- |||||||||| Germanin (suramin) / Optimum Therap
Journal, Metastases: A Landscape on Lymphatic Filariasis with its Effects and Recent Advanced Treatments. (Pubmed Central) - Feb 6, 2024
Different synthetic drugs such as Ivermectin, Doxycycline, Albendazole, and Suramin are used in the treatment...Due to these restrictions, it has been crucial to create new anti-filarial medications, which motivates researchers to find novel pharmaceuticals with anti-filarial action. In this article, we examine the latest achievements in the anti-filarial area, including the many forms of filariasis and their historical contexts, elimination programmes, various therapeutic classes (both synthetic and natural), investigated product-derived targets as well as clinical investigations.
- |||||||||| ivermectin oral / Generic mfg.
Retrospective data, Review, Journal: Comparative efficacy and safety of anti-infective drugs for patients with mild to severe COVID-19: A systematic review and network meta-analysis of randomized controlled trials. (Pubmed Central) - Feb 5, 2024
For clinical recovery at 14 days Ivermectin (OR= 3.00, 95%CI: [1.82; 4.96]; p < 0.0001; moderate certainty evidence), Baricitinib plus Remdesivir (OR= 2.20, 95%CI: [1.35; 3.53]; p = 0.005; low certainty evidence), and Favipiravir (OR= 2.16, 95%CI: [1.27; 3.68]; p = 0.004; moderate certainty evidence) were statistically effective than standard of care...Arbidol (RR= 0.46, 95% CI: [0.23; 0.95]; p = 0.04) was statistically safe drug than standard of care. This Network Meta-analysis suggests that Baricitinib plus Remdesivir is more effective than the other anti-infective drugs in treating patients with COVID-19 in terms of clinical recovery at 14 days, mortality and adverse events outcomes.
- |||||||||| ivermectin oral / Generic mfg.
Journal, Real-world evidence, Real-world: Real-world prescription of anti-COVID-19 drugs in hospitalized patients with COVID-19 in Japan. (Pubmed Central) - Jan 30, 2024
A prescribed drug would depend on the latest scientific evidence, such as efficacy, safety, and approval status, at the time of prescription. Understanding the prescription of anti-COVID-19 drugs will be important for providing the most up-to-date treatments to patients and evaluating the benefit and/or risk of anti-COVID-19 drugs based on the utilization of an electronic medical record database.
- |||||||||| ivermectin oral / Generic mfg., doxycycline / Generic mfg.
Review, Journal: Filarial disease in the Brazilian Amazon and emerging opportunities for treatment and control. (Pubmed Central) - Jan 29, 2024
While the long treatment courses required for doxycycline-based mansonellosis therapies preclude their use in control programmes, new fast-acting filarial drug treatments are likely to soon become available for the treatment of both onchocerciasis and mansonellosis in the Amazon region. Filarial disease management in the Brazilian Amazon is thus likely to become dramatically more viable at a time when the public health importance of these diseases is increasingly being recognized.
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EXPLORING THE SKIN-HEART LINK: REVEALING EOSINOPHILIC MYOCARDITIS IN AN ENIGMATIC CASE (Hall B4-5) - Jan 26, 2024 - Abstract #ACC2024ACC_3300;
Filarial disease management in the Brazilian Amazon is thus likely to become dramatically more viable at a time when the public health importance of these diseases is increasingly being recognized. For patients who present with cardiac symptoms and hypersensitivity features like rash and eosinophilia, eosinophilic myocarditis should be high on differential diagnosis.
- |||||||||| ivermectin oral / Generic mfg., albendazole / Generic mfg., ivermectin topical / Generic mfg.
TRICHINELLOSIS-INDUCED EOSINOPHILIC MYOCARDITIS EXACERBATING AORTIC STENOSIS (Hall B4-5) - Jan 26, 2024 - Abstract #ACC2024ACC_1319;
Parasite-induced inflammation and myocardial invasion may potentially exacerbate, or even accelerate valvular disease, however further research is needed. Muscle biopsy can be useful in patients unable to tolerate conventional diagnostics.
- |||||||||| ivermectin oral / Generic mfg.
Review, Journal: Strongyloidiasis. (Pubmed Central) - Jan 25, 2024
Ivermectin is the treatment of choice. Control and elimination of strongyloidiasis will require a multifaceted, integrated approach, including highly sensitive and standardized diagnostics, active surveillance, health information, education and communication strategies, improved water, sanitation and hygiene, access to efficacious treatment, vaccine development and better integration and acknowledgement in current helminth control programmes.
