules consisting of nelfinavir, favipiravir, azithromycin, clofoctol, clofazimine, ivermectin, nitazoxanide, amodiaquine, heparin, chloroquine and hydroxychloroquine, show an interesting antiviral activity that could be exploited as possible drug candidates for COVID-19 treatment.
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Review, Journal: Photo-mediated and advanced oxidative processes applied for the treatment of effluents with drugs used for the treatment of early COVID-19: Review. (Pubmed Central) - Dec 1, 2021 Among them are chloroquine (CQ), hydroxychloroquine (HCQ), ivermectin (IVM), and the combination of QC or HCQ and azithromycin (AZI)...As the conventional effluent treatment processes do not have high efficiency for removal, it was concentrated in the literature that had as scope advanced and photo-mediated techniques to remove CQ, HCQ, IVM, and AZI. It is expected, with this work, to highlight the importance of conducting research that contributes to the control of pollution and contamination.
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Review, Journal: Potential use of ivermectin for the treatment and prophylaxis of SARS-CoV-2 infection. (Pubmed Central) - Dec 1, 2021 In the view of the available evidence, the Frontline COVID-19 Critical Care Alliance (FLCCC) recommends the use of oral ivermectin for both prophylaxis and early-treatment of COVID-19. Further well-designed studies should be conducted in order to explore the efficacy and safety of invermectin at low and high doses, following different dosing schedules, in both, the short and long-term treatment.
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Clinical, Journal: Formulation, Physical Stability, and the Clinical Effectiveness of Extemporaneous Ivermectin Oral Solution. (Pubmed Central) - Dec 1, 2021 This formula provides a stable, efficient oral solution for those who suffer from swallowing difficulties or patients in the intensive care unit who cannot receive the medication in a solid dosage form. Using the suggested formula, community and hospital pharmacists could prepare an effective, high quality ivermectin oral solution using pure ivermectin powder.
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Journal: Strongyloidiasis: the most neglected tropical disease in Ethiopia. (Pubmed Central) - Nov 29, 2021 Moreover, studies on strongyloidiasis should use sensitive diagnostic tools. Strongyloidiasis control and elimination programs should be based on reliable evidence of epidemiology of the disease in Ethiopia.
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Journal: Early-life exposure to Ivermectin alters long-term growth and disease susceptibility. (Pubmed Central) - Nov 25, 2021 More research is needed to understand the underlying mechanism behind this phenomenon. Given that Ivermectin exposure altered disease susceptibility, proper controls should be implemented when utilizing this drug as an antiparasitic treatment in research studies.
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Myeloid/Lymphoid Neoplasm with Eosinophilia and a Novel RUFY1-Pdgfrb Rearrangement () - Nov 24, 2021 - Abstract #ASH2021ASH_6623; Initial treatment included high dose steroids for 7 days and hydroxyurea briefly...Six weeks after starting imatinib he had renal recovery and has achieved a complete hematologic response except for mild anemia due to resolving acute kidney injury...These reports and ours highlight the clinical relevance of NGS in identifying novel rearrangement partners. Furthermore, patient-specific ddPCR assays can be designed for sensitive monitoring.
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Journal: Data on known anti-virals in combating CoVid-19. (Pubmed Central) - Nov 24, 2021 Known drugs such as chloroquine, lopinavir, favipiravir and remdesivir are used in the management of CoVid - 19...Available data also shows that ivermectin and remedesivir repress the replication of SARS-CoV-2. Thus, we document the potential use of ivermectin and remdesivir in the management of CoVid -19.
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Journal: Event-Based Surveillance of Poisonings and Potentially Hazardous Exposures over 12 Months of the COVID-19 Pandemic. (Pubmed Central) - Nov 24, 2021 At least two chemical incidents also occurred at industrial sites in India, after sites were left unattended or were closed and reopened due to lockdown measures. Reports of poisoning identified in the international media were provided to the UK National Poisons Information Service (NPIS) and contributed to the UK COVID-19 public health response.
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