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- ||||| ivermectin oral / Generic mfg.
Clinical: @fortis_hospital @AIIMSNagpur @AIIMSRDA @aiims_rpr @yogrishiramdev @BLK_Hospital @HospitalsApollo @COVIDNewsByMIB @CovidIndiaSeva @DrDatta_AIIMS @Aiims1742 @DrRakeshGarg8 @nsgunionaiims @AjayMohanAIIMS @dr_maheshsharma @PypAyurved @IvermectinDrug https://t.co/0m8FK3MPzS (Twitter) - May 6, 2022
- | ivermectin oral / Generic mfg.
Journal: High infection rates for onchocerciasis and soil-transmitted helminthiasis in children under five not receiving preventive chemotherapy: a bottleneck to elimination. (Pubmed Central) - May 6, 2022
This study reveals that children < 5 years of age are highly infected with STH and onchocerciasis, and could contribute to the spread of these diseases, perpetuating a vicious circle of transmission and hampering elimination efforts. These findings reveal the urgent need to provide (or scale) treatments (likely pediatric formulations) to these preschool-aged children, especially in areas of high transmission, to accelerate efforts to reach WHO 2030 target.
- |||| ivermectin oral / Generic mfg.
Clinical: 🤔I seem to recall Rolling Stone mag not always being the most reliable source…recall the “fake news”…about people over flowing hospitals w overdoses of ivermectin treatments for Covid. Proved to be a complete lie but influenced a LOT of people. They clearly have an agenda! (Twitter) - May 6, 2022
- | ivermectin oral / Generic mfg.
Journal: Ivermectin for the prevention of COVID-19: addressing potential bias and medical fraud. (Pubmed Central) - May 6, 2022
In this meta-analysis, the use of ivermectin was not associated with the prevention of RT-PCR-confirmed or symptomatic COVID-19. The currently available randomized trials evaluating ivermectin for the prevention of COVID-19 are insufficient and of poor quality.
- ||| ivermectin oral / Generic mfg.
I had 3 in my household with bad breathing issues 1 week into symptoms Covid-19 and no one known to having Covid-19 ever went from having a cough,breathing issues,no sense of smell,loss taste body aches and have them all go away except the cough in 3 days. All started ivermectin. (Twitter) - May 6, 2022
- ||||| ivermectin oral / Generic mfg.
FDA event: The U.S. Food and Drug Administration (FDA) has not authorized or approved using ivermectin to prevent or treat COVID-19 in humans and has cautioned about the potential risks of using ivermectin for COVID-19.Feb 1, 2022 (Twitter) - May 5, 2022
- | ivermectin oral / Generic mfg.
Journal: A VSV-based assay quantifies coronavirus Mpro/3CLpro/Nsp5 main protease activity and chemical inhibition. (Pubmed Central) - May 5, 2022
Moreover, we show that the system can be adapted to report both the function and the chemical inhibition of proteases from different coronavirus species as well as from distantly related viruses. Together with the fact that live cell assays also reflect compound permeability and toxicity, we anticipate that this system will be useful for both identification and optimization of additional coronavirus protease inhibitors.
- |||| ivermectin oral / Generic mfg.
Clinical: Effect of Early Treatment with Ivermectin among Patients with Covid-19 | NEJM https://t.co/fTs7Qyy6pi (Twitter) - May 5, 2022
- ||| ivermectin oral / Generic mfg.
Clinical: @NEJM: #Ivermectin nicht besser als #Placebo bei Verhinderung schwerer Verläufe von #COVID19. https://t.co/c6Kz8v7jFE (Twitter) - May 5, 2022
- | ivermectin oral / Generic mfg.
New P1 trial: CMHatd-ETH-23-derm-22: Comparative Study Between Topical Permethrin 5% and Oral Ivermectin for the Treatment of Scabies (clinicaltrials.gov) - May 5, 2022
P1, N=100, Completed, Sponsor: Combined Military Hospital Abbottabad
- || ivermectin oral / Generic mfg.