- |||||||||| ivermectin oral / Generic mfg.
Review, Journal: Obesity and its Relationship with Covid-19: A Review of the Main Pharmaceutical Aspects. (Pubmed Central) - Jan 23, 2024
Several drugs have been suggested to control COVID- 19 like Lopinavir, Ritonavir, Ribavirin, Sofosbuvir, Remdesivir, Oseltamivir, Oseltamivir phosphate, Oseltamivir carboxylate, Hydroxychloroquine, Chloroquine, Azithromycin, Teicoplanin, Tocilizumab, Anakinra, Methylprednisolone, Prednisolone, Ciclesonide and Ivermectin...Additionally, different aspects make the obese population more prone to persistent symptoms of the disease (long COVID), which makes understanding these mechanisms fundamental to addressing the implications of the disease. Thus, this review provides an overview of the relationship between COVID-19 and obesity, considering aspects related to pharmacokinetics, immunosuppression, immunization, and possible implications of long COVID in these individuals.
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Trial completion date: RIMDAMAL II: Repeat Ivermectin Mass Drug Administrations for MALaria Control II (clinicaltrials.gov) - Jan 11, 2024
P3, N=4124, Active, not recruiting,
New studies using more standardized approaches should be initiated to address the scarcity and inconsistency of data on morbidity management. Trial completion date: Aug 2023 --> Aug 2024
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Review, Journal: Effectiveness of Drug Repurposing and Natural Products Against SARS-CoV-2: A Comprehensive Review. (Pubmed Central) - Jan 10, 2024
Using these tools, new uses for approved drugs such as chloroquine, hydroxychloroquine, ivermectin, zidovudine, ribavirin, lamivudine, remdesivir, lopinavir and tenofovir/emtricitabine have been conducted, showing effectiveness in vitro and in silico against SARS-CoV-2 and some of these, also in clinical trials...This review shows the evidence of drug repurposing efficacy and the potential use of natural products as a treatment for COVID-19. For this, a search was carried out in PubMed, SciELO and ScienceDirect databases for articles about drugs approved or under study and natural compounds recognized for their antiviral activity against SARS-CoV-2.
- |||||||||| Preclinical, Journal: Ascaridia galli, a common nematode in semiscavenging indigenous chickens in Bangladesh: epidemiology, genetic diversity, pathobiology, ex vivo culture, and anthelmintic efficacy. (Pubmed Central) - Jan 7, 2024
However, albendazole (ABZ), mebendazole (MBZ), and piperazine (PPZ) did not kill the worms even at 120 ?g/mL and 1mg/mL concentrations, respectively...Ascaridia galli can be easily maintained ex vivo in egg white supplemented M199 medium. LEV and IVM, but not ABZ, MBZ and PPZ, can be used for treating and controlling A. galli infections in chickens.
- |||||||||| chloroquine phosphate / Generic mfg., ivermectin oral / Generic mfg., erythromycin / Generic mfg.
Journal: Microfluidic Diffusion Sizing Applied to the Study of Natural Products and Extracts That Modulate the SARS-CoV-2 Spike RBD/ACE2 Interaction. (Pubmed Central) - Dec 27, 2023
Concentrations of 10 The aim of this study was to evaluate the capacity of various natural product classes, including flavonoids, anthraquinones, saponins, ivermectin, chloroquine, and erythromycin, to modulate this interaction...A methanol extract of Chenopodium quinoa Willd bitter seed husks (50
- |||||||||| ivermectin oral / Generic mfg., albendazole / Generic mfg.
Journal: Cutaneous Larva Migrans as a frequent problem in travellers. (Pubmed Central) - Dec 23, 2023
Prevention of CLM involves avoiding skin contact with potentially contaminated soil by wearing shoes and using towels and mats on the beach. Due to the high interest in travel and the risk of importing exotic diseases, it is important to promote knowledge of tropical medicine among healthcare professionals as well as the travellers.
- |||||||||| ivermectin oral / Generic mfg., albendazole / Generic mfg.
Enrollment open, Trial completion date, Trial primary completion date: Broad One Health Endectocide-based Malaria Intervention in Africa (BOHEMIA) (clinicaltrials.gov) - Dec 19, 2023
P3, N=53000, Recruiting,
were found to be 177? Active, not recruiting --> Recruiting | Trial completion date: Jul 2024 --> Oct 2024 | Trial primary completion date: Jul 2023 --> Apr 2024
- |||||||||| moxidectin / Generic mfg., ivermectin oral / Generic mfg., levamisole / Generic mfg.
