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Journal: Discovery of common molecular signatures and drug repurposing for COVID-19/Asthma comorbidity: ACE2 and multi-partite networks. (Pubmed Central) - Apr 19, 2024
Molecular docking simulations led to the proposal of 10 top-ranked repurposable drug molecules (Rapamycin, Ivermectin, Everolimus, Quercetin, Estradiol, Entrectinib, Nilotinib, Conivaptan, Radotinib, and Venetoclax) as potential treatment options for COVID-19 in individuals with comorbid asthma...This study unveils the common pathogenesis and genetic signature underlying asthma and SARS-CoV-2 infection, delineated by the interaction networks of ACE2-related host factors. These findings provide valuable insights for the design and discovery of drugs aimed at more effective therapeutics within the context of lung disease comorbidities.
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Review, Journal: COVID-19: An Update on Epidemiology, Prevention and Treatment, September-2023. (Pubmed Central) - Apr 18, 2024
At the current phase of the pandemic, nirmatrelvir/ritonavir, remdesivir, molnupiravir, sotrovimab (for patients from XBB.1.5 variant dominant settings), and convalescent plasma can be considered for the treatment of high-risk early-stage outpatients with COVID-19, while hospitalized patients with more severe disease can be treated with dexamethasone, anti cytokines including tocilizumab, sarilumab, baricitinib, and tofacitinib and antithrombotic agents including enoxaparin. Remdesivir oral analogues and ensitrelvir fumarate are promising agents for treating acute COVID-19, which are in phase trials now; however, ivermectin, fluvoxamine, and metformin were shown to be ineffective.
- |||||||||| ivermectin oral / Generic mfg., ivermectin topical / Generic mfg.
Journal: Considering ivermectin for treatment of schistosomiasis. (Pubmed Central) - Apr 13, 2024
In order to ascertain possible damage and elimination of worms, we used ivermectin by oral gavage in infected mice, at a high dose (30.1 mg/kg, bordering toxicity)...We assume that the reported lack of activity of ivermectin, in comparison with praziquantel and artemisinins, originates from the difference in their mode of action. In wake of our results, we suggest that ivermectin is not a suitable drug for treatment of schistosomiasis.
- |||||||||| ivermectin oral / Generic mfg., ivermectin topical / Generic mfg.
Review, Journal: Ivermectin: A Multifaceted Drug With a Potential Beyond Anti-parasitic Therapy. (Pubmed Central) - Apr 12, 2024
It has also been suggested that ivermectin can inhibit the proliferation of tumorigenic cells through various pathways that lead to the management of certain cancers. The review aimed to evaluate its multifaceted effects and potential clinical applications beyond its traditional use as an anthelmintic agent.
- |||||||||| monepantel (PAA1) / Pharmaust
Journal: Revisiting anthelmintic resistance in sheep flocks from S (Pubmed Central) - Apr 8, 2024
Treatment studies on ivermectin use in children weighing <15 kg, user-friendly diagnostic tools, new treatment protocols, and child-friendly dosage forms are needed to improve the diagnosis and treatment of children with scabies. In each one of the 15 flocks evaluated, animals (n
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Review, Journal: Scabies in infants and children - a narrative review. (Pubmed Central) - Mar 27, 2024
The study design, combined with administration route plans and safety considerations for humans and animals, may expedite the rational optimization of IVM nanoformulations for swift clinical translation. What is New:
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Journal: Identification of inositol monophosphatase as a broad-spectrum antiviral target of ivermectin. (Pubmed Central) - Mar 25, 2024
As phosphatidylinositol phosphate is crucial for the replication of many RNA viruses, inhibition of cellular myo-inositol biosynthesis may be an important antiviral mechanism of ivermectin. Hence, inhibition of IMPase could serve as a potential target for broad-spectrum antiviral development.
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Retrospective data, Review, Journal: Ivermectin for treatment of COVID-19: A systematic review and meta-analysis. (Pubmed Central) - Mar 21, 2024
Ivermectin could reduce the risk of MV requirement and AEs in patients with COVID-19, without increasing other risks. In the absence of a better alternative, clinicians could use it with caution.
- |||||||||| moxidectin / Generic mfg., ivermectin oral / Generic mfg.
P3 data, Journal, Adverse events: Onchocerca volvulus microfilariae in the anterior chambers of the eye and ocular adverse events after a single dose of 8 (Pubmed Central) - Mar 20, 2024
The impact of SmfD and mfAC levels before and early after treatment on ocular AEs needs to be better understood before making decisions on the risk-benefit of strategies including DEC. Such decisions should take into account interindividual variability in SmfD, mfAC levels and treatment response and risks to even a small percentage of individuals.