Review, Journal: Antimicrobials in COVID-19: strategies for treating a COVID-19 pandemic. (Pubmed Central) - May 4, 2022
During the initial phase of this pandemic, hydroxychloroquine, ivermectin, azithromycin and doxycycline were widely suggested for possible prophylaxis or treatment for COVID-19 in outpatient as well as hospitalized settings...Antimicrobial resistance (AMR) was one of the top problems for global public health before the coronavirus 2019 (COVID-19) pandemic began. AMR, which is already a difficult problem, must now be handled in the context of a changing healthcare sector.
- ||| ivermectin oral / Generic mfg.
You know bc we have this “Additional adequately powered, well-designed, and well-conducted trials are needed to evaluate the effect of ivermectin on COVID-19” and then all the trials are being delayed just a little weird to me after 3 years (Twitter) - May 3, 2022
- ||| ivermectin oral / Generic mfg.
There is no magic pill for COVID and there likely never will be. All this talk just reminds me of the Ivermectin talk last year. (Twitter) - May 3, 2022
- || ivermectin oral / Generic mfg.
Review, Journal: Drug safety of frequently used drugs and substances for self-medication in COVID-19. (Pubmed Central) - May 3, 2022
The aim of this review is to describe the available evidence regarding the efficacy, safety, and monitoring of the drugs and substances that have been shown to be frequently used for self-medication in patients with COVID-19 (hydroxychloroquine, non-steroidal anti-inflammatory drugs, ivermectin, azithromycin, vitamins, aspirin, and chlorine dioxide) to adequately characterize their risks, safe use, monitoring strategies, and to reinforce the concept that these substances should not be used for self-medication and require a medical prescription...In this review, we included drugs that are frequently used for self-medication and commonly advertised such as ivermectin, hydroxychloroquine, chlorine dioxide, azithromycin, and non-steroidal anti-inflammatory drugs, among others. A brief introduction of the drug and its mechanism of action, followed by a summary of the efficacy in COVID-19 and safety, will be described for each drug in order to promote their responsible use.
- | ivermectin oral / Generic mfg., albendazole / Generic mfg.
Journal: New 1H-benzimidazole-2-yl hydrazones with combined antiparasitic and antioxidant activity. (Pubmed Central) - May 3, 2022
The anthelmintic activity on encapsulated T. spiralis was studied in vitro thus indicating that all hydrazones were more active than the clinically used anthelmintic drugs albendazole and ivermectin...The relative radical scavenging ability of compounds 5a-l showed a good correlation to the experimentally observed trends. It was found that the studied compounds are capable to react with various free radicals - ˙OCH, ˙OOH and ˙OOCH, through several possible reaction pathways - HAT in nonpolar medium, SPLET in polar medium and RAF in both media.
- | ivermectin oral / Generic mfg., albendazole / Generic mfg.
Enrollment open, Trial completion date, Trial primary completion date: Broad One Health Endectocide-based Malaria Intervention in Africa (BOHEMIA) (clinicaltrials.gov) - May 3, 2022
P3, N=100000, Recruiting, Sponsor: Barcelona Institute for Global Health
It was found that the studied compounds are capable to react with various free radicals - ˙OCH, ˙OOH and ˙OOCH, through several possible reaction pathways - HAT in nonpolar medium, SPLET in polar medium and RAF in both media. Not yet recruiting --> Recruiting | Trial completion date: Mar 2023 --> Mar 2024 | Trial primary completion date: Jun 2022 --> Oct 2022
- || ivermectin oral / Generic mfg.
Ohio… the state where it may soon be illegal for doctors NOT to suggest Ivermectin for Covid… https://t.co/63O1vumF2W (Twitter) - May 2, 2022
- ||||| ivermectin oral / Generic mfg.
Clinical: Ivermectin can be easily produced in any lab and no company owns the rights to produce it. Merck, on the other hand, produces their own pills to combat Covid, and just recently shut down their own vaccine trials. The fact that you cited a Merck article here is laughable at best (Twitter) - May 2, 2022
- ||| ivermectin oral / Generic mfg.