Journal: Efficacy of levamisole, ivermectin and moxidectin against Capillaria spp. in European hedgehogs (Erinaceus europaeus). (Pubmed Central) - Dec 18, 2023
striatum often appeared refractory to treatment, and managing these infections requires additional anthelmintic therapy. Based on the formulations and dosages trialled, moxidectin is not recommended for treating capillariosis in European hedgehogs, whereas levamisole given orally for two consecutive days at 25-35 mg/kg is suggested as the treatment of choice.
- |||||||||| atorvastatin / Generic mfg., ivermectin oral / Generic mfg., ivermectin topical / Generic mfg.
Preclinical, Journal: Impact of atorvastatin and mesenchymal stem cells combined with ivermectin on murine trichinellosis. (Pubmed Central) - Dec 18, 2023
The combined mesenchymal stem cells and atorvastatin added to ivermectin showed the highest significant reduction in adult worms and encysted larvae counts, the most noticeable improvement of the histopathological changes, the most potent anti-inflammatory (lowest level of IL-17) and anti-angiogenic (lowest expression of CD31 and VEGF) activities, and also revealed the highly effective one to relieve the oxidative stress (lowest level of SOD, GSH, and lipid peroxidase enzymes). These observed outcomes indicate that adding mesenchymal stem cells and atorvastatin to ivermectin synergistically potentiates its therapeutic efficacy and provides a promising candidate against trichinellosis.
- |||||||||| Altabax (retapamulin) / GSK, Almirall
Journal: Erythromycin, retapamulin, pyridoxine, folic acid, and ivermectin inhibit cytopathic effect, papain-like protease, and M enzymes of SARS-CoV-2. (Pubmed Central) - Dec 17, 2023
The IC for all the drugs, except ivermectin, was at the clinically achievable plasma concentration in humans, which supports a possible role for the drugs in the management of COVID-19. The lack of inhibition of CPE by ivermectin at clinical concentrations could be part of the explanation for its lack of effectiveness in clinical trials.
- |||||||||| ivermectin oral / Generic mfg., levamisole / Generic mfg.
Journal: Efficacy of a fixed-dose combination injectable (0.2 (Pubmed Central) - Dec 17, 2023
Compared to ivermectin-treated heifers, overall average daily gain from all evaluation periods (Day 0-14, Day 14-56, and Day 0-56) was greater (p The post-treatment FEC and genus-specific efficacy estimations indicate the doramectin +
- |||||||||| ivermectin oral / Generic mfg., levamisole / Generic mfg.
Journal: Efficacy of a new fixed-dose combination injectable (0.2 (Pubmed Central) - Dec 17, 2023
The post-treatment FEC and genus-specific efficacy estimations indicate the doramectin + In contrast, the novel FDCI was 100% effective in treating adult and immature life stages of all cattle GINs included in the artificial infections, with no worms recovered at necropsy from doramectin +
- |||||||||| ivermectin oral / Generic mfg., albendazole / Generic mfg.
Journal: Anthelmintic Resistance of Gastrointestinal Nematodes of Communally-Grazing Goats in Humbo District, Southern Ethiopia. (Pubmed Central) - Dec 6, 2023
The FECR levels for albendazole, ivermectin, and tetramisole were 94.6, 95.9, and 97.3%, respectively...Tetramisole should be used cautiously to prevent the development of resistant strains, as it was still effective in the study area. Additionally, regular monitoring of anthelmintic effectiveness is necessary.
- |||||||||| ivermectin oral / Generic mfg.
Enrollment open: ISSC: Ivermectin Safety in Small Children (clinicaltrials.gov) - Dec 4, 2023
P2, N=398, Recruiting,
Neither ivermectin nor, isoprinosine was found to significantly decrease hospital mortality. Not yet recruiting --> Recruiting
- |||||||||| ivermectin oral / Generic mfg.
Retrospective data, Journal: The Use of Antimicrobial Drug in Patients During the COVID-19 Pandemic: A Meta-Analysis. (Pubmed Central) - Dec 4, 2023
None of the four azithromycin articles with a clinical effect as the effect index was statistically significant (P > .05), suggesting no publication bias. During the COVID-19 pandemic, the patient's use of antibiotics does not significantly improve clinical efficacy, so antibiotic use is recommended only for patients with complicated bacterial infections.
