ivermectin oral / Generic mfg. 
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  • ||||||||||  amiodarone / Generic mfg.
    Primary Cardiac Allograft Dysfunction Caused by Pretransplantation Amiodarone Therapy (Zone 2, Science and Technology Hall, Level 3; Poster Board no. 2158) -  Aug 11, 2022 - Abstract #AHA2022AHA_4648;    
    Induction therapy was administered with ATG, Solumedrol and mycophenolate mofetil... Amiodarone associated PGD may be underreported and increasing awareness of this etiology may warrant early empiric discontinuation of the medication if transplantation remains a therapeutic option in the future.
  • ||||||||||  ivermectin oral / Generic mfg.
    Enrollment closed:  A Phase III Confirmatory Study of K-237 (clinicaltrials.gov) -  Aug 9, 2022   
    P3,  N=1030, Active, not recruiting, 
    Finally, the results showed that Paxlovid despite beingbound in different sites through covalent or non-covalent forms behaves similarly in terms of its structural flexibility and volumetric behaviour. Recruiting --> Active, not recruiting
  • ||||||||||  metformin / Generic mfg., ivermectin oral / Generic mfg., fluvoxamine / Generic mfg.
    Trial primary completion date:  COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19) (clinicaltrials.gov) -  Aug 8, 2022   
    P3,  N=1350, Active, not recruiting, 
    Recruiting --> Active, not recruiting Trial primary completion date: Feb 2023 --> Feb 2022
  • ||||||||||  ivermectin oral / Generic mfg.
    Immune Thrombocytopenic Purpura Secondary To Covid-19 (Screen # 1) -  Aug 7, 2022 - Abstract #PANLAR2022PANLAR_140;    
    Immune thrombocytopenic purpura (ITP) is diagnosed and prednisone 40 mg once daily for one month with clinical remission of skin lesions...When treatment is started, platelet count start to increase and it usually resolves within the first two months without necessarily identifying the cause. If not, splenectomy may be performed.
  • ||||||||||  ivermectin oral / Generic mfg.
    Review, Journal:  COVID-19 in Latin America and the Caribbean: Two years of the pandemic. (Pubmed Central) -  Aug 7, 2022   
    While there were hopes that herd immunity could beachieved after the region's disastrous first peak, the emergence of the Gamma, Lambda, and Mu variants made this unattainable. This review explores how Latin America and the Caribbean fared during the first two years of the pandemic, and how, despite all the challenges, the region became a global leader in COVID-19 vaccination, with 63% of its population fully vaccinated.
  • ||||||||||  ivermectin oral / Generic mfg.
    Journal:  Adoption and Deadoption of Medications to Treat Hospitalized Patients With COVID-19. (Pubmed Central) -  Aug 6, 2022   
    During the COVID-19 pandemic, medication treatment patterns evolved reliably in response to emerging evidence and changes in policy. These findings may inform efforts to promote optimal adoption and deadoption of treatments for acute care conditions.
  • ||||||||||  hydroxychloroquine / Generic mfg., darunavir/ritonavir / Generic mfg., ivermectin oral / Generic mfg.
    Journal:  A Randomized Controlled Trial of Combined Ivermectin and Zinc Sulfate versus Combined Hydroxychloroquine, Darunavir/Ritonavir, and Zinc Sulfate among Adult Patients with Asymptomatic or Mild Coronavirus-19 Infection. (Pubmed Central) -  Aug 3, 2022   
    We conducted an open-labeled, randomized, controlled trial to compare the efficacy between a 3-day course of once-daily high-dose oral ivermectin plus zinc sulfate (Group A) and a combination of HQ, darunavir/ritonavir, and zinc sulfate (HQ + antiretroviral, Group B) for 5 days in asymptomatic or mild SARS-CoV-2 infection...Two patients in Group A and one patient in Group B were considered clinically worsening and received 10 days of favipiravir treatment...We demonstrated that both treatment regimens were safe, but both treatment regimens had no virological or clinical benefit. Based on this result and current data, there is no supporting evidence for the clinical benefit of ivermectin for coronavirus-19.
  • ||||||||||  ivermectin oral / Generic mfg., albendazole / Generic mfg.
    Journal:  Loa loa in the Vitreous Cavity of the Eye: A Case Report and State of Art. (Pubmed Central) -  Aug 2, 2022   
    Unlike other endemic parasite infections, L. loa is not included in the Global Program to Eliminate Lymphatic Filariasis, because it is not mentioned in the WHO and CDC list of neglected tropical diseases. This can result in an overall risk of lack of attention and studies on loiasis, with lack of data on global burden of the disease.
  • ||||||||||  ivermectin oral / Generic mfg.
    Journal:  Misleading Meta-Analyses during COVID-19 Pandemic: Examples of Methodological Biases in Evidence Synthesis. (Pubmed Central) -  Jul 29, 2022   
    Through these selected examples, we highlight the need to address biases related to the methodological quality and relevance of study designs and effect size computations and considerations for critical appraisal of available data in the evidence synthesis process for better quality evidence. Such considerations help researchers and decision makers avoid misleading conclusions, while encouraging the provision of the best policy recommendations for individual and public health.
  • ||||||||||  ivermectin oral / Generic mfg.
    Journal:  Manipulation of Spray-Drying Conditions to Develop an Inhalable Ivermectin Dry Powder. (Pubmed Central) -  Jul 29, 2022   
    In summary, we were able to manipulate the spray-drying conditions to develop an effective ivermectin inhalable dry powder. Ongoing studies based on this system will allow the development of novel formulations based on single or combinations of drugs that could be used to inhibit SARS-CoV-2 replication in the respiratory tract.
  • ||||||||||  ivermectin oral / Generic mfg.
    Journal, Adverse drug reaction:  Sales of "COVID kit" drugs and adverse drug reactions reported by the Brazilian Health Regulatory Agency. (Pubmed Central) -  Jul 28, 2022   
    Off-label use of azithromycin, hydroxychloroquine, and ivermectin (the "COVID kit") has been suggested for COVID-19 treatment in Brazil without clinical or scientific evidence of efficacy...Data must be interpreted cautiously since no active search for ADR was performed. Our results show that the increased and indiscriminate use of "COVID kit" during the pandemic correlates to an increased occurrence of ADRs.
  • ||||||||||  ivermectin oral / Generic mfg.
    Journal:  Evidence in decision-making in the context of COVID-19 in Latin America. (Pubmed Central) -  Jul 27, 2022   
    This study was undertaken between February-May 2021 and aims to characterise the best available evidence (BAE) and assess the extent to which it was used to inform decision-making in 21 Latin American countries, in relation to pharmaceutical (PI) and non-pharmaceutical interventions (NPI) related to COVID-19, including the use of therapeutics (corticosteroids, hydroxychloroquine/chloroquine and ivermectin), facemask use in the community setting and the use of diagnostic tests as a requirement for international travel...Institutionalising this process and grounding it in existing and emerging methodologies can facilitate the rapid response in an emergency setting. No funding was sourced for this work.