🤣🤣🤣 Ya me dio COVID, me cure con ivermectina, ibuprofeno, antigripal y dioxido de cloro. NO me voy a vacunar contra COVID Gracias a Dios no tuve que consultar a los matarnos de @jlunamd, @easturia ni @DrCalgua (Twitter) - May 1, 2022
- ||| ivermectin oral / Generic mfg.
Sounds like their symptoms were minimal, while they were both high risk and not likely to have such minimal effects from the virus. Ivermectin has shown to be an effective early treatment for Covid. https://t.co/SaGdSK2mSK (Twitter) - May 1, 2022
- |||| ivermectin oral / Generic mfg.
Clinical: At the time I became infected 1st time, the vaccines weren’t available and I was high risk with three co-morbidities. I had researched and found FLCCC. They offered practices that prescribed therapeutics. Ivermectin significantly reduced my viral load. Much less severe infection. (Twitter) - May 1, 2022
- |||| ivermectin oral / Generic mfg.
Clinical: I'm referring to people accusing the gov't both of lockdown tyranny and covid conspiracy coverups (autoimmune hepatitis). Make up your mind. With hepatitis the truth is nobody knows but "medtwitter" has solved the mystery. No different than Ivermectin being the cure! (Twitter) - May 1, 2022
- ||| ivermectin oral / Generic mfg.
Part D: Superfund proven antiviral treatments, again, with free masks, air filters, and help to hurt businesses and employees. Unfortunately ivermectin does NOT work for Covid according to numerous peer-reviewed RCT studies: that debate is over. Rinse and repeat... (Twitter) - Apr 30, 2022
- |||| hydroxychloroquine / Generic mfg., ivermectin oral / Generic mfg., oseltamivir / Generic mfg.
Clinical: That’s also why most experienced people assumed hydroxychloroquine, ivermectin, etc., would not actually be helpful. If Tamiflu is the best we’ve made for influenza over all these years, it would have been quite remarkable for something useful vs. COVID to just be laying around. (Twitter) - Apr 30, 2022
- ||| ivermectin oral / Generic mfg.
And yet Fauci is on record recognizing ivermectin as a treatment for covid in the 90s. Weird, huh? (Twitter) - Apr 30, 2022
- || ivermectin oral / Generic mfg.
PK/PD data, Preclinical, Journal: Pharmacokinetics and Safety of Inhaled Ivermectin in Mice as a Potential COVID-19 Treatment. (Pubmed Central) - Apr 29, 2022
Pharmacokinetic limitations associated with oral ivermectin may limit its success as a potential COVID-19 treatment based on in vitro experiments which demonstrate antiviral efficacy against SARS-CoV-2 at high concentrations...Inhalation delivery of ivermectin formulation showed improved pharmacokinetic performance as it avoided protein binding encountered in systemic delivery and maintained a high exposure above the in vitro antiviral concentration in the respiratory tract for at least 24 hr. The local toxicity was mild with less than 20% of the lung showing histological damage at 24 hr, which resolved to 10% by 48 hr.
- | ivermectin oral / Generic mfg., ivermectin topical / Generic mfg.
Journal: Red blood cells-hitchhiking mediated pulmonary delivery of ivermectin: effects of nanoparticles properties. (Pubmed Central) - Apr 29, 2022
Therefore, RBC-hitchhiking provides an alternative strategy to improve IVM pharmacokinetics and bioavailability for repurposing of IVM to treat COVID-19. Furthermore, according to different redistribution effects of different NPs, RBCs-hitchhiked NPs may achieve various accumulation rates and circulation times for different requirements of drug delivery.
- |||| prednisone / Generic mfg., ivermectin oral / Generic mfg.
Clinical, Cytokine storm: If ivermectin was preventing deaths by preventing cytokine storms, a steroid like prednisone would be much more effective. But no most people die from the damage done to their respiratory system while they fight the virus. Hence why people die weeks after contracting covid (Twitter) - Apr 29, 2022
- || ivermectin oral / Generic mfg.