- |||||||||| ivermectin oral / Generic mfg.
Observational data, Journal: Dissemination of Registered COVID-19 Clinical Trials (DIRECCT): a cross-sectional study. (Pubmed Central) - Nov 30, 2023
Maintaining registry data enables accurate representation of clinical research; failing to do so undermines these registries' use for public accountability and analysis. Addressing rapid reporting and registry data quality must be emphasized at global, national, and institutional levels.
- |||||||||| ivermectin oral / Generic mfg.
Enrollment change, Trial termination: Treatment of Strongyloides Infection (clinicaltrials.gov) - Nov 30, 2023
P3, N=51, Terminated,
N=200 --> 51 | Recruiting --> Terminated; The original study PI passed away. Primary and Study Completion dates revised to reflect last participant examination date.
- |||||||||| ivermectin oral / Generic mfg.
Preclinical, Journal: In Vitro Analysis of SARS-CoV-2 Spike Protein and Ivermectin Interaction. (Pubmed Central) - Nov 29, 2023
The interaction was demonstrated in ratios of 1:50 pmol and 1:100 pmol (S: ivermectin) by the DARTS technique. The results obtained with these two different techniques demonstrate an interaction between S and ivermectin previously explored in silico, suggesting its clinical uses to stop the viral spread among susceptible human hosts.
- |||||||||| ivermectin oral / Generic mfg.
Observational data, Journal: Strongyloidiasis in humans and dogs in Southern Italy: an observational study. (Pubmed Central) - Nov 27, 2023
RT-PCR performed on 13 human faecal samples resulted negative. These findings suggest that strongyloidiasis is present in humans and dogs in Southern Italy, and screening in larger cohorts would be needed for more accurate estimates.
- |||||||||| ivermectin oral / Generic mfg.
Preclinical, Journal: Synergistic In Vitro Antiviral Effect of Combinations of Ivermectin, Essential Oils, and 18-(Phthalimid-2-yl)ferruginol against Arboviruses and Herpesvirus. (Pubmed Central) - Nov 25, 2023
We analyzed the possible reduction in the antiviral effective concentration of drugs already approved by the FDA, such as ivermectin (IVM), ribavirin (RIBA), and acyclovir (ACV) against Zika virus (ZIKV), Chikungunya virus (CHIKV), and herpes virus type 2 (HHV-2)...Statistical analysis showed significant differences among the combination groups tested, especially in the HHV-2 and CHIKV models, with p = 0.0098. Additionally, phthFGL showed a good pharmacokinetic profile that should encourage future optimization studies.
- |||||||||| ivermectin oral / Generic mfg., ivermectin topical / Generic mfg.
Journal: Has the Use of the Mask Exacerbated Rosacea During the Pandemic? (Pubmed Central) - Nov 22, 2023
We did not find a significant increase in relapses of papulopustular rosacea during the pandemic. An appropriate anti-parasitic treatment may reduce the number of recurrences due to mask use.
- |||||||||| ivermectin oral / Generic mfg., albendazole / Generic mfg.
Preclinical, Journal: In silico exploration and in (Pubmed Central) - Nov 22, 2023
Previous studies have revealed that routine administration of the available drugs (albendazole, ivermectin and albendazole) sometime is associated with severe adverse effects (SAEs) in co-infection state...Parasite death upon exposure to Scytonemin can be correlated with the TrxR inhibiting capacity of the compound. Therefore, this cyanobacterial-derived compound may possibly be used further as novel and safe therapeutic candidate against filarial infection.Communicated by Ramaswamy H. Sarma.
- |||||||||| ivermectin oral / Generic mfg.
Review, Journal: Assessing the Potential Contribution of In Silico Studies in Discovering Drug Candidates That Interact with Various SARS-CoV-2 Receptors. (Pubmed Central) - Nov 18, 2023
In silico studies have identified several promising drug candidates, including Remdesivir, Favipiravir, Ribavirin, Ivermectin, Lopinavir/Ritonavir, and Camostat Mesylate, among others...This study is aimed at assessing the useful contributions of the application of computational instruments in the discovery of receptors targeted in SARS-CoV-2. It further highlights some identified advantages and limitations of these studies, thereby revealing some complementary experimental validation to ensure the efficacy and safety of identified drug candidates.
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