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Journal: Wheel Replacing Pyramid: Better Paradigm Representing Totality of Evidence-Based Medicine. (Pubmed Central) - Mar 8, 2024
A T-EBM Wheel can be created for any proprietary or generic medicine. The ivermectin (IVM) T-EBM Wheel displays the efficacy of IVM-based treatments of COVID-19 in a color-coded graphic, visualizing each type of evidence and the proportions of each of their outcomes (positive, inconclusive, negative).
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PK/PD data, Journal: Utility of sustainable ratio derivative spectrophotometry for the concurrent assay of synergistic repurposed drugs for COVID-19 infections; Insilico pharmacokinetics proof. (Pubmed Central) - Mar 8, 2024
The cutting-edge combination of fluvoxamine (FVM) and ivermectin (IVM) has been presented as a proposed dosage form for the treatment of COVID-19 infections in early diagnosed patients...Continuing the constant pursuit of greenness, drug-drug interactions (DDIs) between FVM & IVM were predicted by insilico tools to ensure the safety of the suggested mixture as a preliminary step before invitro and in vivo studies. Because they were deemed sustainable, affordable, and successful, the suggested UV-methods may be used for routine quality control investigations of the indicated formulations FVM & IVM.
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DRUGS USED FOR COVID-19, IMPLICATIONS TO THE RENAL FUNCTION, AND PROSPECTS (TUE-092; Main Foyer) - Mar 8, 2024 - Abstract #ISNWCN2024ISN_WCN_984;
Medicines used without proof may have had negative consequences for the population, not just by the nephrologic diseases, but to the other areas of health, including the drop in supply. Furthermore, research has evolved to reduce mortality rates through the most diverse pharmacological routes, however, the only safe way to combat the disease still remains prevention.
- |||||||||| emodepside (BAY 44-4400) / Bayer
Enrollment closed: DNDi-EMO-04: Emodepside Phase II Trial for Treatment of Onchocerciasis (clinicaltrials.gov) - Mar 5, 2024
P2, N=578, Active, not recruiting,
Furthermore, research has evolved to reduce mortality rates through the most diverse pharmacological routes, however, the only safe way to combat the disease still remains prevention. Recruiting --> Active, not recruiting
- |||||||||| chloroquine phosphate / Generic mfg., ivermectin oral / Generic mfg.
Journal: Inefficacious drugs against covid-19: analysis of sales, tweets, and search engines. (Pubmed Central) - Mar 4, 2024
The results contribute to decision making in crisis management by governments, industries, and stores. In times of crisis, as observed during the covid-19 pandemic, some variables can help sales forecasting, especially Google
- |||||||||| ivermectin oral / Generic mfg., albendazole / Generic mfg.
Enrollment closed: Broad One Health Endectocide-based Malaria Intervention in Africa (BOHEMIA) (clinicaltrials.gov) - Feb 29, 2024
P3, N=53000, Active, not recruiting,
Further trials of ivermectin for SARS-Cov-2 infection in vaccinated community populations appear unwarranted. Recruiting --> Active, not recruiting
- |||||||||| Journal: Repurposed Drugs That Activate Autophagy in Filarial Worms Act as Effective Macrofilaricides. (Pubmed Central) - Feb 24, 2024
Current control strategies are based on annual or biannual mass drug administration (MDA) of the drugs Ivermectin or Ivermectin plus Albendazole, respectively...A 4-6-week antibiotic therapy with doxycycline, for example, resulted in the loss of Wolbachia that subsequently led to extensive apoptosis of somatic cells, germline, embryos, and microfilariae, as well as inhibition of fourth-stage larval development...All three drugs given orally significantly reduced Wolbachia loads and induced an increase in levels of lysosome-associated membrane protein in worms from treated animals, suggesting that Niclosamide, NEN, and Rottlerin were effective in causing drug-induced autophagy in these filarial worms. These repurposed drugs provide a new avenue for the clearance of adult worms in filarial infections.
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Demodicosis and ivermectin-associated Mazzotti-like reactions in hematopoietic cell transplant recipients: a case series () - Feb 20, 2024 - Abstract #AAD2024AAD_2867;
A total of 16 patients were treated with oral ivermectin and one received topical steroids...When evaluating folliculocentric facial eruptions in patients after HCT, demodicosis should be considered. Further research is needed to determine if demodicosis in this context represents an infestation or a post-engraftment inflammatory response to commensal mites.
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Chronic Strongyloides Infection Causing Pulmonary Eosinophilia (San Diego Convention Center, Area H (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_4067;
This is an often neglected etiology of helminth infections within the USA, as most recent studies have focused on imported cases. Our case highlights endemic Strongyloides infection as an important cause of pulmonary pathology in the USA and the need for screening prior to initiation of immunosuppression, in order to avoid feared consequences such as hyperinfection syndrome.