Clinical, Journal: Effects of the Covid-19 pandemic on head lice and scabies infestation dynamics: a population based study in France. (Pubmed Central) - Apr 28, 2022
COVID-19 lockdown and physical distancing reduce circulation of head lice and scabies in France. Further studies are needed to assess the long-term impact of these social behaviour changes.
- | ivermectin oral / Generic mfg.
Journal: A Multimodal Strategy to Reduce the Risk of Hospitalization/death in Ambulatory Patients with COVID-19. (Pubmed Central) - Apr 28, 2022
Further studies are needed to assess the long-term impact of these social behaviour changes. Use of a multimodal strategy may reduce the risk of hospitalization and death in adult outpatients with mild COVID-19.
- || ivermectin oral / Generic mfg.
Review, Journal: Strongyloides stercoralis. (Pubmed Central) - Apr 28, 2022
Patients with exposure to endemic areas and those expected to become immune suppressed should be screened and treated before starting immune suppressive agents. Empiric treatment should be considered when timely testing is not readily available.
- || ivermectin oral / Generic mfg.
Review, Journal: Advancing a Human Onchocerciasis Vaccine From Antigen Discovery to Efficacy Studies Against Natural Infection of Cattle With Onchocerca ochengi. (Pubmed Central) - Apr 28, 2022
Thus, the development of a vaccine that would induce protective immunity and reduce infection burden is essential. Efforts to develop prophylactic and/or therapeutic vaccines for onchocerciasis have been explored since the late 1980s by many researchers and entities, and here we summarize the recent advances made in the development of vaccines against the infection of O. volvulus and onchocerciasis.
- | ivermectin oral / Generic mfg.
Journal: Black flies and Onchocerciasis: Knowledge, attitude and practices among inhabitants of Alabameta, Osun State, Southwestern, Nigeria. (Pubmed Central) - Apr 28, 2022
Efforts to develop prophylactic and/or therapeutic vaccines for onchocerciasis have been explored since the late 1980s by many researchers and entities, and here we summarize the recent advances made in the development of vaccines against the infection of O. volvulus and onchocerciasis. Due to lack of resident's knowledge on black flies bioecology which may continuously expose them to the bite of the flies and ultimately infection, it is paramount that the Osun State government and the NTD implementing partner map out new public health education strategies during routine Mass Administration of Medicines with Ivermectin with a view to preventing onchocerciasis infection as well as man-vector contact.
- |||| ivermectin oral / Generic mfg.
Clinical: Abundant amount of research studies showing the opposites. Questioning the findings of multiple meta-analyses is penultimate anti-science. And can someone explain why the lowest rates of Covid are in sub-Saharan African countries regularly taking ivermectin? (Twitter) - Apr 28, 2022
- |||| hydroxychloroquine / Generic mfg., ivermectin oral / Generic mfg.
Clinical: Bullshit. Covid is just a cold. Ivermectin, hydroxychloroquine, zinc etc. all lessen symptoms of this cold. Thousands of reputable doctors have reported on this but morons like Fauci, yourself and Twitter censored the truth so the masses won’t find out about depopulation. (Twitter) - Apr 28, 2022
- |||| ivermectin oral / Generic mfg.
Clinical: Ivermectin has never been claimed by anyone worth their salt to be the sole reducer to risk of Covid but instead they stated it in conjunction of other medications and vitamins do you see a reduction. This double blind placebo doesn’t address the actual claim. (Twitter) - Apr 28, 2022
- |||| ivermectin oral / Generic mfg.
Clinical: My 81 year old Father-in-law was in hospital with COVID, on his deathbed…family asked doctor to try Ivermectin, he was better the next morning!!! People need to mind their own freaking business, and let patients & doctors decide what’s right for them, PERIOD!!! (Twitter) - Apr 28, 2022
- ||| ivermectin oral / Generic mfg.