- |||||||||| prednisone / Generic mfg., ivermectin oral / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
Acute Hypoxic Respiratory Failure After Steroid Treatment in a Case of Strongyloidiasis Masquerading as Asthma (San Diego Convention Center, Area H (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_4066;
The patient was treated with multiple nebulizers, solumedrol 125 mg, and antibiotics and discharged on 50 mg prednisone for five days...Further, worsening symptoms following steroid administration may be delayed several weeks. While routine screening for Strongyloidiasis is not recommended for all patients before steroid treatment for COPD or asthma, it should be considered in patients with a history of immigration or travel to endemic areas.
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Pulmonary Strongyloidiasis and Hyperinfection in a High-Risk Factors Patient (San Diego Convention Center, Area H (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_4065;
March 2022 the patient was diagnosed with lymphoma non-hogkin and commencing with chemotherapy every 3 weeks including:Rituximab 1400mg,Cyclophosphamid 500 mg, Epirubicin hydroclorid 50 mg, Vincristin sulfat 2 mg, Methylprednisolon 40 mg...Chest CTscan: diffuse glass -ground opacities in both lungs and the cavitary lesion in upper right lung S5Patient's Progress:Patient was started on treatment Meropenem 1g,Tygacil 50 mg, Ivermectin 6 mg plus Albendazole 400 mg and his immunosuppressants were stopped...Cyclophosphamidec...However, diagnosis might be challenging due to non-specific clinical features. Thus, a high level of suspicion is mandatory for early diagnosis,especially in immunocompromised patients.
- |||||||||| prednisone / Generic mfg., ivermectin oral / Generic mfg., fluconazole oral / Generic mfg.
Enigmatic Eosinophils (San Diego Convention Center, Area E (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_3520;
Repeat CT imaging improved rapidly over the next few days and the patient was discharged home on fluconazole and a prednisone taper...We present two cases of hypoxemic respiratory failure associated with severe peripheral and intrapulmonary eosinophilia as well as elevated IgE in the setting of acute pulmonary coccidioidomycosis and presence of strongyloides antibody. The roles of steroids, antihelminthic therapy, and dual antifungal therapy complicated the already complex clinical picture given the need to balance the risks and benefits of immunosuppression for acute eosinophilic pneumonia or hypereosinophilic syndrome while treating concurrent infections.
- |||||||||| prednisone / Generic mfg., ivermectin oral / Generic mfg., ivermectin topical / Generic mfg.
The Complexity of Diagnosing Secondary Organizing Pneumonia (San Diego Convention Center, Area C (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_1647;
The patient was given systemic corticosteroids and discharged on a prolonged prednisone taper...Nonetheless, it was an important finding given the need for corticosteroids for OP, and risk for Strongyloides hyperinfection syndrome if untreated. This case points to the difficulty in making the diagnosis of secondary organizing pneumonia as well as the importance of screening in patients with exposure risk for organisms that can complicate OP therapy.
- |||||||||| Veramyst (fluticasone furoate nasal spray) / GSK
Trial completion date, Trial primary completion date: ACTIV-6: COVID-19 Study of Repurposed Medications (clinicaltrials.gov) - Feb 15, 2024
P3, N=15000, Active, not recruiting,
The majority of Malaysians have moderate levels of knowledge and attitude towards ivermectin use as COVID-19 treatment, with a low prevalence of actual use. Trial completion date: Mar 2024 --> Jun 2024 | Trial primary completion date: Mar 2024 --> Jun 2024
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CLINICAL OUTCOMES OF STRONGYLOIDIASIS IN HEMATOPOIETIC CELL TRANSPLANT (HCT) RECIPIENTS (CLYDE) - Feb 14, 2024 - Abstract #EBMT2024EBMT_1144;
Strongyloidiasis occurs early post-HCT posing diagnostic challenges due to multiple factors such as false negative serology, absence of eosinophilia, and presence of GVHD of the gut which can confound the clinical scenario. SQ ivermectin should be considered early on in patients with disseminated infection.
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CLINICAL OUTCOMES OF STRONGYLOIDIASIS IN HEMATOPOIETIC CELL TRANSPLANT (HCT) RECIPIENTS (ePoster area) - Feb 14, 2024 - Abstract #EBMT2024EBMT_1143;
Strongyloidiasis occurs early post-HCT posing diagnostic challenges due to multiple factors such as false negative serology, absence of eosinophilia, and presence of GVHD of the gut which can confound the clinical scenario. SQ ivermectin should be considered early on in patients with disseminated infection.
- |||||||||| ivermectin oral / Generic mfg., albendazole / Generic mfg.
PEDIATRIC STRONGILOIDIOSIS: ONLY AN IMPORTED DISEASE IN SPAIN? (Hall C1M4) - Feb 9, 2024 - Abstract #ESPID2024ESPID_316;
Learning Points/Discussion In conclusion, recognizing strongyloidiosis in children with eosinophilia and relevant symptoms is crucial, considering its cosmopolitan nature and presence in Mediterranean regions. Swift treatment and monitoring are imperative for eradication, especially in potential immunocompromised scenarios.
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