If you have a roundworm infestation that's sensitive to it, #ivermectin is a *fantastic* drug. For #COVID19, not so much... (Twitter) - Apr 28, 2022
- |||| ivermectin oral / Generic mfg.
Clinical: Sub-Saharan Africa, too, where they regularly take ivermectin - as recommended by the WHO. Wonder where we find the lowest cases of Covid? (Twitter) - Apr 28, 2022
- |||| ivermectin oral / Generic mfg.
Clinical: I don't know anyone that took ivermectin while they had covid but I did personally know people that were vexed up and still died so listen to whoever you want I guess. (Twitter) - Apr 28, 2022
- |||| ivermectin oral / Generic mfg., ivermectin topical / Generic mfg.
Clinical, Cytokine storm: Search up on DuckDuckGo, “research ivermectin anti-inflammatory” between 2010-2019. Nobody has said it’s an anti-viral. People are arguing that it lowers mortality because of its effect on the cytokine storm in Covid (Twitter) - Apr 28, 2022
- ||| ivermectin oral / Generic mfg.
Where does it say that in the study? I can’t see anything that compares effectiveness based on how long after someone had Covid and received ivermectin. Just that it is within 7 days. Which is, telling. You would that an extremely important piece of information to share (Twitter) - Apr 28, 2022
- |||| ivermectin oral / Generic mfg., ivermectin topical / Generic mfg.
Clinical, Cytokine storm: Not only this, but early on we had discovered the mechanism by which ivermectin worked. Most Covid deaths occur from cytokine storms, and ivermectin has known anti-inflammatory effects for toll-like receptors, esp. those causing respiratory issues in adv. Covid cases. (Twitter) - Apr 28, 2022
- ||| ivermectin oral / Generic mfg.
Ivermectin cures Covid. (Twitter) - Apr 27, 2022
- ||| ivermectin oral / Generic mfg.
Translation: If you get Covid, taking Ivermectin after you've had it for 7 days won't help at all. Great, thanks. Look in the report for mentions of use as a prophylactic, which is exactly where studies have shown it to be effective. (Twitter) - Apr 27, 2022
- |||| ivermectin oral / Generic mfg.
Clinical: Well, It worked for me. SO well in fact, I didn't get sick AT ALL. Took as a prophylactic and was 100% knee deep in COVID for a week. Multiple people tested positive for COVID... Including my wife. She used Ivermectin & was better in 3 days. Others didn't & were sick for 3 weeks. (Twitter) - Apr 27, 2022
- ||| ivermectin oral / Generic mfg.
Ivermectin works against Covid. Period. (Twitter) - Apr 27, 2022
- || ivermectin oral / Generic mfg.
So you knew as a kid that ivermectin wasn’t effective against corona? Are you like a soothsayer? (Twitter) - Apr 27, 2022
- | ivermectin oral / Generic mfg.
Journal: Clinical parameters of hypervirulent Klebsiella pneumoniae disease and ivermectin treatment in New Zealand sea lion (Phocarctos hookeri) pups. (Pubmed Central) - Apr 27, 2022
On comparison of haematological parameters between ivermectin-treated and control pups, significantly lower total plasma protein and higher eosinophil counts were seen in control versus treated pups, however standard length as a surrogate for age was a more important influence on parameters overall than ivermectin treatment. This study also highlighted a cohort of pups with severe clinical signs suggestive of hypervirulent K. pneumoniae infection were lost to follow up at the end of the monitored season, which could be contributing to cryptic juvenile mortality.
- || ivermectin oral / Generic mfg., indomethacin / Generic mfg.
Clinical, Journal: An open label randomized clinical trial of Indomethacin for mild and moderate hospitalised Covid-19 patients. (Pubmed Central) - Apr 27, 2022
The fourteenth-day follow-up revealed that the paracetamol arm patients had faced several discomforts; indomethacin arm patients mostly complained only of tiredness. Indomethacin is a safe and effective drug for treating patients with mild and moderate covid-19.